| MeSH term | MeSH ID | Detail |
|---|---|---|
| Infant, Premature, Diseases | D007235 | 7 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Klebsiella Infections | D007710 | 7 associated lipids |
| Leukemia | D007938 | 74 associated lipids |
| Leukemia, Experimental | D007942 | 42 associated lipids |
| Leukopenia | D007970 | 9 associated lipids |
| Liver Cirrhosis | D008103 | 67 associated lipids |
| Liver Cirrhosis, Experimental | D008106 | 36 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lupus Nephritis | D008181 | 8 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Malabsorption Syndromes | D008286 | 16 associated lipids |
| Mammary Neoplasms, Experimental | D008325 | 67 associated lipids |
| Medulloblastoma | D008527 | 22 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chen JJ and Liew CC | Phosphorylation of an acid-soluble nuclear protein in response to catecholamine in cultured rat cardiocytes. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8439325 |
| Muguruma K et al. | Platelet-activating factor (PAF) in male reproductive organs of guinea pigs and rats: effect of androgen on PAF in seminal vesicles. | 1993 | Biol. Reprod. | pmid:8439628 |
| Garcia C et al. | Biosynthesis of platelet-activating factor (PAF) induced by chemotactic peptide is modulated at the lyso-PAF:acetyl-CoA acetyltransferase level by calcium transient and phosphatidic acid. | 1993 | J. Biol. Chem. | pmid:8440692 |
| Noris M et al. | Urinary excretion of platelet activating factor in patients with immune-mediated glomerulonephritis. | 1993 | Kidney Int. | pmid:8441238 |
| Wucherpfennig AL et al. | Platelet activating factor increases intracellular calcium in isolated osteoclasts but does not modify bone resorption. | 1993 | Bone | pmid:8442997 |
| Tanaka T et al. | Formation of platelet-activating factor-like phospholipids by Fe2+/ascorbate/EDTA-induced lipid peroxidation. | 1993 | Biochim. Biophys. Acta | pmid:8443246 |
| Tsuruta S et al. | Effects of adenosine and its analogues on actin polymerization in human polymorphonuclear leucocytes. | 1993 | Clin. Exp. Pharmacol. Physiol. | pmid:8443979 |
| Huang YC et al. | Protection against platelet-activating factor-induced injury by interferon inducer in perfused rabbit lung. | 1993 | J. Appl. Physiol. | pmid:8444700 |
| Mózes T et al. | Protective effect of diclofenac sodium against endotoxic shock in anaesthetized pigs. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8446657 |
| Wang F et al. | A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8447826 |
| Filep JG et al. | Nitric oxide modulates vascular permeability in the rat coronary circulation. | 1993 | Br. J. Pharmacol. | pmid:8448583 |
| Matthews JS and Jones RL | Potentiation of aggregation and inhibition of adenylate cyclase in human platelets by prostaglandin E analogues. | 1993 | Br. J. Pharmacol. | pmid:8448586 |
| Arreto CD et al. | Pharmacological differentiation by pertussis toxin of the in vivo acute responses to fMLP and PAF in guinea-pig lungs. | 1993 | Br. J. Pharmacol. | pmid:8448592 |
| Hirata Y et al. | Roles of platelet-activating factor, thromboxane A2, ADP and thrombin in thrombogenesis in the guinea pig. | 1993 | Eur. J. Pharmacol. | pmid:8449234 |
| Hirashima Y et al. | Platelet-activating factor and cerebral vasospasm following subarachnoid hemorrhage. | 1993 | J. Neurosurg. | pmid:8450333 |
| Mounier C et al. | Competitive inhibition of phospholipase A2 activity by the platelet-activating factor antagonist Ro 19-3704 and evidence for a novel suppressive effect on platelet activation. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8450479 |
| Green PG et al. | Neurogenic and non-neurogenic mechanisms of plasma extravasation in the rat. | 1993 | Neuroscience | pmid:8450970 |
| Minami T et al. | Regional blood flow volume in the eustachian tube. | 1993 | Acta Otolaryngol Suppl | pmid:8452027 |
| Church DJ et al. | Protein kinase C-mediated phospholipase A2 activation, platelet-activating factor generation and prostacyclin release in spontaneously beating rat cardiomyocytes. | 1993 | Biochem. J. | pmid:8452537 |
| Pretolani M and Vargaftig BB | From lung hypersensitivity to bronchial hyperreactivity. What can we learn from studies on animal models? | 1993 | Biochem. Pharmacol. | pmid:8452553 |
| Newman GE et al. | Utilization by human amniocytes for prostaglandin synthesis of [1-14C]arachidonate derived from 2-[1-14C]arachidonylphosphatidylcholine associated with human fetal pulmonary surfactant. | 1993 | Biochim. Biophys. Acta | pmid:8452866 |
| Matsuda Y et al. | Role of sympathetic nervous system in hypotension induced by platelet-activating factor in anesthetized dogs. | 1993 | Circ. Shock | pmid:8453742 |
| Damas J et al. | Platelet-activating factor and the vascular effects of zymosan in rats. | 1993 | Eur. J. Pharmacol. | pmid:8453979 |
| Hatmi M et al. | Carrageenan-induced activation of human platelets is dependent on the phospholipase C pathway. | 1993 | Br. J. Haematol. | pmid:8457475 |
| Lachapelle MH et al. | Effect of lysoplatelet-activating factor on human sperm fertilizing ability. | 1993 | Fertil. Steril. | pmid:8458509 |
| Naraba H et al. | Enhanced production of platelet-activating factor in stimulated rat leukocytes caused by the blockade of lysophospholipid acylation. | 1993 | Jpn. J. Pharmacol. | pmid:8459648 |
| Kosugi T et al. | Inhalation of platelet-activating factor increases respiratory resistance in rats: determination by means of an astograph under nonanesthetized conditions. | 1993 | Laryngoscope | pmid:8459752 |
| Kertscher HP et al. | [PAF-antagonists with a phospholipid structure. 5. Propanediol phospholipids with various substituted pyridinium and quinuclidinium head groups and variations of the phosphorus-nitrogen distance;synthesis, characterization and structure activity relationship]. | 1993 | Pharmazie | pmid:8460172 |
| Olson NC et al. | Pertussis toxin attenuates platelet-activating factor-induced pulmonary hemodynamic alterations in pigs. | 1993 | Am. J. Physiol. | pmid:8460710 |
| Wieraszko A et al. | Long-term potentiation in the hippocampus induced by platelet-activating factor. | 1993 | Neuron | pmid:8461142 |
| Venable ME et al. | Enzymatic studies of lyso platelet-activating factor acylation in human neutrophils and changes upon stimulation. | 1993 | J. Biol. Chem. | pmid:8463317 |
| Battye KM et al. | Potential synergism between platelet-activating factor and alpha 1-recombinant interferon in promoting luteal maintenance in cyclic ewes. | 1993 | J. Reprod. Fertil. | pmid:8464013 |
| Nagai H et al. | Priming with murine recombinant interleukin-5 resulted in the augmentation of PAF-induced airway hyperresponsiveness to histamine in guinea pigs. | 1993 | Life Sci. | pmid:8464339 |
| Korth R et al. | Human platelets release a paf-acether: acetylhydrolase similar to that in plasma. | 1993 | Lipids | pmid:8464350 |
| Ono S et al. | Clinical and experimental studies on the role of platelet-activating factor (PAF) in the pathogenesis of septic DIC. | 1993 | Surg. Today | pmid:8467174 |
| McCafferty DM et al. | Inhibition of platelet-activating factor-induced leukocyte adhesion in vivo by a leumedin. | 1993 | Eur. J. Pharmacol. | pmid:8467855 |
| Wong CW et al. | Comparative effects of tetrandrine and berbamine on guineapig airway microvascular leakage induced by platelet-activating factor and other allergic mediators. | 1993 | Int. J. Immunopharmacol. | pmid:8468119 |
| Shikano M et al. | Effect of docosahexaenoic acid on the generation of platelet-activating factor by eosinophilic leukemia cells, Eol-1. | 1993 | J. Immunol. | pmid:8468486 |
| Tetta C et al. | Role of platelet activating factor in hemodialysis. | 1993 | Kidney Int. Suppl. | pmid:8468919 |
| Fukuoka T et al. | Platelet activating factor mediates systemic circulatory collapse after temporary hepatic inflow occlusion. | 1993 | Transplant. Proc. | pmid:8470175 |
| Sandberg-Gertzén H | An open trial of Cedemin, a Gingko biloba extract with PAF-antagonistic effects for ulcerative colitis. | 1993 | Am. J. Gastroenterol. | pmid:8470656 |
| Taylor ML et al. | The differential effect of aspirin on human platelet activation in aspirin-sensitive asthmatics and normal subjects. | 1993 | Br J Clin Pharmacol | pmid:8471399 |
| Kroegel C and Matthys H | Platelet-activating factor-induced human eosinophil activation. Generation and release of cyclo-oxygenase metabolites in human blood eosinophils from asthmatics. | 1993 | Immunology | pmid:8473016 |
| Juncos LA et al. | Vasodilator and constrictor actions of platelet-activating factor in the isolated microperfused afferent arteriole of the rabbit kidney. Role of endothelium-derived relaxing factor/nitric oxide and cyclooxygenase products. | 1993 | J. Clin. Invest. | pmid:8473488 |
| Inui K | [Participation of platelet activating factor in the pulmonary injury during cardiopulmonary bypass]. | 1993 | Nihon Kyobu Geka Gakkai Zasshi | pmid:8473789 |
| Minhas BS | Platelet-activating factor treatment of human spermatozoa enhances fertilization potential. | 1993 | Am. J. Obstet. Gynecol. | pmid:8475981 |
| Björck T and Dahlén SE | Leukotrienes and histamine mediate IgE-dependent contractions of human bronchi: pharmacological evidence obtained with tissues from asthmatic and non-asthmatic subjects. | 1993 | Pulm Pharmacol | pmid:8477156 |
| Makristathis A et al. | Bacteria induce release of platelet-activating factor (PAF) from polymorphonuclear neutrophil granulocytes: possible role for PAF in pathogenesis of experimentally induced bacterial pneumonia. | 1993 | Infect. Immun. | pmid:8478087 |
| Walker TS and Mellott GE | Rickettsial stimulation of endothelial platelet-activating factor synthesis. | 1993 | Infect. Immun. | pmid:8478089 |
| Lamouri A et al. | Design and modeling of new platelet-activating factor antagonists. 1. Synthesis and biological activity of 1,4-bis(3',4',5'-trimethoxybenzoyl)-2-[[(substituted carbonyl and carbamoyl)oxy]methyl]piperazines. | 1993 | J. Med. Chem. | pmid:8478911 |
| Ranaut K and Singh M | BN-50739: a PAF antagonist and limitation of myocardial infarct size. | 1993 Jan-Feb | Methods Find Exp Clin Pharmacol | pmid:8479250 |
| Murphy G | Report of the 14th meeting of the British Inflammation Research Association. Topic: cellular and molecular aspects of inflammatory bowel disease. | 1993 | Agents Actions | pmid:8480529 |
| Hebra A et al. | Systemic and mesenteric vascular effects of platelet-activating factor and cocaine. In vivo effects on a neonatal swine model. | 1993 | Am Surg | pmid:8480932 |
| Koenderman L et al. | Granulocyte-macrophage colony-stimulating factor induces sequential activation and deactivation of binding via a low-affinity IgG Fc receptor, hFc gamma RII, on human eosinophils. | 1993 | Blood | pmid:8481520 |
| Kroegel C et al. | Ultrastructural characterization of platelet-activating factor-stimulated human eosinophils from patients with asthma. | 1993 | Clin. Sci. | pmid:8482044 |
| Kiyohara T et al. | Effect of endothelin 1 on ion transport in isolated rat colon. | 1993 | Gastroenterology | pmid:8482447 |
| Sakamoto T et al. | Effect of inhaled lyso-platelet-activating factor on airway microvascular leakage in the guinea pig. | 1993 | J. Appl. Physiol. | pmid:8482649 |
| van der Bruggen T et al. | Cytokine priming of the respiratory burst in human eosinophils is Ca2+ independent and accompanied by induction of tyrosine kinase activity. | 1993 | J. Leukoc. Biol. | pmid:8482914 |
| Yamanaka S et al. | 11-Dehydro thromboxane B2: a reliable parameter of thromboxane A2 production in dogs. | 1993 | Prostaglandins | pmid:8484010 |
| Lohman IC and Halonen M | The effects of combined histamine and platelet-activating factor antagonism on systemic anaphylaxis induced by immunoglobulin E in the rabbit. | 1993 | Am. Rev. Respir. Dis. | pmid:8484635 |
| Catalán RE et al. | Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8484756 |
| Barthelson RA | Quantitation of IL-4 expression in small numbers of cells from mice. | 1993 | J. Immunol. Methods | pmid:8486929 |
| Steinke B et al. | [Biological standardization of Ginkgo extracts]. | 1993 | Planta Med. | pmid:8488195 |
| Lekka M et al. | Isolation of a phospholipid inhibitor of platelet activating factor-induced activity from perfused rat liver: identification as phosphatidylglycerol. | 1993 | Arch. Biochem. Biophys. | pmid:8489242 |
| Sablina MA et al. | [Synthesis of platelet activation factor analogs]. | 1993 | Bioorg. Khim. | pmid:8489534 |
| Cipolle MD et al. | Secondary organ dysfunction. From clinical perspectives to molecular mediators. | 1993 | Crit Care Clin | pmid:8490763 |
| Kawada I and Takahashi K | [A new method for the isolation of peripheral blood eosinophils using flow cytometry (FCM)]. | 1993 | Nippon Rinsho | pmid:8492447 |
| Iwahisa Y et al. | [Advance in eosinophil chemotaxis assay method--automatic count of migrated cells by the image analyzing system in the Boyden method]. | 1993 | Nippon Rinsho | pmid:8492448 |
| Fukuda T | [The eosinophil and bronchial asthma]. | 1993 | Nippon Rinsho | pmid:8492453 |
| Wagner G et al. | [Synthesis of N-(2-carboxy-thieno(2,3-b)pyridin-3-yl)-formamidines corresponding alkyl esters with antianaphylactic activity]. | 1993 | Pharmazie | pmid:8493283 |
| Alabaster VA and Moore BA | New perspectives on basic mechanisms in lung disease. 3. Drug intervention in asthma: present and future. | 1993 | Thorax | pmid:8493636 |
| Zhou W et al. | Platelet-activating factor: a mediator of pancreatic inflammation during cerulein hyperstimulation. | 1993 | Am. J. Pathol. | pmid:8494049 |
| Nathan N and Denizot Y | Tumor necrosis factor and platelet-activating factor during cardiopulmonary bypass. | 1993 | Ann. Thorac. Surg. | pmid:8494455 |
| Pons F et al. | Role of platelet-activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long-acting PAF antagonist, UK-74,505. | 1993 | Br. J. Pharmacol. | pmid:8495241 |
| Jarvi K et al. | Effect of platelet-activating factor, lyso-platelet-activating factor, and lysophosphatidylcholine on sperm motion: importance of albumin for motility stimulation. | 1993 | Fertil. Steril. | pmid:8495776 |
| Trova MP et al. | Analogues of platelet activating factor. 8. Antagonists of PAF containing an aromatic ring linked to a pyridinium ring. | 1993 | J. Med. Chem. | pmid:8496938 |
| Miura S et al. | Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid. | 1993 | Am. J. Physiol. | pmid:8498509 |
| Shibamoto T et al. | PAF increases capillary pressure but not vascular permeability in isolated blood-perfused canine lungs. | 1993 | Am. J. Physiol. | pmid:8498559 |
| Wilson DV and Stick JA | Effect of a specific platelet-activating factor antagonist on cardiovascular and peripheral cellular responses to colonic ischemia and reperfusion in anesthetized ponies. | 1993 | Am. J. Vet. Res. | pmid:8498751 |
| Roudebush WE et al. | Enhanced embryo development of rabbit oocytes fertilized in vitro with platelet activating factor (PAF)-treated spermatozoa. | 1993 | J. Assist. Reprod. Genet. | pmid:8499686 |
| Chu M et al. | A novel class of platelet activating factor antagonists from Phoma sp. | 1993 | J. Antibiot. | pmid:8500998 |
| Inoue H et al. | Study on the metabolism of lyso-platelet activating factor (lyso-PAF) in human paranasal sinus mucosa. The cultured ciliated epithelium can convert lyso-PAF to PAF. | 1993 | Life Sci. | pmid:8502110 |
| Pfliegler G et al. | Sodium fluoride induced activation of phospholipase C in intact human platelets does not depend on ADP, PAF or arachidonate products. | 1993 | Thromb. Res. | pmid:8503122 |
| Sun DX et al. | Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8503282 |
| Baldi E et al. | Stimulation of platelet-activating factor synthesis by progesterone and A23187 in human spermatozoa. | 1993 | Biochem. J. | pmid:8503848 |
| Ferraris L et al. | Intestinal epithelial cells contribute to the enhanced generation of platelet activating factor in ulcerative colitis. | 1993 | Gut | pmid:8504968 |
| Davis TM et al. | Platelet-activating factor and lipid metabolism in acute malaria. | 1993 | J. Infect. | pmid:8505562 |
| Sirén AL et al. | Increased release of tumor necrosis factor-alpha into the cerebrospinal fluid and peripheral circulation of aged rats. | 1993 | Stroke | pmid:8506560 |
| Misawa M and Sugiyama Y | An airway hyperresponsiveness model in rat allergic asthma. | 1993 | Arerugi | pmid:8507151 |
| Tsukioka K et al. | [Increased plasma levels of platelet-activating factor (PAF) and low serum PAF acetylhydrolase (PAFAH) activity in adult patients with bronchial asthma]. | 1993 | Arerugi | pmid:8507159 |
| Ono I et al. | Effects of a platelet activating factor antagonist on oedema formation following burns. | 1993 | Burns | pmid:8507364 |
| van den Bosch H et al. | Ether lipid synthesis and its deficiency in peroxisomal disorders. | 1993 | Biochimie | pmid:8507680 |
| Warringa RA et al. | Upregulation of formyl-peptide and interleukin-8-induced eosinophil chemotaxis in patients with allergic asthma. | 1993 | J. Allergy Clin. Immunol. | pmid:8509580 |
| Dell' Albani P et al. | Platelet-activating factor and its methoxy-analogue ET-18-OCH3 stimulate immediate early gene expression in rat astroglial cultures. | 1993 | Neurochem. Int. | pmid:8513284 |
| Koyama N et al. | Increased platelet activating factor in the tracheal aspirates from neonates with patent ductus arteriosus. | 1993 | Clin. Chim. Acta | pmid:8513570 |
| Rabinovici R et al. | ARDS-like lung injury produced by endotoxin in platelet-activating factor-primed rats. | 1993 | J. Appl. Physiol. | pmid:8514698 |
| Nishiyama R et al. | Platelet-activating factor in hepatic ischemia/reperfusion injury. The effects of a PAF antagonist combined with a prostaglandin I2 analogue. | 1993 | Transplantation | pmid:8516812 |
| Kawahara K et al. | The effect of the platelet-activating factor inhibitor TCV-309 on reperfusion injury in a canine model of ischemic lung. | 1993 | Transplantation | pmid:8516834 |
| Amorim CZ et al. | Involvement of platelet-activating factor in death following anaphylactic shock in boosted and in unboosted mice. | 1993 | Eur. J. Pharmacol. | pmid:8519279 |
| Okano S et al. | Effect of platelet activating factor antagonist (TCV-309) on lung injury in dogs with experimentally endotoxin-induced shock. | 1995 | J. Vet. Med. Sci. | pmid:8519912 |