Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Bastos da Silva M et al. | Morphological alterations of blood platelets induced by platelet activating factor (PAF) and partial inhibition by ketoprofen in calves. | 1997 Sep-Oct | Vet. Res. | pmid:9342825 |
Bastos da Silva MB et al. | The effect of intravenous administration of WEB 2086 on PAF-induced platelet aggregation in healthy Friesian calves. | 1997 | Vet. Res. Commun. | pmid:9345719 |
da Silva MB et al. | Protective effects of WEB 2086 (PAF antagonist) and ketoprofen (NSAID) on PAF-induced changes in the morphological ultrastructure of blood platelets in calves. | 1998 | Vet. Res. Commun. | pmid:9686442 |
Dawson J et al. | Platelet activating factor as a mediator of equine cell locomotion. | 1988 | Vet. Res. Commun. | pmid:3188378 |
Venugopalan CS et al. | Responses of guinea-pig lung parenchymal strips to tracheobronchial lavage fluid from horses affected with summer pasture-associated obstructive pulmonary disease. | 1998 | Vet. Res. Commun. | pmid:9868763 |
DaÄkhin EI et al. | [Clinical significance of studies of platelet activating factor (review of the literature)]. | 1989 Mar-Apr | Vopr. Med. Khim. | pmid:2662595 |
Shebzukhov IuV and Mysiakin EB | [Platelet activating factor--role in regulating the functional activity of the mononuclear phagocyte system]. | 1996 Oct-Dec | Vopr. Med. Khim. | pmid:9254510 |
Muzia GI et al. | [Inhibition of formation of superoxide radicals in leukocytes of hypercholesteremic patients under the effect of a lipid platelet activation factor antagonist]. | 1995 Jul-Aug | Vopr. Med. Khim. | pmid:8571587 |
Denizot Y and Nathan N | Platelet-activating factor in operative salvaged blood. | 1994 | Vox Sang. | pmid:7801619 |
Silliman CC et al. | Stored blood components contain agents that prime the neutrophil NADPH oxidase through the platelet-activating-factor receptor. | 1992 | Vox Sang. | pmid:1332255 |
Sieunarine K et al. | Plasma levels of the lipid mediators, leukotriene B4 and lyso platelet-activating factor, in intraoperative salvaged blood. | 1992 | Vox Sang. | pmid:1333134 |
Robeva R et al. | [Changes in blood coagulation in glomerulonephritis]. | 1982 | Vutr Boles | pmid:6219496 |
Guan Z et al. | [Role of interleukin-6 and platelet-activating factor in delaying neutrophil apoptosis]. | 2000 | Wei Sheng Yan Jiu | pmid:12725051 |
Chmiel B | [The influence of select pathophysiologic factors of acute pancreatitis on erythrocytes' deformability examined in vitro]. | 2002 | Wiad. Lek. | pmid:12715347 |
Keck M et al. | Pathophysiology of burns. | 2009 | Wien Med Wochenschr | pmid:19652939 |
Czarnetzki BM | [Mediators and the bronchial system. Pathophysiologic and biochemical aspects of mediators of the bronchial system]. | 1987 | Wien Med Wochenschr Suppl | pmid:3078398 |
Connolly AB and Vernon DR | Manipulations of the metabolic response for management of patients with severe surgical illness: review. | 2000 | World J Surg | pmid:10773122 |
Bang UC et al. | Pharmacological approach to acute pancreatitis. | 2008 | World J. Gastroenterol. | pmid:18494044 |
Cao HC et al. | Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. | 2005 | World J. Gastroenterol. | pmid:16437644 |
Karidis NP et al. | Platelet-activating factor in liver injury: a relational scope. | 2006 | World J. Gastroenterol. | pmid:16773686 |