Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
Loading... please refresh the page if content is not showing up.

Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Spasm D001986 18 associated lipids
Shock, Septic D012772 11 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Conjunctivitis D003231 7 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Death, Sudden D003645 12 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Per page 10 20 50 100 | Total 288

PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
Loading... please refresh the page if content is not showing up.

NCBI Entrez Crosslinks

All references with Platelet activating factor

Download all related citations
Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Göggel R et al. PAF-mediated pulmonary edema: a new role for acid sphingomyelinase and ceramide. 2004 Nat. Med. pmid:14704790
Tsutsumi T et al. Phorbol myristate acetate stimulates degradation of a structural analogue of platelet-activating factor to a neutral lipid in human leukemic K562 cells: relevance to the release of lipids. 2004 Biol. Pharm. Bull. pmid:14709893
Nakagawa K et al. Sperm-immobilizing antibodies suppress an increase in the plasma membrane fluidity of human spermatozoa. 2004 Fertil. Steril. pmid:15474073
Nie ZG et al. [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. 2004 Yao Xue Xue Bao pmid:15491096
Barnes PJ Ceramide lances the lungs. 2004 Nat. Med. pmid:14760419
Goldring WP and Pattenden G Total synthesis of (+/-)-phomactin G, a platelet activating factor antagonist from the marine fungus Phoma sp. 2004 Org. Biomol. Chem. pmid:14770224
Chami O et al. Components of a platelet-activating factor-signaling loop are assembled in the ovine endometrium late in the estrous cycle. 2004 Am. J. Physiol. Endocrinol. Metab. pmid:15271646
Zhelev DV et al. Controlled pseudopod extension of human neutrophils stimulated with different chemoattractants. 2004 Biophys. J. pmid:15240502
Seyffarth G et al. Lipopolysaccharide induces nitric oxide synthase expression and platelet-activating factor increases nitric oxide production in human fetal membranes in culture. 2004 Reprod. Biol. Endocrinol. pmid:15191613
Lekka ME et al. The impact of intravenous fat emulsion administration in acute lung injury. 2004 Am. J. Respir. Crit. Care Med. pmid:14656749
Lu J et al. Platelet-activating factor-induced apoptosis is blocked by Bcl-2 in rat intestinal epithelial cells. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:14512286
Buduneli E et al. Effects of combined systemic administration of low-dose doxycycline and alendronate on endotoxin-induced periodontitis in rats. 2004 J. Periodontol. pmid:15633329
Vardar S et al. Therapeutic versus prophylactic plus therapeutic administration of omega-3 fatty acid on endotoxin-induced periodontitis in rats. 2004 J. Periodontol. pmid:15732866
Morita K et al. Development of tactile allodynia and thermal hyperalgesia by intrathecally administered platelet-activating factor in mice. 2004 Pain pmid:15363879
Nemcsik J et al. Synergistic interaction of endogenous platelet-activating factor and vasopressin in generating angina in rats. 2004 Eur. J. Pharmacol. pmid:15363995
Roudebush WE et al. Exposure of preimplantation embryos to platelet-activating factor increases birth rate. 2004 J. Assist. Reprod. Genet. pmid:15568330
Zinchuk O et al. Dynamics of PAF-induced conjunctivitis reveals differential expression of PAF receptor by macrophages and eosinophils in the rat. 2004 Cell Tissue Res. pmid:15290234
Tarricone C et al. Coupling PAF signaling to dynein regulation: structure of LIS1 in complex with PAF-acetylhydrolase. 2004 Neuron pmid:15572112
Xu Y et al. Targeted disruption of PSD-93 gene reduces platelet-activating factor-induced neurotoxicity in cultured cortical neurons. 2004 Exp. Neurol. pmid:15296832
Wanten G et al. Lipid effects on neutrophil calcium signaling induced by opsonized particles: platelet activating factor is only part of the story. 2004 Clin Nutr pmid:15297099
Han XB et al. Macrophage inflammatory protein-2 mediates the bowel injury induced by platelet-activating factor. 2004 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:15319184
Bossi F et al. Platelet-activating factor and kinin-dependent vascular leakage as a novel functional activity of the soluble terminal complement complex. 2004 J. Immunol. pmid:15557188
Sumita C et al. Pioglitazone induces plasma platelet activating factor-acetylhydrolase and inhibits platelet activating factor-mediated cytoskeletal reorganization in macrophage. 2004 Biochim. Biophys. Acta pmid:15279882
Zimmerman GA and McIntyre TM PAF, ceramide and pulmonary edema: alveolar flooding and a flood of questions. 2004 Trends Mol Med pmid:15177186
Lee SH et al. Role of messenger RNA expression of platelet activating factor and its receptor in porcine in vitro-fertilized and cloned embryo development. 2004 Biol. Reprod. pmid:15151927
Ishii S et al. Platelet-activating factor receptor develops airway hyperresponsiveness independently of airway inflammation in a murine asthma model. 2004 J. Immunol. pmid:15153532
Zhang C et al. The effect of Ginkgo biloba extract (EGb 761) on hepatic sinusoidal endothelial cells and hepatic microcirculation in CCl4 rats. 2004 Am. J. Chin. Med. pmid:15154282
Saint-Martin F et al. A randomized, double-blind, parallel-group study, comparing the efficacy and safety of rupatadine (20 and 10 mg), a new PAF and H1 receptor-specific histamine antagonist, to loratadine 10 mg in the treatment of seasonal allergic rhinitis. 2004 J Investig Allergol Clin Immunol pmid:15160440
Xu Y and Tao YX Involvement of the NMDA receptor/nitric oxide signal pathway in platelet-activating factor-induced neurotoxicity. 2004 Neuroreport pmid:15076749
Slomiany BL and Slomiany A Platelet-activating factor mediates Porphyromonas gingivalis lipopolysaccharide interference with salivary mucin synthesis via phosphatidylinositol 3-kinase-dependent constitutive nitric-oxide synthase activation. 2004 J. Physiol. Pharmacol. pmid:15082869
Ramos G et al. Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. 2004 Toxicol. Appl. Pharmacol. pmid:15020195
McDonagh PF et al. Chronic expression of platelet adhesion proteins is associated with severe ischemic heart disease in type 2 diabetic patients: Chronic platelet activation in diabetic heart patients. 2003 Sep-Oct J. Diabetes Complicat. pmid:12954156
Kerek M et al. Effects of recombinant platelet activating factor acetylhydrolase in obstructive jaundice. 2003 Jul-Aug Hepatogastroenterology pmid:12845989
Baltás E et al. Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. 2003 Jul-Aug Skin Pharmacol. Appl. Skin Physiol. pmid:12784066
Hsueh W et al. Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. 2003 Jan-Feb Pediatr. Dev. Pathol. pmid:12424605
Diez-Fraile A et al. Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. 2003 Jan-Feb Vet. Res. pmid:12588684
Koyama N Platelet activating factor in surfactant-TA is inhibited by coexisting inhibitors. 2003 Lung pmid:14692561
Russo S et al. Platelet-activating factor mediates CD40-dependent angiogenesis and endothelial-smooth muscle cell interaction. 2003 J. Immunol. pmid:14607955
Slomiany BL and Slomiany A Biphasic role of platelet-activating factor in oral mucosal ulcer healing. 2003 IUBMB Life pmid:14609204
Shigematsu S et al. Resveratrol, a red wine constituent polyphenol, prevents superoxide-dependent inflammatory responses induced by ischemia/reperfusion, platelet-activating factor, or oxidants. 2003 Free Radic. Biol. Med. pmid:12654468
Zhang Y et al. Antioxidant superoxide dismutase attenuates increased endothelial permeability induced by platelet-activating factor. 2003 J. Soc. Gynecol. Investig. pmid:12517587
Collado MP et al. Endothelin-1 decreases ethanolamine plasmalogen levels and evokes PAF production in brain microvessels. 2003 Microvasc. Res. pmid:14609525
Odeh AI et al. Effect of platelet-activating factor (PAF) on stallion sperm motility, capacitation and the acrosome reaction. 2003 Reproduction pmid:14611633
Kuo RY et al. Antiplatelet activity of benzylisoquinoline derivatives oxidized by cerium(IV) ammonium nitrate. 2003 Bioorg. Med. Chem. Lett. pmid:12873516
Sugimoto Y et al. Inhibitory effects of glucocorticoids on rat eosinophil superoxide generation and chemotaxis. 2003 Int. Immunopharmacol. pmid:12781701
Yang Y et al. Kupffer cells are a major source of increased platelet activating factor in the CCl4-induced cirrhotic rat liver. 2003 J. Hepatol. pmid:12873816
Biffl WL et al. Clinically relevant hypertonicity prevents stored blood- and lipid-mediated delayed neutrophil apoptosis independent of p38 MAPK or caspase-3 activation. 2003 Surgery pmid:12874587
Akisu M et al. Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. 2003 Prostaglandins Leukot. Essent. Fatty Acids pmid:12878450
Zhu X et al. Structural determinants of blockade of eosinophil activation, adhesion and secretion by synthetic analogs of phomactin. 2003 Life Sci. pmid:14519449
Møller CH and Steinbrüchel DA Platelet function after coronary artery bypass grafting: is there a procoagulant activity after off-pump compared with on-pump surgery? 2003 Scand. Cardiovasc. J. pmid:12881156
Guarino MP et al. PAF-like lipids- and PAF-induced gallbladder muscle contraction is mediated by different pathways in guinea pigs. 2003 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:12936911
Curry FE et al. Thrombin increases permeability only in venules exposed to inflammatory conditions. 2003 Am. J. Physiol. Heart Circ. Physiol. pmid:12893636
Mayer K et al. Omega-3 vs. omega-6 lipid emulsions exert differential influence on neutrophils in septic shock patients: impact on plasma fatty acids and lipid mediator generation. 2003 Intensive Care Med pmid:12897994
Gabrijelcic J et al. Neutrophil airway influx by platelet-activating factor in asthma: role of adhesion molecules and LTB4 expression. 2003 Eur. Respir. J. pmid:12952263
Nomikos TN et al. Acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (lyso-PAF AT) activity in cortical and medullary human renal tissue. 2003 Eur. J. Biochem. pmid:12846832
Suzuki M et al. Actin assembly is a crucial factor for superoxide anion generation from adherent human eosinophils. 2003 J. Allergy Clin. Immunol. pmid:12847489
Liu J et al. Lipopolysaccharide induces anandamide synthesis in macrophages via CD14/MAPK/phosphoinositide 3-kinase/NF-kappaB independently of platelet-activating factor. 2003 J. Biol. Chem. pmid:12949078
Mano T et al. Novel imidazole compounds as a new series of potent, orally active inhibitors of 5-lipoxygenase. 2003 Bioorg. Med. Chem. pmid:12927848
Talvani A et al. Experimental Trypanosoma cruzi infection in platelet-activating factor receptor-deficient mice. 2003 Microbes Infect. pmid:12850205
Lie WJ et al. Regulation and kinetics of platelet-activating factor and leukotriene C4 synthesis by activated human basophils. 2003 Clin. Exp. Allergy pmid:12911788
Beck-Speier I et al. Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. 2003 Prostaglandins Other Lipid Mediat. pmid:14518563
Kusunoki H et al. Relation between serum 3-deoxyglucosone and development of diabetic microangiopathy. 2003 Diabetes Care pmid:12766129
Gödecke A PAF, PIP(3) and NO: emerging role in reperfusion injury. 2003 Cardiovasc. Res. pmid:14613846
Strümper D et al. Effects of antidepressants on function and viability of human neutrophils. 2003 Anesthesiology pmid:12766643
Alloatti G et al. Phosphoinositide 3-kinase gamma-deficient hearts are protected from the PAF-dependent depression of cardiac contractility. 2003 Cardiovasc. Res. pmid:14613853
Pizurki L et al. Angiopoietin-1 inhibits endothelial permeability, neutrophil adherence and IL-8 production. 2003 Br. J. Pharmacol. pmid:12770938
Akisu M et al. Supplementation with Saccharomyces boulardii ameliorates hypoxia/reoxygenation-induced necrotizing enterocolitis in young mice. 2003 Eur J Pediatr Surg pmid:14618522
Takizawa T et al. Distinct isoforms of protein kinase C are involved in human eosinophil functions induced by platelet-activating factor. 2003 Int. Arch. Allergy Immunol. pmid:12771544
Fernandes LB and Goldie RG The single mediator approach to asthma therapy: is it so unreasonable? 2003 Curr Opin Pharmacol pmid:12810188
Zhang X et al. Age-related increase of plasma platelet-activating factor concentrations in Chinese. 2003 Clin. Chim. Acta pmid:14568193
Watanabe J et al. Endotoxins stimulate neutrophil adhesion followed by synthesis and release of platelet-activating factor in microparticles. 2003 J. Biol. Chem. pmid:12810708
Toledo AA et al. Fertilization potential of human sperm is correlated with endogenous platelet-activating factor content. 2003 J. Assist. Reprod. Genet. pmid:12812462
De Vriese AS and Bourgeois M Pharmacologic treatment of acute renal failure in sepsis. 2003 Curr Opin Crit Care pmid:14639066
Souza DG et al. Role of PAF receptors during intestinal ischemia and reperfusion injury. A comparative study between PAF receptor-deficient mice and PAF receptor antagonist treatment. 2003 Br. J. Pharmacol. pmid:12812996
Alviano DS et al. Differentiation of Fonsecaea pedrosoi mycelial forms into sclerotic cells is induced by platelet-activating factor. 2003 Res. Microbiol. pmid:14643407
Brown RA et al. Effects of heparin and related molecules upon neutrophil aggregation and elastase release in vitro. 2003 Br. J. Pharmacol. pmid:12813008
Chlopicki S et al. Obligatory role of lipid mediators in platelet-neutrophil adhesion. 2003 Thromb. Res. pmid:14592550
Montrucchio G et al. Mechanisms of the priming effect of low doses of lipopoly-saccharides on leukocyte-dependent platelet aggregation in whole blood. 2003 Thromb. Haemost. pmid:14597983
Shabanov VV [Cytokines and other signal molecules in the pathogenesis of acute pancreatitis]. 2003 Vestn. Akad. Med. Nauk SSSR pmid:14598737
Estellés R et al. Effect of two phenanthrene alkaloids on angiotensin II-induced leukocyte-endothelial cell interactions in vivo. 2003 Br. J. Pharmacol. pmid:14559857
Fragopoulou E et al. Structure elucidation of phenolic compounds from red/white wine with antiatherogenic properties. 2003 Biochim. Biophys. Acta pmid:12782155
Marshall JC Such stuff as dreams are made on: mediator-directed therapy in sepsis. 2003 Nat Rev Drug Discov pmid:12750742
Bayar MA et al. The effect of EGb-761 on morphologic vasospasm in canine basilar artery after subarachnoid hemorrhage. 2003 J. Cardiovasc. Pharmacol. pmid:12960685
Kato M et al. The role of platelet activating factor and the efficacy of apafant ophthalmic solution in experimental allergic conjunctivitis. 2003 J Ocul Pharmacol Ther pmid:12964956
Ishiura Y et al. Airway eosinophil accumulation on sensory neuropeptide release in a guinea pig model of distilled-water-induced bronchoconstriction. 2003 J Investig Allergol Clin Immunol pmid:12968390
Calabresi L et al. Endothelial protection by high-density lipoproteins: from bench to bedside. 2003 Arterioscler. Thromb. Vasc. Biol. pmid:12969988
Zhao XY et al. [Effects of BIO-1211 on eosinophil chemotaxis, recruitment and mediator release]. 2003 Zhejiang Da Xue Xue Bao Yi Xue Ban pmid:12970925
Izquierdo I et al. Rupatadine: a new selective histamine H1 receptor and platelet-activating factor (PAF) antagonist. A review of pharmacological profile and clinical management of allergic rhinitis. 2003 Drugs Today pmid:12944997
Zang BX et al. [Antagonistic effect of myricetin on platelet activing factor]. 2003 Yao Xue Xue Bao pmid:14991995
Benelli R et al. Neutrophils and angiogenesis: potential initiators of the angiogenic cascade. 2003 Chem Immunol Allergy pmid:12947984
Wierzbicki T et al. IL-4 primes human endothelial cells for secondary responses to histamine. 2003 J. Leukoc. Biol. pmid:12949246
Khanna A et al. Beneficial effects of intraluminal nitroglycerin in intestinal ischemia-reperfusion injury in rats. 2003 J. Surg. Res. pmid:13678693
Bazan NG Synaptic lipid signaling: significance of polyunsaturated fatty acids and platelet-activating factor. 2003 J. Lipid Res. pmid:13130128
Lee JM et al. Identification of the NF-E2-related factor-2-dependent genes conferring protection against oxidative stress in primary cortical astrocytes using oligonucleotide microarray analysis. 2003 J. Biol. Chem. pmid:12556532
Handa RK et al. Platelet-activating factor and solute transport processes in the kidney. 2003 Am. J. Physiol. Renal Physiol. pmid:12529272
Zhao H et al. Influence of platelet activating factor on expression of adhesion molecules in experimental pancreatitis. 2003 World J. Gastroenterol. pmid:12532462
Kolko M et al. Neuronal damage by secretory phospholipase A2: modulation by cytosolic phospholipase A2, platelet-activating factor, and cyclooxygenase-2 in neuronal cells in culture. 2003 Neurosci. Lett. pmid:12566178
Vogensen SB et al. Preparation of 7-substituted ginkgolide derivatives: potent platelet activating factor (PAF) receptor antagonists. 2003 J. Med. Chem. pmid:12570381
Gabbianelli R et al. A new method to evaluate spontaneous platelet aggregation in type 2 diabetes by Cellfacts. 2003 Clin. Chim. Acta pmid:12589971
D'Andrea G et al. Platelet aggregation profiles in cluster headache. 2003 Headache pmid:12603647