| MeSH term | MeSH ID | Detail |
|---|---|---|
| Leukemia | D007938 | 74 associated lipids |
| Klebsiella Infections | D007710 | 7 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Ischemia | D007511 | 18 associated lipids |
| Intestinal Obstruction | D007415 | 6 associated lipids |
| Inflammation | D007249 | 119 associated lipids |
| Infertility, Male | D007248 | 11 associated lipids |
| Infant, Premature, Diseases | D007235 | 7 associated lipids |
| Immune Complex Diseases | D007105 | 9 associated lipids |
| Ileitis | D007079 | 2 associated lipids |
| Ileal Diseases | D007077 | 3 associated lipids |
| Hypotension | D007022 | 41 associated lipids |
| Hypertension, Pulmonary | D006976 | 32 associated lipids |
| Hypertension, Portal | D006975 | 12 associated lipids |
| Hypertension | D006973 | 115 associated lipids |
| Hypersensitivity, Immediate | D006969 | 14 associated lipids |
| Hypersensitivity, Delayed | D006968 | 43 associated lipids |
| Hypersensitivity | D006967 | 22 associated lipids |
| Hyperinsulinism | D006946 | 27 associated lipids |
| Hyperlipoproteinemia Type II | D006938 | 22 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Cervoni P et al. | Evidence for the lack of interaction between (+/-)-1-O-octadecyl-2-acetylglyceryl-3-phosphorylcholine and alpha-adrenoceptors in vivo and in vitro. | 1984 | Br. J. Pharmacol. | pmid:6091835 |
| Fink KL and Gross RW | Modulation of canine myocardial sarcolemmal membrane fluidity by amphiphilic compounds. | 1984 | Circ. Res. | pmid:6091941 |
| Kulikov VI and Bergel'son LD | [Binding of 1-0-alkyl-2-0-acetyl-sn-glycero-3-phosphocholine (thrombocyte activating factor) by plasma components. Exchange of the thrombocyte activating factor between lipoproteins and thrombocytes]. | 1984 | Biokhimiia | pmid:6093897 |
| Haye B et al. | Interactions between thyreostimulin and PAF-acether on thyroid cell metabolism. | 1984 | Eur. J. Pharmacol. | pmid:6094205 |
| Gordeev KIu et al. | [A bioregulator of lipid nature--a platelet activating factor (PAF)]. | 1984 | Bioorg. Khim. | pmid:6099122 |
| Wang ZY | [Advances in the physiopathology of platelets]. | 1984 | Zhonghua Nei Ke Za Zhi | pmid:6099795 |
| Sills RH | Thrombotic thrombocytopenic purpura. I. Pathophysiology and clinical manifestations. | 1984 | Am J Pediatr Hematol Oncol | pmid:6442830 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |
| Kulikov VI et al. | [Incorporation of 1-0-alkyl-2-acetyl-sn-glycerol-3-phosphocholine into human plasma lipoproteins in vitro. Effect of the lecithin:cholesterol acyltransferase activity of plasma]. | 1984 | Biokhimiia | pmid:6542803 |
| Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
| Pirotzky E et al. | PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. | 1984 | Microcirc Endothelium Lymphatics | pmid:6546141 |
| Bussolino F et al. | Platelet-activating factor phosphatidate, but not platelet-activating factor, is a powerful calcium ionophore in the human red cell. | 1984 | Cell Calcium | pmid:6549153 |
| Pirotzky E et al. | Biosynthesis of platelet-activating factor. VI. Precursor of platelet-activating factor and acetyltransferase activity in isolated rat kidney cells. | 1984 | Lab. Invest. | pmid:6492758 |
| Handley DA et al. | Evaluation of dose and route effects of platelet activating factor-induced extravasation in the guinea pig. | 1984 | Thromb. Haemost. | pmid:6495262 |
| Riess H and Hiller E | Heparin and thrombocytopenia. | 1984 | Ann. Intern. Med. | pmid:6497200 |
| Blank ML et al. | Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6497876 |
| Lichey J et al. | Pressure effects and uptake of platelet-activating factor in isolated rat lung. | 1984 | J Appl Physiol Respir Environ Exerc Physiol | pmid:6501025 |
| Buxton DB et al. | Stimulation of glycogenolysis and platelet-activating factor production by heat-aggregated immunoglobulin G in the perfused rat liver. | 1984 | J. Biol. Chem. | pmid:6501277 |
| Mueller HW et al. | The molecular species distribution of platelet-activating factor synthesized by rabbit and human neutrophils. | 1984 | J. Biol. Chem. | pmid:6501307 |
| Buxton DB et al. | Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine. | 1984 | J. Biol. Chem. | pmid:6693418 |
| Hwang SB et al. | Effects of nonsteroid antiinflammatory drugs on the specific binding of platelet activating factor to membrane preparations of rabbit platelets. | 1984 | Thromb. Res. | pmid:6429890 |
| Colditz IG and Movat HZ | Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens. | 1984 | J. Immunol. | pmid:6470487 |
| Patterson R et al. | Airway responses to sequential challenges with platelet-activating factor and leukotriene D4 in rhesus monkeys. | 1984 | J. Lab. Clin. Med. | pmid:6470563 |
| Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+. | 1984 | Arch. Biochem. Biophys. | pmid:6430234 |
| Söling HD et al. | Acetylcholine-like effects of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine ('platelet-activating factor') and its analogues in exocrine secretory glands. | 1984 | Eur. J. Biochem. | pmid:6207023 |
| Albert DH and Snyder F | Release of arachidonic acid from 1-alkyl-2-acyl-sn-glycero-3-phosphocholine, a precursor of platelet-activating factor, in rat alveolar macrophages. | 1984 | Biochim. Biophys. Acta | pmid:6435681 |
| Denburg JA et al. | Platelet activating factor: regulation by mast cells and aspirin. | 1984 | Agents Actions | pmid:6711391 |
| El Tamer A et al. | Studies on ether phospholipids. I. A new method of determination using phospholipase A1 from guinea pig pancreas: application to Krebs II ascites cells. | 1984 | Biochim. Biophys. Acta | pmid:6712966 |
| Touqui L et al. | Dissociation between inhibition of phospholipid methylation and production of PAF-acether by rabbit platelets. | 1984 | Experientia | pmid:6714369 |
| Kawaguchi H and Yasuda H | Platelet-activating factor stimulates phospholipase in quiescent Swiss mouse 3T3 fibroblast. | 1984 | FEBS Lett. | pmid:6436057 |
| Kramer RM et al. | Metabolism of platelet-activating factor in human platelets. Transacylase-mediated synthesis of 1-O-alkyl-2-arachidonoyl-sn-glycero-3-phosphocholine. | 1984 | J. Biol. Chem. | pmid:6436245 |
| Kornecki E et al. | Platelet-activating factor-induced aggregation of human platelets specifically inhibited by triazolobenzodiazepines. | 1984 | Science | pmid:6150550 |
| Chignard M et al. | Paf-acether formation and arachidonic acid freeing from platelet ether-linked glyceryl-phosphorylcholine. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6437404 |
| Hechtman HB et al. | Role of humoral mediators in adult respiratory distress syndrome. | 1984 | Chest | pmid:6383742 |
| Kelton JG et al. | The detection of a platelet-agglutinating factor in thrombotic thrombocytopenic purpura. | 1984 | Ann. Intern. Med. | pmid:6333196 |
| Bussolino F et al. | Release of platelet-activating factor (PAF)-like material from human lymphoid cell lines. | 1984 | Exp. Hematol. | pmid:6333353 |
| Wodzinowska B and Krajewski T | [Role of blood platelets and their membrane in the process of hemostasis]. | 1984 Jan-Feb | Postepy Hig Med Dosw | pmid:6093087 |
| Vemulapalli S et al. | Cardiovascular and renal action of platelet-activating factor in anesthetized dogs. | 1984 Jul-Aug | Hypertension | pmid:6378787 |
| Cox CP et al. | VIP elevates platelet cyclic AMP (cAMP) levels and inhibits in vitro platelet activation induced by platelet-activating factor (PAF). | 1984 Mar-Apr | Peptides | pmid:6206481 |
| Terashita Z et al. | Beneficial effects of (RS)-2-methoxy-3-(octadecylcarbamoyloxy)propyl 2-(3-thiazolio)ethyl phosphate, a specific PAF antagonist, in endotoxin and anaphylactic shock. | 1985 | Adv. Prostaglandin Thromboxane Leukot. Res. | pmid:3004156 |
| Michel L and Dubertret L | A simple method for studying chemotaxis, vascular permeability and histological modifications induced by mediators of inflammation in vivo in man. | 1985 | Br. J. Dermatol. | pmid:2990519 |
| Morris HG | Mechanisms of glucocorticoid action in pulmonary disease. | 1985 | Chest | pmid:2410202 |
| McKean ML and Silver MJ | Phospholipid biosynthesis in human platelets. The acylation of lyso-platelet-activating factor. | 1985 | Biochem. J. | pmid:3919710 |
| Bruynzeel PL et al. | Exclusive leukotriene C4 synthesis by purified human eosinophils induced by opsonized zymosan. | 1985 | FEBS Lett. | pmid:2995125 |
| Archer CB et al. | Actions of disodium cromoglycate (DSCG) on human skin responses to histamine, codeine and Paf-acether. | 1985 | Agents Actions | pmid:3923788 |
| Terashita Z et al. | Inhibition by CV-3988 of the binding of [3H]-platelet activating factor (PAF) to the platelet. | 1985 | Biochem. Pharmacol. | pmid:2986648 |
| Morley J et al. | Pharmacology of the late response to allergen and its relevance to asthma prophylaxis. | 1985 | Int. Arch. Allergy Appl. Immunol. | pmid:3924841 |
| Hwang SB et al. | Characterization of cutaneous vascular permeability induced by platelet-activating factor in guinea pigs and rats and its inhibition by a platelet-activating factor receptor antagonist. | 1985 | Lab. Invest. | pmid:3925239 |
| Vanderwel M and Haslam RJ | Inhibition and subsequent enhancement of platelet responsiveness by prostacyclin in the rabbit. Relationship to platelet adenosine 3',5'-cyclic monophosphate. | 1985 | J. Clin. Invest. | pmid:2991338 |
| Naccache PH et al. | Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2992480 |
| MacIntyre DE et al. | Regulation of platelet cytosolic free calcium by cyclic nucleotides and protein kinase C. | 1985 | FEBS Lett. | pmid:2993027 |
| Bourgain RH et al. | The effect of 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (paf-acether) on the arterial wall. | 1985 | Prostaglandins | pmid:3931178 |
| Hayashi H et al. | Activation of guinea pig peritoneal macrophages by platelet activating factor (PAF) and its agonists. | 1985 | J. Biochem. | pmid:2993272 |
| Avdonin PV et al. | Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994653 |
| Ribbes G et al. | Evidence that biosynthesis of platelet-activating factor (paf-acether) by human neutrophils occurs in an intracellular membrane. | 1985 | FEBS Lett. | pmid:3932094 |
| Maridonneau-Parini I et al. | Desensitization to PAF-induced bronchoconstriction and to activation of alveolar macrophages by repeated inhalations of PAF in the guinea pig. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994661 |
| GarcÃa-Sáinz JA and Hernández-Sotomayor SM | Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933497 |
| Zukowska-Grojec Z et al. | The adrenergic system and the cardiovascular effects of platelet activating factor (1-0-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine) in SHR and WKY rats. | 1985 | Clin Exp Hypertens A | pmid:2994912 |
| Shen TY et al. | The isolation and characterization of kadsurenone from haifenteng (Piper futokadsura) as an orally active specific receptor antagonist of platelet-activating factor. | 1985 | Int J Tissue React | pmid:2997065 |
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| Lad PM et al. | Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2990462 |
| Tokumura A et al. | Structural analogs of alkylacetylglycerophosphocholine inhibitory behavior on platelet activation. | 1985 | J. Biol. Chem. | pmid:3840169 |
| Sánchez-Crespo M et al. | Inhibition of the vascular actions of IgG aggregates by BN 52021, a highly specific antagonist of paf-acether. | 1985 | Immunopharmacology | pmid:3840779 |
| Foa R et al. | Release of platelet-activating factor in human leukemia. | 1985 | Cancer Res. | pmid:3861246 |
| Otsuka A et al. | Hypotensive mechanism of acetyl glyceryl ether phosphorylcholine (AGEPC) in dogs. Effects on hemodynamics and humoral factors. | 1985 | Prostaglandins Leukot Med | pmid:3862138 |
| Haslam RJ et al. | Receptor-effector coupling in platelets: roles of guanine nucleotides. | 1985 | Adv. Exp. Med. Biol. | pmid:3010668 |
| Teng CM et al. | Action mechanism of the platelet aggregation inducer and inhibitor from Echis carinatus snake venom. | 1985 | Biochim. Biophys. Acta | pmid:3926005 |
| Ostermann G et al. | Platelet-stimulating and membranolytic properties of racemic PAF-acether and analogues. | 1985 | Biomed. Biochim. Acta | pmid:4004829 |
| Touqui L et al. | Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. | 1985 | Biochem. J. | pmid:4052028 |
| Satouchi K et al. | Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004866 |
| Detsouli A et al. | Histamine and leukotriene-independent guinea-pig anaphylactic shock unaccounted for by Paf-acether. | 1985 | Br. J. Pharmacol. | pmid:4005486 |
| Apprill P et al. | Cyclic blood flow variations induced by platelet-activating factor in stenosed canine coronary arteries despite inhibition of thromboxane synthetase, serotonin receptors, and alpha-adrenergic receptors. | 1985 | Circulation | pmid:2988822 |
| Emeis JJ and Kluft C | PAF-acether-induced release of tissue-type plasminogen activator from vessel walls. | 1985 | Blood | pmid:3924144 |
| Yousufzai SY and Abdel-Latif AA | Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists. | 1985 | Biochem. J. | pmid:3927898 |
| Benveniste J and Chignard M | A role for PAF-acether (platelet-activating factor) in platelet-dependent vascular diseases? | 1985 | Circulation | pmid:3928192 |
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| McManus LM and Pinckard RN | Kinetics of acetyl glyceryl ether phosphorylcholine (AGEPC)-induced acute lung alterations in the rabbit. | 1985 | Am. J. Pathol. | pmid:4050977 |
| Disselnkötter H et al. | [Synthesis of phosphono analogs of 2-O-acetyl-1-O-hexadecyl(octadecyl)-sn-3-glycerylphosphorylcholine (platelet-activating factor)]. | 1985 | Arch. Pharm. (Weinheim) | pmid:4051690 |
| Ogunbiyi PO and Eyre P | Pharmacological studies of pulmonary anaphylaxis in vitro: a review. | 1985 | Agents Actions | pmid:2420161 |
| Robinson M and Snyder F | Metabolism of platelet-activating factor by rat alveolar macrophages: lyso-PAF as an obligatory intermediate in the formation of alkylarachidonoyl glycerophosphocholine species. | 1985 | Biochim. Biophys. Acta | pmid:4052436 |
| Kozlov VK et al. | [Characteristics of the activation of rabbit platelets induced by 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine (platelet activation factor)]. | 1985 | Biull Eksp Biol Med | pmid:4052603 |
| Page CP et al. | Properties of PAF-acether appropriate to a mediator of the inflammatory aspects of asthma. | 1985 | Int J Tissue React | pmid:4055261 |
| Wardlow ML | Rapid isocratic procedure for the separation of platelet-activating factor from phospholipids in human saliva by high-performance liquid chromatography. | 1985 | J. Chromatogr. | pmid:4055961 |
| Hubbard JW et al. | Cardiac output and peripheral vascular resistance during intravenous infusion of 1-hexadecyl-2-acetyl-sn-glycero-3-phosphocholine in conscious normotensive and spontaneously hypertensive rats. | 1985 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:4059660 |
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| Tokumura A et al. | Gas chromatographic-mass spectrometric analysis of biologically active phospholipids having an sn-2-acetyl group. | 1985 | J. Chromatogr. | pmid:4066848 |
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| Vanhoutte PM and Houston DS | Platelets, endothelium, and vasospasm. | 1985 | Circulation | pmid:3861273 |
| Tencé M et al. | Ether-phospholipid composition in neutrophils and platelets. | 1985 | Thromb. Res. | pmid:4024039 |
| Tan EL and Snyder F | Metabolism of platelet activating factor (1-alkyl-2-acetyl-sn-glycero-3-phosphocholine) by capillary endothelial cells isolated from rat epididymal adipose tissue. | 1985 | Thromb. Res. | pmid:4024051 |
| Weisman SM et al. | Platelet-activating factor is a potent stimulus for renal prostaglandin synthesis: possible significance in unilateral ureteral obstruction. | 1985 | J. Pharmacol. Exp. Ther. | pmid:3862805 |
| Morley J et al. | PAF and airway hyperreactivity. | 1985 | Lancet | pmid:2863479 |
| Morley J et al. | Platelets in asthma. | 1985 | Lancet | pmid:2863708 |
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| Hallam TJ and Rink TJ | Agonists stimulate divalent cation channels in the plasma membrane of human platelets. | 1985 | FEBS Lett. | pmid:2408921 |
| O'Neill C et al. | Maternal recognition of pregnancy prior to implantation: methods for monitoring embryonic viability in vitro and in vivo. | 1985 | Ann. N. Y. Acad. Sci. | pmid:2409860 |
| Sage SO and Rink TJ | Inhibition by forskolin of cytosolic calcium rise, shape change and aggregation in quin2-loaded human platelets. | 1985 | FEBS Lett. | pmid:2410292 |