Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Powell WS et al. | 5-oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of L-selectin shedding, surface expression of CD11b, actin polymerization, and calcium mobilization in human eosinophils. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:9870930 |
Chen JZ et al. | A 3D-QSAR study on ginkgolides and their analogues with comparative molecular field analysis. | 1998 | Bioorg. Med. Chem. Lett. | pmid:9871752 |
Dutra PM et al. | A novel ecto-phosphatase activity of Herpetomonas muscarum muscarum inhibited by platelet-activating factor. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9875238 |
Huh H et al. | PAF antagonistic activity of 2-hydroxy-3-methoxybenzoic acid glucose ester from Gentiana scabra. | 1998 | Arch. Pharm. Res. | pmid:9875472 |
Zhang J et al. | Strategies of myocardial protection for operation in chronic model of cyanotic heart disease. | 1998 | Ann. Thorac. Surg. | pmid:9875743 |
Dhainaut JF et al. | Confirmatory platelet-activating factor receptor antagonist trial in patients with severe gram-negative bacterial sepsis: a phase III, randomized, double-blind, placebo-controlled, multicenter trial. BN 52021 Sepsis Investigator Group. | 1998 | Crit. Care Med. | pmid:9875905 |
Kawasaki Y et al. | Specific detections of the early process of the glycation reaction by fructose and glucose in diabetic rat lens. | 1998 | FEBS Lett. | pmid:9877177 |
Todoroki H et al. | Possible role of platelet-activating factor in the in vivo expression of tissue factor in neutrophils. | 1998 | J. Surg. Res. | pmid:9878306 |
Nakano T et al. | Roxythromycin reinforces epithelial defence function in rabbit trachea. | 1998 | Acta Otolaryngol Suppl | pmid:9879427 |
Chang FR et al. | Two new 7-dehydroaporphine alkaloids and antiplatelet action aporphines from the leaves of Annona purpurea. | 1998 | Phytochemistry | pmid:9883592 |