| MeSH term | MeSH ID | Detail |
|---|---|---|
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Hypercholesterolemia | D006937 | 91 associated lipids |
| Thrombosis | D013927 | 49 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Peritonitis | D010538 | 38 associated lipids |
| Hemorrhage | D006470 | 15 associated lipids |
| Proteinuria | D011507 | 30 associated lipids |
| Spasm | D013035 | 5 associated lipids |
| Lymphoma | D008223 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lukiw WJ et al. | Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9520467 |
| Tsuji H et al. | The presence of platelet-activating factor-acetylhydrolase in human middle ear effusions. | 1998 Jan-Feb | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:9519378 |
| Cannon TR et al. | Mechanisms of acute vasodilator response to bacterial lipopolysaccharide in the rat coronary microcirculation. | 1998 | Br. J. Pharmacol. | pmid:9517382 |
| Shindo K et al. | Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor. | 1997 | Thorax | pmid:9516893 |
| Chung KF | Platelet activating factor revisited. | 1997 | Thorax | pmid:9516891 |
| Balsa D et al. | Effects of a new platelet-activating factor antagonist, UR-12670, on several endotoxic shock markers in rats. | 1997 | Drugs Exp Clin Res | pmid:9515229 |
| Webber SE et al. | PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition. | 1997 | Pulm Pharmacol Ther | pmid:9514626 |
| Qayumi KA et al. | A new platelet-activating factor antagonist (CV-6209) in preservation of heart and lung for transplantation. | 1997 | Cardiovasc Drugs Ther | pmid:9512873 |
| Fink MP | Therapeutic options directed against platelet activating factor, eicosanoids and bradykinin in sepsis. | 1998 | J. Antimicrob. Chemother. | pmid:9511090 |
| Wilson PG et al. | Acute pancreatitis as a model of sepsis. | 1998 | J. Antimicrob. Chemother. | pmid:9511087 |
| Roy Baker R and Chang H | Substrate specificities of neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor: differences in the use of 1-alkyl and 1-acyl lysophospholipid acceptors. | 1998 | Biochim. Biophys. Acta | pmid:9507140 |
| Kimura K et al. | Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. | 1998 | J. Biochem. | pmid:9504421 |
| Pettit EJ and Hallett MB | Ca2+ signalling delays in neutrophils: effects of prior exposure to platelet activating factor or formyl-met-leu-phe. | 1998 | Cell. Signal. | pmid:9502117 |
| Moritani C et al. | Activation of platelets in bronchial asthma. | 1998 | Chest | pmid:9498966 |
| Rice SQ et al. | Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. | 1998 | Biochem. J. | pmid:9494101 |
| Yang HO and Han BH | Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis. | 1998 | Planta Med. | pmid:9491770 |
| Matusiewicz R and Rotkiewicz-Piorun A | Inflammatory cells in skin immunological infiltrations. | 1997 Nov-Dec | J Investig Allergol Clin Immunol | pmid:9491202 |
| Shi LC et al. | Involvement of platelet-activating factor in cell death induced under ischemia/postischemia-like conditions in an immortalized hippocampal cell line. | 1998 | J. Neurochem. | pmid:9489723 |
| Borman RA et al. | Investigation of the effects of platelet-activating factor (PAF) on ion transport and prostaglandin synthesis in human colonic mucosa in vitro. | 1998 | Br. J. Pharmacol. | pmid:9489610 |
| Yamawaki I et al. | Inhaled cromoglycate reduces airway neurogenic inflammation via tachykinin antagonism. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9485521 |