Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Chinybaeva LA | [Comparative characterization of hemostatic parameters in patients with cerebral stroke]. | 2004 | Klin Med (Mosk) | pmid:15449775 |
| Gambero A et al. | Signalling pathways regulating human neutrophil migration induced by secretory phospholipases A2. | 2004 | Toxicon | pmid:15450921 |
| Amer MD et al. | Platelet-activating factor concentration in the stool of human newborns: effects of enteral feeding and neonatal necrotizing enterocolitis. | 2004 | Biol. Neonate | pmid:14646336 |
| Cinamon G et al. | Chemoattractant signals and beta 2 integrin occupancy at apical endothelial contacts combine with shear stress signals to promote transendothelial neutrophil migration. | 2004 | J. Immunol. | pmid:15585851 |
| Bender A et al. | Molecular surface point environments for virtual screening and the elucidation of binding patterns (MOLPRINT 3D). | 2004 | J. Med. Chem. | pmid:15588092 |
| Rasheed H and Saeed SA | Involvement of thromboxane A2 and tyrosine kinase in the synergistic interaction of platelet activating factor and calcium ionophore A23187 in human platelet aggregation. | 2004 | Exp. Mol. Med. | pmid:15272233 |
| Bate C et al. | Phospholipase A2 inhibitors or platelet-activating factor antagonists prevent prion replication. | 2004 | J. Biol. Chem. | pmid:15210691 |
| Yamano S et al. | Human spermatozoa capacitated with progesterone or a long incubation show accelerated internalization by an alkyl ether lysophospholipid. | 2004 | Fertil. Steril. | pmid:15037409 |
| Jakubowski A et al. | Involvement of platelet activating factor in immediate heart response to lipopolysaccharide. | 2004 | J. Physiol. Pharmacol. | pmid:15213362 |
| Taylor KE | Familial cancer and developmental dyslexia: an observational pilot study. | 2004 | Dev Med Child Neurol | pmid:14974637 |
| Seo KH et al. | Essential role for platelet-activating factor-induced NF-kappaB activation in macrophage-derived angiogenesis. | 2004 | Eur. J. Immunol. | pmid:15259010 |
| Zhu P et al. | Interplay among platelet-activating factor, oxidative stress, and group I metabotropic glutamate receptors modulates neuronal survival. | 2004 | J. Neurosci. Res. | pmid:15264222 |
| Lu DP et al. | Trophic signals acting via phosphatidylinositol-3 kinase are required for normal pre-implantation mouse embryo development. | 2004 | J. Cell. Sci. | pmid:15020683 |
| Sarchielli P et al. | Platelet-activating factor (PAF) in internal jugular venous blood of migraine without aura patients assessed during migraine attacks. | 2004 | Cephalalgia | pmid:15265050 |
| Ziche M | Absence of PAF actions increases angiogenesis. | 2004 | Br. J. Pharmacol. | pmid:15023858 |
| Ferreira MA et al. | Sponge-induced angiogenesis and inflammation in PAF receptor-deficient mice (PAFR-KO). | 2004 | Br. J. Pharmacol. | pmid:15023865 |
| Alloatti G et al. | Phosphoinositide 3-kinase gamma: kinase-dependent and -independent activities in cardiovascular function and disease. | 2004 | Biochem. Soc. Trans. | pmid:15046613 |
| Khreiss T et al. | Activation of extracellular signal-regulated kinase couples platelet-activating factor-induced adhesion and delayed apoptosis of human neutrophils. | 2004 | Cell. Signal. | pmid:15115659 |
| Ninio E et al. | Platelet-activating factor-acetylhydrolase and PAF-receptor gene haplotypes in relation to future cardiovascular event in patients with coronary artery disease. | 2004 | Hum. Mol. Genet. | pmid:15115767 |
| Bonin F et al. | Anti-apoptotic actions of the platelet-activating factor acetylhydrolase I alpha2 catalytic subunit. | 2004 | J. Biol. Chem. | pmid:15456758 |
| Martin C et al. | Pressor responses to platelet-activating factor and thromboxane are mediated by Rho-kinase. | 2004 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:15064228 |
| Alfaro V | Role of histamine and platelet-activating factor in allergic rhinitis. | 2004 | J. Physiol. Biochem. | pmid:15457928 |
| Baker KE and Curtis MJ | Left regional cardiac perfusion in vitro with platelet-activating factor, norepinephrine and K+ reveals that ischaemic arrhythmias are caused by independent effects of endogenous "mediators" facilitated by interactions, and moderated by paradoxical antagonism. | 2004 | Br. J. Pharmacol. | pmid:15066909 |
| Uemura K et al. | Superoxide production from human polymorphonuclear leukocytes by human mannan-binding protein (MBP). | 2004 | Glycoconj. J. | pmid:15467404 |
| Victorino GP et al. | Modulation of microvascular hydraulic permeability by platelet-activating factor. | 2004 | J Trauma | pmid:14960983 |
| Ko HH et al. | Structure-activity relationship studies on chalcone derivatives: potent inhibition of platelet aggregation. | 2004 | J. Pharm. Pharmacol. | pmid:15482650 |
| Ewer AK et al. | The role of platelet activating factor in a neonatal piglet model of necrotising enterocolitis. | 2004 | Gut | pmid:14724152 |
| Angeli V et al. | Dyslipidemia associated with atherosclerotic disease systemically alters dendritic cell mobilization. | 2004 | Immunity | pmid:15485633 |
| Tai H et al. | TMVA, a snake C-type lectin-like protein from Trimeresurus mucrosquamatus venom, activates platelet via GPIb. | 2004 | Toxicon | pmid:15501291 |
| Buke AC et al. | Tumor necrosis factor alpha and interleukin 6 productions in response to platelet-activating factor in chronic hepatitis B virus infection. | 2004 Sep-Oct | Med Princ Pract | pmid:15316260 |
| Michibayashi T | Platelet aggregation and vasoconstriction related to platelet cyclooxygenase and 12-lipoxygenase pathways. | 2005 | J. Atheroscler. Thromb. | pmid:16020916 |
| Owen JS et al. | An improved assay for platelet-activating factor using HPLC-tandem mass spectrometry. | 2005 | J. Lipid Res. | pmid:15520455 |
| Lemieux C et al. | Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. | 2005 | Blood | pmid:15498854 |
| Mishra RK et al. | Differential dependence of eosinophil chemotactic responses on phosphoinositide 3-kinase (PI3K). | 2005 | Allergy | pmid:16076309 |
| Jin Y et al. | Human resting CD16-, CD16+ and IL-2-, IL-12-, IL-15- or IFN-alpha-activated natural killer cells differentially respond to sphingosylphosphorylcholine, lysophosphatidylcholine and platelet-activating factor. | 2005 | Eur. J. Immunol. | pmid:16078278 |
| Meyer MC et al. | Potential role for mast cell tryptase in recruitment of inflammatory cells to endothelium. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:16079184 |
| Fernandes ES et al. | Cytokines and neutrophils as important mediators of platelet-activating factor-induced kinin B1 receptor expression. | 2005 | Br. J. Pharmacol. | pmid:16025141 |
| Bazan HE | Cellular and molecular events in corneal wound healing: significance of lipid signalling. | 2005 | Exp. Eye Res. | pmid:15781273 |
| Cuschieri J et al. | Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming. | 2005 | Shock | pmid:15665723 |
| Roudebush WE et al. | The significance of platelet-activating factor and fertility in the male primate: a review. | 2005 | J. Med. Primatol. | pmid:15667340 |
| Ottino P et al. | PAF-induced furin and MT1-MMP expression is independent of MMP-2 activation in corneal myofibroblasts. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:15671273 |
| Hidalgo MA et al. | Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells. | 2005 | Br. J. Pharmacol. | pmid:15678086 |
| Oku H et al. | Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. | 2005 | Planta Med. | pmid:15678383 |
| Lin P et al. | Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP. | 2005 | J. Immunol. | pmid:15728511 |
| Shimada T et al. | Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms. | 2005 | J. Endocrinol. | pmid:15684346 |
| Yasu T et al. | Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules. | 2005 | Int. J. Cardiol. | pmid:15686774 |
| Fell JM | Neonatal inflammatory intestinal diseases: necrotising enterocolitis and allergic colitis. | 2005 | Early Hum. Dev. | pmid:15707723 |
| Schaloske RH et al. | Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages. | 2005 | Biochim. Biophys. Acta | pmid:15708354 |
| Mann NS and Leung JW | Pathogenesis of esophageal rings in eosinophilic esophagitis. | 2005 | Med. Hypotheses | pmid:15617859 |
| Cheng L et al. | Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15890711 |
| Qu XW et al. | Tetrahydrobiopterin prevents platelet-activating factor-induced intestinal hypoperfusion and necrosis: Role of neuronal nitric oxide synthase. | 2005 | Crit. Care Med. | pmid:15891335 |
| Gilli UO et al. | Human polymorphonuclear neutrophils are recruited by porcine chemokines acting on CXC chemokine receptor 2, and platelet-activating factor. | 2005 | Transplantation | pmid:15912099 |
| Park EJ et al. | Dietary ganglioside decreases cholesterol content, caveolin expression and inflammatory mediators in rat intestinal microdomains. | 2005 | Glycobiology | pmid:15917432 |
| Fulkerson PC et al. | CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. | 2005 | Blood | pmid:15802529 |
| Guo NJ et al. | [Activation of platelet-neutrophil mediated by platelet-activating factor]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15972139 |
| Souza DG and Teixeira MM | The balance between the production of tumor necrosis factor-alpha and interleukin-10 determines tissue injury and lethality during intestinal ischemia and reperfusion. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962100 |
| Castro Faria Neto HC et al. | Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962103 |
| White DC et al. | Feasibility of assessment of regulatory lipids in breath condensate as potential presymptomatic harbingers of pulmonary pathobiology. | 2005 | J. Microbiol. Methods | pmid:15963585 |
| Jeon SY et al. | Rat model of platelet-activating factor-induced rhinosinusitis. | 2005 | Ann. Otol. Rhinol. Laryngol. | pmid:15966528 |
| Tiemann U et al. | Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating factor receptor in endometrial explant perfusion cultures from ovariectomized bovine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967160 |
| Lang KS et al. | Mechanisms of suicidal erythrocyte death. | 2005 | Cell. Physiol. Biochem. | pmid:15956782 |
| Kita Y et al. | A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15958190 |
| Fang YH et al. | [Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy]. | 2005 | Di Yi Jun Yi Da Xue Xue Bao | pmid:15958323 |
| Vinson SM et al. | Neutrophil adherence to bladder microvascular endothelial cells following platelet-activating factor acetylhydrolase inhibition. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15937147 |
| Sumita C et al. | Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages. | 2005 | FEBS Lett. | pmid:16004986 |
| Ou-Yang XY et al. | [Inhibitory effect of ginkgolide B on angiogenesis in chronic inflammation]. | 2005 | Yao Xue Xue Bao | pmid:16011257 |
| Estellés R et al. | Effect of boldine, secoboldine, and boldine methine on angiotensin II-induced neutrophil recruitment in vivo. | 2005 | J. Leukoc. Biol. | pmid:15944212 |
| Zhao T and Bokoch GM | Critical role of proline-rich tyrosine kinase 2 in reversion of the adhesion-mediated suppression of reactive oxygen species generation by human neutrophils. | 2005 | J. Immunol. | pmid:15944312 |
| Echazarreta AL et al. | Lack of systemic oxidative stress during PAF challenge in mild asthma. | 2005 | Respir Med | pmid:15823446 |
| Cao HC et al. | Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. | 2005 | World J. Gastroenterol. | pmid:16437644 |
| Asada Y | [Inflammatory and immune responses in arterial thrombus formation]. | 2005 | Rinsho Ketsueki | pmid:16447700 |
| Kira J | [Multiple sclerosis]. | 2005 | Rinsho Shinkeigaku | pmid:16447761 |
| Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
| Vardar S et al. | Individual and combined effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on endotoxin-induced periodontitis in rats. | 2005 | J. Periodontol. | pmid:15830643 |
| Rubin BB et al. | Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. | 2005 | J. Biol. Chem. | pmid:15475363 |
| Zinchuk O et al. | Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. | 2005 | Mol. Vis. | pmid:15735601 |
| Lang PA et al. | Stimulation of erythrocyte ceramide formation by platelet-activating factor. | 2005 | J. Cell. Sci. | pmid:15741229 |
| Cheng HH et al. | Defect in regulation of Ca2+ movement in platelets from patients with systemic lupus erythematosus. | 2005 | Pharmacology | pmid:15591819 |
| Penna C et al. | Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15637120 |
| Connelly PW et al. | Paraoxonase-1 does not reduce or modify oxidation of phospholipids by peroxynitrite. | 2005 | Free Radic. Biol. Med. | pmid:15607900 |
| Ivanov AI et al. | Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of alpha1-acid glycoprotein. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15576666 |
| Denizot Y et al. | Platelet-activating factor does not stimulate cAMP formation from immature forms of freshly isolated leukaemic blasts. | 2005 | Leuk. Lymphoma | pmid:15621790 |
| Meyer MC et al. | Calcium-independent phospholipase A2 is regulated by a novel protein kinase C in human coronary artery endothelial cells. | 2005 | Am. J. Physiol., Cell Physiol. | pmid:15643055 |
| Granger J and Remick D | Acute pancreatitis: models, markers, and mediators. | 2005 | Shock | pmid:16374372 |
| Tran KC et al. | Induction of angiogenesis by platelet-activating factor in the rat striatum. | 2005 | Neuroreport | pmid:16148749 |
| Milias GA et al. | Effects of eccentric exercise-induced muscle injury on blood levels of platelet activating factor (PAF) and other inflammatory markers. | 2005 | Eur. J. Appl. Physiol. | pmid:16151835 |
| Hauser CJ et al. | Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16168959 |
| Kihara Y et al. | Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. | 2005 | J. Exp. Med. | pmid:16172262 |
| Tian X and Bazan NG | Neuroprotection by platelet-activating factor antagonism. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16179552 |
| Zhang Q et al. | Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. | 2005 | J. Clin. Invest. | pmid:16184199 |
| Pexa A and Deussen A | Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC). | 2005 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16200394 |
| Karantonis HC et al. | Synthesis and biological evaluation of novel steroid-modified ether phospholipids. | 2005 | Chem. Phys. Lipids | pmid:16202400 |
| Nagata M et al. | Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947477 |
| Antonopoulou S et al. | Bioactive polar lipids from Chroococcidiopsis sp. (Cyanobacteria). | 2005 | Comp. Biochem. Physiol. B, Biochem. Mol. Biol. | pmid:16198133 |
| Tunc SE et al. | Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients. | 2005 | Rheumatol. Int. | pmid:15004723 |
| Hu G et al. | Isoflurane prevents platelets from enhancing neutrophil-induced coronary endothelial dysfunction. | 2005 | Anesth. Analg. | pmid:16243978 |
| Okumura N et al. | Platelet-activating factor in human normal tears. | 2005 | Curr. Eye Res. | pmid:16251126 |
| Ko HM et al. | Platelet-activating factor induces matrix metalloproteinase-9 expression through Ca(2+)- or PI3K-dependent signaling pathway in a human vascular endothelial cell line. | 2005 | FEBS Lett. | pmid:16288746 |
| Löhrke B et al. | Polar phospholipids from bovine endogenously oxidized low density lipoprotein interfere with follicular thecal function. | 2005 | J. Mol. Endocrinol. | pmid:16326838 |
| Besana A et al. | Lipids and two-pore domain K+ channels in excitable cells. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099395 |