Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Ren J et al. | Protective effect of dexmedetomidine against myocardial ischemia-reperfusion injury in rabbits. | 2018 | Acta Cir Bras | pmid:29412230 |
Shi K et al. | Identification and functional analyses of differentially expressed metabolites in early stage endometrial carcinoma. | 2018 | Cancer Sci. | pmid:29436067 |
Hasegawa A et al. | Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29269296 |
Zhang X et al. | Serum metabolomics of laryngeal cancer based on liquid chromatography coupled with quadrupole time-of-flight mass spectrometry. | 2018 | Biomed. Chromatogr. | pmid:29272549 |
Moschos MM et al. | Anti-platelet effects of anti-glaucomatous eye drops: an in vitro study on human platelets. | 2017 | Drug Des Devel Ther | pmid:28458520 |
Argyrou C et al. | Postprandial effects of wine consumption on Platelet Activating Factor metabolic enzymes. | 2017 | Prostaglandins Other Lipid Mediat. | pmid:28323197 |
Holdfeldt A et al. | Reactivation of Gαi-coupled formyl peptide receptors is inhibited by Gαq-selective inhibitors when induced by signals generated by the platelet-activating factor receptor. | 2017 | J. Leukoc. Biol. | pmid:28760822 |
Smith LJ | Leukotrienes and sex: strange bedfellows? | 2017 | J. Clin. Invest. | pmid:28737507 |
Lukic A et al. | GM-CSF- and M-CSF-primed macrophages present similar resolving but distinct inflammatory lipid mediator signatures. | 2017 | FASEB J. | pmid:28637652 |
Xanthopoulou MN et al. | Wine consumption reduced postprandial platelet sensitivity against platelet activating factor in healthy men. | 2017 | Eur J Nutr | pmid:26936842 |
Kispert S et al. | Cigarette Smoke Regulates Calcium-Independent Phospholipase A Metabolic Pathways in Breast Cancer. | 2017 | Am. J. Pathol. | pmid:28618256 |
Kelly AM et al. | The effect of variation in donor platelet function on transfusion outcome: a semirandomized controlled trial. | 2017 | Blood | pmid:28487294 |
Meyer AF et al. | Stereochemistry- and concentration-dependent effects of phosphatidylserine enrichment on platelet function. | 2017 | Biochim. Biophys. Acta | pmid:28472616 |
Malavige GN and Ogg GS | Pathogenesis of vascular leak in dengue virus infection. | 2017 | Immunology | pmid:28437586 |
Shindou H et al. | Relief from neuropathic pain by blocking of the platelet-activating factor-pain loop. | 2017 | FASEB J. | pmid:28341636 |
Kispert SE et al. | Cigarette smoke-induced urothelial cell damage: potential role of platelet-activating factor. | 2017 | Physiol Rep | pmid:28270596 |
Noh KT et al. | Platelet-activating Factor Mediates Endotoxin Tolerance by Regulating Indoleamine 2,3-Dioxygenase-dependent Expression of the Suppressor of Cytokine Signaling 3. | 2017 | J. Biol. Chem. | pmid:28077574 |
Liao YR et al. | Bioactive chemical constituents from the root bark of Morus australis. | 2017 | Bioorg. Med. Chem. Lett. | pmid:27908762 |
Sanz-Vicente I et al. | Enzymatic methods for choline-containing water soluble phospholipids based on fluorescence of choline oxidase: Application to lyso-PAF. | 2017 | Anal. Biochem. | pmid:27956151 |
Moschos MM et al. | In Vitro Effects of Anti-Glaucomatous Eye Drops on Platelet-Activating Factor and its Metabolism. | 2017 | Semin Ophthalmol | pmid:26270771 |