Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Spasm D001986 18 associated lipids
Shock, Septic D012772 11 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Conjunctivitis D003231 7 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Death, Sudden D003645 12 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Bouayad A et al. Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus. 2004 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:14715488
Axelrad TW et al. Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration. 2004 FASEB J. pmid:14715700
Chinybaeva LA [Comparative characterization of hemostatic parameters in patients with cerebral stroke]. 2004 Klin Med (Mosk) pmid:15449775
Gambero A et al. Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2. 2004 Toxicon pmid:15450921
Chou KJ et al. Platelet hyperreactivity in hemodialysis patients with frequently occluded vascular access. 2004 Thromb. Haemost. pmid:15351860
Llodrá J et al. Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. 2004 Proc. Natl. Acad. Sci. U.S.A. pmid:15280540
Zhu L et al. Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability. 2004 Am. J. Physiol. Heart Circ. Physiol. pmid:12946927
Kato M et al. Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. 2004 J. Pharmacol. Sci. pmid:15286429
Jung TT et al. Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells. 2004 Ann. Otol. Rhinol. Laryngol. pmid:14994775
Fourcade O et al. Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. 2004 Anesth. Analg. pmid:15271713
Getting SJ et al. Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. 2004 J. Pharmacol. Exp. Ther. pmid:14996949
Rasheed H and Saeed SA Involvement of thromboxane A2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation. 2004 Exp. Mol. Med. pmid:15272233
Bate C et al. Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication. 2004 J. Biol. Chem. pmid:15210691
Yamano S et al. Human spermatozoa capacitated with progesterone or a long incubation show accelerated internalization by an alkyl ether lysophospholipid. 2004 Fertil. Steril. pmid:15037409
Jakubowski A et al. Involvement of platelet activating factor in immediate heart response to lipopolysaccharide. 2004 J. Physiol. Pharmacol. pmid:15213362
Taylor KE Familial cancer and developmental dyslexia: an observational pilot study. 2004 Dev Med Child Neurol pmid:14974637
Seo KH et al. Essential role for platelet-activating factor-induced NF-kappaB activation in macrophage-derived angiogenesis. 2004 Eur. J. Immunol. pmid:15259010
Lu DP et al. Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. 2004 J. Cell. Sci. pmid:15020683
Ziche M Absence of PAF actions increases angiogenesis. 2004 Br. J. Pharmacol. pmid:15023858
Steel HC and Anderson R Itraconazole antagonizes store-operated influx of calcium into chemoattractant-activated human neutrophils. 2004 Clin. Exp. Immunol. pmid:15086388
Reeves SR and Gozal D Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice. 2004 Am. J. Physiol. Regul. Integr. Comp. Physiol. pmid:15087283
Hollmann MW et al. Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics. 2004 Anesthesiology pmid:15087620
Bate C et al. The role of platelet activating factor in prion and amyloid-beta neurotoxicity. 2004 Neuroreport pmid:15094513
Khreiss T et al. Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils. 2004 Cell. Signal. pmid:15115659
Ninio E et al. Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. 2004 Hum. Mol. Genet. pmid:15115767
Bonin F et al. Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. 2004 J. Biol. Chem. pmid:15456758
Martin C et al. Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase. 2004 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:15064228
Alfaro V Role of histamine and platelet-activating factor in allergic rhinitis. 2004 J. Physiol. Biochem. pmid:15457928
Baker KE and Curtis MJ Left regional cardiac perfusion in vitro with platelet-activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous "mediators" facilitated by interactions, and moderated by paradoxical antagonism. 2004 Br. J. Pharmacol. pmid:15066909
Uemura K et al. Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP). 2004 Glycoconj. J. pmid:15467404
Ko HH et al. Structure-activity relationship studies on chalcone derivatives: potent inhibition of platelet aggregation. 2004 J. Pharm. Pharmacol. pmid:15482650
McDonagh PF et al. Chronic expression of platelet adhesion proteins is associated with severe ischemic heart disease in type 2 diabetic patients: Chronic platelet activation in diabetic heart patients. 2003 Sep-Oct J. Diabetes Complicat. pmid:12954156
Kerek M et al. Effects of recombinant platelet activating factor acetylhydrolase in obstructive jaundice. 2003 Jul-Aug Hepatogastroenterology pmid:12845989
Baltás E et al. Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. 2003 Jul-Aug Skin Pharmacol. Appl. Skin Physiol. pmid:12784066
Hsueh W et al. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. 2003 Jan-Feb Pediatr. Dev. Pathol. pmid:12424605
Diez-Fraile A et al. Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. 2003 Jan-Feb Vet. Res. pmid:12588684
Zhang GQ et al. [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. 2003 Zhonghua Er Ke Za Zhi pmid:14751060
Mayerle J et al. [Conservative treatment of acute pancreatitis]. 2003 Med. Klin. (Munich) pmid:14685675
Tellis C et al. Localization of an alkyl-acetyl-glycerol-CDP-choline: cholinephosphotransferase activity in submitochondrial fractions of Tetrahymena pyriformis. 2003 Eur. J. Cell Biol. pmid:14703014
Stafforini DM et al. Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. 2003 Crit Rev Clin Lab Sci pmid:14708958
Narahara H et al. Platelet-activating factor inhibits the secretion of platelet-activating factor acetylhydrolase by human decidual macrophages. 2003 J. Clin. Endocrinol. Metab. pmid:14671207
Gálvez J et al. The intestinal anti-inflammatory activity of UR-12746S on reactivated experimental colitis is mediated through downregulation of cytokine production. 2003 Inflamm. Bowel Dis. pmid:14671485
Saeed SA and Rasheed H Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. 2003 Acta Pharmacol. Sin. pmid:12511226
Ishizuka S et al. Effects of rhinovirus infection on the adherence of Streptococcus pneumoniae to cultured human airway epithelial cells. 2003 J. Infect. Dis. pmid:14673774
Hu H et al. Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. 2003 J. Thromb. Haemost. pmid:12911597
Kalia N and Bardhan KD Of blood and guts: association between Helicobacter pylori and the gastric microcirculation. 2003 J. Gastroenterol. Hepatol. pmid:12911655
Tokuoka SM et al. Involvement of platelet-activating factor and LIS1 in neuronal migration. 2003 Eur. J. Neurosci. pmid:12911752
Lupia E et al. Intra-plaque production of platelet-activating factor correlates with neoangiogenesis in human carotid atherosclerotic lesions. 2003 Int. J. Mol. Med. pmid:12883648
Handa RK et al. Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo. 2003 Kidney Blood Press. Res. pmid:12886044
Taggart DP et al. Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist. 2003 Heart pmid:12860868
Takafuji S et al. Matrix metalloproteinase-9 release from human leukocytes. 2003 J Investig Allergol Clin Immunol pmid:12861851
Bar-Or D et al. Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. 2003 Shock pmid:12865660
Kujiraoka T et al. Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus. 2003 J. Lipid Res. pmid:12867534
D'Andrea D et al. Induction of tissue factor in the arterial wall during recurrent thrombus formation. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12869352
Lupia E et al. The membrane attack complex of complement contributes to plasmin-induced synthesis of platelet-activating factor by endothelial cells and neutrophils. 2003 Immunology pmid:12871223
Fernandes ES et al. Mechanisms underlying the modulatory action of platelet activating factor (PAF) on the upregulation of kinin B1 receptors in the rat paw. 2003 Br. J. Pharmacol. pmid:12839871
Casillan AJ et al. Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. 2003 J. Appl. Physiol. pmid:12598480
Rios-Santos F et al. A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. 2003 Shock pmid:12558146
Lukashova V et al. Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. 2003 J. Immunol. pmid:14500680
Brandt EB et al. Mast cells are required for experimental oral allergen-induced diarrhea. 2003 J. Clin. Invest. pmid:14660743
Rhee CK Candidate's thesis: Platelet-activating factor-induced hearing loss: mediated by nitric oxide? 2003 Laryngoscope pmid:14660903
Diaper CM et al. A total synthesis of (+/-)-phomactin A. 2003 Org. Biomol. Chem. pmid:14664384
Choi IW et al. Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. 2003 J. Exp. Med. pmid:12835479
Ivanov AI et al. Platelet-activating factor: a previously unrecognized mediator of fever. 2003 J. Physiol. (Lond.) pmid:14565987
Proudfoot JM et al. Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1. 2003 J. Pharmacol. Exp. Ther. pmid:12626661
Fang HY et al. Cyclooxygenase-2 in human non-small cell lung cancer. 2003 Eur J Surg Oncol pmid:12633561
Cole KP and Hsung RP Intramolecular formal oxa-[3 + 3] cycloaddition approach to the ABD system of phomactin A. 2003 Org. Lett. pmid:14653688
Hao J et al. [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. 2003 Zhongguo Wei Zhong Bing Ji Jiu Yi Xue pmid:14552687
Witko-Sarsat V et al. AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients. 2003 Kidney Int. pmid:12787398
Elovitz MA et al. A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. 2003 Am. J. Pathol. pmid:14578208
Slomiany BL and Slomiany A Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. 2003 Biochem. Biophys. Res. Commun. pmid:12788098
Kogure K et al. Temporary membrane distortion of vascular smooth muscle cells is responsible for their apoptosis induced by platelet-activating factor-like oxidized phospholipids and their degradation product, lysophosphatidylcholine. 2003 Chem. Phys. Lipids pmid:14580708
Schuster DP et al. Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. 2003 Crit. Care Med. pmid:12794395
Rabinovici R Platelet activating factor inhibition in sepsis: the end? 2003 Crit. Care Med. pmid:12794432
Bernatchez PN et al. Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. 2003 J. Cell. Biochem. pmid:14587028
Saraf MK et al. Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. 2003 Behav. Brain Res. pmid:12798263
Denizot Y et al. Platelet-activating factor and normal or leukaemic haematopoiesis. 2003 Leuk. Lymphoma pmid:12802913
Olanders K et al. Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. 2003 Scand. J. Gastroenterol. pmid:12825870
Adamson RH et al. PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12649070
Haraldsen P et al. Multimodal management - of value in fulminant acute pancreatitis? 2003 Pancreatology pmid:12649560
Li XG and Luo HM [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. 2003 Zhongguo Zhong Yao Za Zhi pmid:15617488
Denizot Y et al. No evidence for a putative involvement of platelet-activating factor in systemic lupus erythematosus without active nephritis. 2003 Mediators Inflamm. pmid:12775360
Yan W et al. Previously uncharacterized roles of platelet-activating factor acetylhydrolase 1b complex in mouse spermatogenesis. 2003 Proc. Natl. Acad. Sci. U.S.A. pmid:12775763
Mariano F et al. Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. 2003 Shock pmid:12688545
Thaete LG et al. Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. 2003 J. Soc. Gynecol. Investig. pmid:12699876
Simon HU et al. Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. 2003 Eur. J. Immunol. pmid:12672048
Teather LA and Wurtman RJ Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. 2003 Neurosci. Lett. pmid:12672535
Kordan W et al. Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review. 2003 Pol J Vet Sci pmid:12675470
Loucks EB et al. Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. 2003 Can J Cardiol pmid:12677282
Ginesta MM et al. Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. 2003 APMIS pmid:12752216
Peri A et al. The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin. 2003 Hum. Cell pmid:15005239
Wu B et al. Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. 2003 FASEB J. pmid:12709415
Ueda Y et al. Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ. 2003 Biol. Pharm. Bull. pmid:14519965
Akisu M et al. The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis. 2003 Ann. Nutr. Metab. pmid:14520021
Bussolati B et al. The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. 2003 J. Immunol. pmid:12538709
Frostegård J et al. Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion. 2003 Am. J. Obstet. Gynecol. pmid:14520236
Ahlemeyer B and Krieglstein J Neuroprotective effects of Ginkgo biloba extract. 2003 Cell. Mol. Life Sci. pmid:14523543
Hirayama K et al. Platelet-activating factor, a critical mediator in the pathogenesis of dextran sulfate sodium-induced colitis in rats. 2003 Dis. Colon Rectum pmid:12544529
Corl CM et al. Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. 2003 Biochem. Biophys. Res. Commun. pmid:12615078
Chen L et al. [Determination of platelet activating factor in middle ear effusion of patients with secretory oitits media]. 2003 Lin Chuang Er Bi Yan Hou Ke Za Zhi pmid:14727433