| MeSH term | MeSH ID | Detail |
|---|---|---|
| Blood Loss, Surgical | D016063 | 6 associated lipids |
| Leishmaniasis, Cutaneous | D016773 | 6 associated lipids |
| Purpura, Thrombotic Thrombocytopenic | D011697 | 6 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Thrombophilia | D019851 | 6 associated lipids |
| Rheumatic Diseases | D012216 | 7 associated lipids |
| Coronary Thrombosis | D003328 | 7 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Pelvic Pain | D017699 | 7 associated lipids |
| Postoperative Hemorrhage | D019106 | 7 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lohde C et al. | Influence of platelet activating factor antagonists on the protamine sulphate stimulated release of histamine from peritoneal mast cells of rats in vitro. | 1992 | Arzneimittelforschung | pmid:1375025 |
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| Berti F et al. | New pharmacological data on the bronchospasmolytic activity of bamifylline. | 1988 | Arzneimittelforschung | pmid:3365275 |
| Akagi M et al. | Inhibitor effect of apafant on bronchopulmonary responses to platelet activating factor and to antigen in rats. | 1997 | Arzneimittelforschung | pmid:9450165 |
| David S et al. | Production of platelet activating factor by human neutrophils after backfiltration of endotoxin contaminated dialysate. | 1993 Jul-Sep | ASAIO J. | pmid:8268642 |
| Takayama K et al. | Changes in endothelial vasoactive substances under recombinant human erythropoietin therapy in hemodialysis patients. | 1991 Jul-Sep | ASAIO Trans | pmid:1836334 |
| Akizawa T et al. | Endothelin and platelet activating factor. Possible indices for biocompatibility of hemodialysis. | 1991 Jul-Sep | ASAIO Trans | pmid:1751199 |
| Ando M et al. | Pregnancy suppression by a platelet activating factor antagonist, ONO-6240, in mice. | 1990 | Asia Oceania J Obstet Gynaecol | pmid:2378595 |
| Ando M et al. | Pregnancy suppression by a structurally related antagonist for platelet activating factor, CV-6209, in mice. | 1990 | Asia Oceania J Obstet Gynaecol | pmid:2088253 |
| Roudebush WE | Role of platelet-activating factor in reproduction: sperm function. | 2001 | Asian J. Androl. | pmid:11404790 |
| Tsai JJ et al. | The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs. | 1995 | Asian Pac. J. Allergy Immunol. | pmid:8703249 |
| Tsai JJ et al. | Enhanced eosinophil luminol-dependent chemiluminescence and complement receptor expression by platelet-activating factor and interleukin-5. | 1993 | Asian Pac. J. Allergy Immunol. | pmid:8216559 |
| Tselepis AD and John Chapman M | Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase. | 2002 | Atheroscler Suppl | pmid:12573364 |
| Feliste R et al. | Protective effect of BN 52021, a specific antagonist of platelet-activating factor (PAF-acether) against diet-induced cholesteryl ester deposition in rabbit aorta. | 1989 | Atherosclerosis | pmid:2783199 |
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| Beck JC et al. | Effects of ginkgolide B, a platelet-activating factor inhibitor on insulitis in the spontaneously diabetic BB rat. | 1991 | Autoimmunity | pmid:1777555 |
| Jauchem JR | The role of autacoids and the autonomic nervous system in cardiovascular responses to radio-frequency energy heating. | 2006 | Auton Autacoid Pharmacol | pmid:16553641 |
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| Harper MJ | The implantation window. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1424330 |
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| Pearson JD | The control of production and release of haemostatic factors in the endothelial cell. | 1993 | Baillieres Clin. Haematol. | pmid:8025346 |
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| Chu WF et al. | Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16433899 |
| Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
| Colton CA and Gilbert DL | An endogenous source of the superoxide anion in the central nervous system. | 1988 | Basic Life Sci. | pmid:2854971 |
| Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
| Napoli C et al. | Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein. | 1997 | Basic Res. Cardiol. | pmid:9166989 |
| Auchampach JA et al. | Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. | 1998 | Basic Res. Cardiol. | pmid:9833148 |
| Felix SB et al. | Cardiovascular reactions and respiratory events during platelet activating factor-induced shock. | 1990 May-Jun | Basic Res. Cardiol. | pmid:2383216 |
| Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
| Giessler C et al. | Effects of PAF on cardiac function and eicosanoid release in the isolated perfused rat heart: comparison between normotensive and spontaneously hypertensive rats. | 1995 Jul-Aug | Basic Res. Cardiol. | pmid:8534259 |
| Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
| Jerusalinsky D et al. | Effect of antagonists of platelet-activating factor receptors on memory of inhibitory avoidance in rats. | 1994 | Behav. Neural Biol. | pmid:7945139 |
| Palmblad J et al. | Leukotriene B4 induced hyperadhesiveness of endothelial cells for neutrophils. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2154222 |
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| Chesney CM et al. | Triazolobenzodiazepines competitively inhibit the binding of platelet activating factor (PAF) to human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3579913 |
| O'Flaherty JT et al. | 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820395 |
| Wymann MP et al. | Oscillatory motion in human neutrophils responding to chemotactic stimuli. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820398 |
| Sozzani S et al. | Synergism between platelet activating factor and C-C chemokines for arachidonate release in human monocytes. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7510961 |
| Rodrigues CO et al. | Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10581161 |
| Yeo YK et al. | The effect of long-term consumption of fish oil on platelet-activating factor synthesis in rat renal microsomes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543394 |
| Maridonneau-Parini I et al. | Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994661 |
| Elzi DJ et al. | Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9398641 |
| Ieyasu H et al. | A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7181916 |
| Hanahan DJ et al. | Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7236259 |
| Bastien Y and Mazer BD | Detection of the human platelet-activating factor receptor mRNA in human B lymphocytes by polymerase chain reaction on reverse transcripts (RT-PCR) | 1994 | Biochem. Biophys. Res. Commun. | pmid:8060316 |
| Rola-Pleszczynski M et al. | Inhibition of human lymphocyte proliferation and interleukin 2 production by platelet activating factor (PAF-acether): reversal by a specific antagonist, BN 52021. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3493773 |
| Ashmore RC et al. | Aggregating platelets increase intracellular calcium in endothelial cells through release of adenine nucleotides. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2302246 |
| Murphy CT et al. | Evidence for the presence and location of annexins in human platelets. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1482379 |
| Mallet AI and Cunningham FM | Structural identification of platelet activating factor in psoriatic scale. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970690 |
| Valone FH | Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3970703 |
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| Lee TC et al. | 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) stimulates calcium influx in rabbit platelets. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6797422 |
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| Patrignani P et al. | Platelet-activating factor (PAF) receptor antagonists inhibit mitogen-induced human peripheral blood T-cell proliferation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2825672 |
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| Crouch MF and Lapetina EG | Spacial isolation of protein kinase C activation in thrombin stimulated human platelets. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3178827 |
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| Tamura N et al. | Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030295 |
| Hasegawa A et al. | Influence of glucocorticoids on time-of-day-dependent variations in IgE-, histamine-, and platelet-activating factor-mediated systemic anaphylaxis in different mouse strains. | 2018 | Biochem. Biophys. Res. Commun. | pmid:29269296 |
| Levi R et al. | Alkyl chain homologs of platelet-activating factor and their effects on the mammalian heart. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2742592 |
| Touvay C et al. | Role of platelet-activating factor (PAF) in the bronchopulmonary alterations and beta-adrenoceptor function induced by endotoxin. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2835036 |
| Yamada T et al. | Effects of YM264, a novel PAF antagonist, on puromycin aminonucleoside-induced nephropathy in the rat. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2025290 |
| Ng DS and Wong K | Specific binding of platelet-activating factor (PAF) by human peripheral blood mononuclear leukocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2843182 |
| Harris JG et al. | Relative contribution of the selectins in the neutrophil recruitment caused by the chemokine cytokine-induced neutrophil chemoattractant (CINC). | 1996 | Biochem. Biophys. Res. Commun. | pmid:8630023 |
| Sugiura T and Waku K | CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3919727 |
| Dutra PM et al. | A novel ecto-phosphatase activity of Herpetomonas muscarum muscarum inhibited by platelet-activating factor. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9875238 |
| Kroegel C et al. | Evidence for two platelet activating factor receptors on eosinophils: dissociation between PAF-induced intracellular calcium mobilization degranulation and superoxides anion generation in eosinophils. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2546554 |
| Parent JL and Stankova J | Transforming growth factor-beta up-regulates the gene expression of the human platelet-activating factor receptor in monocytic and B cell lines. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8280163 |
| Ng DS and Wong K | GTP regulation of platelet-activating factor binding to human neutrophil membranes. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3026378 |