Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Ischemia D007511 18 associated lipids
Albuminuria D000419 18 associated lipids
Lymphoma D008223 18 associated lipids
Pancreatitis, Acute Necrotizing D019283 18 associated lipids
Bronchial Spasm D001986 18 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Leukemia, Myeloid, Acute D015470 19 associated lipids
Wounds and Injuries D014947 20 associated lipids
Dermatitis, Allergic Contact D017449 20 associated lipids
Pleurisy D010998 20 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Brain Edema D001929 20 associated lipids
HIV Infections D015658 20 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Helicobacter Infections D016481 21 associated lipids
Hypoxia-Ischemia, Brain D020925 22 associated lipids
Hypersensitivity D006967 22 associated lipids
Medulloblastoma D008527 22 associated lipids
Malaria, Falciparum D016778 22 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Malone B et al. Inactivation of platelet activating factor by rabbit platelets. Lyso-platelet activating factor as a key intermediate with phosphatidylcholine as the source of arachidonic acid in its conversion to a tetraenoic acylated product. 1985 J. Biol. Chem. pmid:3918041
Steiner M et al. Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). 1985 Biochem. Biophys. Res. Commun. pmid:3936503
Zukowska-Grojec Z et al. The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. 1985 Clin Exp Hypertens A pmid:2994912
Shen TY et al. The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. 1985 Int J Tissue React pmid:2997065
Sánchez Crespo M et al. Synthesis of platelet-activating factor from human polymorphonuclear leukocytes: regulation and pharmacological approaches. 1985 Int J Tissue React pmid:2997066
Proll MA et al. Phosphatidate and monooleylphosphatidate inhibition of fibroblast adenylate cyclase is mediated by the inhibitory coupling protein, Ni. 1985 Mol. Pharmacol. pmid:2997592
MacIntyre DE et al. Endogenous and pharmacological mechanisms for the regulation of human platelet cytosolic free Ca2+. 1985 Nouv Rev Fr Hematol pmid:2997706
Lachachi H et al. Inhibition of transmembrane movement and metabolism of platelet activating factor (PAF-acether) by a specific antagonist, BN 52021. 1985 Biochem. Biophys. Res. Commun. pmid:2998370
Hwang SB et al. trans-2,5-Bis-(3,4,5-trimethoxyphenyl)tetrahydrofuran. An orally active specific and competitive receptor antagonist of platelet activating factor. 1985 J. Biol. Chem. pmid:2999126
Khan SN et al. Response to platelet-activating factor of platelets from patients with multiple sclerosis. 1985 Acta Neurol. Scand. pmid:3993327
Tamargo J et al. Electrophysiological effects of platelet-activating factor (PAF-acether) in guinea-pig papillary muscles. 1985 Eur. J. Pharmacol. pmid:3996472
Terashita Z et al. Is platelet activating factor (PAF) a mediator of endotoxin shock? 1985 Eur. J. Pharmacol. pmid:3996473
Heymans F et al. Structure-activity relationship in PAF-acether. 2. rac-1-O-Octadecyl-2-O-acetyl-3-O-[gamma-(dimethylamino)propyl]glycerol . 1985 J. Med. Chem. pmid:4020830
Brain SD and Williams TJ Inflammatory oedema induced by synergism between calcitonin gene-related peptide (CGRP) and mediators of increased vascular permeability. 1985 Br. J. Pharmacol. pmid:2416378
Touqui L et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. 1985 Biochim. Biophys. Acta pmid:3967037
Weber N and Benning H Ether glycerolipids: novel substrates for studying specificity of enzymes involved in glycerolipid biosynthesis in higher plants. 1985 Eur. J. Biochem. pmid:3967662
Mallet AI and Cunningham FM Structural identification of platelet activating factor in psoriatic scale. 1985 Biochem. Biophys. Res. Commun. pmid:3970690
Valone FH Inhibition of binding of the platelet-activating factor AGEPC to platelets by the AGEPC analog rac-3-(N-n-octadecylcarbamoyloxy)-2-methoxypropyl 2-thiazolioethyl phosphate (CV-3988). 1985 Biochem. Biophys. Res. Commun. pmid:3970703
Camussi G and Brentjens JR Inhalation of horseradish peroxidase by rabbits with specific IgE antibodies results in release into the circulation of platelet-activating factor and in lung lesions. 1985 Clin. Immunol. Immunopathol. pmid:3971603
Ardaillou N et al. Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. 1985 Am. J. Physiol. pmid:3918460
Lee TC Biosynthesis of platelet activating factor. Substrate specificity of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase in rat spleen microsomes. 1985 J. Biol. Chem. pmid:4030776
Wissner A et al. Analogues of platelet activating factor (PAF). 2. Some modifications of the glycerine backbone. 1985 J. Med. Chem. pmid:4032422
Pritchard PH et al. The degradation of platelet-activating factor in the plasma of a patient with familial high density lipoprotein deficiency (Tangier disease). 1985 Blood pmid:4063532
Wissner A et al. Analogues of platelet activating factor. 3. Replacement of the phosphate moiety with a sulfonylbismethylene group. 1985 J. Med. Chem. pmid:4032438
Wimberly HC et al. Functional and biochemical characterization of immunologically derived equine platelet-activating factor. 1985 Vet. Pathol. pmid:4035942
MacIntyre DE et al. Tumour-promoting phorbol esters inhibit agonist-induced phosphatidate formation and Ca2+ flux in human platelets. 1985 FEBS Lett. pmid:2981715
Ludwig JC et al. Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular albumin. 1985 Arch. Biochem. Biophys. pmid:4037794
Surles JR et al. Facile synthesis of platelet-activating factor and racemic analogues containing unsaturation in the sn-1-alkyl chain. 1985 J. Med. Chem. pmid:4038418
Sugiura T et al. Transacylation of 1-O-alkyl-SN-glycero-3-phosphocholine (lyso platelet-activating factor) and 1-O-alkenyl-SN-glycero-3-phosphoethanolamine with docosahexaenoic acid (22:6 omega 3). 1985 Biochem. Biophys. Res. Commun. pmid:2935146
Fouque F and Vargaftig BB Adrenaline/PAF acether synergism on human platelets: involvement of Hydergine. 1985 J Pharmacol pmid:4094442
Oda M et al. Molecular species of platelet-activating factor generated by human neutrophils challenged with ionophore A23187. 1985 J. Immunol. pmid:3917470
Bergelson LD et al. Influence of platelet activation factor and prostaglandins on cholesterol esterification in human plasma. 1985 FEBS Lett. pmid:4043408
Kilpatrick JM and Virella G Inhibition of platelet-activating factor by rabbit C-reactive protein. 1985 Clin. Immunol. Immunopathol. pmid:4042435
Monnens L et al. Platelet aggregating factor in the epidemic form of hemolytic-uremic syndrome in childhood. 1985 Clin. Nephrol. pmid:4042442
Pirotzky E et al. Vascular permeability induced by Paf-acether (platelet-activating factor) in the isolated perfused rat kidney. 1985 Agents Actions pmid:4003192
Vigo C Effect of C-reactive protein on platelet-activating factor-induced platelet aggregation and membrane stabilization. 1985 J. Biol. Chem. pmid:3919022
Sugiura T and Waku K CoA-independent transfer of arachidonic acid from 1,2-diacyl-sn-glycero-3-phosphocholine to 1-O-alkyl-sn-glycero-3-phosphocholine (lyso platelet-activating factor) by macrophage microsomes. 1985 Biochem. Biophys. Res. Commun. pmid:3919727
Wasserman SI The mast cell and theophylline in asthma. 1985 Am. J. Med. pmid:3002176
O'Neill C et al. Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. 1985 Ann. N. Y. Acad. Sci. pmid:2409860
Sage SO and Rink TJ Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. 1985 FEBS Lett. pmid:2410292
Grandel KE et al. Association of platelet-activating factor with primary acquired cold urticaria. 1985 N. Engl. J. Med. pmid:2410790
Bussolino F et al. Alkyl-ether phosphoglycerides influence calcium fluxes into human endothelial cells. 1985 J. Immunol. pmid:2411812
Tou J Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. 1985 Biochem. Biophys. Res. Commun. pmid:3921017
Avdonin PV et al. [Mechanism of increase in Ca2+ level in platelet cytoplasm induced by aggregating factors]. 1985 Biokhimiia pmid:3000463
Snyder F Chemical and biochemical aspects of platelet activating factor: a novel class of acetylated ether-linked choline-phospholipids. 1985 Jan-Mar Med Res Rev pmid:2984489
Kozubski W and Stańczyk L [Platelet aggregation in patients with migraine during the pain attack and in the pain-free period]. 1985 Jul-Aug Neurol. Neurochir. Pol. pmid:4094642
Bette-Bobillo P et al. Synthesis and characterization of a radioiodinated, photoreactive and physiologically active analogue of platelet activating factor. 1985 Jun-Jul Chem. Phys. Lipids pmid:4042252
Leprán I and Lefer AM Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. 1985 Mar-Apr Basic Res. Cardiol. pmid:4039929
Feuerstein G et al. Thyrotropin-releasing hormone blocks the hypotensive effects of platelet-activating factor in the unanesthetized guinea pig. 1985 Mar-Apr J. Cardiovasc. Pharmacol. pmid:2581089
Mencia-Huerta JM Possible role of the T-cell-factor-dependent mast cell subclass in the generation of leukotrienes from lung. 1985 Sep-Oct Ann. Inst. Pasteur Immunol. pmid:3878684
Masugi F et al. Role of acetyl glyceryl ether phosphorylcholine in blood pressure regulation in rats. 1985 Sep-Oct Hypertension pmid:4030044
Lewis RE and Granger HJ Neutrophil-dependent mediation of microvascular permeability. 1986 Fed. Proc. pmid:3510911
Ramesha CS and Pickett WC Platelet-activating factor and leukotriene biosynthesis is inhibited in polymorphonuclear leukocytes depleted of arachidonic acid. 1986 J. Biol. Chem. pmid:3011789
Hellewell PG and Williams TJ A specific antagonist of platelet-activating factor suppresses oedema formation in an Arthus reaction but not oedema induced by leukocyte chemoattractants in rabbit skin. 1986 J. Immunol. pmid:2940300
Weber N [A platelet-activating factor--a physiologically active ether lipid]. 1986 Pharm Unserer Zeit pmid:3749211
Page CP et al. Inflammatory mediators of asthma. 1986 Eur J Respir Dis Suppl pmid:3527737
Berti F et al. Cardiovascular and pulmonary activity of platelet-activating factor (PAF-acether) and its derivatives. 1986 Pharmacol Res Commun pmid:3749244
Burhop KE et al. Pulmonary vascular response to platelet-activating factor in awake sheep and the role of cyclooxygenase metabolites. 1986 Am. Rev. Respir. Dis. pmid:3752711
Metz SA Ether-linked lysophospholipids initiate insulin secretion. Lysophospholipids may mediate effects of phospholipase A2 activation on hormone release. 1986 Diabetes pmid:3087803
Schlondorff D and Neuwirth R Platelet-activating factor and the kidney. 1986 Am. J. Physiol. pmid:3089026
Nishihira J and Ishibashi T A phospholipase C with a high specificity for platelet-activating factor in rabbit liver light mitochondria. 1986 Lipids pmid:3821393
Lauri D et al. Contribution of ADP to the amplification of primary platelet aggregation by platelet activating factor (PAF): modulatory role of aspirin. 1986 Agents Actions pmid:3706054
Nijssen JG et al. Identification of a calcium-independent phospholipase A2 in rat lung cytosol and differentiation from acetylhydrolase for 1-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF-acether). 1986 Biochim. Biophys. Acta pmid:3707986
Fitzgerald MF et al. The anaphylactic release of platelet-activating factor from perfused guinea-pig lungs. 1986 Br. J. Pharmacol. pmid:3708213
Chand N et al. The amplifier role of platelet activating factor (PAF), other chemical mediators and antigen in the induction of airway hyperreactivity to cold. 1986 Eur. J. Pharmacol. pmid:3709669
Kloprogge E et al. Stimulus-aggregation coupling in platelets activated with PAF-acether. 1986 Biochim. Biophys. Acta pmid:3089297
Osborne JA et al. In vivo anti-platelet properties of anipamil, a calcium channel blocker, in the rabbit. 1986 Res. Commun. Chem. Pathol. Pharmacol. pmid:3715198
Westwick J et al. Comparison of the effects of low molecular weight heparin and unfractionated heparin on activation of human platelets in vitro. 1986 Thromb. Res. pmid:3715810
Issekutz AC and Ripley M The effect of intravascular neutrophil chemotactic factors on blood neutrophil and platelet kinetics. 1986 Am. J. Hematol. pmid:2934975
Alexandre A et al. Inhibition by antioxidants of agonist evoked cytosolic Ca++ increase, ATP secretion and aggregation of aspirinated human platelets. 1986 Biochem. Biophys. Res. Commun. pmid:3094518
Alam I and Silver MJ Acetyltransferase activity in human platelet microsomes and washed platelets. 1986 Biochim. Biophys. Acta pmid:3094588
Benhamou M et al. Decrease in IgE Fc receptor expression on mouse bone marrow-derived mast cells and inhibition of paf-acether formation and of beta-hexosaminidase release by dexamethasone. 1986 J. Immunol. pmid:2935578
Morley J Platelet activating factor and asthma. 1986 Agents Actions pmid:3099555
Orchard MA et al. Basophil histamine release induced by a substance from stimulated human platelets. 1986 J. Immunol. pmid:2419428
Anderson RC et al. Platelet-activating factor analogs. II. Synthesis of the 1-O-(4-decyloxymethylphenyl)- and 1-O-(4-decyloxyphenylmethyl) analogs. 1986 Chem. Phys. Lipids pmid:3948294
Tselepis A et al. Effects of AGEPC on the intracellular levels of ions in Tetrahymena pyriformis. 1986 Biochem. Int. pmid:3099798
Hwang SB et al. Release of platelet activating factor and its involvement in the first phase of carrageenin-induced rat foot edema. 1986 Eur. J. Pharmacol. pmid:3948914
Doyle VM et al. Platelet-activating factor mobilizes intracellular calcium in vascular smooth muscle cells. 1986 FEBS Lett. pmid:3949010
Wissner A et al. Analogues of platelet activating factor. 4. Some modifications of the phosphocholine moiety. 1986 J. Med. Chem. pmid:3950913
Issekutz AC and Szpejda M Evidence that platelet activating factor may mediate some acute inflammatory responses. Studies with the platelet-activating factor antagonist, CV3988. 1986 Lab. Invest. pmid:3951199
Shukla SD Action of phosphatidylinositol specific phospholipase C on platelets: nonlytic release of acetylcholinesterase, effect on thrombin and PAF induced aggregation. 1986 Life Sci. pmid:3951330
Patscheke H and Dierichs R Cationized ferritin as a platelet-stimulating surface probe. Binding to platelets and effects on platelet function. 1986 Eur. J. Cell Biol. pmid:3084260
Billah MM et al. Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by human promyelocytic leukemic HL60 cells. Stimulated expression of phospholipase A2 and acetyltransferase requires differentiation. 1986 J. Biol. Chem. pmid:3084473
Piper PJ and Stewart AG Coronary vasoconstriction in the rat, isolated perfused heart induced by platelet-activating factor is mediated by leukotriene C4. 1986 Br. J. Pharmacol. pmid:3091131
Ban C et al. Metabolism of platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) in human fetal membranes and decidua vera. 1986 Arch. Biochem. Biophys. pmid:3963833
Touvay C et al. Proof of the involvement of platelet activating factor (paf-acether) in pulmonary complex immune systems using a specific paf-acether receptor antagonist: BN 52021. 1986 Prog. Lipid Res. pmid:2827186
Jackson CV et al. Platelet-activating factor and the release of a platelet-derived coronary artery vasodilator substance in the canine. 1986 Circ. Res. pmid:2868810
Bussolino F et al. Interleukin 1 stimulates platelet-activating factor production in cultured human endothelial cells. 1986 J. Clin. Invest. pmid:2872233
Henocq E and Vargaftig BB Accumulation of eosinophils in response to intracutaneous PAF-acether and allergens in man. 1986 Lancet pmid:2872485
Hoffman DR et al. Metabolism and function of platelet-activating factor in fetal rabbit lung development. 1986 Biochim. Biophys. Acta pmid:3768390
Okamoto M et al. Studies of platelet activating factor (PAF) antagonists from microbial products. III. Pharmacological studies of FR-900452 in animal models. 1986 Chem. Pharm. Bull. pmid:3769104
Ohga Y and Nakanishi M Stopped-flow spectrophotometry monitoring the initial processes of platelet activation by platelet-activating factor. 1986 FEBS Lett. pmid:3770190
Patterson R et al. Inhibition of rhesus monkey airway and cutaneous responses to platelet-activating factor (PAF) (AGEPC) with the anti-PAF agent SRI 63-072. 1986 Int. Arch. Allergy Appl. Immunol. pmid:3770978
Smith PF et al. The responsiveness of rabbit bronchial rings to antigen, AGEPC and histamine. 1986 Immunopharmacology pmid:3771195
Andrikopoulos NK et al. High-performance liquid chromatographic analysis of platelet activating factor on a cation-exchange column by direct ultraviolet detection. 1986 J. Chromatogr. pmid:3771693
Cordeiro RS et al. Desensitization to PAF-induced rat paw oedema by repeated intraplantar injections. 1986 Life Sci. pmid:3773645
Hsueh W et al. Release of leukotriene C4 by isolated, perfused rat small intestine in response to platelet-activating factor. 1986 J. Clin. Invest. pmid:3459734
Cordeiro RS et al. Salicylates inhibit PAF-acether-induced rat paw oedema when cyclooxygenase inhibitors are ineffective. 1986 Prostaglandins pmid:3103172
Hwang SB et al. Ionic and GTP regulation of binding of platelet-activating factor to receptors and platelet-activating factor-induced activation of GTPase in rabbit platelet membranes. 1986 J. Biol. Chem. pmid:3001070
Buxton DB et al. Platelet-activating factor-mediated vasoconstriction and glycogenolysis in the perfused rat liver. 1986 J. Biol. Chem. pmid:3001074