| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infant, Premature, Diseases | D007235 | 7 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Klebsiella Infections | D007710 | 7 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lupus Nephritis | D008181 | 8 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Namm DH and High JA | Thrombin-induced formation of a polar lipid material within platelets that possesses platelet-activating activity. | 1980 | Thromb. Res. | pmid:7209881 |
| Tencé V et al. | Release, purification, and characterization of platelet-activating factor (PAF). | 1980 | Biochimie | pmid:17941181 |
| Bussolino F and Benveniste J | Pharmacological modulation of platelet-activating factor (PAF) release from rabbit leucocytes. I. Role of cAMP. | 1980 | Immunology | pmid:6159308 |
| Bussolino F and Camussi G | Effect of prostacyclin on platelet-activating factor induced rabbit and platelet aggregation. | 1980 | Prostaglandins | pmid:6258196 |
| Cusack NJ | Platelet-activating factor. | 1980 | Nature | pmid:7374771 |
| Hanahan DJ et al. | Identification of platelet activating factor isolated from rabbit basophils as acetyl glyceryl ether phosphorylcholine. | 1980 | J. Biol. Chem. | pmid:7380824 |
| Kirchmaier CM et al. | A platelet stimulating fraction in human and animal tissues. | 1980 | Artery | pmid:6971084 |
| Shaw JO and Henson PM | The binding of rabbit basophil-derived platelet-activating factor to rabbit platelets. | 1980 | Am. J. Pathol. | pmid:6987890 |
| Check WA | A new age in asthma research: study of chemical mediators. | 1980 Aug 22-29 | JAMA | pmid:6104737 |
| Suzuki K et al. | The influence of 2-mercaptoethanol on von Willebrand factor and bovine platelet aggregating factor. | 1980 Feb 1-15 | Thromb. Res. | pmid:6966083 |
| Chignard M et al. | [Platelet aggregation and platelet activating factor (author's transl)]. | 1980 Oct-Dec | J Pharmacol | pmid:7206730 |
| Camussi G et al. | Platelet-activating factor (PAF), a mediator of platelet aggregation. Effect of corticosteroids on PAF-induced platelet aggregation. | 1980 Oct-Dec | Minerva Nefrol | pmid:7254682 |
| Halonen M et al. | Differential effects of platelet depletion on the physiologic alterations of IgE anaphylaxis and acetyl glyceryl ether phosphorylcholine infusion in the rabbit. | 1981 | Am. Rev. Respir. Dis. | pmid:7294504 |
| Wykle RL et al. | Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7295320 |
| O'Flaherty JT et al. | Neutrophil responses to platelet-activating factor. | 1981 | Inflammation | pmid:7298160 |
| Blank ML et al. | In vivo metabolism of a new class of biologically active phospholipids: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine, a platelet activating-hypotensive phospholipid. | 1981 | Life Sci. | pmid:7300575 |
| O'Flaherty JT et al. | Role of extracellular calcium and neutrophil degranulation responses to 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. | 1981 | Am. J. Pathol. | pmid:6271016 |
| Vargaftig BB et al. | Present concepts on the mechanisms of platelet aggregation. | 1981 | Biochem. Pharmacol. | pmid:7011325 |
| Colwell JA | Studies on the pathogenesis of diabetic vascular disease. | 1981 | J S C Med Assoc | pmid:7022022 |
| Wintroub BU and Soter NA | Biology of the mast cell and its role in cutaneous inflammation. | 1981 | Springer Semin. Immunopathol. | pmid:7022722 |