Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mike I et al. | The differences in 12-hydroxyeicosatetraenoic acid and thromboxane B2 release from guinea pig platelets. | 1991 | Prostaglandins | pmid:1763200 |
| Rossi AG and O'Flaherty JT | Prostaglandin binding sites in human polymorphonuclear neutrophils. | 1989 | Prostaglandins | pmid:2549574 |
| Montrucchio G et al. | In vitro contractile effect of platelet-activating factor on guinea-pig myometrium. | 1986 | Prostaglandins | pmid:3797692 |
| Sakuma Y et al. | Inhibitory effects of a novel PAF antagonist E6123 on anaphylactic responses in passively and actively sensitized guinea pigs and passively sensitized mice. | 1991 | Prostaglandins | pmid:1801063 |
| Abstracts of the meeting: The role of platelet-activating factors in the immune response. Paris, France, June 25 and 26, 1987. | 1987 | Prostaglandins | pmid:3671731 | |
| Stratton MD et al. | The effect of Clostridium difficile toxin on colonocyte prostanoid activity. | 1994 | Prostaglandins | pmid:7892508 |
| Adnot S et al. | Interference of the PAF-acether antagonist BN 52021 with endotoxin-induced hypotension in the guinea-pig. | 1986 | Prostaglandins | pmid:3562865 |
| Levine L | Actions of vanadate on arachidonic acid metabolism by cells in culture. | 1991 | Prostaglandins | pmid:2020748 |
| Levine L | Effects of okadaic acid on agonist-stimulated PGI2 production by rat liver cells (the C-9 cell line). | 1991 | Prostaglandins | pmid:1647047 |
| Dembinska-Kiec A et al. | The effects of platelet-activating factor on flow rate and eicosanoid release in the isolated perfused rat gastric vascular bed. | 1989 | Prostaglandins | pmid:2717778 |
| Takehara S et al. | Pharmacological actions of Y-24180, a new specific antagonist of platelet activating factor (PAF): II. Interactions with PAF and benzodiazepine receptors. | 1990 | Prostaglandins | pmid:1965554 |
| Kim CJ et al. | Eosinophils recruited to the lung by segmental antigen challenge show a reduced chemotactic response to leukotriene B4. | 1994 | Prostaglandins | pmid:8066187 |
| Kikukawa Y et al. | The effect of platelet activating factor on ovulation. | 1991 | Prostaglandins | pmid:1775639 |
| Pons L et al. | Role of platelet-activating factor (PAF) and prostaglandins in colonic motor and secretory disturbances induced by Escherichia coli endotoxin in conscious rats. | 1994 | Prostaglandins | pmid:8016383 |
| Lee MJ et al. | Endothelial cell 1-acyl-platelet-activating factor synthesis in response to anticardiolipin antibody-positive serum fractions. | 1994 | Prostaglandins | pmid:8016391 |
| Levine L | Effects of the protein kinase inhibitors, staurosporine and K-252a, on PGI2 production by rat liver cells (the C-9 cell line). | 1990 | Prostaglandins | pmid:2247616 |
| Radeau T et al. | Enhanced esterification process of 5-hydroxyeicosatetraenoic acid (5-HETE) in PMN from asthmatic patients. | 1992 | Prostaglandins | pmid:1410523 |
| Yue TL et al. | Pharmacologic profile of BN 50739, a new PAF antagonist in vitro and in vivo. | 1990 | Prostaglandins | pmid:2353116 |
| Terasawa M et al. | Pharmacological actions of Y-24180: I. A potent and specific antagonist of platelet-activating factor. | 1990 | Prostaglandins | pmid:2093935 |
| Jancar S et al. | Immune complex induced pancreatitis: effect of BN 52021, a selective antagonist of platelet-activating factor. | 1988 | Prostaglandins | pmid:2969600 |
| Ashida Y et al. | A novel anti-asthmatic quinone derivative, AA-2414 with a potent antagonistic activity against a variety of spasmogenic prostanoids. | 1989 | Prostaglandins | pmid:2748922 |
| Myers SI et al. | Platelet activating factor (PAF) stimulates release of PGI2 from inflamed rabbit gallbladder cell cultures. | 1995 | Prostaglandins | pmid:8588069 |
| Spinnewyn B et al. | Involvement of platelet-activating factor (PAF) in cerebral post-ischemic phase in Mongolian gerbils. | 1987 | Prostaglandins | pmid:3432553 |
| Guinot P et al. | Effect of BN 52063, a specific PAF-acether antagonist, on bronchial provocation test to allergens in asthmatic patients. A preliminary study. | 1987 | Prostaglandins | pmid:3432562 |
| Chan WP and Levy JV | Effects of antiplatelet agents on platelet aggregation induced by platelet--activating factor (PAF) in human whole blood. | 1991 | Prostaglandins | pmid:1665568 |
| Kioumis I et al. | Effect of inhaled platelet-activating factor on circulating neutrophils and platelets in vivo and ex vivo in man. | 1988 | Prostaglandins | pmid:3237997 |
| Sirois MG et al. | PAF increases vascular permeability in selected tissues: effect of BN-52021 and L-655,240. | 1988 | Prostaglandins | pmid:3238010 |
| Sakuma Y et al. | Pharmacological effects of oral E6123, a novel PAF antagonist, on biological changes induced by PAF inhalation in guinea pigs. | 1991 | Prostaglandins | pmid:1763202 |
| Voelkel NF et al. | PAF antagonists: different effects on platelets, neutrophils, guinea pig ileum and PAF-induced vasodilation in isolated rat lung. | 1986 | Prostaglandins | pmid:3024235 |
| Camussi G et al. | Inhibitory effect of prostacyclin (PGI2) on neutropenia induced by intravenous injection of platelet-activating-factor (PAF) in the rabbit. | 1983 | Prostaglandins | pmid:6346397 |
| Cordeiro RS et al. | Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. | 1986 | Prostaglandins | pmid:3103172 |
| Fernandes AJ et al. | Mechanisms of thrombocytopenia in the acute phase of antigen-induced arthritis in rabbits. | 1991 | Prostaglandins | pmid:1801060 |
| Ezra D et al. | Cardiac and coronary consequences of intracoronary platelet activating factor infusion in the domestic pig. | 1987 | Prostaglandins | pmid:3685397 |
| Hébert RL et al. | Hemodynamic effects of PAF-acether on the dog kidney. | 1987 | Prostaglandins Leukot Med | pmid:3033688 |
| Otsuka A et al. | Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. | 1985 | Prostaglandins Leukot Med | pmid:3862138 |
| Riedel A and Mest HJ | The effect of PAF (platelet-activating factor) on experimental cardiac arrhythmias and its inhibition by substances influencing arachidonic acid metabolites. | 1987 | Prostaglandins Leukot Med | pmid:3112804 |
| Mehta J et al. | Biphasic effects of platelet-activating factor on coronary blood flow in anesthetized dog. | 1986 | Prostaglandins Leukot Med | pmid:3456620 |
| Oh S et al. | Inflammatory effects of acetylglycerylether phosphorylcholine: vascular permeability increase and induction of pleurisy in rats. | 1986 | Prostaglandins Leukot Med | pmid:3459197 |
| Acharya SB and MacIntyre DE | Platelet products and vascular PGI2 production. | 1983 | Prostaglandins Leukot Med | pmid:6338532 |
| Hertelendy F and Zakár T | Prostaglandins and the myometrium and cervix. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:14683694 |
| Herron D et al. | Inhibition of PAF-induced human platelet aggregation by antithrombotic nipecotomides. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7630919 |
| Gáti I et al. | Effects of the PAF-analog and -antagonist CV-6209 on cultured human glioma cell lines. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1886907 |
| Norman SJ and Poyser NL | The effects of platelet-activating factor on the output of prostaglandins from the guinea-pig uterus. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1492106 |
| Taylor KE et al. | Could platelet activating factor play a role in developmental dyslexia? | 2001 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:11334553 |
| Mózes T et al. | Protective effect of diclofenac sodium against endotoxic shock in anaesthetized pigs. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8446657 |
| Shindo K et al. | Inhibitory effect of azelastine hydrochloride on synthesis and release of platelet activating factor from human alveolar macrophages. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9431823 |
| Akisu M et al. | Selective head cooling with hypothermia suppresses the generation of platelet-activating factor in cerebrospinal fluid of newborn infants with perinatal asphyxia. | 2003 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12878450 |
| Landgraf RG et al. | Prostaglandins, leukotrienes and PAF selectively modulate lymphocyte subset and eosinophil infiltration into the airways in a murine model of asthma. | 2007 Oct-Nov | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17923399 |
| Sugatani J et al. | The role of platelet activating factor (PAF) in the pathogenesis of gastric ulcers. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1808623 |
| Cui S et al. | L-NAME augments PAF-induced venoconstriction in isolated perfused livers of rat and guinea pig, but not mouse. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17395449 |
| Becker K et al. | Influence of some prostaglandins and prostaglandin analogues on PAF-induced shock in mice. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1696744 |
| Wang HG et al. | Effect of platelet-activating factor on hepatic capillary pressure in isolated dog liver. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9384519 |
| Hardy P et al. | New insights into the retinal circulation: inflammatory lipid mediators in ischemic retinopathy. | 2005 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15850712 |
| Mentz P et al. | Interactions of prostanoids with the platelet activating factors. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1279731 |
| Richter M et al. | Endothelin, PAF and thromboxane A2 in allergic pulmonary hyperreactivity in mice. | 2007 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:17448648 |
| Louis NA et al. | Lipid mediator networks and leukocyte transmigration. | 2005 Sep-Oct | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15979294 |
| Akisu M et al. | The effect of dietary supplementation with n-3 polyunsaturated fatty acids on the generation of platelet-activating factor and leukotriene B4 in hypoxic-ischemic brain in young mice. | 2002 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:12468264 |
| de Lima WT et al. | Studies on the mechanism of PAF-induced vasopermeability in rat lungs. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7784472 |
| Hughes H et al. | PAF formation by H2O2-stimulated perfused canine carotid arteries. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846103 |
| Albertini M and Clement MG | In pigs, inhaled nitric oxide (NO) counterbalances PAF-induced pulmonary hypertension. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7846107 |
| Hirata Y et al. | Enhancement of thrombotic arterial occlusion following cholesterol feeding in the guinea-pig: a role for thromboxane A2. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972270 |
| Sakurai T et al. | Pharmacological studies of platelet-activating factor (PAF)-induced augmentation of response to histamine in guinea-pigs. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7972272 |
| Galli C et al. | Modulation of lipid derived mediators by polyunsaturated fatty acids. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8424123 |
| Tsunoda H et al. | Involvement of leukotriene C4 in PAF-induced death in mice. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2353029 |
| Ichimaru T and Tai HH | Alteration of platelet activating factor (PAF) metabolism in rat pulmonary alveolar macrophages and plasma by cigarette smoking. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1461922 |
| Becker K et al. | PAF effects on eicosanoid release in neonatal rat cardiomyocytes. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7480082 |
| Evans RD et al. | Platelet-activating factor and its metabolic effects. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946557 |
| Salamonsen LA | Effect of platelet activating factor on prostaglandin release from ovine endometrial cells in culture. | 1991 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1946564 |
| Travis SP and Jewell DP | The role of platelet-activating factor in the pathogenesis of gastrointestinal disease. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8208748 |
| Albertini M and Clement MG | Inhaled nitric oxide reverses PAF-dependent bronchoconstriction in the pig. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7644558 |
| Evangelou AM | Platelet-activating factor (PAF): implications for coronary heart and vascular diseases. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8146205 |
| Viossat I et al. | Effects of platelet activating factor (PAF) and its receptor antagonist BN 52021 on isolated perfused guinea-pig heart. | 1989 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2622972 |
| Shindo K and Fukumura M | Azelastine hydrochloride inhibits platelet activating factor-like activity in human eosinophils. | 1996 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8951989 |
| González E et al. | A novel enhancing effect of platelet activating factor (PAF) on glucose oxidation in uteri from pregnant rats. Participation of prostaglandins and leukotrienes. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2399270 |
| Peplow PV and Mikhailidis DP | Platelet-activating factor (PAF) and its relation to prostaglandins, leukotrienes and other aspects of arachidonate metabolism. | 1990 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:2274568 |
| Jeremy JY et al. | Eicosanoids and septicaemia. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:7938078 |
| Monthly prostaglandin bibliography prepared by the University of Sheffield Biomedical Information Service. | 1995 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8577776 | |
| Berdeli A et al. | Meconium enhances platelet-activating factor and tumor necrosis factor production by rat alveolar macrophages. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15301793 |
| Shindo K et al. | Effect of azelastine hydrochloride on release and production of platelet activating factor in human neutrophils. | 1997 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9175174 |
| Clement MG et al. | PAF and the role of the vagus nerve in the breathing pattern of the pig. | 1992 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:1561234 |
| Saito M et al. | Role of leukotrienes and platelet activating factor in allergic bronchoconstriction and their interactions in guinea pig airway in vivo. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415807 |
| Arribas I et al. | Direct interactions between platelets and cultured rat mesangial cells. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8415809 |
| Plante GE et al. | Platelet activating factor antagonism with BN52021 protects the kidney against acute ischemic injury. | 1988 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:3231663 |
| Pédrono F et al. | Natural 1-O-alkylglycerols reduce platelet-activating factor-induced release of [3H]-serotonin in rabbit platelets. | 2004 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:15172680 |
| Becker K et al. | PAF-induced death in NMRI mice--a suitable shock model for testing new PAF receptor antagonists. Correlation with eicosanoid related substances. | 1993 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8385779 |
| Wise H | Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482170 |
| Peplow PV | Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10509861 |
| Kikuchi M et al. | Platelet-activating factor (PAF) increases NO production in human endothelial cells-real-time monitoring by DAR-4M AM. | 2008 Apr-May | Prostaglandins Leukot. Essent. Fatty Acids | pmid:18502110 |
| Shindo K and Fukumura M | Oxatomide inhibits synthesis and release of platelet-activating factor in human neutrophils. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9578146 |
| Miguel BG et al. | Increase of phosphoinositide hydrolysis and diacylglycerol production by PAF in isolated rat liver nuclei. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11444588 |
| Tiemann U et al. | Platelet-activating factor (PAF)-like activity, localization of PAF receptor (PAF-R) and PAF-acetylhydrolase (PAF-AH) activity in bovine endometrium at different stages of the estrous cycle and early pregnancy. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11403499 |
| Balestrieri ML et al. | Types of purinoceptors and phospholipase A2 involved in the activation of the platelet-activating factor-dependent transacetylase activity and arachidonate release by ATP in endothelial cells. | 1998 | Prostaglandins Other Lipid Mediat. | pmid:9990678 |
| Kudolo GB and DeFronzo RA | Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410380 |
| Martin-Chouly CA et al. | Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10751643 |
| Benito E and Bosch MA | Role of platelet-activating factor in phosphatidylcholine secretion in primary cultures of rat type II pneumocytes. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12013527 |
| Watanabe S et al. | Suppression of platelet-activating factor generation and modulation of arachidonate metabolism by dietary enrichment with (n-9) eicosatrienoic acid or docosahexaenoic acid in mouse peritoneal cells. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11534547 |
| Beck-Speier I et al. | Sulfur-related air pollutants induce the generation of platelet-activating factor, 5-lipoxygenase- and cyclooxygenase-products in canine alveolar macrophages via activation of phospholipases A2. | 2003 | Prostaglandins Other Lipid Mediat. | pmid:14518563 |
| Shibata K et al. | Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060901 |
| Hiran T et al. | Evidence for the involvement of the NADPH oxidase enzyme complex in the optimal accumulation of Platelet-activating factor in the human cell line PLB-985. | 2001 | Prostaglandins Other Lipid Mediat. | pmid:11785782 |
| Shibamoto T et al. | Involvement of platelet-activating factor and leukotrienes in anaphylactic segmental venoconstriction in ovalbumin sensitized guinea pig livers. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16303618 |