Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hyperalgesia D006930 42 associated lipids
Spinal Cord Injuries D013119 34 associated lipids
Ventricular Fibrillation D014693 16 associated lipids
Fever D005334 35 associated lipids
Anaphylaxis D000707 35 associated lipids
Pneumococcal Infections D011008 7 associated lipids
Thrombocytopenia D013921 15 associated lipids
Bronchial Spasm D001986 18 associated lipids
Shock, Septic D012772 11 associated lipids
Immune Complex Diseases D007105 9 associated lipids
Conjunctivitis D003231 7 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Rheumatic Diseases D012216 7 associated lipids
Death, Sudden D003645 12 associated lipids
Vitamin E Deficiency D014811 29 associated lipids
Cardiomegaly D006332 31 associated lipids
Leukemia, T-Cell D015458 23 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Foster AP et al. Effects of WEB 2086, an antagonist to the receptor for platelet-activating factor (PAF), on PAF-induced responses in the horse. 1992 Equine Vet. J. pmid:1318830
Asako H et al. Modulation of leukocyte adhesion in rat mesenteric venules by aspirin and salicylate. 1992 Gastroenterology pmid:1319367
Smither RL and Fan TP Effects of platelet-activating factor on endothelial cells and fibroblasts in vitro. 1992 EXS pmid:1319778
Zeng N [Determination of plasma level of platelet activating factor in cirrhotic patients and its relation to endotoxemia]. 1992 Zhonghua Yi Xue Za Zhi pmid:1319804
Sakamoto T et al. Effect of Hoe 140, a new bradykinin receptor antagonist, on bradykinin- and platelet-activating factor-induced bronchoconstriction and airway microvascular leakage in guinea pig. 1992 Eur. J. Pharmacol. pmid:1319919
Travis SP and Jewell DP Regional differences in the response to platelet-activating factor in rabbit colon. 1992 Clin. Sci. pmid:1320548
Di Maria GU et al. Nedocromil sodium inhibits the increase in airway reactivity induced by platelet activating factor in humans. 1992 Chest pmid:1320563
Casale TB et al. Degree of neutrophil chemotaxis is dependent upon the chemoattractant and barrier. 1992 Am. J. Respir. Cell Mol. Biol. pmid:1320901
Mabuchi K et al. Differential effects of platelet-activating factor on superoxide anion production in human eosinophils and neutrophils. 1992 Biochem. Int. pmid:1321621
Patel KD et al. Novel leukocyte agonists are released by endothelial cells exposed to peroxide. 1992 J. Biol. Chem. pmid:1321830
Tufano MA et al. Salmonella typhimurium porins stimulate platelet-activating factor synthesis by human polymorphonuclear neutrophils. 1992 J. Immunol. pmid:1321849
Hennet T et al. A kinetic study of immune mediators in the lungs of mice infected with influenza A virus. 1992 J. Immunol. pmid:1321855
Schwinger RH et al. Existence of PAF receptors in human platelets and human lung tissue but not in the human myocardium. 1992 Am. Heart J. pmid:1322030
Seyfried CE et al. The human platelet-activating factor receptor gene (PTAFR) contains no introns and maps to chromosome 1. 1992 Genomics pmid:1322356
Heller R et al. Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells. 1992 Biochem. Pharmacol. pmid:1322663
Kowanko IC et al. Platelet-activating factor inhibits proteoglycan synthesis and enhances neutrophil-mediated proteoglycan degradation in cartilage explants. 1992 Arthritis Rheum. pmid:1322671
Gandhi CR et al. Platelet-activating factor-mediated synthesis of prostaglandins in rat Kupffer cells. 1992 Biochim. Biophys. Acta pmid:1322709
Cabellos C et al. Differing roles for platelet-activating factor during inflammation of the lung and subarachnoid space. The special case of Streptococcus pneumoniae. 1992 J. Clin. Invest. pmid:1322943
Chau LY et al. Possible existence of two subsets of platelet-activating factor receptor to mediate polyphosphoinositide breakdown and calcium influx in neuroblastoma x glioma hybrid NG 108-15 cells. 1992 J. Neurochem. pmid:1322966
Lee TC and Snyder F 1-alkyl-2-acetyl-sn-glycerol cholinephosphotransferase. 1992 Meth. Enzymol. pmid:1323043
Snyder F et al. 1-alkyl-2-lyso-sn-glycero-3-phosphate acetyltransferase. 1992 Meth. Enzymol. pmid:1323050
Jones MA et al. Rabbit blastocysts accumulate platelet-activating factor (PAF) and lyso-PAF in vitro. 1992 Mol. Reprod. Dev. pmid:1323306
Bito H et al. Platelet-activating factor (PAF) receptor in rat brain: PAF mobilizes intracellular Ca2+ in hippocampal neurons. 1992 Neuron pmid:1323312
Hanahan DJ Platelet-activating factor: a novel lipid agonist. 1992 Curr. Top. Cell. Regul. pmid:1323447
de Lima WT et al. Immune-complex alveolitis in the rat: evidence for platelet activating factor and leukotrienes as mediators of the vascular lesions. 1992 Eur. J. Pharmacol. pmid:1323472
Filep JG et al. Dexamethasone-induced gastric mucosal damage in the rat: possible role of platelet-activating factor. 1992 Br. J. Pharmacol. pmid:1324056
Brodie C et al. Ethanol inhibits ligand-activated Ca2+ channels in human B lymphocytes. 1992 J. Cell. Physiol. pmid:1324242
Rabinovici R et al. Role of complement in endotoxin/platelet-activating factor-induced lung injury. 1992 J. Immunol. pmid:1324280
Yue TL et al. Protein kinase C activator phorbol 12, 13-dibutyrate inhibits platelet activating factor-stimulated Ca2+ mobilization and phosphoinositide turnover in neurohybrid NG108-15 cells. 1992 Neurochem. Res. pmid:1324441
Wang S and Townley RG Effects of platelet activating factor on cyclic AMP accumulation in human lymphocytes. 1992 Ann Allergy pmid:1324627
Salari H et al. Two different sites of action for platelet activating factor and 1-O-alkyl-2-O-methyl-sn-glycero-3-phosphocholine on platelets and leukemic cells. 1992 Biochem. Cell Biol. pmid:1324692
Hiltz ME et al. Alpha-MSH peptides inhibit acute inflammation induced in mice by rIL-1 beta, rIL-6, rTNF-alpha and endogenous pyrogen but not that caused by LTB4, PAF and rIL-8. 1992 Cytokine pmid:1325196
Travers JB et al. Binding of carbamyl-platelet-activating factor to the Raji lymphoblast platelet-activating factor receptor. 1992 Int. J. Immunopharmacol. pmid:1325953
Mazer BD et al. Platelet-activating factor-mediated transmembrane signaling in human B lymphocytes is regulated through a pertussis- and cholera toxin-sensitive pathway. 1992 J. Clin. Invest. pmid:1325997
Sung CP et al. CGRP stimulates the adhesion of leukocytes to vascular endothelial cells. 1992 May-Jun Peptides pmid:1326102
Agrawal DK et al. PAF receptors and G-proteins in human blood eosinophils and neutrophils. 1992 Jun-Jul J Lipid Mediat pmid:1326343
Honda Z et al. Properties of the guinea-pig lung platelet-activating factor receptor encoded by the cloned cDNA. 1992 Jun-Jul J Lipid Mediat pmid:1326344
Sugiura T et al. Synthesis and action of PAF in human eosinophils. 1992 Jun-Jul J Lipid Mediat pmid:1326345
Ikegami K et al. Hetrazepine PAF antagonists. 1992 Jun-Jul J Lipid Mediat pmid:1326346
Turner NC and Wood LJ Characterization of the antagonist activity of the PAF antagonists RP 59227 and WEB 2086 on elicited guinea pig peritoneal macrophages. Evidence for variable affinities and kinetics. 1992 J. Pharmacol. Exp. Ther. pmid:1326625
Jamil KM et al. Expression of platelet activating factor receptor in renal tubular cell line (LLC-PK1). 1992 Biochem. Biophys. Res. Commun. pmid:1326956
Nieminen MM et al. Inhaled budesonide fails to inhibit the PAF-induced increase in plasma leukotriene B4 in man. 1992 Br J Clin Pharmacol pmid:1327049
Kuznetsova TI and Kulikov VI [The effect of aldehydogenic and acyl structural analogs of platelet activating factor on the formation of superoxide radicals by human blood leukocytes]. 1992 Biokhimiia pmid:1327185
Herbert JM et al. Ex vivo effects of SR 27417, a novel PAF antagonist, on rabbit platelet aggregation and [3H]-PAF binding. 1992 J Lipid Mediat pmid:1327264
Schmidt J et al. Characterization of platelet-activating factor induced superoxide anion generation by guinea-pig alveolar macrophages. 1992 J Lipid Mediat pmid:1327265
Chung KF Platelet-activating factor in inflammation and pulmonary disorders. 1992 Clin. Sci. pmid:1327626
Ko FN et al. PAF antagonism in vitro and in vivo by aglafoline from Aglaia elliptifolia Merr. 1992 Eur. J. Pharmacol. pmid:1327822
Liu H et al. Regulation of the surface expression of the platelet-activating factor receptor in IC-21 peritoneal macrophages. Effects of lipopolysaccharide. 1992 J. Biol. Chem. pmid:1328211
Alvaro RF et al. Determination of enantiomeric concentrations of a 2,5-diaryltetrahydrofuran (L-668,750), a platelet-activating factor receptor antagonist, in rat plasma using a chiral alpha 1-acid glycoprotein high-performance liquid chromatographic column. 1992 J. Chromatogr. pmid:1328270
Nguer CM et al. Regulation of paf-acether receptor expression in human B cells. 1992 J. Immunol. pmid:1328384