| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infant, Premature, Diseases | D007235 | 7 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Klebsiella Infections | D007710 | 7 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lupus Nephritis | D008181 | 8 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Leff AR | Neurohumoral regulation of airway contractile responses. | 1988 | Chest | pmid:2897271 |
| Junier MP et al. | Inhibitory effect of platelet-activating factor (PAF) on luteinizing hormone-releasing hormone and somatostatin release from rat median eminence in vitro correlated with the characterization of specific PAF receptor sites in rat hypothalamus. | 1988 | Endocrinology | pmid:2898362 |
| Guinot P et al. | Treatment of adult systemic mastocytosis with a PAF-acether antagonist BN52063. | 1988 | Lancet | pmid:2898694 |
| Bachelet M et al. | Interaction between PAF-acether and drugs that stimulate cyclic AMP in guinea-pig alveolar macrophages. | 1988 | Eur. J. Pharmacol. | pmid:2840303 |
| Mangold HK | Synthesis of biologically active ether lipids. | 1988 | Prog Biochem Pharmacol | pmid:3136454 |
| Anderson GP et al. | Increased airways responsiveness to histamine induced by platelet activating factor in the guinea-pig: possible role of lipoxygenase metabolites. | 1988 | Agents Actions | pmid:3136622 |
| Fernandez-Gallardo S et al. | Role of paf-acether in the mediation of pathophysiological responses to aggregated immunoglobulins. Studies with the platelet-activating factor receptor antagonist BN 52021. | 1988 | Int. J. Immunopharmacol. | pmid:3139574 |
| López-Farré A et al. | Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3358756 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Valone FH and Epstein LB | Biphasic platelet-activating factor synthesis by human monocytes stimulated with IL-1-beta, tumor necrosis factor, or IFN-gamma. | 1988 | J. Immunol. | pmid:3141509 |
| Calignano A et al. | Isolation and identification of platelet-activating factor in UV-irradiated guinea pig skin. | 1988 | J Pharmacol Methods | pmid:3367652 |
| Nolte D | [Bronchial hyperreactivity: pingpong between cells, nerves and mediators]. | 1988 | Med. Klin. (Munich) | pmid:3367876 |
| Spinks NR and O'Neill C | Antagonists of embryo-derived platelet-activating factor prevent implantation of mouse embryos. | 1988 | J. Reprod. Fertil. | pmid:2460623 |
| Dorsch W et al. | Anti-asthmatic effects of onions. Alk(en)ylsulfinothioic acid alk(en)yl-esters inhibit histamine release, leukotriene and thromboxane biosynthesis in vitro and counteract PAF and allergen-induced bronchial obstruction in vivo. | 1988 | Biochem. Pharmacol. | pmid:2462422 |
| Groscurth P et al. | Effects of platelet activating factor (PAF) on human citrated whole blood. | 1988 | Eur. J. Haematol. | pmid:3402585 |
| Rylander R et al. | Modulation of pulmonary inflammation after endotoxin inhalation with a platelet-activating factor antagonist (48740 RP). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:3403044 |
| Satoh K et al. | [Endothelial injury as an initiating factor: vascular endothelial cell injury and biosynthesis of PAF]. | 1988 | Nippon Rinsho | pmid:3404682 |
| Tamura N et al. | Leukotriene C4 production from human eosinophils in vitro. Role of eosinophil chemotactic factors on eosinophil activation. | 1988 | J. Immunol. | pmid:2848892 |
| Bass DA et al. | Selective priming of rate and duration of the respiratory burst of neutrophils by 1,2-diacyl and 1-O-alkyl-2-acyl diglycerides. Possible relation to effects on protein kinase C. | 1988 | J. Biol. Chem. | pmid:3198643 |
| Lewis MS et al. | Hydrogen peroxide stimulates the synthesis of platelet-activating factor by endothelium and induces endothelial cell-dependent neutrophil adhesion. | 1988 | J. Clin. Invest. | pmid:3198764 |
| Misawa M and Takata T | Effects of platelet-activating factor on rat airways. | 1988 | Jpn. J. Pharmacol. | pmid:3199608 |
| Jancar S et al. | Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor. | 1988 | Prostaglandins | pmid:2969600 |
| Tkhostov EB et al. | [Calcium metabolism in arterial hypertension. I. Myocardial hypertrophy and hormone-dependent increase in Ca2+ levels in the thrombocytes of patients with arterial hypertension]. | 1988 | Biull Vsesoiuznogo Kardiol Nauchn Tsentra AMN SSSR | pmid:2969736 |
| Leprevost C et al. | Inhibition of eosinophil chemotaxis by a new antiallergic compound (cetirizine). | 1988 | Int. Arch. Allergy Appl. Immunol. | pmid:2971624 |
| Moriyama T et al. | Elevation of cytosolic free Ca2+ is directly evoked by thromboxane A2 in human platelets during activation with collagen. | 1988 | J. Biochem. | pmid:3170519 |
| Lagente V et al. | PAF-acether and endotoxin display similar effects on rat mesenteric microvessels: inhibition by specific antagonists. | 1988 | J. Pharmacol. Exp. Ther. | pmid:3171975 |
| Danko G et al. | Effect of the PAF antagonists, CV-3988 and L-652,731 on the pulmonary and hematological responses to guinea pig anaphylaxis. | 1988 | Pharmacol Res Commun | pmid:3174804 |
| Ferguson MK et al. | Lymphatic smooth muscle responses to leukotrienes, histamine and platelet activating factor. | 1988 | J. Surg. Res. | pmid:3339877 |
| Kelefiotis D et al. | Study of digoxin as inhibitor of the in vivo effects of acetyl glyceryl ether phosphorylcholine (AGEPC) in mice. | 1988 | Life Sci. | pmid:3339951 |
| Soybel DI et al. | Effects of platelet-activating factor on canine gastric mucosal blood flow and permeability to luminal acid. | 1988 | Am. J. Surg. | pmid:3341532 |
| O'Donnell SR and Barnett CJ | pA2 values for antagonists of platelet activating factor on aggregation of rabbit platelets. | 1988 | Br. J. Pharmacol. | pmid:3293683 |
| Giovannini L et al. | N-acetyl-beta-glucosaminidase (NAG) and alpha-glycosidase released by PAF in isolated perfused rat kidney. | 1988 | Int J Tissue React | pmid:3294206 |
| Kramer RM et al. | Hydrolysis of 1-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine, a common precursor of platelet-activating factor and eicosanoids, by human platelet phospholipase A2. | 1988 | Biochim. Biophys. Acta | pmid:3355850 |
| McGowan HM et al. | Increased levels of platelet-activating factor (1-O-alkyl-2-acetylglycerophosphocholine) in blood after reversal of renal clip hypertension in the rat. | 1988 | Clin. Sci. | pmid:3356112 |
| Quinn MT et al. | Lysophosphatidylcholine: a chemotactic factor for human monocytes and its potential role in atherogenesis. | 1988 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3357891 |
| Rola-Pleszczynski M et al. | Immune regulation by platelet-activating factor. I. Induction of suppressor cell activity in human monocytes and CD8+ T cells and of helper cell activity in CD4+ T cells. | 1988 | J. Immunol. | pmid:2834440 |
| Worthen GS et al. | The priming of neutrophils by lipopolysaccharide for production of intracellular platelet-activating factor. Potential role in mediation of enhanced superoxide secretion. | 1988 | J. Immunol. | pmid:2834441 |
| Leslie CC et al. | Properties and purification of an arachidonoyl-hydrolyzing phospholipase A2 from a macrophage cell line, RAW 264.7. | 1988 | Biochim. Biophys. Acta | pmid:3143418 |
| Shkhvatsabaia IK et al. | [Receptor-dependent regulation of the concentration of Ca2+ in the cytoplasm of thrombocytes in hypertensive patients]. | 1988 | Kardiologiia | pmid:2842537 |
| Tahraoui L et al. | High affinity specific binding sites for tritiated platelet-activating factor in canine platelet membranes: counterparts of platelet-activating factor receptors mediating platelet aggregation. | 1988 | Mol. Pharmacol. | pmid:2842653 |
| Garcia JG et al. | Effect of platelet activating factor on leukocyte-endothelial cell interactions. | 1988 | Thromb. Res. | pmid:2842887 |
| Breviario F et al. | IL-1-induced adhesion of polymorphonuclear leukocytes to cultured human endothelial cells. Role of platelet-activating factor. | 1988 | J. Immunol. | pmid:3263425 |
| Page CP | The role of platelet-activating factor in asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276759 |
| Barnes PJ | Platelet-activating factor and asthma. | 1988 | J. Allergy Clin. Immunol. | pmid:3276760 |
| Doni MG et al. | Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847730 |
| Ghigo D et al. | Role of Na+/H+ exchange in thrombin-induced platelet-activating factor production by human endothelial cells. | 1988 | J. Biol. Chem. | pmid:2848827 |
| Dillon PK et al. | Effect of platelet-activating factor on leukocyte adhesion to microvascular endothelium. Time course and dose-response relationships. | 1988 | Inflammation | pmid:3220518 |
| Lohmann HF et al. | Idiopathic thrombocytopenia treated with Paf-acether antagonist WEB 2086. | 1988 | Lancet | pmid:2903365 |
| Lakin KM et al. | [Action of calcium antagonists on thrombocyte aggregation]. | 1987 Sep-Oct | Farmakol Toksikol | pmid:2826225 |
| Berdel WE et al. | Lack of correlation between cytotoxicity of agonists and antagonists of platelet activating factor [paf-acether] in neoplastic cells and modulation of [3H]-paf-acether binding to platelets from humans in vitro. | 1987 Nov-Dec | Anticancer Res. | pmid:3442414 |
| Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
| Arnoux B et al. | Antigenic release of paf-acether and beta-glucuronidase from alveolar macrophages of asthmatics. | 1987 Mar-Apr | Bull Eur Physiopathol Respir | pmid:3607326 |
| Lurie A et al. | Exercise- and allergen-induced asthma do not change the production of Paf-acether by neutrophils and platelets. | 1987 Jul-Aug | Bull Eur Physiopathol Respir | pmid:3690021 |
| Auriault C et al. | The effector function of platelets is induced and regulated by T lymphocytes. | 1987 Jul-Aug | Ann. Inst. Pasteur Immunol. | pmid:3118905 |
| Liu BN | [Neoplastic membrane-toxic activity as one of the pathogenetic factors in blood cell and tumor growth changes]. | 1987 Jan-Feb | Patol Fiziol Eksp Ter | pmid:3550649 |
| Ozaki Y et al. | Potentiation of neutrophil biosynthesis of platelet-activating factor by cytochalasin B: evaluation of acetyltransferase activity. | 1987 | Nippon Ketsueki Gakkai Zasshi | pmid:3687329 |
| Ramesha CS et al. | Identification and quantitation of PAF from psoriatic scales. | 1987 | Agents Actions | pmid:3687590 |
| Ponpipom MM et al. | Structure-activity relationships of kadsurenone analogues. | 1987 | J. Med. Chem. | pmid:3027330 |
| Ramesha CS and Pickett WC | Human neutrophil platelet-activating factor: molecular heterogeneity in unstimulated and ionophore-stimulated cells. | 1987 | Biochim. Biophys. Acta | pmid:3113489 |
| Kurosawa M | Effect of platelet activating factor on histamine release from rat mast cells. | 1987 | Agents Actions Suppl. | pmid:2445185 |
| Gerard NP | Characterization of substance P contractile activity on isolated guinea pig lung tissues. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2447271 |
| Beijer L et al. | The involvement of platelet activating factor in endotoxin-induced pulmonary platelet recruitment in the guinea-pig. | 1987 | Br. J. Pharmacol. | pmid:2447993 |
| Belch JJ et al. | Whole blood white cell aggregation: a novel technique. | 1987 | Thromb. Res. | pmid:2448894 |
| Rylander R and Beijer L | Inhalation of endotoxin stimulates alveolar macrophage production of platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3541718 |
| Dejana E et al. | Modulation of endothelial cell functions by different molecular species of interleukin 1. | 1987 | Blood | pmid:3542082 |
| Woodard DS et al. | The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats. | 1987 | J. Biol. Chem. | pmid:3029085 |
| Argyroudi-Akoyunoglou JH and Vakirtzi-Lemonias C | Low-temperature fluorescence emission changes in thylakoids induced by acetyl glyceryl ether phosphorylcholine (AGEPC). | 1987 | Arch. Biochem. Biophys. | pmid:3813566 |
| Valone FH | Inhibition of platelet-activating factor binding to human platelets by calcium channel blockers. | 1987 | Thromb. Res. | pmid:3590086 |
| Tokumura A et al. | Platelet aggregation induced by ether-linked phospholipids. 2. Mechanism of desensitization of rabbit platelets by platelet activating factor and reversibility of inhibitory actions of its antagonists. | 1987 | Thromb. Res. | pmid:3590110 |
| Christman BW et al. | Effect of platelet-activating factor on aerosol histamine responsiveness in awake sheep. | 1987 | Am. Rev. Respir. Dis. | pmid:3592402 |
| Benveniste J | A role for paf-acether (platelet-activating factor) in bronchial hyperreactivity? | 1987 | Am. Rev. Respir. Dis. | pmid:3592414 |
| Tokumura A et al. | Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593346 |
| Rola-Pleszczynski M et al. | Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether): reversal by a specific antagonist, BN 52021. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3493773 |
| Knox P et al. | Role of plasminogen, plasmin, and plasminogen activators in the migration of fibroblasts into plasma clots. | 1987 | J. Cell. Physiol. | pmid:2958486 |
| Wilcox RW et al. | The degradation of platelet-activating factor and related lipids: susceptibility to phospholipases C and D. | 1987 | Lipids | pmid:3444369 |
| Kudo I et al. | Antitumor activity of synthetic alkylphospholipids with or without PAF activity. | 1987 | Lipids | pmid:3444379 |
| Söling U et al. | Effect of synthetic phospholipids on platelet aggregation and serotonin release. | 1987 | Lipids | pmid:3444380 |
| Schick HD et al. | Cytotoxic effects of ether lipids and derivatives in human nonneoplastic bone marrow cells and leukemic cells in vitro. | 1987 | Lipids | pmid:3444383 |
| Danhauser S et al. | Structure-cytotoxicity studies on alkyl lysophospholipids and some analogs in leukemic blasts of human origin in vitro. | 1987 | Lipids | pmid:3444384 |
| Stenmark KR et al. | Potential role of eicosanoids and PAF in the pathophysiology of bronchopulmonary dysplasia. | 1987 | Am. Rev. Respir. Dis. | pmid:3631747 |
| O'Donnell SR and Barnett CJ | Microvascular leakage to platelet activating factor in guinea-pig trachea and bronchi. | 1987 | Eur. J. Pharmacol. | pmid:3040440 |
| Okayasu T et al. | Platelet-activating factor stimulates metabolism of phosphoinositides via phospholipase A2 in primary cultured rat hepatocytes. | 1987 | J. Lipid Res. | pmid:3040878 |
| Grigorian GY and Ryan US | Platelet-activating factor effects on bovine pulmonary artery endothelial cells. | 1987 | Circ. Res. | pmid:3040294 |
| Codde JP et al. | Can the synthesis of platelet-activating factor, a potent vasodilator and pro-aggregatory agent, be altered by dietary marine oils? | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:2822306 |
| Wallace JL et al. | Evidence for platelet-activating factor as a mediator of endotoxin-induced gastrointestinal damage in the rat. Effects of three platelet-activating factor antagonists. | 1987 | Gastroenterology | pmid:3305134 |
| Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
| Földes-Filep E et al. | Inhibition by BN 52021 (ginkgolide B) of the binding of [3H]-platelet-activating factor to human neutrophil granulocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825685 |
| Di Marzo V et al. | Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2822041 |
| O'Flaherty JT | Phospholipid metabolism and stimulus-response coupling. | 1987 | Biochem. Pharmacol. | pmid:3030324 |
| Page CP | A role for platelet activating factor and platelets in the induction of bronchial hyperreactivity. | 1987 | Int J Tissue React | pmid:3298115 |
| Lian EC | Pathogenesis of thrombotic thrombocytopenic purpura. | 1987 | Semin. Hematol. | pmid:3299722 |
| Camussi G et al. | Release of platelet-activating factor from rabbit heart perfused in vitro by sera with transplantation alloantibodies. | 1987 | Transplantation | pmid:3299910 |
| Zimmerman GA et al. | Production of platelet-activating factor, a biologically active lipid, by vascular endothelial cells. | 1987 | Am. Rev. Respir. Dis. | pmid:3300444 |
| Murphy RC and Clay KL | Measurement of platelet-activating factor by physicochemical technique s. | 1987 | Am. Rev. Respir. Dis. | pmid:3300445 |
| Caramelo C et al. | Increased levels of platelet-activating factor in blood from patients with cirrhosis of the liver. | 1987 | Eur. J. Clin. Invest. | pmid:3106053 |
| Wymann MP et al. | The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process. | 1987 | J. Biol. Chem. | pmid:3040727 |
| Gomez-Cambronero J et al. | The diacylglycerol kinase inhibitor R59022 potentiates superoxide production but not secretion induced by fMet-Leu-Phe: effects of leupeptin and the protein kinase C inhibitor H-7. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2823810 |
| Bertani T et al. | Platelet activating factor (PAF) as a mediator of injury in nephrotoxic nephritis. | 1987 | Kidney Int. | pmid:3039232 |
| Kurgan J | [Blood platelets and asthma and other lung diseases]. | 1987 | Pol Tyg Lek | pmid:3684765 |
| Ezra D et al. | Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig. | 1987 | Prostaglandins | pmid:3685397 |