Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
Location | Cross reference | Weighted score | Related literatures |
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Gene | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Matsubara C et al. | [Densitometric quantitation of platelet activating factor and other phospholipids in human saliva using enzyme reaction on a silica plate]. | 1994 | Yakugaku Zasshi | pmid:7965653 |
Nie ZG et al. | [Effects of ginkgolide B on lipopolysaccharide-induced TNFalpha production in mouse peritoneal macrophages and NF-kappaB activation in rat pleural polymorphonuclear leukocytes]. | 2004 | Yao Xue Xue Bao | pmid:15491096 |
Li SH et al. | Effects of platelet-activating factor antagonist SRI 63-441 on endotoxin-induced changes in rat mesenteric microcirculation. | 1991 | Yao Xue Xue Bao | pmid:1887797 |
Zhang LL et al. | [Protective effect of rupatadine against oleic acid-induced acute lung injury in rabbits]. | 2007 | Yao Xue Xue Bao | pmid:17520822 |
Ju DW et al. | [Leflunomide inhibits PAF induced DNA synthesis in rabbit synovial cells and PAF production from rat peritoneal macrophages]. | 1994 | Yao Xue Xue Bao | pmid:8042517 |
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Hu JH et al. | [Effects of calcimycin on platelet adhesion to cultured bovine cerebral microvascular endothelial cells and its antagonism by drugs]. | 1994 | Yao Xue Xue Bao | pmid:7976350 |
Ju DW et al. | Effect of platelet activating factor antagonist WEB 2086 on the production of TNF from murine peritoneal macrophages. | 1993 | Yao Xue Xue Bao | pmid:8009983 |
Cheng NN et al. | [The composition of phospholipid and biosynthesis of platelet-activating factor in earthworm (Eisenia foetida)]. | 1992 | Yao Xue Xue Bao | pmid:1299136 |
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Fang J and Zheng QY | [Inhibitory effect of esculentoside A on platelet activating factor released from calcimycin induced rat peritoneal macrophages]. | 1991 | Yao Xue Xue Bao | pmid:1823713 |
Zeng GQ et al. | Effects of dauricine and tetrandrine on [3H] WEB 2086 specific binding to bovine anterior cerebral arterial smooth muscle cells in vitro. | 1993 | Yao Xue Xue Bao | pmid:8285049 |
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Peng SY et al. | Effect of ginkgolide B on the platelet-activating factor induced changes of chemotaxis and cytoskeleton of macrophages. | 2006 | Yao Xue Xue Bao | pmid:16671547 |
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Van de Weerdt ML et al. | Role of the cholinergic pathway in mediating platelet-activating factor-induced pulmonary dysfunctions in unsedated calves. | 1999 | Zentralbl Veterinarmed A | pmid:10216447 |
Bastos da Silva M et al. | Combined effect of Web 2086 (Paf antagonist) and ketoprofen (Nsaid) on Paf-induced ex vivo platelet aggregation in bovine. | 1997 | Zentralbl Veterinarmed A | pmid:9284631 |
da Silva MB et al. | Inhibition of PAF-induced platelet aggregation by WEB 2086 'in-vitro', an antagonist to the receptor for platelet-activating factor, in bovine. | 1996 | Zentralbl Veterinarmed A | pmid:8921726 |
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Xie DS and Xie YT | [Role of platelet activating factor in hepatorenal syndrome]. | 2005 | Zhong Nan Da Xue Xue Bao Yi Xue Ban | pmid:16045031 |
Zong RK and Liu J | [Effects of Chinese herbal medicine Xinfeng Capsule on expressions of platelet-activating factor and interleukins 6 and 17 in peripheral blood of rats with adjuvant arthritis]. | 2011 | Zhong Xi Yi Jie He Xue Bao | pmid:22152774 |
Xiao HS | [Relation of blood platelets and the cause of bronchial asthma]. | 1989 | Zhong Xi Yi Jie He Za Zhi | pmid:2532572 |
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Zhang XT et al. | [Study on the pharmacokinetics of ginkgolide B for injection in rats]. | 2012 | Zhong Yao Cai | pmid:22876684 |
Zhang XT et al. | [Study on pharmacokinetics of ginkgolide B injection in Beagle dogs]. | 2012 | Zhong Yao Cai | pmid:23213741 |
Huang GD et al. | [Observation on the expression of PS2 and platelet activating factor affected by Jianwei Yuyang granules and study its potential mechanisim against peptic ulcer]. | 2007 | Zhong Yao Cai | pmid:18422199 |
Wang LJ et al. | [Role of platelet activating factor in the injury of intestinal immuno-barrier function in young rats]. | 2006 | Zhongguo Dang Dai Er Ke Za Zhi | pmid:16522243 |
Ding DD et al. | [Changes of platelet α-particle membrane protein, platelet activating factor and platelet parameters in patients with hyperuricemia]. | 2012 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:22541106 |
Guo NJ et al. | [Activation of platelet-neutrophil mediated by platelet-activating factor]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15972139 |
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Jia XQ et al. | [Changes in coagulation and fibrinolysis in the patients with coronary heart disease in acute period and effect of drug intervention]. | 2012 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:22464576 |
Shi B et al. | [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19695175 |
Chen S et al. | [Induction effect of platelet-activating factor on Src-suppressed C kinase substrate gene expression in rat pulmonary microvascular endothelial cells]. | 2010 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:20367900 |
Hao J et al. | [Dynamic changes of platelet number in early multiple injury and it is effect on prognosis]. | 2003 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:14552687 |
Song SQ and Hu YM | Effects of tetrandrine, Fura 2-AM, and Bay k 8644 on platelet-activating factor release from rat peritoneal macrophages stimulated by lipopolysaccharides. | 1996 | Zhongguo Yao Li Xue Bao | pmid:9812743 |
Chen SF et al. | Three drugs inhibit phospholipase A2-induced high permeability of endothelial monolayers. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7801767 |
Shen ZQ et al. | Effect of protopine on cytosolic Ca2+ in rabbit platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452120 |
Zeng S et al. | Platelet activating factor-induced P-selectin expression in platelets and its related signal transduction. | 1999 | Zhongguo Yao Li Xue Bao | pmid:11270998 |
Li SH et al. | Effects of platelet-activating factor on rat mesenteric microcirculation. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2104488 |
Zeng GQ and Rui YC | [Inhibitory effect of dauricine on platelet activating factor released from calcimycin-induced mouse peritoneal macrophages]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2104489 |
Fu Y and Hu YM | Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678147 |
Wang XD and Bian RL | [Effects of ketotifen on rabbit platelet aggregation and platelet activating factor formation from rat neutrophils]. | 1990 | Zhongguo Yao Li Xue Bao | pmid:2130617 |
Yi FX and Guo ZG | Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375790 |
Sun DX et al. | Specific binding sites of platelet activating factor on the intact bovine cerebral microvascular endothelial cells and antagonism of drugs. | 1992 | Zhongguo Yao Li Xue Bao | pmid:1333718 |
Li SH et al. | Pentoxifylline attenuates platelet activating factor-induced permeable edema in isolated perfused guinea pig lungs. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7976374 |
Hu JH et al. | Platelet adhesion to cultured bovine cerebral microvascular endothelial cells by stimulation of platelet activating factor and antagonism of drugs. | 1995 | Zhongguo Yao Li Xue Bao | pmid:7668100 |
Zhang M et al. | Effects of tetrandrine on rabbit platelet aggregation and platelet activating factor generation. | 1995 | Zhongguo Yao Li Xue Bao | pmid:7660812 |
Ju DW et al. | Inhibitory effects of triazolodiazepine on mouse splenocytes and peritoneal macrophages in vitro. | 1994 | Zhongguo Yao Li Xue Bao | pmid:8010089 |
Qian R et al. | Platelet activation by platelet aggregation factor from Eisenia foelide. | 1994 | Zhongguo Yao Li Xue Bao | pmid:7717070 |
Hong JL et al. | [Effects of tetrandrine on cytoplasmic free calcium in rat neutrophils]. | 1989 | Zhongguo Yao Li Xue Bao | pmid:2561935 |
Zeng S and Guo ZG | Mepyramine inhibits platelet activating factor-induced rabbit platelet aggregation: role of intracellular histamine. | 1997 | Zhongguo Yao Li Xue Bao | pmid:10072970 |
Zeng GQ et al. | Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249627 |
Zhang B and Long K | Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249632 |
Sun DX et al. | Platelet activating factor production in bovine cerebral microvascular endothelial cells and its drug inhibition. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8503282 |
Zeng S et al. | Regulatory role of protein tyrosine phosphorylation in platelet activating factor-induced signal transduction in platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10437164 |
Zhao W et al. | [Expression and regulation of pituitary adenylate cyclase-activating polypeptide mRNA in pregnant rat corpus luteum]. | 2010 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21038678 |
Di Y et al. | [Effect of ginkgolide B on plasma levels of interleukin-12 and PAF in severe acute pancreatitis in rats]. | 2008 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21141514 |
Zhao W et al. | [Effect of PAF on the expression of PACAP mRNA in the granulosa cells of rat ovary]. | 2007 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21180114 |
Dong J et al. | [Effect of platelet-activating factor on long-term potentiation in rat hippocampal slices]. | 2005 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21171322 |
Liu SH et al. | [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21189571 |
Dong JC et al. | [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:10322836 |
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Zhang J et al. | [Experimental study on effect of Buyang Huanwu decoction on arterial blood platelet activating factor content pre- and post-arterial thrombosis of rats]. | 1998 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:11475720 |
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Chen WM et al. | [Experimental study on inhibitory effect of rutin against platelet activation induced by platelet activating factor in rabbits]. | 2002 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:12584792 |
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Li SH et al. | [Effect of an extract from the cauline of Piper kadsura ohwi on endotoxin-induced hypotension and lung injury in rats]. | 1989 | Zhongguo Zhong Yao Za Zhi | pmid:2619897 |
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Wang F et al. | [The effect of platelet activating factor on the biosynthesis of thromboxane A2 and prostaglandin I2 in human placental villi and umbilical artery]. | 1997 | Zhonghua Fu Chan Ke Za Zhi | pmid:9596897 |
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Li Q | [Effects of inhaled aerosol of platelet activating factor on pulmonary function and airway responsiveness in normal subjects]. | 1992 | Zhonghua Jie He He Hu Xi Za Zhi | pmid:1307517 |