| MeSH term | MeSH ID | Detail |
|---|---|---|
| Diabetic Retinopathy | D003930 | 39 associated lipids |
| Dictyocaulus Infections | D004022 | 1 associated lipids |
| Disseminated Intravascular Coagulation | D004211 | 7 associated lipids |
| Drug Hypersensitivity | D004342 | 20 associated lipids |
| Duodenal Ulcer | D004381 | 12 associated lipids |
| Dyslexia | D004410 | 3 associated lipids |
| Ear Diseases | D004427 | 7 associated lipids |
| Edema | D004487 | 152 associated lipids |
| Encephalitis | D004660 | 15 associated lipids |
| Encephalomyelitis, Autoimmune, Experimental | D004681 | 26 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kakishita E et al. | Inhibitory effect of vitamin E (alpha-tocopherol) on spontaneous platelet aggregation in whole blood. | 1990 | Thromb. Res. | pmid:2082481 |
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| Simon MF et al. | Effect of BN 52021, a specific antagonist of platelet activating factor (PAF-acether), on calcium movements and phosphatidic acid production induced by PAF-acether in human platelets. | 1987 | Thromb. Res. | pmid:3576518 |
| Alam I and Silver MJ | Metabolism of 1-alkyl-2-acyl-GPC in human platelets in response to stimulation by thrombin. | 1987 | Thromb. Res. | pmid:3576519 |
| Liu X et al. | Ginkgolide B inhibits platelet release by blocking Syk and p38 MAPK phosphorylation in thrombin-stimulated platelets. | 2014 | Thromb. Res. | pmid:25223809 |
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| Hofmann B et al. | Proaggregatory and inhibitory effects of 2-O-ethyl analogues of platelet-activating factor (PAF) on human and rabbit platelets. | 1988 | Thromb. Res. | pmid:3381200 |
| Heinrich J and Zimmermann RE | Compound 48/80 is a potent inhibitor of human platelet aggregation antagonizing the calmodulin-dependent platelet reaction in vitro. | 1984 | Thromb. Res. | pmid:6523451 |
| Hwang SB et al. | Effects of nonsteroid antiinflammatory drugs on the specific binding of platelet activating factor to membrane preparations of rabbit platelets. | 1984 | Thromb. Res. | pmid:6429890 |
| Janero DR et al. | Specific binding of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor) to the intact canine platelet. | 1988 | Thromb. Res. | pmid:3413730 |
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| Valone FH and Johnson B | Decay of the activating signal after platelet stimulation with 1-0-alkyl-2-acetyl-SN-glycero-3-phosphorylcholine: changes in calcium permeability. | 1985 | Thromb. Res. | pmid:4082115 |
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| Ezoulin MJ et al. | Study of PMS777, a new type of acetylcholinesterase inhibitor, in human HepG2 cells. Comparison with tacrine and galanthamine on oxidative stress and mitochondrial impairment. | 2006 | Toxicol In Vitro | pmid:16472967 |
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| Wright DT et al. | Ozone stimulates release of platelet activating factor and activates phospholipases in guinea pig tracheal epithelial cells in primary culture. | 1994 | Toxicol. Appl. Pharmacol. | pmid:8048050 |
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| Hanslik T et al. | Effect of the platelet activating factor antagonist BN52021 in rabbits: role in gentamicin nephrotoxicity. | 1994 | Toxicol. Appl. Pharmacol. | pmid:8079343 |
| Ramos G et al. | Platelet activating factor receptor binding plays a critical role in jet fuel-induced immune suppression. | 2004 | Toxicol. Appl. Pharmacol. | pmid:15020195 |
| Feuerstein G et al. | Protective effect of a PAF-acether antagonist, BN 52021, in trichothecene toxicosis. | 1987 | Toxicol. Lett. | pmid:3660430 |
| Bailie MB et al. | Platelet activating factor receptor blockade alone or in combination with leukotriene synthesis inhibition does not ameliorate alpha-naphthylisothiocyanate-induced hepatotoxicity. | 1996 | Toxicol. Lett. | pmid:8614909 |
| Mahgoub AA | Thymoquinone protects against experimental colitis in rats. | 2003 | Toxicol. Lett. | pmid:12749817 |
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| Grandoni KM et al. | Trichothecene mycotoxins inhibit phosphoinositide hydrolysis in bovine platelets stimulated with platelet activating factor. | 1992 | Toxicology | pmid:1311467 |
| Pearson JM et al. | Neither platelet activating factor nor leukotrienes are critical mediators of liver injury after lipopolysaccharide administration. | 1997 | Toxicology | pmid:9231696 |
| Gambero A et al. | Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2. | 2004 | Toxicon | pmid:15450921 |
| Teixeira CF et al. | Hyperalgesia induced by Bothrops jararaca venom in rats: role of eicosanoids and platelet activating factor (PAF). | 1994 | Toxicon | pmid:8052996 |
| Shiroma N et al. | Haemodynamic and haematologic effects of Acanthaster planci venom in dogs. | 1994 | Toxicon | pmid:7846692 |
| Havt A et al. | The renal effects of Bothrops jararacussu venom and the role of PLA(2) and PAF blockers. | 2001 | Toxicon | pmid:11600146 |
| Castro-Faria-Neto HC et al. | Pro-inflammatory activity of enterolobin: a haemolytic protein purified from seeds of the Brazilian tree Enterolobium contortisiliquum. | 1991 | Toxicon | pmid:1796477 |
| Yara A et al. | Cardiovascular effects of Acanthaster planci venom in the rat: possible involvement of PAF in its hypotensive effect. | 1992 | Toxicon | pmid:1440631 |
| Rees RS et al. | Plasma components are required for platelet activation by the toxin of Loxosceles reclusa. | 1988 | Toxicon | pmid:3245050 |
| Freire-Maia L and de Matos IM | Heparin or a PAF antagonist (BN-52021) prevents the acute pulmonary edema induced by Tityus serrulatus scorpion venom in the rat. | 1993 | Toxicon | pmid:8266352 |
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| Melo RC et al. | Intragranular vesiculotubular compartments are involved in piecemeal degranulation by activated human eosinophils. | 2005 | Traffic | pmid:16138901 |
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| Shukla SD et al. | Response to platelet-activating factor in human platelets stored and aged in plasma. Decrease in aggregation, phosphoinositide turnover, and receptor affinity. | 1989 Jul-Aug | Transfusion | pmid:2546298 |
| Hirt SW et al. | Antagonisation of platelet activating factor--a new therapeutic concept for improvement of organ quality in lung preservation. | 1992 | Transpl. Int. | pmid:14621825 |
| Torras J et al. | Protective effect of the PAF antagonist BN 52021 in an experimental renal warm ischemia model. | 1993 | Transpl. Int. | pmid:8347271 |
| Räisänen A et al. | Effect of platelet-activating factor (PAF) receptor blockers on smooth muscle cell replication in vitro and allograft arteriosclerosis in vivo. | 1993 | Transpl. Int. | pmid:8216700 |
| Wang KS et al. | Protective effects of a PAF antagonist against liver injury induced by warm ischemia or cold preservation. | 1992 | Transplant. Proc. | pmid:1496669 |
| Takada Y et al. | Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. | 2000 | Transplant. Proc. | pmid:10715416 |
| Fukuoka T et al. | Platelet activating factor mediates systemic circulatory collapse after temporary hepatic inflow occlusion. | 1993 | Transplant. Proc. | pmid:8470175 |
| Peyman JA et al. | HLA-DR genes are silenced in human trophoblasts and stimulation of signal transduction pathways does not circumvent interferon-gamma unresponsiveness. | 1992 | Transplant. Proc. | pmid:1533073 |
| Taniguchi S et al. | Effects of a platelet-activating factor antagonist at different doses given simultaneously with double-filtration plasmapheresis on cardiac xenograft survival. | 1994 | Transplant. Proc. | pmid:8171719 |
| Coughlan AF et al. | In vivo studies of P-selectin and platelet activating factor during endotoxemia, accelerated allograft rejection, and discordant xenograft rejection. | 1993 | Transplant. Proc. | pmid:7692651 |
| Hammer C et al. | Xenogeneic rejection mechanisms shown by intravital microscopy. | 1998 | Transplant. Proc. | pmid:9865335 |
| Takada Y et al. | Energy metabolism of hepatic allografts subjected to prolonged warm ischemia and pharmacologic modulation with FK506 and platelet activating factor antagonist. | 1998 | Transplant. Proc. | pmid:9838621 |
| Fukunaga K et al. | Successful liver transplantation from non-heart-beating donors by blockade of endothelin and PAE. | 1998 | Transplant. Proc. | pmid:9838664 |
| Lloberas N et al. | The ether phospholipids trail: blood timing in renal ischemia-reperfusion injury. | 2002 | Transplant. Proc. | pmid:11959179 |
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| Metcalfe SM et al. | Survival of renal allografted dogs after limited therapy with cyclosporine and the PAF antagonist WEB 2170. | 1991 | Transplant. Proc. | pmid:1871852 |
| Pirotzky E et al. | Cyclosporine-induced nephrotoxicity: preventive effect of a PAF-acether antagonist, BN 52063. | 1988 | Transplant. Proc. | pmid:3388505 |
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| Otte KE et al. | Xenoperfusion of rabbit kidney and the impact of BN 52021: a specific antagonist of platelet-activating factor. | 1990 | Transplant. Proc. | pmid:2349668 |
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| Spiegel HU et al. | Beneficial effect of the platelet-activating factor antagonist WEB 2170 on reperfusion injury after orthotopic liver transplantation. | 1995 | Transplant. Proc. | pmid:7482955 |
| Foegh ML | Eicosanoids and platelet activating factor mechanisms in organ rejection. | 1988 | Transplant. Proc. | pmid:3059615 |
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| Immunomodulation: other approaches. | 1988 | Transplant. Proc. | pmid:3347955 | |
| Renkonen R et al. | Second messenger pathways in lymphocyte binding and penetration through graft vascular endothelium. | 1991 | Transplant. Proc. | pmid:1846709 |
| O'Hair DP et al. | Platelet activating factor antagonist RP-59227 reduces vascular injury in discordant cardiac xenograft rejection. | 1992 | Transplant. Proc. | pmid:1566490 |
| Pignol B et al. | Potentiation of immunosuppressive action of cyclosporine A by platelet-activating factor antagonists: an approach of the mechanism of action of these drugs in the prevention of graft rejection. | 1988 | Transplant. Proc. | pmid:3259039 |
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| First International Alexis Carrel Conference on Lipid Mediators in Organ Transplantation. April 8-10, 1986, Washington, DC. | 1986 | Transplant. Proc. | pmid:3765055 | |
| Minor T et al. | Treatment of preservation/reperfusion injury by platelet-activating factor antagonism in the rat liver graft. | 1995 | Transplant. Proc. | pmid:7879086 |
| Ide S et al. | Donor administration of PAF antagonist (TCV-309) enhances lung preservation. | 1995 | Transplant. Proc. | pmid:7879103 |
| Takada Y et al. | Platelet activating factor antagonist has a protective effect on preservation/reperfusion injury of the graft in pig liver transplantation. | 1995 | Transplant. Proc. | pmid:7879169 |
| Yin M et al. | Beneficial effect of platelet-activating factor antagonist TCV-309 on renal ischemia-reperfusion injury. | 1995 | Transplant. Proc. | pmid:7879180 |
| Chávez-Cartaya RE et al. | Rat liver blood flow after ischemia and reperfusion. The effects of the platelet-activating factor antagonist WEB-2170 and of removing circulating leukocytes. | 1994 | Transplantation | pmid:8197604 |
| Pi F et al. | Effect of a platelet-activating factor antagonist and desferrioxamine administration on eicosanoid production in rat pancreas transplantation. | 1994 | Transplantation | pmid:8291097 |
| Herrero-Fresneda I et al. | Cold ischemia in the absence of alloreactivity induces chronic transplant nephropathy through a process mediated by the platelet-activating factor. | 2000 | Transplantation | pmid:11190497 |
| Freiche JC et al. | Prolonged survival of renal transplants in nonimmunized and hyperimmunized rats receiving a platelet-activating factor antagonist. | 1990 | Transplantation | pmid:2368154 |
| dos Santos OF et al. | Effect of platelet-activating factor antagonist on cyclosporine nephrotoxicity. Glomerular hemodynamics evaluation. | 1989 | Transplantation | pmid:2705209 |
| Gu M et al. | Pharmacologic graft protection without donor pretreatment in liver transplantation from non-heart-beating donors. | 2000 | Transplantation | pmid:11045637 |
| Biancone L et al. | Role of platelet-activating factor in functional alterations induced by xenoreactive antibodies in porcine endothelial cells. | 2000 | Transplantation | pmid:11063341 |
| Yin M et al. | The PAF antagonist TCV-309 reduces graft PMN infiltration and enhances early function of 24-hour-preserved rat kidneys with long warm ischemia. | 1996 | Transplantation | pmid:8633367 |
| Takada Y et al. | Effects of platelet-activating factor antagonist on preservation/reperfusion injury of the graft in porcine orthotopic liver transplantation. | 1995 | Transplantation | pmid:7839408 |
| Watson CJ et al. | The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival. | 1993 | Transplantation | pmid:8212192 |
| Suzuki S et al. | The roles of platelet-activating factor and endothelin-1 in renal damage after total hepatic ischemia and reperfusion. | 2000 | Transplantation | pmid:10868624 |