Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Melanoma D008545 69 associated lipids
Memory Disorders D008569 33 associated lipids
Meningioma D008579 11 associated lipids
Metabolism, Inborn Errors D008661 46 associated lipids
Migraine Disorders D008881 11 associated lipids
Mouth, Edentulous D009066 1 associated lipids
Multiple Sclerosis D009103 13 associated lipids
Multiple Trauma D009104 2 associated lipids
Nasal Polyps D009298 26 associated lipids
Neoplastic Cells, Circulating D009360 5 associated lipids
Neoplasms, Germ Cell and Embryonal D009373 4 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Nerve Degeneration D009410 53 associated lipids
Nervous System Diseases D009422 37 associated lipids
Neuralgia D009437 28 associated lipids
Neuroblastoma D009447 66 associated lipids
Neurologic Manifestations D009461 1 associated lipids
Neutropenia D009503 15 associated lipids
Osteonecrosis D010020 5 associated lipids
Pain D010146 64 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
O'Flaherty JT et al. Metabolism of 5-hydroxyicosatetraenoate by human neutrophils: production of a novel omega-oxidized derivative. 1986 J. Immunol. pmid:3095426
Roubin R et al. Biosynthesis of paf-acether: VIII: Impairment of paf-acether production in activated macrophages does not depend upon acetyltransferase activity. 1986 J. Immunol. pmid:3950403
Nishihira J and Ishibashi T A phospholipase C with a high specificity for platelet-activating factor in rabbit liver light mitochondria. 1986 Lipids pmid:3821393
Lauri D et al. Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. 1986 Agents Actions pmid:3706054
Nijssen JG et al. Identification of a calcium-independent phospholipase A2 in rat lung cytosol and differentiation from acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF-acether). 1986 Biochim. Biophys. Acta pmid:3707986
Fitzgerald MF et al. The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs. 1986 Br. J. Pharmacol. pmid:3708213
Issekutz AC and Ripley M The effect of intravascular neutrophil chemotactic factors on blood neutrophil and platelet kinetics. 1986 Am. J. Hematol. pmid:2934975
Alam I and Silver MJ Acetyltransferase activity in human platelet microsomes and washed platelets. 1986 Biochim. Biophys. Acta pmid:3094588
D'Humières S et al. PAF-acether-induced synthesis of prostacyclin by human endothelial cells. 1986 Eur. J. Pharmacol. pmid:3102256
Morley J Platelet activating factor and asthma. 1986 Agents Actions pmid:3099555
Orchard MA et al. Basophil histamine release induced by a substance from stimulated human platelets. 1986 J. Immunol. pmid:2419428
Anderson RC et al. Platelet-activating factor analogs. II. Synthesis of the 1-O-(4-decyloxymethylphenyl)- and 1-O-(4-decyloxyphenylmethyl) analogs. 1986 Chem. Phys. Lipids pmid:3948294
Tselepis A et al. Effects of AGEPC on the intracellular levels of ions in Tetrahymena pyriformis. 1986 Biochem. Int. pmid:3099798
Hwang SB et al. Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema. 1986 Eur. J. Pharmacol. pmid:3948914
Doyle VM et al. Platelet-activating factor mobilizes intracellular calcium in vascular smooth muscle cells. 1986 FEBS Lett. pmid:3949010
Wissner A et al. Analogues of platelet activating factor. 4. Some modifications of the phosphocholine moiety. 1986 J. Med. Chem. pmid:3950913
Schlondorff D et al. Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. 1986 Biochem. Biophys. Res. Commun. pmid:3099783
Okayasu T et al. Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. 1986 Biochim. Biophys. Acta pmid:3947669
Billah MM et al. Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human promyelocytic leukemic HL60 cells. Stimulated expression of phospholipase A2 and acetyltransferase requires differentiation. 1986 J. Biol. Chem. pmid:3084473
Herrmann DB et al. Ether phospholipids as inhibitors of the arachidonoyl-CoA: 1-acyl-sn-glycero-3-phosphocholine acyltransferase in macrophages. 1986 Biochim. Biophys. Acta pmid:3947667
Okamoto M et al. Studies of platelet activating factor (PAF) antagonists from microbial products. III. Pharmacological studies of FR-900452 in animal models. 1986 Chem. Pharm. Bull. pmid:3769104
Ohga Y and Nakanishi M Stopped-flow spectrophotometry monitoring the initial processes of platelet activation by platelet-activating factor. 1986 FEBS Lett. pmid:3770190
Ramesha CS and Pickett WC Metabolism of platelet-activating factor by arachidonic acid-depleted rat polymorphonuclear leukocytes. 1986 J. Biol. Chem. pmid:3096991
Patterson R et al. Inhibition of rhesus monkey airway and cutaneous responses to platelet-activating factor (PAF) (AGEPC) with the anti-PAF agent SRI 63-072. 1986 Int. Arch. Allergy Appl. Immunol. pmid:3770978
Kawaguchi H and Yasuda H Platelet-activating factor stimulates prostaglandin synthesis in cultured cells. 1986 Hypertension pmid:3081442
Cordeiro RS et al. Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. 1986 Prostaglandins pmid:3103172
Hwang SB et al. Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. 1986 J. Biol. Chem. pmid:3001070
Buxton DB et al. Platelet-activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. 1986 J. Biol. Chem. pmid:3001074
Rosam AC et al. Potent ulcerogenic actions of platelet-activating factor on the stomach. 1986 Jan 2-8 Nature pmid:3510396
Kako KJ Membrane phospholipids and plasmalogens in the ischemic myocardium. 1986 May-Jun Can J Cardiol pmid:2424580
von Tscharner V et al. Ion channels in human neutrophils activated by a rise in free cytosolic calcium concentration. 1986 Nov 27-Dec 3 Nature pmid:2431318
Benhamou M and Mencia-Huerta JM Effect of glucocorticosteroids on the expression of Fc epsilon R1 and on mediator release from mast cells. 1986 Sep-Oct Ann. Inst. Pasteur Immunol. pmid:2948525
Morley J Theophylline in asthma. 1986 Sep-Oct Bull Eur Physiopathol Respir pmid:3801711
Bolin RW et al. Lung endothelial and epithelial permeability after platelet-activating factor. 1987 J. Appl. Physiol. pmid:3693212
Robertson DA et al. Negative inotropic effect of platelet-activating factor on human myocardium: a pharmacological study. 1987 J. Pharmacol. Exp. Ther. pmid:3694533
Nomura H Biological action and structural specificity of diacylglycerol in platelet activation. 1987 Kobe J Med Sci pmid:3695296
Davenas E et al. Effect of mouse peritoneal macrophages of orally administered very high dilutions of silica. 1987 Eur. J. Pharmacol. pmid:3034632
Kawasaki T and Snyder F The metabolism of lyso-platelet-activating factor (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by a calcium-dependent lysophospholipase D in rabbit kidney medulla. 1987 Biochim. Biophys. Acta pmid:3036238
Shukla SD et al. Activation of phospholipase C in platelets by platelet activating factor and thrombin causes hydrolysis of a common pool of phosphatidylinositol 4,5-bisphosphate. 1987 Biochim. Biophys. Acta pmid:3036249
Grignani G and Jamieson GA Tissue factor-dependent activation of platelets by cells and microvesicles of SK-OS-10 human osteogenic sarcoma cell line. 1987 Invasion Metastasis pmid:3036740
Snyder F et al. Measurement of key enzyme activities involved in the metabolism of platelet activating factor. 1987 Meth. Enzymol. pmid:3037250
Robertson DN and Smith GM Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2959049
d'Humieres S et al. Platelet activating factor acether is involved in thrombin-induced synthesis of prostacyclin by human endothelial cells. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2959051
Ingraham LM et al. In vitro and in vivo effects of treatment by platelet-activating factor on N-formyl-met-leu-phe-mediated responses of polymorphonuclear leucocytes. 1987 Br. J. Haematol. pmid:3038160
Whittle BJ et al. Gastric vascular and mucosal damaging actions of platelet activating factor in the canine stomach. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2959063
Englberger W et al. Influence of lysophospholipids and PAF on the oxidative burst of PMNL. 1987 Int. J. Immunopharmacol. pmid:3038761
Handley DA et al. Inhibition by SRI 63-072 and SRI 63-119 of PAF-acether and immune complex effects in the guinea pig. 1987 Eur. J. Pharmacol. pmid:2959489
Montrucchio G et al. In vitro oxytocic activity of platelet-activating factor on human myometrium. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960158
Mallet AI et al. Platelet activating factor in chronic plaque psoriasis. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960170
Terasawa M et al. Antagonistic activity of etizolam on platelet-activating factor in vivo experiments. 1987 Jpn. J. Pharmacol. pmid:3682404
Bourgain RH et al. Effect of ginkgolide PAF-acether antagonists on arterial thrombosis. 1987 Adv. Prostaglandin Thromboxane Leukot. Res. pmid:2960196
Martin TR et al. Relative contribution of leukotriene B4 to the neutrophil chemotactic activity produced by the resident human alveolar macrophage. 1987 J. Clin. Invest. pmid:2821074
Woodard DS et al. The final step in the de novo biosynthesis of platelet-activating factor. Properties of a unique CDP-choline:1-alkyl-2-acetyl-sn-glycerol choline-phosphotransferase in microsomes from the renal inner medulla of rats. 1987 J. Biol. Chem. pmid:3029085
Egido J et al. Role of platelet-activating factor in adriamycin-induced nephropathy in rats. 1987 Eur. J. Pharmacol. pmid:3622604
Kawaguchi H and Yasuda H Effects of platelet-activating factor on conversion of angiotensin I to II. 1987 FEBS Lett. pmid:3622769
Ninio E et al. Biosynthesis of paf-acether. IX. Role for a phosphorylation-dependent activation of acetyltransferase in antigen-stimulated mouse mast cells. 1987 J. Immunol. pmid:3584983
Casals-Stenzel J Triazolodiazepines are potent antagonists of platelet activating factor (PAF) in vitro and in vivo. 1987 Naunyn Schmiedebergs Arch. Pharmacol. pmid:3587377
Brambilla A et al. WEB 2086. A potent PAF antagonist exerts protective effect toward PAF-induced gastric damage. 1987 Pharmacol Res Commun pmid:3588650
Jancar S et al. Comparative effects of platelet activating factor, leukotriene D4 and histamine on guinea pig trachea, bronchus and lung parenchyma. 1987 Prostaglandins pmid:3588970
Malo PE et al. Enhancement of leukotriene D4-induced contraction of guinea-pig isolated trachea by platelet activating factor. 1987 Prostaglandins pmid:3588971
Ramesha CS and Pickett WC Fatty acid composition of diacyl, alkylacyl, and alkenylacyl phospholipids of control and arachidonate-depleted rat polymorphonuclear leukocytes. 1987 J. Lipid Res. pmid:3106551
Dallob A et al. Pharmacological evidence for a role of lipoxygenase products in platelet-activating factor (PAF)-induced hyperalgesia. 1987 Biochem. Pharmacol. pmid:2822047
Purdon AD et al. Ionophore-stimulated rat basophilic leukemia cells produce PAF-acether. 1987 Int. Arch. Allergy Appl. Immunol. pmid:3100454
Casals-Stenzel J et al. Bronchial and vascular effects of Paf in the rat isolated lung are completely blocked by WEB 2086, a novel specific Paf antagonist. 1987 Br. J. Pharmacol. pmid:3664079
Coëffier E et al. Platelet-leukocyte interaction: activation of rabbit platelets by FMLP-stimulated neutrophils. 1987 Br. J. Pharmacol. pmid:3118996
Robertson DN and Page CP Effect of platelet agonists on airway reactivity and intrathoracic platelet accumulation. 1987 Br. J. Pharmacol. pmid:3664082
Whittle BJ et al. Increased intestinal formation of Paf in endotoxin-induced damage in the rat. 1987 Br. J. Pharmacol. pmid:3664090
Shigenobu K et al. Potentiation by bovine serum albumin (BSA) of endothelium-dependent vasodilator response to acetyl glyceryl ether phosphorylcholine (AGEPC). 1987 J. Pharmacobio-dyn. pmid:3625454
Hirafuji M et al. Regulation of PAF-acether (platelet-activating factor) biosynthesis in cultured human vascular endothelial cells stimulated with thrombin. 1987 Biochim. Biophys. Acta pmid:2888488
Jensen NJ et al. FAB MS/MS for phosphatidylinositol, -glycerol, -ethanolamine and other complex phospholipids. 1987 Lipids pmid:3626775
Cox CP and Wood KL Selective antagonism of platelet-activating factor (PAF)-induced aggregation and secretion in washed rabbit platelets by CV-3988, L-652731, triazolam and alprazolam. 1987 Thromb. Res. pmid:3629553
Ostermann G et al. Plasma from atherosclerotic patients exerts an increased degradation of platelet-activating factor. 1987 Thromb. Res. pmid:3629555
Tahara T et al. PAF antagonistic activity of some thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepines. 1987 Chem. Pharm. Bull. pmid:3664818
Hansen JF and Hansen BF [Unstable angina pectoris, acute myocardial infarct, sudden heart death. Patho-anatomy and pathophysiology]. 1987 Ugeskr. Laeg. pmid:3324429
Ramesha CS and Pickett WC Species-specific variations in the molecular heterogeneity of the platelet-activating factor. 1987 J. Immunol. pmid:3100641
Codde JP et al. Can the synthesis of platelet-activating factor, a potent vasodilator and pro-aggregatory agent, be altered by dietary marine oils? 1987 Clin. Exp. Pharmacol. Physiol. pmid:2822306
Levin M et al. Platelet immune complex interaction in the pathogenesis of Kawasaki disease. 1987 Prog. Clin. Biol. Res. pmid:3423040
Violi F et al. Human platelet aggregation by PAF and thromboxane production. 1987 Thromb. Res. pmid:3424290
Muirhead EE Vasodepressor lipid of the renomedullary interstitial cells of the renal papilla is a prohormone activated by the liver. 1987 Agents Actions Suppl. pmid:3324720
Di Marzo V et al. Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. 1987 Biochem. Biophys. Res. Commun. pmid:2822041
Kester M et al. Elevation of cytosolic free calcium by platelet-activating factor in cultured rat mesangial cells. 1987 FASEB J. pmid:2442057
Wang J and Dunn MJ Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. 1987 Am. J. Physiol. pmid:2827506
Panetta T et al. Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. 1987 Biochem. Biophys. Res. Commun. pmid:2827647
Bazan HE et al. The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. 1987 Biochem. Biophys. Res. Commun. pmid:2827658
Czarnetzki BM [Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system]. 1987 Wien Med Wochenschr Suppl pmid:3078398
O'Flaherty JT Phospholipid metabolism and stimulus-response coupling. 1987 Biochem. Pharmacol. pmid:3030324
Matsumoto T et al. G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. 1987 Biochem. Biophys. Res. Commun. pmid:3032170
Wymann MP et al. The onset of the respiratory burst in human neutrophils. Real-time studies of H2O2 formation reveal a rapid agonist-induced transduction process. 1987 J. Biol. Chem. pmid:3040727
Bossant MJ et al. Characterization and quantification of PAF-acether (platelet-activating factor) as a heptafluorobutyrate derivative of 1-O-alkyl-2-acetyl-sn-glycerol by capillary column gas chromatography with electron-capture detection. 1987 J. Chromatogr. pmid:3443654
Shimizu K et al. [Actions of platelet activating factor in pulmonary circulation--experimental investigation using rabbit blood vessel smooth muscle preparations]. 1987 Nihon Kyobu Shikkan Gakkai Zasshi pmid:3444152
Lagente V et al. Platelet-activating factor (PAF-acether) and microcirculation: effect of Lyso-PAF and PAF-antagonists. 1987 Braz. J. Med. Biol. Res. pmid:3452452
Shimokawa H et al. Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. 1987 Circ. Res. pmid:3113760
Gentry PA et al. Inhibitory effect of trichothecene mycotoxins on bovine platelets stimulated by platelet activating factor. 1987 Can. J. Vet. Res. pmid:3453270
Adnot S et al. Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. 1987 Agents Actions pmid:3115070
Montrucchio G et al. The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. 1987 Agents Actions pmid:3115072
Evans TW et al. Effect of platelet-activating factor on airway vascular permeability: possible mechanisms. 1987 J. Appl. Physiol. pmid:3115939
Knudsen BS et al. Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells. 1987 J. Clin. Invest. pmid:3116043
Bussolino F et al. Human endothelial cells are target for platelet-activating factor. I. Platelet-activating factor induces changes in cytoskeleton structures. 1987 J. Immunol. pmid:3116081
Bitterman H et al. Beneficial actions of RO 15-1788, a benzodiazepine receptor antagonist, in hemorrhagic shock. 1987 Methods Find Exp Clin Pharmacol pmid:3116357
Krishnamurthi S et al. Effect of phorbol 12-myristate 13-acetate (PMA) on agonist-induced arachidonate release and 5-hydroxytryptamine secretion in human platelets. Dependence of effects on agonist type and time of incubation with PMA. 1987 Biochim. Biophys. Acta pmid:3101746