| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infant, Premature, Diseases | D007235 | 7 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Klebsiella Infections | D007710 | 7 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lupus Nephritis | D008181 | 8 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ajiro Y et al. | Platelet-activating factor stimulates sodium-hydrogen exchange in ventricular myocytes. | 2011 | Am. J. Physiol. Heart Circ. Physiol. | pmid:21949111 |
| Ma J et al. | ATP: a mediator for HCl-induced TRPV1 activation in esophageal mucosa. | 2011 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:21960521 |
| Bragado MJ et al. | Platelet-activating factor in Iberian pig spermatozoa: receptor expression and role as enhancer of the calcium-induced acrosome reaction. | 2011 | Reprod. Domest. Anim. | pmid:22023717 |
| Uriarte SM et al. | Granule exocytosis contributes to priming and activation of the human neutrophil respiratory burst. | 2011 | J. Immunol. | pmid:21642540 |
| Frelinger AL et al. | Intrinsic platelet reactivity before P2Y12 blockade contributes to residual platelet reactivity despite high-level P2Y12 blockade by prasugrel or high-dose clopidogrel. Results from PRINCIPLE-TIMI 44. | 2011 | Thromb. Haemost. | pmid:21713327 |
| Byrne SN et al. | The immune-modulating cytokine and endogenous Alarmin interleukin-33 is upregulated in skin exposed to inflammatory UVB radiation. | 2011 | Am. J. Pathol. | pmid:21703403 |
| Semini G et al. | Impact of alkylphospholipids on the gene expression profile of HaCaT cells. | 2011 | Pharmacogenet. Genomics | pmid:21681147 |
| Khan BQ and Kemp SF | Pathophysiology of anaphylaxis. | 2011 | Curr Opin Allergy Clin Immunol | pmid:21659865 |
| Lacy P et al. | Agonist activation of f-actin-mediated eosinophil shape change and mediator release is dependent on Rac2. | 2011 | Int. Arch. Allergy Immunol. | pmid:21576984 |
| Howard KM et al. | Lipopolysaccharide and platelet-activating factor stimulate expression of platelet-activating factor acetylhydrolase via distinct signaling pathways. | 2011 | Inflamm. Res. | pmid:21432021 |
| Jönsson F et al. | Mouse and human neutrophils induce anaphylaxis. | 2011 | J. Clin. Invest. | pmid:21436586 |
| Côrte-Real R et al. | The activity of platelet activating factor-acetyl hydrolase (PAF-AH) in the salivary glands of Rhodnius prolixus. | 2011 | J. Insect Physiol. | pmid:21439293 |
| Orlando RC et al. | Esophageal disease: updated information on inflammation. | 2011 | Ann. N. Y. Acad. Sci. | pmid:21950828 |
| Singh TP et al. | Platelet-activating factor blockade inhibits the T-helper type 17 cell pathway and suppresses psoriasis-like skin disease in K5.hTGF-β1 transgenic mice. | 2011 | Am. J. Pathol. | pmid:21281802 |
| Metz M and Maurer M | Rupatadine for the treatment of allergic rhinitis and urticaria. | 2011 | Expert Rev Clin Immunol | pmid:21162645 |
| Cureton EL et al. | Endothelin-1 attenuates increases in hydraulic conductivity due to platelet-activating factor via prostacyclin release. | 2011 | J. Appl. Physiol. | pmid:21183623 |
| Liu J et al. | Circulating platelet-activating factor is primarily cleared by transport, not intravascular hydrolysis by lipoprotein-associated phospholipase A2/ PAF acetylhydrolase. | 2011 | Circ. Res. | pmid:21183738 |
| Soares PM et al. | Role of platelet-activating factor in the pathogenesis of 5-fluorouracil-induced intestinal mucositis in mice. | 2011 | Cancer Chemother. Pharmacol. | pmid:21153821 |
| Zimmermann LT et al. | Effects of platelet-activating factor on the interaction of Trypanosoma cruzi with Rhodnius prolixus. | 2011 | Parasitol. Res. | pmid:21161276 |
| Lowry P | 1-O-alkenyl-sn-glyceryl-3-phosphorylcholine may be a novel posttranslational modification used by the placenta. | 2011 | Biopolymers | pmid:20564011 |
| Kennedy MA et al. | Srf1 is a novel regulator of phospholipase D activity and is essential to buffer the toxic effects of C16:0 platelet activating factor. | 2011 | PLoS Genet. | pmid:21347278 |
| Saihkay HN et al. | Validating 123I-metaiodobenzylguanidine as a platelet marker for non-invasive imaging in rabbits. | 2011 Jan-Feb | J Pharmacol Toxicol Methods | pmid:20646985 |
| Cingi C et al. | The histopathological effect of thymoquinone on experimentally induced rhinosinusitis in rats. | 2011 Nov-Dec | Am J Rhinol Allergy | pmid:22185737 |
| Chini M et al. | Effects of HAART on platelet-activating factor metabolism in naive HIV-infected patients I: study of the tenofovir-DF/emtricitabine/efavirenz HAART regimen. | 2012 | AIDS Res. Hum. Retroviruses | pmid:22050695 |
| Nordin N et al. | Platelet-activating factor (PAF) receptor binding activity of the roots of Enicosanthellum pulchrum. | 2012 | Pharm Biol | pmid:22103812 |
| Tanaka Y et al. | Stimulation of Ly-6G on neutrophils in LPS-primed mice induces platelet-activating factor (PAF)-mediated anaphylaxis-like shock. | 2012 | J. Leukoc. Biol. | pmid:22131343 |
| Shi W et al. | The nondepolarizing, normokalemic cardioplegia formulation adenosine-lidocaine (adenocaine) exerts anti-neutrophil effects by synergistic actions of its components. | 2012 | J. Thorac. Cardiovasc. Surg. | pmid:22079877 |
| Detopoulou P et al. | PAF and its metabolic enzymes in healthy volunteers: interrelations and correlations with basic characteristics. | 2012 | Prostaglandins Other Lipid Mediat. | pmid:22079887 |
| Jalil J et al. | Platelet-activating factor (PAF) antagonistic activity of a new biflavonoid from Garcinia nervosa var. pubescens King. | 2012 | Molecules | pmid:22964504 |
| Kakazu A et al. | Lipoxin Aâ‚„ inhibits platelet-activating factor inflammatory response and stimulates corneal wound healing of injuries that compromise the stroma. | 2012 | Exp. Eye Res. | pmid:22828048 |
| Uomo G | Lesson from acute experimental pancreatitis: multidrug strategies is effective than single-target therapy. | 2012 | JOP | pmid:22964964 |
| Huang LG et al. | [Effects of glycomacropeptide on damage to intestinal tissue and apoptosis of intestinal epithelial cells in neonatal rats with necrotizing enterocolitis]. | 2012 | Zhonghua Er Ke Za Zhi | pmid:22932017 |
| Pawlowic MC and Zhang K | Leishmania parasites possess a platelet-activating factor acetylhydrolase important for virulence. | 2012 | Mol. Biochem. Parasitol. | pmid:22954769 |
| Nitoda E et al. | Ocular actions of platelet-activating factor: clinical implications. | 2012 | Expert Opin. Ther. Targets | pmid:22924390 |
| Sahu RP et al. | Loss of the platelet activating factor receptor in mice augments PMA-induced inflammation and cutaneous chemical carcinogenesis. | 2012 | Carcinogenesis | pmid:22223848 |
| Conejeros I et al. | 2-Aminoethoxydiphenyl borate (2-APB) reduces alkaline phosphatase release, CD63 expression, F-actin polymerization and chemotaxis without affecting the phagocytosis activity in bovine neutrophils. | 2012 | Vet. Immunol. Immunopathol. | pmid:22226550 |
| Dumas E et al. | Angiopoietin-1 but not angiopoietin-2 promotes neutrophil viability: Role of interleukin-8 and platelet-activating factor. | 2012 | Biochim. Biophys. Acta | pmid:22198097 |
| López-Sagaseta J et al. | sPLA2-V inhibits EPCR anticoagulant and antiapoptotic properties by accommodating lysophosphatidylcholine or PAF in the hydrophobic groove. | 2012 | Blood | pmid:22167755 |
| Iyú D et al. | The role of prostanoid receptors in mediating the effects of PGE3 on human platelet function. | 2012 | Thromb. Haemost. | pmid:22318645 |
| Xu LF et al. | Protective effect of intestinal trefoil factor on injury of intestinal epithelial tight junction induced by platelet activating factor. | 2012 | Inflammation | pmid:21452036 |
| Flasiński M et al. | Behavior of platelet activating factor in membrane-mimicking environment. Langmuir monolayer study complemented with grazing incidence X-ray diffraction and Brewster angle microscopy. | 2012 | J Phys Chem B | pmid:22834697 |
| Yuan D and He P | Vascular remodeling alters adhesion protein and cytoskeleton reactions to inflammatory stimuli resulting in enhanced permeability increases in rat venules. | 2012 | J. Appl. Physiol. | pmid:22837164 |
| Gorman S and Hart PH | The current state of play of rodent models to study the role of vitamin D in UV-induced immunomodulation. | 2012 | Photochem. Photobiol. Sci. | pmid:22898802 |
| Zhang XT et al. | [Study on the pharmacokinetics of ginkgolide B for injection in rats]. | 2012 | Zhong Yao Cai | pmid:22876684 |
| Flamm MH et al. | Multiscale prediction of patient-specific platelet function under flow. | 2012 | Blood | pmid:22517902 |
| Kim HA et al. | PTEN/MAPK pathways play a key role in platelet-activating factor-induced experimental pulmonary tumor metastasis. | 2012 | FEBS Lett. | pmid:23137704 |
| Jiang Z et al. | The effect of lipoprotein-associated phospholipase A2 deficiency on pulmonary allergic responses in Aspergillus fumigatus sensitized mice. | 2012 | Respir. Res. | pmid:23140447 |
| Juchem G et al. | Regulation of coronary venular barrier function by blood borne inflammatory mediators and pharmacological tools: insights from novel microvascular wall models. | 2012 | Am. J. Physiol. Heart Circ. Physiol. | pmid:22081707 |
| Saadawi S et al. | Inhibitory effects of acetylmelodorinol, chrysin and polycarpol from Mitrella kentii on prostaglandin Eâ‚‚ and Thromboxane Bâ‚‚ production and platelet activating factor receptor binding. | 2012 | Molecules | pmid:22538486 |
| Oh SF et al. | Resolvin E2 formation and impact in inflammation resolution. | 2012 | J. Immunol. | pmid:22450811 |