Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Bouayad A et al. | Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14715488 |
| Axelrad TW et al. | Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration. | 2004 | FASEB J. | pmid:14715700 |
| Chinybaeva LA | [Comparative characterization of hemostatic parameters in patients with cerebral stroke]. | 2004 | Klin Med (Mosk) | pmid:15449775 |
| Gambero A et al. | Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2. | 2004 | Toxicon | pmid:15450921 |
| Kondratskaya EL et al. | Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. | 2004 | Neurochem. Int. | pmid:14568560 |
| Ma X et al. | Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. | 2004 | Invest. Ophthalmol. Vis. Sci. | pmid:15326102 |
| Wright CS et al. | Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor. | 2004 | J. Mol. Biol. | pmid:15327957 |
| Thanou PG and Tsoukatos DC | Non-enzymatic platelet-activating factor formation by acetylated proteins. | 2004 | FEBS Lett. | pmid:15327967 |
| Chou KJ et al. | Platelet hyperreactivity in hemodialysis patients with frequently occluded vascular access. | 2004 | Thromb. Haemost. | pmid:15351860 |
| Llodrá J et al. | Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15280540 |
| Zhu L et al. | Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12946927 |
| Kato M et al. | Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. | 2004 | J. Pharmacol. Sci. | pmid:15286429 |
| Slomiany BL and Slomiany A | Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis. | 2004 | IUBMB Life | pmid:14992379 |
| Jung TT et al. | Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells. | 2004 | Ann. Otol. Rhinol. Laryngol. | pmid:14994775 |
| Fourcade O et al. | Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. | 2004 | Anesth. Analg. | pmid:15271713 |
| Getting SJ et al. | Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14996949 |
| Rasheed H and Saeed SA | Involvement of thromboxane A2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation. | 2004 | Exp. Mol. Med. | pmid:15272233 |
| Bate C et al. | Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication. | 2004 | J. Biol. Chem. | pmid:15210691 |
| Yamano S et al. | Human spermatozoa capacitated with progesterone or a long incubation show accelerated internalization by an alkyl ether lysophospholipid. | 2004 | Fertil. Steril. | pmid:15037409 |
| Taylor KE | Familial cancer and developmental dyslexia: an observational pilot study. | 2004 | Dev Med Child Neurol | pmid:14974637 |
| Fu H et al. | The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. | 2004 | Immunology | pmid:15147563 |
| Beaudeux JL et al. | Activation of PAF receptor by oxidised LDL in human monocytes stimulates chemokine releases but not urokinase-type plasminogen activator expression. | 2004 | Clin. Chim. Acta | pmid:15149885 |
| Yang Y et al. | Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis. | 2004 | Gut | pmid:15138217 |
| Steel HC and Anderson R | Itraconazole antagonizes store-operated influx of calcium into chemoattractant-activated human neutrophils. | 2004 | Clin. Exp. Immunol. | pmid:15086388 |
| Reeves SR and Gozal D | Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15087283 |
| Hollmann MW et al. | Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics. | 2004 | Anesthesiology | pmid:15087620 |
| Bate C et al. | The role of platelet activating factor in prion and amyloid-beta neurotoxicity. | 2004 | Neuroreport | pmid:15094513 |
| Khreiss T et al. | Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils. | 2004 | Cell. Signal. | pmid:15115659 |
| Ninio E et al. | Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. | 2004 | Hum. Mol. Genet. | pmid:15115767 |
| Bonin F et al. | Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. | 2004 | J. Biol. Chem. | pmid:15456758 |
| Alfaro V | Role of histamine and platelet-activating factor in allergic rhinitis. | 2004 | J. Physiol. Biochem. | pmid:15457928 |
| McDonagh PF et al. | Chronic expression of platelet adhesion proteins is associated with severe ischemic heart disease in type 2 diabetic patients: Chronic platelet activation in diabetic heart patients. | 2003 Sep-Oct | J. Diabetes Complicat. | pmid:12954156 |
| Kerek M et al. | Effects of recombinant platelet activating factor acetylhydrolase in obstructive jaundice. | 2003 Jul-Aug | Hepatogastroenterology | pmid:12845989 |
| Baltás E et al. | Platelet-activating factor antagonist WEB 2086 inhibits ultraviolet-B radiation-induced dermatitis in the human skin. | 2003 Jul-Aug | Skin Pharmacol. Appl. Skin Physiol. | pmid:12784066 |
| Hsueh W et al. | Neonatal necrotizing enterocolitis: clinical considerations and pathogenetic concepts. | 2003 Jan-Feb | Pediatr. Dev. Pathol. | pmid:12424605 |
| Diez-Fraile A et al. | Analysis of selective mobilization of L-selectin and Mac-1 reservoirs in bovine neutrophils and eosinophils. | 2003 Jan-Feb | Vet. Res. | pmid:12588684 |
| Zhang GQ et al. | [The effects of milkvetch and memantain on the synthesis of cerebral PAF in neonatal rats with hypoxic-ischemic reperfusion]. | 2003 | Zhonghua Er Ke Za Zhi | pmid:14751060 |
| Mayerle J et al. | [Conservative treatment of acute pancreatitis]. | 2003 | Med. Klin. (Munich) | pmid:14685675 |
| Tellis C et al. | Localization of an alkyl-acetyl-glycerol-CDP-choline: cholinephosphotransferase activity in submitochondrial fractions of Tetrahymena pyriformis. | 2003 | Eur. J. Cell Biol. | pmid:14703014 |
| Stafforini DM et al. | Platelet-activating factor, a pleiotrophic mediator of physiological and pathological processes. | 2003 | Crit Rev Clin Lab Sci | pmid:14708958 |
| Saeed SA and Rasheed H | Calcium-dependent synergistic interaction of platelet activating factor and epinephrine in human platelet aggregation. | 2003 | Acta Pharmacol. Sin. | pmid:12511226 |
| Shen Z et al. | Effects of plumbagin on platelet aggregation and platelet-neutrophil interactions. | 2003 | Planta Med. | pmid:12898414 |
| de Assis EF et al. | Synergism between platelet-activating factor-like phospholipids and peroxisome proliferator-activated receptor gamma agonists generated during low density lipoprotein oxidation that induces lipid body formation in leukocytes. | 2003 | J. Immunol. | pmid:12902515 |
| Hu H et al. | Glycoprotein IIb/IIIa inhibition attenuates platelet-activating factor-induced platelet activation by reducing protein kinase C activity. | 2003 | J. Thromb. Haemost. | pmid:12911597 |
| Kalia N and Bardhan KD | Of blood and guts: association between Helicobacter pylori and the gastric microcirculation. | 2003 | J. Gastroenterol. Hepatol. | pmid:12911655 |
| Tokuoka SM et al. | Involvement of platelet-activating factor and LIS1 in neuronal migration. | 2003 | Eur. J. Neurosci. | pmid:12911752 |
| Lupia E et al. | Intra-plaque production of platelet-activating factor correlates with neoangiogenesis in human carotid atherosclerotic lesions. | 2003 | Int. J. Mol. Med. | pmid:12883648 |
| Handa RK et al. | Role of Nitric oxide in the renal and systemic vasodilatory responses to platelet-activating factor in the rat, in vivo. | 2003 | Kidney Blood Press. Res. | pmid:12886044 |
| Taggart DP et al. | Neuroprotection during cardiac surgery: a randomised trial of a platelet activating factor antagonist. | 2003 | Heart | pmid:12860868 |
| Takafuji S et al. | Matrix metalloproteinase-9 release from human leukocytes. | 2003 | J Investig Allergol Clin Immunol | pmid:12861851 |
| Bar-Or D et al. | Copper stimulates the synthesis and release of interleukin-8 in human endothelial cells: a possible early role in systemic inflammatory responses. | 2003 | Shock | pmid:12865660 |
| Kujiraoka T et al. | Altered distribution of plasma PAF-AH between HDLs and other lipoproteins in hyperlipidemia and diabetes mellitus. | 2003 | J. Lipid Res. | pmid:12867534 |
| Casillan AJ et al. | Mesenteric microvascular inflammatory responses to systemic hypoxia are mediated by PAF and LTB4. | 2003 | J. Appl. Physiol. | pmid:12598480 |
| Rios-Santos F et al. | A critical role of leukotriene B4 in neutrophil migration to infectious focus in cecal ligaton and puncture sepsis. | 2003 | Shock | pmid:12558146 |
| Triggiani M et al. | Secretory phospholipases A2 activate selective functions in human eosinophils. | 2003 | J. Immunol. | pmid:12626587 |
| Al-Darmaki S et al. | Differential expression of platelet-activating factor acetylhydrolase in macrophages and monocyte-derived dendritic cells. | 2003 | J. Immunol. | pmid:12496397 |
| Lukashova V et al. | Janus kinase 2 activation by the platelet-activating factor receptor (PAFR): roles of Tyk2 and PAFR C terminus. | 2003 | J. Immunol. | pmid:14500680 |
| Brandt EB et al. | Mast cells are required for experimental oral allergen-induced diarrhea. | 2003 | J. Clin. Invest. | pmid:14660743 |
| Toledo DP et al. | Microvascular reactivity in experimental diabetes: responses of male and female rats. | 2003 | Inflamm. Res. | pmid:12813623 |
| Tonks AJ et al. | Regulation of platelet-activating factor synthesis in human monocytes by dipalmitoyl phosphatidylcholine. | 2003 | J. Leukoc. Biol. | pmid:12832447 |
| Choi IW et al. | Platelet-activating factor-mediated NF-kappaB dependency of a late anaphylactic reaction. | 2003 | J. Exp. Med. | pmid:12835479 |
| Kell PJ et al. | Inhibition of platelet-activating factor (PAF) acetylhydrolase by methyl arachidonyl fluorophosphonate potentiates PAF synthesis in thrombin-stimulated human coronary artery endothelial cells. | 2003 | J. Pharmacol. Exp. Ther. | pmid:14560038 |
| Denizot Y et al. | Tissue concentrations of platelet-activating factor in colorectal carcinoma: inverse relationships with Dukes' stage of patients. | 2003 | Oncogene | pmid:14562051 |
| Ivanov AI et al. | Platelet-activating factor: a previously unrecognized mediator of fever. | 2003 | J. Physiol. (Lond.) | pmid:14565987 |
| Proudfoot JM et al. | Angiotensin II type 1 receptor antagonists inhibit basal as well as low-density lipoprotein and platelet-activating factor-stimulated human monocyte chemoattractant protein-1. | 2003 | J. Pharmacol. Exp. Ther. | pmid:12626661 |
| Fang HY et al. | Cyclooxygenase-2 in human non-small cell lung cancer. | 2003 | Eur J Surg Oncol | pmid:12633561 |
| Cole KP and Hsung RP | Intramolecular formal oxa-[3 + 3] cycloaddition approach to the ABD system of phomactin A. | 2003 | Org. Lett. | pmid:14653688 |
| Hao J et al. | [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. | 2003 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:14552687 |
| Witko-Sarsat V et al. | AOPP-induced activation of human neutrophil and monocyte oxidative metabolism: a potential target for N-acetylcysteine treatment in dialysis patients. | 2003 | Kidney Int. | pmid:12787398 |
| Elovitz MA et al. | A new model for inflammation-induced preterm birth: the role of platelet-activating factor and Toll-like receptor-4. | 2003 | Am. J. Pathol. | pmid:14578208 |
| Slomiany BL and Slomiany A | Platelet-activating factor modulates gastric mucosal inflammatory responses to Helicobacter pylori lipopolysaccharide. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12788098 |
| Kogure K et al. | Temporary membrane distortion of vascular smooth muscle cells is responsible for their apoptosis induced by platelet-activating factor-like oxidized phospholipids and their degradation product, lysophosphatidylcholine. | 2003 | Chem. Phys. Lipids | pmid:14580708 |
| Schuster DP et al. | Recombinant platelet-activating factor acetylhydrolase to prevent acute respiratory distress syndrome and mortality in severe sepsis: Phase IIb, multicenter, randomized, placebo-controlled, clinical trial. | 2003 | Crit. Care Med. | pmid:12794395 |
| Rabinovici R | Platelet activating factor inhibition in sepsis: the end? | 2003 | Crit. Care Med. | pmid:12794432 |
| Bernatchez PN et al. | Sphingosine 1-phosphate effect on endothelial cell PAF synthesis: role in cellular migration. | 2003 | J. Cell. Biochem. | pmid:14587028 |
| Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
| Denizot Y et al. | Platelet-activating factor and normal or leukaemic haematopoiesis. | 2003 | Leuk. Lymphoma | pmid:12802913 |
| Olanders K et al. | Protective effects of N-acetyl-L-cysteine and platelet activating factor inhibition are not linked to intercellular adhesion molecule-1 expression after intestinal ischemia and reperfusion injury in rats. | 2003 | Scand. J. Gastroenterol. | pmid:12825870 |
| Adamson RH et al. | PAF- and bradykinin-induced hyperpermeability of rat venules is independent of actin-myosin contraction. | 2003 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12649070 |
| Li XG and Luo HM | [Progress in studies of chemical constituents and pharmacological activities of Kadsura]. | 2003 | Zhongguo Zhong Yao Za Zhi | pmid:15617488 |
| Chatterjee SS et al. | Structure-activity studies with Ginkgo biloba extract constituents as receptor-gated chloride channel blockers and modulators. | 2003 | Pharmacopsychiatry | pmid:13130392 |
| Mahgoub AA | Thymoquinone protects against experimental colitis in rats. | 2003 | Toxicol. Lett. | pmid:12749817 |
| Mariano F et al. | Platelet-activating factor synthesis by neutrophils, monocytes, and endothelial cells is modulated by nitric oxide production. | 2003 | Shock | pmid:12688545 |
| Thaete LG et al. | Infusion of exogenous platelet-activating factor produces intrauterine growth restriction in the rat. | 2003 | J. Soc. Gynecol. Investig. | pmid:12699876 |
| Simon HU et al. | Interleukin-2 primes eosinophil degranulation in hypereosinophilia and Wells' syndrome. | 2003 | Eur. J. Immunol. | pmid:12672048 |
| Teather LA and Wurtman RJ | Cyclooxygenase-2 mediates platelet-activating factor-induced prostaglandin E2 release from rat primary astrocytes. | 2003 | Neurosci. Lett. | pmid:12672535 |
| Kordan W et al. | Functions of platelet activating factor (PAF) in mammalian reproductive processes: a review. | 2003 | Pol J Vet Sci | pmid:12675470 |
| Loucks EB et al. | Role of platelet activating factor in cardiac dysfunction, apoptosis and nitric oxide synthase mRNA expression in the ischemic-reperfused rabbit heart. | 2003 | Can J Cardiol | pmid:12677282 |
| Ginesta MM et al. | Modulation of the pathology of late xenograft rejection by PAF-antagonist UR-12670 in the hamster-to-rat liver xenotransplant model. | 2003 | APMIS | pmid:12752216 |
| Peri A et al. | The effects of an autocrine loop mediated by platelet-activating factor (PAF) in HEC-1A cells are reverted by uteroglobin. | 2003 | Hum. Cell | pmid:15005239 |
| Wu B et al. | Platelet-activating factor promotes mucosal apoptosis via FasL-mediating caspase-9 active pathway in rat small intestine after ischemia-reperfusion. | 2003 | FASEB J. | pmid:12709415 |
| Ueda Y et al. | Effects on blood pressure decrease in response to PAF of Impatiens textori MIQ. | 2003 | Biol. Pharm. Bull. | pmid:14519965 |
| Akisu M et al. | The role of dietary supplementation with L-glutamine in inflammatory mediator release and intestinal injury in hypoxia/reoxygenation-induced experimental necrotizing enterocolitis. | 2003 | Ann. Nutr. Metab. | pmid:14520021 |
| Bussolati B et al. | The long pentraxin PTX3 is synthesized in IgA glomerulonephritis and activates mesangial cells. | 2003 | J. Immunol. | pmid:12538709 |
| Frostegård J et al. | Antibodies against platelet-activating factor and platelet-activating factor-like lipids are raised in women with primary recurrent abortion. | 2003 | Am. J. Obstet. Gynecol. | pmid:14520236 |
| Hou X et al. | Increased platelet-activating factor-induced periventricular brain microvascular constriction associated with immaturity. | 2003 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:12626359 |
| Lu DP et al. | Ligand-activated signal transduction in the 2-cell embryo. | 2003 | Biol. Reprod. | pmid:12606379 |
| Hu G et al. | Neutrophils pretreated with volatile anesthetics lose ability to cause cardiac dysfunction. | 2003 | Anesthesiology | pmid:12606916 |
| Corl CM et al. | Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12615078 |
| Chen L et al. | [Determination of platelet activating factor in middle ear effusion of patients with secretory oitits media]. | 2003 | Lin Chuang Er Bi Yan Hou Ke Za Zhi | pmid:14727433 |