| MeSH term | MeSH ID | Detail |
|---|---|---|
| Melanoma | D008545 | 69 associated lipids |
| Memory Disorders | D008569 | 33 associated lipids |
| Meningioma | D008579 | 11 associated lipids |
| Metabolism, Inborn Errors | D008661 | 46 associated lipids |
| Migraine Disorders | D008881 | 11 associated lipids |
| Mouth, Edentulous | D009066 | 1 associated lipids |
| Multiple Sclerosis | D009103 | 13 associated lipids |
| Multiple Trauma | D009104 | 2 associated lipids |
| Nasal Polyps | D009298 | 26 associated lipids |
| Neoplastic Cells, Circulating | D009360 | 5 associated lipids |
| Neoplasms, Germ Cell and Embryonal | D009373 | 4 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Nerve Degeneration | D009410 | 53 associated lipids |
| Nervous System Diseases | D009422 | 37 associated lipids |
| Neuralgia | D009437 | 28 associated lipids |
| Neuroblastoma | D009447 | 66 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
| Neutropenia | D009503 | 15 associated lipids |
| Osteonecrosis | D010020 | 5 associated lipids |
| Pain | D010146 | 64 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Friedlander G et al. | Renal effects of platelet-activating factor in the rat. | 1987 | Agents Actions | pmid:3687594 |
| Joly F et al. | Ketotifen inhibits paf-acether biosynthesis and beta-hexosaminidase release in mouse mast cells stimulated with antigen. | 1987 | Eur. J. Pharmacol. | pmid:2963750 |
| Lagente V et al. | Interference of the PAF-acether antagonist BN 52021 with passive anaphylaxis in the guinea-pig. | 1987 | Prostaglandins | pmid:2438723 |
| Pritchard PH | The degradation of platelet-activating factor by high-density lipoprotein in rat plasma. Effect of ethynyloestradiol administration. | 1987 | Biochem. J. | pmid:3689334 |
| Hill CE and Olson MS | Stimulation of uric acid release from the perfused rat liver by platelet activating factor or potassium. | 1987 | Biochem. J. | pmid:3689345 |
| Bolin RW et al. | Lung endothelial and epithelial permeability after platelet-activating factor. | 1987 | J. Appl. Physiol. | pmid:3693212 |
| Smallbone BW et al. | Effects of L-652,731, a platelet-activating factor (PAF) receptor antagonist, on PAF- and complement-induced pulmonary hypertension in sheep. | 1987 | J. Pharmacol. Exp. Ther. | pmid:2821222 |
| Sugiyama T et al. | A novel platelet aggregating factor found in a patient with defective collagen-induced platelet aggregation and autoimmune thrombocytopenia. | 1987 | Blood | pmid:3580576 |
| Robertson DA et al. | Negative inotropic effect of platelet-activating factor on human myocardium: a pharmacological study. | 1987 | J. Pharmacol. Exp. Ther. | pmid:3694533 |
| Agrawal DK and Townley RG | Effect of platelet-activating factor on beta-adrenoceptors in human lung. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030311 |
| Hébert RL et al. | Hemodynamic effects of PAF-acether on the dog kidney. | 1987 | Prostaglandins Leukot Med | pmid:3033688 |
| Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
| Barnes PJ et al. | The effect of platelet activating factor on pulmonary beta-adrenoceptors. | 1987 | Br. J. Pharmacol. | pmid:3034367 |
| Gordeev KIu et al. | [Synthesis of 1-(1-alkenyl)-2-acetyl-sn-glycero-3-phosphocholines, the aldehyded analogs of platelet activating factor]. | 1987 | Bioorg. Khim. | pmid:3566815 |
| Davenas E et al. | Effect of mouse peritoneal macrophages of orally administered very high dilutions of silica. | 1987 | Eur. J. Pharmacol. | pmid:3034632 |
| Stahl GL and Lefer AM | Heterogeneity of vascular smooth muscle responsiveness to lipid vasoactive mediators. | 1987 | Blood Vessels | pmid:3567363 |
| Sigal CE et al. | Preferential human eosinophil chemotactic activity of the platelet-activating factor (PAF) 1-0-hexadecyl-2-acetyl-sn-glyceryl-3-phosphocholine (AGEPC). | 1987 | J. Clin. Immunol. | pmid:3571436 |
| Godfroid JJ et al. | Structure-activity relationship in PAF-acether. 3. Hydrophobic contribution to agonistic activity. | 1987 | J. Med. Chem. | pmid:3572968 |
| Simon MF et al. | Effect of BN 52021, a specific antagonist of platelet activating factor (PAF-acether), on calcium movements and phosphatidic acid production induced by PAF-acether in human platelets. | 1987 | Thromb. Res. | pmid:3576518 |
| Alam I and Silver MJ | Metabolism of 1-alkyl-2-acyl-GPC in human platelets in response to stimulation by thrombin. | 1987 | Thromb. Res. | pmid:3576519 |
| Barrio V et al. | Atrial natriuretic peptide inhibits glomerular contraction induced by angiotensin II and platelet activating factor. | 1987 | Eur. J. Pharmacol. | pmid:2952517 |
| Kawasaki T and Snyder F | The metabolism of lyso-platelet-activating factor (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by a calcium-dependent lysophospholipase D in rabbit kidney medulla. | 1987 | Biochim. Biophys. Acta | pmid:3036238 |
| Camussi G et al. | Receptor antagonist of platelet activating factor inhibits inflammatory injury induced by in situ formation of immune complexes in renal glomeruli and in the skin. | 1987 | J. Lab. Clin. Med. | pmid:2955066 |
| Shukla SD et al. | Activation of phospholipase C in platelets by platelet activating factor and thrombin causes hydrolysis of a common pool of phosphatidylinositol 4,5-bisphosphate. | 1987 | Biochim. Biophys. Acta | pmid:3036249 |
| Foegh ML et al. | Leukotrienes, thromboxane, and platelet activating factor in organ transplantation. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959038 |
| Robertson DN and Smith GM | Role of thromboxane A2, 5-hydroxytryptamine, and platelet activating factor in collagen-induced sudden death in rabbits. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959049 |
| d'Humieres S et al. | Platelet activating factor acether is involved in thrombin-induced synthesis of prostacyclin by human endothelial cells. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959051 |
| O'Flaherty JT et al. | 1-O-alkyl-2-N-methylcarbamyl-glycerophosphocholine: a biologically potent, non-metabolizable analog of platelet-activating factor. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820395 |
| Whittle BJ et al. | Gastric vascular and mucosal damaging actions of platelet activating factor in the canine stomach. | 1987 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:2959063 |
| Wymann MP et al. | Oscillatory motion in human neutrophils responding to chemotactic stimuli. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2820398 |
| Lucchesi BR et al. | Interaction of the formed elements of blood with the coronary vasculature in vivo. | 1987 | Fed. Proc. | pmid:3542578 |
| Stafforini DM et al. | Human plasma platelet-activating factor acetylhydrolase. Association with lipoprotein particles and role in the degradation of platelet-activating factor. | 1987 | J. Biol. Chem. | pmid:3549727 |
| Nunez D et al. | [Effects of SIN-1, a metabolite of molsidomine, on paf-acether-blood platelets interactions]. | 1987 | Pathol. Biol. | pmid:3550639 |
| Chang SW et al. | Platelet-activating factor mediates hemodynamic changes and lung injury in endotoxin-treated rats. | 1987 | J. Clin. Invest. | pmid:3553241 |
| Saunders RN and Handley DA | Platelet-activating factor antagonists. | 1987 | Annu. Rev. Pharmacol. Toxicol. | pmid:3555317 |
| Stafforini DM et al. | Human plasma platelet-activating factor acetylhydrolase. Purification and properties. | 1987 | J. Biol. Chem. | pmid:3558407 |
| Adamson LM et al. | Mechanistic studies of early pregnancy associated thrombocytopenia (EPAT) in the mouse. | 1987 | Am J Reprod Immunol Microbiol | pmid:3605486 |
| Baer PG and Cagen LM | Platelet activating factor vasoconstriction of dog kidney. Inhibition by alprazolam. | 1987 | Hypertension | pmid:3818022 |
| Kojima S et al. | Cooperativity between platelet-activating factor and collagen in platelet aggregation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593379 |
| Lapointe DS et al. | Mobilization of hepatic calcium pools by platelet activating factor. | 1987 | Biochemistry | pmid:3593678 |
| Fujita K et al. | Synthesis and biological activity of fluorine-modified platelet activating factors. | 1987 | Chem. Pharm. Bull. | pmid:3594676 |
| O'Neill C et al. | Use of a bioassay for embryo-derived platelet-activating factor as a means of assessing quality and pregnancy potential of human embryos. | 1987 | Fertil. Steril. | pmid:3595903 |
| Etienne A et al. | Inhibition of rat endotoxin-induced lethality by BN 52021 and BN 52063, compounds with PAF-acether antagonistic effect and protease-inhibitory activity. | 1987 | Int J Tissue React | pmid:3596954 |
| Doly M et al. | Effects of PAF-acether on electrophysiological response of isolated retina. | 1987 | Int J Tissue React | pmid:3596955 |
| Casals-Stenzel J | Effects of WEB 2086, a novel antagonist of platelet activating factor, in active and passive anaphylaxis. | 1987 | Immunopharmacology | pmid:3597059 |
| Handley DA et al. | Biological properties of the antagonist SRI 63-441 in the PAF and endotoxin models of hypotension in the rat and dog. | 1987 | Immunopharmacology | pmid:3597060 |
| Purdon AD et al. | Ionophore-stimulated rat basophilic leukemia cells produce PAF-acether. | 1987 | Int. Arch. Allergy Appl. Immunol. | pmid:3100454 |
| Bruijnzeel PL et al. | Platelet-activating factor induces leukotriene C4 synthesis by purified human eosinophils. | 1987 | Prostaglandins | pmid:3118415 |
| Sha'afi RI and Molski TF | Signalling for increased cytoskeletal actin in neutrophils. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3036146 |
| Taylor RR et al. | Whole blood platelet aggregation is not affected by cigarette smoking but is sex-related. | 1987 | Clin. Exp. Pharmacol. Physiol. | pmid:3440324 |
| Oon SH and Williams N | Immature megakaryocytes in the mouse: synergistic response to megakaryocyte potentiator, thrombopoietic stimulatory factor with interleukin 3. | 1987 | Leukemia | pmid:3500375 |
| Pretolani M et al. | Interference by the novel PAF-acether antagonist WEB 2086 with the bronchopulmonary responses to PAF-acether and to active and passive anaphylactic shock in guinea-pigs. | 1987 | Eur. J. Pharmacol. | pmid:3653247 |
| Homma H et al. | Some unique features of the metabolic conversion of platelet-activating factor (AGEPC) to alkyl acyl PC by washed rabbit platelets. | 1987 | Arch. Biochem. Biophys. | pmid:3101596 |
| Deguchi K et al. | [Platelet activating factor]. | 1987 | Nippon Rinsho | pmid:3041069 |
| Takahashi H et al. | [Blood coagulation disorders in thrombotic thrombocytopenic purpura--with special reference to a von Willebrand factor abnormality]. | 1987 | Rinsho Byori | pmid:3501812 |
| Hurst JS et al. | Effects of the lipid peroxidation product 4-hydroxynonenal on the aggregation of human platelets. | 1987 | Chem. Biol. Interact. | pmid:3103933 |
| Brigham KL | Conference summary: lipid mediators in the pulmonary circulation. | 1987 | Am. Rev. Respir. Dis. | pmid:2820285 |
| Morganroth ML et al. | Decreased pulmonary vascular responsiveness in rats raised on an essential fatty acid deficient diet. | 1987 | Prostaglandins | pmid:3108962 |
| Lamant V et al. | Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. | 1987 | Biochem. Pharmacol. | pmid:2820421 |
| Haroldsen PE et al. | Quantitation of lyso-platelet activating factor molecular species from human neutrophils by mass spectrometry. | 1987 | J. Lipid Res. | pmid:3104521 |
| Barnes PJ | The changing face of asthma. | 1987 | Q. J. Med. | pmid:3310071 |
| Schellenberg RR | Airway responses to platelet-activating factor. | 1987 | Am. Rev. Respir. Dis. | pmid:3310779 |
| Makowka L et al. | Prolongation of pig-to-dog renal xenograft survival by modification of the inflammatory mediator response. | 1987 | Ann. Surg. | pmid:3310931 |
| Hanahan DJ and Kumar R | Platelet activating factor; chemical and biochemical characteristics. | 1987 | Prog. Lipid Res. | pmid:3313430 |
| Pignol B et al. | Effect of platelet-activating factor (PAF-acether) and its specific receptor antagonist, BN 52021, on interleukin 1 (IL1) release and synthesis by rat spleen adherent monocytes. | 1987 | Prostaglandins | pmid:3313526 |
| Braquet P and Rola-Pleszczynski M | The role of PAF in immunological responses: a review. | 1987 | Prostaglandins | pmid:3313527 |
| Braquet P and Bourgain RH | Anti-anaphylactic properties of BN 52021: a potent platelet activating factor antagonist. | 1987 | Adv. Exp. Med. Biol. | pmid:3314403 |
| Teng CM et al. | Antiplatelet effect of butylidenephthalide. | 1987 | Biochim. Biophys. Acta | pmid:3109495 |
| Barnes PJ | New concepts in the pathogenesis of bronchial hyperresponsiveness. | 1987 | Agents Actions Suppl. | pmid:3314413 |
| Mustard JF et al. | Platelet activation--an overview. | 1987 | Agents Actions Suppl. | pmid:3314414 |
| Steel G et al. | Failure of prostaglandin E2 and its 16,16-dimethyl analogue to prevent the gastric mucosal damage induced by Paf. | 1987 | Br. J. Pharmacol. | pmid:3470106 |
| Kimura Y et al. | Effects of baicalein on leukotriene biosynthesis and degranulation in human polymorphonuclear leukocytes. | 1987 | Biochim. Biophys. Acta | pmid:2825795 |
| Vargaftig BB and Braquet PG | PAF-acether today--relevance for acute experimental anaphylaxis. | 1987 | Br. Med. Bull. | pmid:2825900 |
| Kochanek PM et al. | Platelet activating factor receptor blockade enhances recovery after multifocal brain ischemia. | 1987 | Life Sci. | pmid:2826947 |
| Wang J and Dunn MJ | Platelet-activating factor mediates endotoxin-induced acute renal insufficiency in rats. | 1987 | Am. J. Physiol. | pmid:2827506 |
| Tamura N et al. | Effects of platelet activating factor on the chemotaxis of normodense eosinophils from normal subjects. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3030295 |
| Braquet P et al. | Perspectives in platelet-activating factor research. | 1987 | Pharmacol. Rev. | pmid:3303066 |
| Murphy WG et al. | Relationship between platelet aggregating factor and von Willebrand factor in thrombotic thrombocytopenic purpura. | 1987 | Br. J. Haematol. | pmid:3499167 |
| Suemune H et al. | Asymmetric synthesis of (+)- and (-)-batyl alcohol, a key synthetic intermediate for platelet-activating factor, by using biocatalysts. | 1987 | Chem. Pharm. Bull. | pmid:3427701 |
| Shimazaki N et al. | Diketopiperazine derivatives, a new series of platelet-activating factor inhibitors. | 1987 | Chem. Pharm. Bull. | pmid:3427732 |
| Lang CH et al. | Attenuation of endotoxin-induced increase in glucose metabolism by platelet-activating factor antagonist. | 1987 | Circ. Shock | pmid:3427772 |
| Korth R and Benveniste J | BN 52021 displaces [3H]paf-acether from, and inhibits its binding to intact human platelets. | 1987 | Eur. J. Pharmacol. | pmid:3428349 |
| Steiger J et al. | Platelet activating factor (PAF) is a potent stimulator of porcine tracheal fluid secretion in vitro. | 1987 | Eur. J. Pharmacol. | pmid:3428351 |
| Ho YS et al. | Chemoattractant-induced activation of c-fos gene expression in human monocytes. | 1987 | J. Exp. Med. | pmid:3108444 |
| Maudsley DJ and Morris AG | Rapid intracellular calcium changes in U937 monocyte cell line: transient increases in response to platelet-activating factor and chemotactic peptide but not interferon-gamma or lipopolysaccharide. | 1987 | Immunology | pmid:3110054 |
| Lianos EA and Zanglis A | Biosynthesis and metabolism of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine in rat glomerular mesangial cells. | 1987 | J. Biol. Chem. | pmid:3110152 |
| Bull HA and Machin SJ | The haemostatic function of the vascular endothelial cell. | 1987 | Blut | pmid:3111566 |
| Parker CW | Lipid mediators produced through the lipoxygenase pathway. | 1987 | Annu. Rev. Immunol. | pmid:3036183 |
| Vane J and Botting R | Inflammation and the mechanism of action of anti-inflammatory drugs. | 1987 | FASEB J. | pmid:3111928 |
| Riedel A and Mest HJ | The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. | 1987 | Prostaglandins Leukot Med | pmid:3112804 |
| Shimokawa H et al. | Porcine coronary arteries with regenerated endothelium have a reduced endothelium-dependent responsiveness to aggregating platelets and serotonin. | 1987 | Circ. Res. | pmid:3113760 |
| Adnot S et al. | Antagonists of PAF-acether do not suppress thrombin-induced aggregation of ADP-deprived and aspirin-treated human platelets. | 1987 | Agents Actions | pmid:3115070 |
| Montrucchio G et al. | The pattern of cardiovascular alterations induced by infusion of platelet-activating factor in rabbit is modified by pretreatment with H1-H2 receptor antagonists but not by cyclooxygenase inhibition. | 1987 | Agents Actions | pmid:3115072 |
| Morley J and Sanjar S | PAF, ketotifen and asthma. | 1987 | N. Z. Med. J. | pmid:3468405 |
| Abramovici Y et al. | Control of the proliferation and differentiation of GEJ under platelet aggregating factor treatment. | 1987 | Acta Endocrinol Suppl (Copenh) | pmid:3475908 |
| Touqui L et al. | The role of Ca2+ in regulating the catabolism of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in rabbit platelets. | 1987 | Biochem. J. | pmid:3109377 |
| Doebber TW and Wu MS | Platelet-activating factor (PAF) stimulates the PAF-synthesizing enzyme acetyl-CoA:1-alkyl-sn-glycero-3-phosphocholine O2-acetyltransferase and PAF synthesis in neutrophils. | 1987 | Proc. Natl. Acad. Sci. U.S.A. | pmid:3478712 |
| PAF, platelets and asthma. Proceedings of a meeting. September 7-9, 1986. | 1987 | Agents Actions Suppl. | pmid:3478993 | |
| Farr RS et al. | Platelet abnormalities in asthma--do they exist in humans? | 1987 | Agents Actions Suppl. | pmid:3478994 |
| Moodley I and Stuttle A | Evidence for a dual pathway in platelet activating factor-induced aggregation of rat polymorphonuclear leucocytes. | 1987 | Prostaglandins | pmid:3035617 |