| MeSH term | MeSH ID | Detail |
|---|---|---|
| Purpura, Thrombotic Thrombocytopenic | D011697 | 6 associated lipids |
| Sneezing | D012912 | 6 associated lipids |
| Thrombophilia | D019851 | 6 associated lipids |
| Gliosis | D005911 | 6 associated lipids |
| Heart Injuries | D006335 | 6 associated lipids |
| Rhinitis, Allergic, Seasonal | D006255 | 7 associated lipids |
| Klebsiella Infections | D007710 | 7 associated lipids |
| Conjunctivitis | D003231 | 7 associated lipids |
| Disseminated Intravascular Coagulation | D004211 | 7 associated lipids |
| Glomerulonephritis, IGA | D005922 | 7 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Lin AH et al. | Acetyl glyceryl ether phosphorylcholine stimulates leukotriene B4 synthesis in human polymorphonuclear leukocytes. | 1982 | J. Clin. Invest. | pmid:6290535 |
| Vargaftig BB et al. | Adrenaline and PAF-acether synergize to trigger cyclooxygenase-independent activation of plasma-free human platelets. | 1982 | Thromb. Res. | pmid:7164036 |
| Page CP et al. | An in vivo model for studying platelet aggregation and disaggregation. | 1982 | Thromb. Haemost. | pmid:7051409 |
| Camussi G et al. | Platelet-activating factor (PAF) in experimentally-induced rabbit acute serum sickness: role of basophil-derived PAF in immune complex deposition. | 1982 | J. Immunol. | pmid:7054286 |
| Ninio E et al. | Biosynthesis of platelet-activating factor. I. Evidence for an acetyl-transferase activity in murine macrophages. | 1982 | Biochim. Biophys. Acta | pmid:7055592 |
| Long MW et al. | Immature megakaryocytes in the mouse: physical characteristics, cell cycle status, and in vitro responsiveness to thrombopoietic stimulatory factor. | 1982 | Blood | pmid:7059669 |
| Humphrey DM et al. | Vasoactive properties of acetyl glyceryl ether phosphorylcholine and analogues. | 1982 | Lab. Invest. | pmid:7070056 |
| Gimbrone MA | Blood vessels and the new mediators of inflammation. | 1982 | Lab. Invest. | pmid:7070058 |
| Mencia-Huerta JM et al. | Biosynthesis of platelet-activating factor (PAF)acether). III. Formation of PAF-acether from synthetic substrates by stimulated murine macrophages. | 1982 | J. Immunol. | pmid:7086143 |
| Prancan A et al. | Relaxation of the guinea-pig trachea induced by platelet-activating factor and by serotonin. | 1982 | Eur. J. Pharmacol. | pmid:7095003 |
| Humphrey DM et al. | Induction of leukocytic infiltrates in rabbit skin by acetyl glyceryl ether phosphorylcholine. | 1982 | Lab. Invest. | pmid:7109542 |
| Karpatkin S et al. | Platelet aggregating material (PAM) of two virally-transformed tumors: SV3T3 mouse fibroblast and PW20 rat renal sarcoma. Role of cell surface sialylation. | 1982 | Prog. Clin. Biol. Res. | pmid:7111309 |
| Voelkel NF et al. | Nonimmunological production of leukotrienes induced by platelet-activating factor. | 1982 | Science | pmid:7123233 |
| Kelly GL and Eiseman B | Development of a new vascular prosthetic: lessons learned. | 1982 | Arch Surg | pmid:7125901 |
| Sugiura T et al. | Ether phospholipids in guinea pig polymorphonuclear leukocytes and macrophages. Occurrence of high levels of 1-O-alkyl-2-acyl-sn-glycero-3-phosphocholine. | 1982 | Biochim. Biophys. Acta | pmid:7126622 |
| Vargaftig BB et al. | Non-steroidal anti-inflammatory drugs if combined with anti-histamine and anti-serotonin agents interfere with the bronchial and platelet effects of "platelet-activating factor" (PAF-acether). | 1982 | Eur. J. Pharmacol. | pmid:7128682 |
| Namm DH et al. | Species specificity of the platelet responses to 1-0-alkyl-2-acetyl-sn-glycero-3-phosphocholine. | 1982 | Thromb. Res. | pmid:7071810 |
| Keraly CL and Benveniste J | Specific desensitization of rabbit platelets by platelet-activating factor (PAF-acether) and derivatives. | 1982 | Br. J. Haematol. | pmid:7082588 |
| Wykle RL et al. | Platelet activating factor (1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine). Activity of analogs lacking oxygen at the 2-position. | 1982 | FEBS Lett. | pmid:7084476 |
| Sánchez-Crespo M et al. | Vascular actions of synthetic PAF-acether (a synthetic platelet-activating factor) in the rat: evidence for a platelet independent mechanism. | 1982 | Immunopharmacology | pmid:7085259 |
| Mueller HW et al. | Ether lipid content and fatty acid distribution in rabbit polymorphonuclear neutrophil phospholipids. | 1982 | Lipids | pmid:7087685 |
| Haslam RJ and Vanderwel M | Inhibition of platelet adenylate cyclase by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphorylcholine (platelet-activating factor). | 1982 | J. Biol. Chem. | pmid:6177688 |
| Page CP et al. | Platelet activation in asthma. | 1982 | N. Engl. J. Med. | pmid:7088080 |
| Chilton FH et al. | Platelet activating factor. Stimulation of the lipoxygenase pathway in polymorphonuclear leukocytes by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine. | 1982 | J. Biol. Chem. | pmid:6802816 |
| Vargaftig BB et al. | Degranulation of rabbit platelets with PAF-acether: a new procedure for unravelling the mode of action of platelet-activating substances. | 1982 | Thromb. Haemost. | pmid:7135345 |
| Sancho J et al. | The effect of the injection of a synthetic platelet-activating factor (PAF-acether) on the fate of IgG aggregates in mice. | 1982 | Immunology | pmid:7141463 |
| Sybertz EJ et al. | Studies on the interactions of acetyl glycerol ether phosphoryl choline with the sympathetic nervous system in rats. | 1982 | J. Pharmacol. Exp. Ther. | pmid:7143227 |
| Cabot MC et al. | Metabolism of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine by cell cultures. | 1982 | Life Sci. | pmid:7162357 |
| Convert O et al. | 1H NMR of PAF-acether: influence of solvent on its structure. | 1982 | Agents Actions | pmid:7164943 |
| Borrel MC et al. | Additional techniques for the total synthesis of PAF-acether. | 1982 | Agents Actions | pmid:7164944 |
| Benveniste J et al. | Release of platelet-activating factor (PAF-acether) and 2-lyso PAF-acether from three cell types. | 1982 | Agents Actions | pmid:7164945 |
| Arnoux B et al. | Release of PAF-acether from human blood monocytes. | 1982 | Agents Actions | pmid:7164946 |
| Fouque F et al. | Platelet-activating factor (PAF-acether): thromboxane-independent synergism with adrenaline on human platelets and recent insights into its mode of action. | 1982 | Agents Actions | pmid:7164947 |
| Lefort J et al. | Pharmacological properties of PAF-acether in the guinea-pig: platelet-dependent and independent reactions. | 1982 | Agents Actions | pmid:7164948 |
| Roubin R et al. | Release of platelet-activating factor (PAF-acether) and leukotrienes C and D from inflammatory macrophages. | 1982 | Eur. J. Immunol. | pmid:6122581 |
| Lanara E et al. | Response of mice and mouse platelets to acetyl glyceryl ether phosphorylcholine. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7168759 |
| O'Flaherty JT | Lipid mediators of inflammation and allergy. | 1982 | Lab. Invest. | pmid:6126615 |
| Sánchez-Crespo M et al. | Rat serum sickness: possible role of inflammatory mediators allowing deposition of immune complexes in the glomerular basement membrane. | 1982 | Clin. Exp. Immunol. | pmid:7172498 |
| Pinckard RN | The "new" chemical mediators of inflammation. | 1982 | Monogr Pathol | pmid:6126808 |
| Ieyasu H et al. | A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7181916 |
| Camussi G et al. | The release of platelet-activating factor during phagocytosis by polymorphonuclear neutrophils and monocytes. | 1982 | Adv. Exp. Med. Biol. | pmid:7090917 |
| Robeva R et al. | [Changes in blood coagulation in glomerulonephritis]. | 1982 | Vutr Boles | pmid:6219496 |
| Isobe J and Mizuno A | Aspects of PAF (platelet activating factor)-induced aggregation by using rabbit platelets. | 1982 | Tokushima J. Exp. Med. | pmid:7170716 |
| Alonso F et al. | Modulatory role of cyclic AMP in the release of platelet-activating factor from human polymorphonuclear leucocytes. | 1982 | Immunology | pmid:6277775 |
| Rao GH et al. | Human platelet activation by an alkylacetyl analogue of phosphatidylcholine. | 1982 | Biochim. Biophys. Acta | pmid:6280777 |
| Ingraham LM et al. | Metabolic, membrane, and functional responses of human polymorphonuclear leukocytes to platelet-activating factor. | 1982 | Blood | pmid:6282362 |
| Valone FH et al. | Specific binding of phospholipid platelet-activating factor by human platelets. | 1982 | J. Immunol. | pmid:6286773 |
| Lüscher EF | The role of blood cells and of the vessel wall in the induction of intravascular coagulation. | 1982 | Klin. Wochenschr. | pmid:6750223 |
| Czarneztki BM | Effect of platelet activating factor on leukocytes. II. Enhancement of eosinophil chemotactic factor and beta-glucuronidase release. | 1982 | Chem. Phys. Lipids | pmid:6814773 |
| Basran GS et al. | Cromoglycate (DSCG) inhibits responses to platelet-activating factor (PAF-acether) in man: an alternative mode of action for DSCG in asthma? | 1982 | Eur. J. Pharmacol. | pmid:6819153 |
| Shaw JO and Lyons RM | Requirements for different Ca2+ pools in the activation of rabbit platelets. I. release reaction and protein phosphorylation. | 1982 | Biochim. Biophys. Acta | pmid:6800409 |
| Aderka D et al. | Morphological platelet anomalies in thrombotic thrombocytopenic purpura. | 1982 | Acta Haematol. | pmid:6801893 |
| Benveniste J et al. | Biosynthesis of platelet-activating factor (PAF-ACETHER). II. Involvement of phospholipase A2 in the formation of PAF-ACETHER and lyso-PAF-ACETHER from rabbit platelets. | 1982 | Thromb. Res. | pmid:6803388 |
| Yasaka T et al. | Monocyte aggregation and superoxide anion release in response to formyl-methionyl-leucyl-phenylalanine (FMLP) and platelet-activating factor (PAF). | 1982 | J. Immunol. | pmid:6278021 |
| Morgan WK et al. | Byssinosis: some unanswered questions. | 1982 | Am. Rev. Respir. Dis. | pmid:6808880 |
| Myśliwiec M and Myśliwiec B | [Blood platelets, prostaglandin and complement interactions in inflammation]. | 1982 | Prz. Lek. | pmid:6753039 |
| Miller OV et al. | Acetyl glycerylphosphorylcholine inhibition of prostaglandin I2-stimulated adenosine 3',5'-cyclic monophosphate levels in human platelets. Evidence for thromboxane A2 dependence. | 1982 | Biochim. Biophys. Acta | pmid:6285985 |
| Miller CL | Infection in massively injured patients. | 1982 | Prog. Clin. Biol. Res. | pmid:6757964 |
| Bruni A and Palatini P | Biological and pharmacological properties of phospholipids. | 1982 | Prog Med Chem | pmid:6758038 |
| Chesney CM et al. | Effect of platelet-activating factor (PAF) on human platelets. | 1982 | Blood | pmid:7037068 |
| Masugi F et al. | [Platelet-activating factor and antihypertensive polar renomedullary lipid: 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine]. | 1982 | Tanpakushitsu Kakusan Koso | pmid:6758041 |
| Modiano A and Belisario A | [Recent information on PAF (Platelet Activating Factor) in hemocoagulative and immuno-allergic processes]. | 1982 | G Clin Med | pmid:6762313 |
| Marcus AJ et al. | Arachidonic acid metabolism in endothelial cells and platelets. | 1982 | Ann. N. Y. Acad. Sci. | pmid:6762834 |
| Masugi F et al. | Potent hypotensive activity of 1-O-hexadecyl-2-O-acetyl-SN-glycero-3-phosphocholine in spontaneously hypertensive rat. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7041899 |
| Lapetina EG | Platelet-activating factor stimulates the phosphatidylinositol cycle. Appearance of phosphatidic acid is associated with the release of serotonin in horse platelets. | 1982 | J. Biol. Chem. | pmid:7045103 |
| Jouvin-Marche E et al. | Platelet-activating factor (PAF-acether), an activator of neutrophil functions. | 1982 | Agents Actions | pmid:6299078 |
| Caillard CG et al. | Hypotensive activity of PAF-acether in rats. | 1982 | Agents Actions | pmid:6299079 |
| Hartung HP et al. | Stimulation of the oxidative burst in macrophages with platelet activating factor (PAF-acether). | 1982 | Agents Actions Suppl. | pmid:6960648 |
| Drapier JC et al. | Lipid-mediator synthesis in peritoneal macrophages from mice injected with immunostimulants. | 1983 | Biochim. Biophys. Acta | pmid:6131693 |
| Otsuka A et al. | alpha-Adrenergic blocking action of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine in rats. | 1983 | Clin Exp Hypertens A | pmid:6133661 |
| Jouvin-Marche E et al. | Effect of the Ca2+ antagonist nifedipine on the release of platelet-activating factor (PAF-acether), slow-reacting substance and beta-glucuronidase from human neutrophils. | 1983 | Eur. J. Pharmacol. | pmid:6134631 |
| Haddad ZH and Green A | State--and dynamics--of the art: a current review. IgE-mediated immediate hypersensitivity reactions: cellular events and pharmacologic mediators. | 1983 | J Asthma | pmid:6190793 |
| Mencia-Huerta JM et al. | Antigen-initiated release of platelet-activating factor (PAF-acether) from mouse bone marrow-derived mast cells sensitized with monoclonal IgE. | 1983 | J. Immunol. | pmid:6315819 |
| Czarnetzki B | Increased monocyte chemotaxis towards leukotriene B4 and platelet activating factor in patients with inflammatory dermatoses. | 1983 | Clin. Exp. Immunol. | pmid:6317241 |
| Randolph AE et al. | Blood pressure and heart rate effects of alkyl ether phospholipids in conscious renal, spontaneously hypertensive, and normotensive rats. | 1983 | Clin Exp Hypertens A | pmid:6684006 |
| Page CP et al. | PAF-acether: a putative mediator of asthma and inflammation. | 1983 | Agents Actions Suppl. | pmid:6575595 |
| Hartung HP et al. | Platelet activating factor (PAF) induces the oxidative burst in macrophages. | 1983 | Int. J. Immunopharmacol. | pmid:6874164 |
| 1st International Symposium on Platelet-Activating Factor (PAF-ACETHER, AGEPC) and structurally related ether-lipids. Paris (France) June 26-29, 1983. Abstracts. | 1983 | J Pharmacol | pmid:6876807 | |
| Camussi G et al. | Acute lung inflammation induced in the rabbit by local instillation of 1-0-octadecyl-2-acetyl-sn-glyceryl-3-phosphorylcholine or of native platelet-activating factor. | 1983 | Am. J. Pathol. | pmid:6859232 |
| Cargill DI et al. | Aggregation, release and desensitization induced in platelets from five species by platelet activating factor (PAF). | 1983 | Thromb. Haemost. | pmid:6879508 |
| Sánchez-Crespo M et al. | Presence in normal human urine of a hypotensive and platelet-activating phospholipid. | 1983 | Am. J. Physiol. | pmid:6859262 |
| Lumb RH et al. | Spontaneous and protein-catalyzed transfer of 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) between phospholipid bilayers. | 1983 | Biochim. Biophys. Acta | pmid:6860678 |
| Suquet CM and Leid RW | Aggregation of equine platelets by PAF (platelet-activating factor). | 1983 | Inflammation | pmid:6862593 |
| Virella G et al. | Release of PAF by human polymorphonuclear leucocytes stimulated by immune complexes bound to Sepharose particles and human erythrocytes. | 1983 | Immunology | pmid:6885111 |
| Blank ML and Snyder F | Improved high-performance liquid chromatographic method for isolation of platelet-activating factor from other phospholipids. | 1983 | J. Chromatogr. | pmid:6863454 |
| Camussi G et al. | Platelet-activating factor-mediated contraction of rabbit lung strips: pharmacologic modulation. | 1983 | Immunopharmacology | pmid:6885382 |
| Simrock R et al. | [Reversible inhibition of thrombocyte stimulation by acetylsalicylic acid and its role in antithrombotic therapy]. | 1983 | Klin. Wochenschr. | pmid:6865264 |
| Hadváry P and Baumgartner HR | Activation of human and rabbit blood platelets by synthetic structural analogs of platelet activating factor. | 1983 | Thromb. Res. | pmid:6868019 |
| Pieroni G and Hanahan DJ | Metabolic behavior of acetyl glyceryl ether phosphorylcholine on interaction with rabbit platelets. | 1983 | Arch. Biochem. Biophys. | pmid:6870274 |
| Lapetina EG and Siegel FL | Shape change induced in human platelets by platelet-activating factor. Correlation with the formation of phosphatidic acid and phosphorylation of a 40,000-dalton protein. | 1983 | J. Biol. Chem. | pmid:6345519 |
| Camussi G et al. | Inhibitory effect of prostacyclin (PGI2) on neutropenia induced by intravenous injection of platelet-activating-factor (PAF) in the rabbit. | 1983 | Prostaglandins | pmid:6346397 |
| Iñarrea P et al. | Platelet-activating factor: an effector substance of the vasopermeability changes induced by the infusion of immune aggregates in the mouse. | 1983 | Immunopharmacology | pmid:6347969 |
| Satouchi K | [Platelet activating factor (PAF)--a new chemical mediator of inflammation]. | 1983 | Seikagaku | pmid:6350499 |
| McGowan EB and Detwiler TC | Characterization of the thrombin-induced desensitization of platelet activation by thrombin. | 1983 | Thromb. Res. | pmid:6356458 |
| Weksler BB | Platelets and the inflammatory response. | 1983 | Clin. Lab. Med. | pmid:6360503 |
| Machin SJ et al. | Defective platelet aggregation to the calcium ionophore A23187 in a patient with a lifelong bleeding disorder. | 1983 | J. Clin. Pathol. | pmid:6413552 |
| Alam I et al. | Metabolism of platelet-activating factor by blood platelets and plasma. | 1983 | Lipids | pmid:6413803 |
| Pinckard RN | Platelet-activating factor. | 1983 | Hosp. Pract. (Off. Ed.) | pmid:6414941 |
| Camussi G et al. | The release of platelet-activating factor from human endothelial cells in culture. | 1983 | J. Immunol. | pmid:6415166 |
| Bonnet J et al. | Dependency of the Paf-acether induced bronchospasm on the lipoxygenase pathway in the guinea-pig. | 1983 | Prostaglandins | pmid:6419289 |