Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
---|
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
---|
Function | Cross reference | Weighted score | Related literatures |
---|
Lipid concept | Cross reference | Weighted score | Related literatures |
---|
Gene | Cross reference | Weighted score | Related literatures |
---|
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
---|
Authors | Title | Published | Journal | PubMed Link |
---|---|---|---|---|
Alloatti G et al. | Role of nitric oxide and platelet-activating factor in cardiac alterations induced by tumor necrosis factor-alpha in the guinea-pig papillary muscle. | 1999 | Cardiovasc. Res. | pmid:10435033 |
Zeng S et al. | Regulatory role of protein tyrosine phosphorylation in platelet activating factor-induced signal transduction in platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10437164 |
Soybir G et al. | The effects of free oxygen radical scavenger and platelet-activating factor antagonist agents in experimental acute pancreatitis. | 1999 | Pancreas | pmid:10438161 |
Dentelli P et al. | Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation. | 1999 | J. Immunol. | pmid:10438956 |
Shehnaz D et al. | Effect of the crude extract of Cestrum parqui on carrageenin-induced rat paw oedema and aggregation of human blood platelets. | 1999 | Phytother Res | pmid:10441792 |
Qu XW et al. | Type I nitric oxide synthase (NOS) is the predominant NOS in rat small intestine. Regulation by platelet-activating factor. | 1999 | Biochim. Biophys. Acta | pmid:10446403 |
Davies D et al. | VCAM-1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM-1 in rat skin. | 1999 | Immunology | pmid:10447726 |
Alvi SA et al. | The production of interleukin-1beta from human fetal membranes is not obligatory for increased prostaglandin output. | 1999 | Immunology | pmid:10447739 |
Wang H et al. | Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora. | 1999 | Immunology | pmid:10447766 |
Birk-Sørensen L et al. | Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. | 1999 | Scand J Plast Reconstr Surg Hand Surg | pmid:10450571 |