| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperalgesia | D006930 | 42 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Ventricular Fibrillation | D014693 | 16 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Pneumococcal Infections | D011008 | 7 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Shock, Septic | D012772 | 11 associated lipids |
| Immune Complex Diseases | D007105 | 9 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Rheumatic Diseases | D012216 | 7 associated lipids |
| Death, Sudden | D003645 | 12 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Carbon Monoxide Poisoning | D002249 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Brady HR et al. | Chemoattractants provoke monocyte adhesion to human mesangial cells and mesangial cell injury. | 1992 | Kidney Int. | pmid:1328754 |
| Bensard DD et al. | Platelet activating factor alters receptor-coupled function in the isolated perfused rat heart. | 1992 | J. Surg. Res. | pmid:1328766 |
| Domingo MT et al. | Reversible or irreversible modification of [3H]PAF binding on rabbit platelet membranes differentiates various PAF receptor antagonists. | 1992 | Lipids | pmid:1328798 |
| Wang YY and Li CL | [Platelet-activating factor antagonists and asthma]. | 1992 | Sheng Li Ke Xue Jin Zhan | pmid:1329195 |
| Shukla SD et al. | Hypersensitivity of diabetic human platelets to platelet activating factor. | 1992 | Thromb. Res. | pmid:1329254 |
| Shimizu T et al. | Platelet-activating factor receptor and signal transduction. | 1992 | Biochem. Pharmacol. | pmid:1329754 |
| Rossi AG et al. | The role of complement, platelet-activating factor and leukotriene B4 in a reversed passive Arthus reaction. | 1992 | Br. J. Pharmacol. | pmid:1330163 |
| Grigoriadis G and Stewart AG | Albumin inhibits platelet-activating factor (PAF)-induced responses in platelets and macrophages: implications for the biologically active form of PAF. | 1992 | Br. J. Pharmacol. | pmid:1330167 |
| Hiraide A et al. | Platelet-activating factor causes hypoketonaemia in starved rats. | 1992 | Clin. Sci. | pmid:1330413 |
| Nagahisa A et al. | Antiinflammatory and analgesic activity of a non-peptide substance P receptor antagonist. | 1992 | Eur. J. Pharmacol. | pmid:1330589 |
| Müller S and Nigam S | Arachidonic acid release and platelet-activating factor formation by staurosporine in human neutrophils challenged with n-formyl peptide. | 1992 | Eur. J. Pharmacol. | pmid:1330596 |
| el-Moatassim C and Dubyak GR | A novel pathway for the activation of phospholipase D by P2z purinergic receptors in BAC1.2F5 macrophages. | 1992 | J. Biol. Chem. | pmid:1331096 |
| Kester M et al. | Platelet-activating factor stimulates multiple signaling pathways in cultured rat mesangial cells. | 1992 | J. Cell. Physiol. | pmid:1331121 |
| Thivierge M and Rola-Pleszczynski M | Platelet-activating factor enhances interleukin-6 production by alveolar macrophages. | 1992 | J. Allergy Clin. Immunol. | pmid:1331218 |
| Atochina EN et al. | Systemic administration of platelet-activating factor in rat reduces specific pulmonary uptake of circulating monoclonal antibody to angiotensin-converting enzyme. | 1992 | Lung | pmid:1331624 |
| Valone FH | Binding of platelet-activating factor 1-O-alkyl-2-acetyl-sn-glycero-3-phosphorylcholine to intact platelets and platelet membranes. | 1992 | Meth. Enzymol. | pmid:1331707 |
| Foster AP et al. | Platelet activating factor is a mediator of equine neutrophil and eosinophil migration in vitro. | 1992 | Res. Vet. Sci. | pmid:1332153 |
| Silliman CC et al. | Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. | 1992 | Vox Sang. | pmid:1332255 |
| Kjeldsen L et al. | Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules. | 1992 | Biochem. J. | pmid:1332677 |
| O'Flaherty JT et al. | Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils. | 1992 | Biochem. J. | pmid:1332696 |
| Sieunarine K et al. | Plasma levels of the lipid mediators, leukotriene B4 and lyso platelet-activating factor, in intraoperative salvaged blood. | 1992 | Vox Sang. | pmid:1333134 |
| Cattaneo M et al. | Identification of a new congenital defect of platelet function characterized by severe impairment of platelet responses to adenosine diphosphate. | 1992 | Blood | pmid:1333302 |
| Selak MA | Neutrophil elastase potentiates cathepsin G-induced platelet activation. | 1992 | Thromb. Haemost. | pmid:1333649 |
| Sun DX et al. | Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1333718 |
| Nakamura M et al. | Endotoxin transduces Ca2+ signaling via platelet-activating factor receptor. | 1992 | FEBS Lett. | pmid:1333988 |
| Bautista AP and Spitzer JJ | Platelet activating factor stimulates and primes the liver, Kupffer cells and neutrophils to release superoxide anion. | 1992 | Free Radic. Res. Commun. | pmid:1334036 |
| Bauldry SA et al. | Activation of NADPH oxidase and phospholipase D in permeabilized human neutrophils. Correlation between oxidase activation and phosphatidic acid production. | 1992 | J. Biol. Chem. | pmid:1334083 |
| Schrör K and Felsch A | Ramiprilat prevents PAF-induced myocellular and endothelial injury in a neutrophil-perfused heart preparation. | 1992 | Agents Actions Suppl. | pmid:1334351 |
| Clark GD et al. | Enhancement of hippocampal excitatory synaptic transmission by platelet-activating factor. | 1992 | Neuron | pmid:1334422 |
| Menegazzi R et al. | A new, one-step assay on whole cell suspensions for peroxidase secretion by human neutrophils and eosinophils. | 1992 | J. Leukoc. Biol. | pmid:1334501 |
| Bochkov VN et al. | Platelets in patients with homozygous familial hypercholesterolemia are sensitive to Ca(2+)-mobilizing activity of low density lipoproteins. | 1992 | Atherosclerosis | pmid:1334652 |
| Qian C et al. | Increased platelet-activating factor (PAF) concentrations in hearts and lungs of Pichinde virus-infected guinea pigs. | 1992 | J Lipid Mediat | pmid:1334721 |
| Kudolo GB and Harper MJ | Pregnancy-associated remodeling of rabbit endometrial platelet-activating factor receptors. | 1992 | J Lipid Mediat | pmid:1334722 |
| Burgers JA and Akkerman JW | Effect of platelet agonists on the binding of platelet-activating factor to human platelets. | 1992 | J Lipid Mediat | pmid:1334723 |
| Kadiri C et al. | Guinea-pig treatment with pertussis toxin suppresses macrophage-dependent bronchoconstriction by fMLP and fails to inhibit the effects of PAF. | 1992 | Br. J. Pharmacol. | pmid:1334747 |
| Tashiro K et al. | Effects of PAF on excitatory neuro-effector transmission in dog airways. | 1992 | Br. J. Pharmacol. | pmid:1334755 |
| Tanimoto Y et al. | Effects of cytokines on human basophil chemotaxis. | 1992 | Clin. Exp. Allergy | pmid:1334781 |
| Sargeant P et al. | Calcium influx evoked by Ca2+ store depletion in human platelets is more susceptible to cytochrome P-450 inhibitors than receptor-mediated calcium entry. | 1992 | Cell Calcium | pmid:1334809 |
| Chao W et al. | Protein tyrosine phosphorylation and regulation of the receptor for platelet-activating factor in rat Kupffer cells. Effect of sodium vanadate. | 1992 | Biochem. J. | pmid:1335232 |
| Hii CS et al. | Basal and phorbol-ester-stimulated turnover of phosphatidylcholine in HeLa cells involve different pathways. | 1992 | Biochem. J. | pmid:1335237 |
| Müller S and Nigam S | Enhancement by staurosporine of platelet-activating factor formation in N-formyl peptide-challenged human neutrophils is mediated by intracellular platelet-activating factor binding sites. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1335246 |
| Camussi G et al. | Porins and lipopolysaccharide stimulate platelet activating factor synthesis by human mesangial cells. | 1992 | Kidney Int. | pmid:1335527 |
| Ahmed AS and Smith SK | The endometrium: prostaglandins and intracellular signalling at implantation. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1335852 |
| Wissner A et al. | Analogues of platelet activating factor. 7. Bis-aryl amide and bis-aryl urea receptor antagonists of PAF. | 1992 | J. Med. Chem. | pmid:1336052 |
| Hayes JP et al. | Attenuation of platelet-activating factor induced bronchoconstriction by nedocromil sodium. | 1992 | Eur. Respir. J. | pmid:1336735 |
| Scappaticci E et al. | Platelet-activating factor in bronchoalveolar lavage from patients with sarcoidosis. | 1992 | Am. Rev. Respir. Dis. | pmid:1336939 |
| Smith IL and Smith EA | Inhibition of PAF-induced activation of human platelets by verapamil. | 1992 | Blood Coagul. Fibrinolysis | pmid:1336985 |
| Watanabe T | [Metabolism and action mechanisms of eicosanoids and platelet-activating factor in the kidney]. | 1992 | Nippon Rinsho | pmid:1337118 |
| Doucet JP and Bazan NG | Excitable membranes, lipid messengers, and immediate-early genes. Alteration of signal transduction in neuromodulation and neurotrauma. | 1992 | Mol. Neurobiol. | pmid:1337456 |
| Walker BA and Ward PA | Priming and signal transduction in neutrophils. | 1992 Sep-Oct | Biol. Signals | pmid:1339178 |