| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hyperalgesia | D006930 | 42 associated lipids |
| Spinal Cord Injuries | D013119 | 34 associated lipids |
| Ventricular Fibrillation | D014693 | 16 associated lipids |
| Fever | D005334 | 35 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Pneumococcal Infections | D011008 | 7 associated lipids |
| Thrombocytopenia | D013921 | 15 associated lipids |
| Bronchial Spasm | D001986 | 18 associated lipids |
| Shock, Septic | D012772 | 11 associated lipids |
| Immune Complex Diseases | D007105 | 9 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Coronary Artery Disease | D003324 | 47 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
| Dermatitis, Atopic | D003876 | 19 associated lipids |
| Rheumatic Diseases | D012216 | 7 associated lipids |
| Death, Sudden | D003645 | 12 associated lipids |
| Vitamin E Deficiency | D014811 | 29 associated lipids |
| Cardiomegaly | D006332 | 31 associated lipids |
| Leukemia, T-Cell | D015458 | 23 associated lipids |
| Carbon Monoxide Poisoning | D002249 | 9 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bellan JA et al. | Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat. | 1992 | Am. J. Physiol. | pmid:1379004 |
| Nossaman BD et al. | Blockade of thromboxane/endoperoxide receptor-mediated responses in the pulmonary vascular bed of the cat by sulotroban. | 1992 | Eur. J. Pharmacol. | pmid:1379928 |
| Pretolani M et al. | Effect of human recombinant interleukin-5 on in vitro responsiveness to PAF of lung from actively sensitized guinea-pigs. | 1992 | Br. J. Pharmacol. | pmid:1380388 |
| Eliakim R and Rachmilewitz D | Inflammatory mediators and the pathogenesis of inflammatory bowel disease. | 1992 Jul-Aug | Ital J Gastroenterol | pmid:1381246 |
| Tripathi YB et al. | Involvement of tyrosine kinase and protein kinase C in platelet-activating-factor-induced c-fos gene expression in A-431 cells. | 1992 | Biochem. J. | pmid:1382409 |
| Andrade SP et al. | Effects of platelet activating factor (PAF) and other vasoconstrictors on a model of angiogenesis in the mouse. | 1992 | Int J Exp Pathol | pmid:1382541 |
| Hayes JP et al. | Involvement of inflammatory mediators in the airway responses to trimellitic anhydride in sensitized guinea-pigs. | 1992 | Br. J. Pharmacol. | pmid:1382788 |
| Yano S | [Drug therapy of asthma by antiallergic agents]. | 1992 | Nippon Naika Gakkai Zasshi | pmid:1383362 |
| Massion PB and Frans A | [Role of platelet activating factor and its antagonists in bronchial asthma]. | 1992 | Rev Pneumol Clin | pmid:1384101 |
| Asako H et al. | Reduction of leukocyte adherence and emigration by cyclosporine and L683,590 (FK506) in postcapillary venules. | 1992 | Transplantation | pmid:1384191 |
| Kimoto M et al. | Dual effects of oleic acid on Ca2+ mobilization and protein phosphorylation in human platelets in presence or absence of platelet activating factor. | 1992 | Arch. Biochem. Biophys. | pmid:1384432 |
| Andrade SP et al. | Effects of tumour cells on angiogenesis and vasoconstrictor responses in sponge implants in mice. | 1992 | Br. J. Cancer | pmid:1384642 |
| Martinez-Cuesta MA et al. | The role of nitric oxide and platelet-activating factor in the inhibition by endotoxin of pentagastrin-stimulated gastric acid secretion. | 1992 | Eur. J. Pharmacol. | pmid:1385169 |
| Fumarola D and Pece S | More on pathogenesis and treatment of septic shock. | 1992 | Eur. J. Epidemiol. | pmid:1385209 |
| Barrett KE | Complex cellular recognition events in acute inflammation. | 1992 | Gastroenterology | pmid:1385256 |
| Konturek SJ et al. | Role of platelet activating factor in pathogenesis of acute pancreatitis in rats. | 1992 | Gut | pmid:1385272 |
| Numao T and Agrawal DK | Neuropeptides modulate human eosinophil chemotaxis. | 1992 | J. Immunol. | pmid:1385521 |
| Hood JS et al. | Daltroban blocks thromboxane responses in the pulmonary vascular bed of the cat. | 1992 | J. Appl. Physiol. | pmid:1385804 |
| Okamoto H et al. | Suppression of the Arthus reaction by Y-24180, a potent and specific antagonist of platelet-activating factor. | 1992 | Agents Actions | pmid:1388318 |
| Kitagawa S et al. | Role of endogenous platelet-activating factor (PAF) in endotoxin-induced portal hypertension in rats. | 1992 Sep-Oct | J. Gastroenterol. Hepatol. | pmid:1391729 |
| Bernat A et al. | Protective effect of SR 27417, a novel PAF antagonist, on PAF- or endotoxin-induced hypotension in the rat and the guinea-pig. | 1992 | J Lipid Mediat | pmid:1391738 |
| Macpherson JL et al. | Production and characterization of antibodies to platelet-activating factor. | 1992 | J Lipid Mediat | pmid:1391739 |
| Yang YQ et al. | Binding of platelet-activating factor to oviductal membranes during early pregnancy in the rabbit. | 1992 | J Lipid Mediat | pmid:1391740 |
| Mathison R et al. | Platelet activating factor and systemic anaphylaxis in Nippostrongylus brasiliensis-sensitized rats: differential effects of PAF antagonists. | 1992 | Br. J. Pharmacol. | pmid:1393261 |
| Shibuya H et al. | Syntheses of a glycerophospholipid, C16-platelet activating factor and a palmitoyl analogue of M-5, an anti-inflammatory glyceroglycolipid. | 1992 | Chem. Pharm. Bull. | pmid:1394629 |
| Iwakami S et al. | Platelet activating factor (PAF) antagonists contained in medicinal plants: lignans and sesquiterpenes. | 1992 | Chem. Pharm. Bull. | pmid:1394633 |
| Yoshikawa D and Goto F | Effect of platelet-activating factor antagonist and leukotriene antagonist on endotoxin shock in the rat: role of the leukocyte. | 1992 | Circ. Shock | pmid:1394861 |
| Chang SW | Endotoxin-induced lung vascular injury: role of platelet activating factor, tumor necrosis factor and neutrophils. | 1992 | Clin Res | pmid:1395440 |
| Taniguchi H et al. | Role of platelet-activating factor in pulmonary edema after coronary ligation in dogs. | 1992 | Chest | pmid:1395776 |
| Sobhani I et al. | Significance and regulation of gastric secretion of platelet-activating factor (PAF-acether) in man. | 1992 | Dig. Dis. Sci. | pmid:1396006 |
| Friedman M et al. | Effects of ozone exposure on lipid metabolism in human alveolar macrophages. | 1992 | Environ. Health Perspect. | pmid:1396473 |
| Pretolani M et al. | Inhibition by azelastine of the effects of platelet-activating factor in lungs from actively sensitised guinea-pigs. | 1992 | Eur. J. Pharmacol. | pmid:1397002 |
| Herbert JM et al. | Effect of SR 27417 on oedema formation induced in rabbit skin by platelet-activating factor or antigen. | 1992 | Eur. J. Pharmacol. | pmid:1397004 |
| Hogaboam CM et al. | PF-5901 inhibits gastrointestinal platelet-activating factor synthesis in vivo. | 1992 | Eur. J. Pharmacol. | pmid:1397016 |
| Ono S et al. | PAF antagonists inhibit pulmonary vascular remodeling induced by hypobaric hypoxia in rats. | 1992 | J. Appl. Physiol. | pmid:1400021 |
| Davidson D and Drafta D | Prolonged pulmonary hypertension caused by platelet-activating factor and leukotriene C4 in the rat lung. | 1992 | J. Appl. Physiol. | pmid:1400062 |
| Lee TC et al. | A novel CoA-independent transacetylase produces the ethanolamine plasmalogen and acyl analogs of platelet-activating factor (PAF) with PAF as the acetate donor in HL-60 cells. | 1992 | J. Biol. Chem. | pmid:1400315 |
| Girotra NN et al. | Development, synthesis, and biological evaluation of (-)-trans-(2S,5S)-2-[3-[(2-oxopropyl)sulfonyl]-4-n-propoxy-5-(3- hydroxypropoxy)-phenyl]-5-(3,4,5-trimethoxyphenyl)tetrahydrofuran, a potent orally active platelet-activating factor (PAF) antagonist and its water-soluble prodrug phosphate ester. | 1992 | J. Med. Chem. | pmid:1404229 |
| Mariano F et al. | Role of alpha 1-proteinase inhibitor in restraining peritoneal inflammation in CAPD patients. | 1992 | Kidney Int. | pmid:1405351 |
| Kraut JA et al. | Platelet-activating factor attenuates the arginine vasopressin-induced fall of transepithelial resistance across inner medullary collecting duct monolayers. | 1992 | Miner Electrolyte Metab | pmid:1406507 |
| Radeau T et al. | Enhanced esterification process of 5-hydroxyeicosatetraenoic acid (5-HETE) in PMN from asthmatic patients. | 1992 | Prostaglandins | pmid:1410523 |
| Csáki C et al. | Role of platelet-activating factor in the development of endothelial dysfunction in hemorrhagic hypotension and retransfusion. | 1992 | Thromb. Res. | pmid:1412179 |
| Wong CW et al. | Comparative effects of tetrandrine and berbamine on subcutaneous air pouch inflammation induced by interleukin-1, tumour necrosis factor and platelet-activating factor. | 1992 | Agents Actions | pmid:1414679 |
| Tran A et al. | Separate induction of human blood platelet aggregation or cytotoxicity by different concentrations of PAF-acether and thrombin. | 1992 | Agents Actions | pmid:1414687 |
| Prescott SM | What are the effects of dietary fatty acid modification on platelet eicosanoid metabolism, platelet-activating factor, and platelet function? How might these metabolic alterations influence thrombosis? | 1992 | Am. J. Clin. Nutr. | pmid:1414987 |
| Duque I et al. | Effects of reactive oxygen species on cultured rat mesangial cells and isolated rat glomeruli. | 1992 | Am. J. Physiol. | pmid:1415575 |
| Kruse-Elliott KT et al. | Differential effects of WEB 2086 and SRI 63-441 on TNF-alpha-induced alterations in cardiopulmonary function. | 1992 | Am. J. Physiol. | pmid:1415600 |
| Milhoan KA et al. | Hypoxia induces endothelial cells to increase their adherence for neutrophils: role of PAF. | 1992 | Am. J. Physiol. | pmid:1415623 |
| Dorn GW and Davis MG | Differential megakaryocytic desensitization to platelet agonists. | 1992 | Am. J. Physiol. | pmid:1415671 |
| Faden AI and Tzendzalian PA | Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma. | 1992 | Am. J. Physiol. | pmid:1415805 |