Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Muacevic G and Heuer HO | Platelet-activating factor antagonists in experimental shock. | 1992 | Arzneimittelforschung | pmid:1418068 |
Asaka N et al. | Effects of the new benzimidazole derivative TAS-203, an orally active phosphodiesterase 4 inhibitor, on airway inflammation in rats and emetic responses in ferrets. | 2010 | Arzneimittelforschung | pmid:21117500 |
Ohmori K et al. | Antiinflammatory and antiallergic effects of a novel metabolite of Nocardiopsis sp. as a potent protein kinase C inhibitor from microbial origin. | 1988 | Arzneimittelforschung | pmid:2972291 |
Sakuma Y et al. | Pharmacological activities of a novel thienodiazepine derivative as a platelet-activating factor antagonist. Effects on microvascular permeability, hypotension and nephrosis. | 1991 | Arzneimittelforschung | pmid:1815526 |
David S et al. | Production of platelet activating factor by human neutrophils after backfiltration of endotoxin contaminated dialysate. | 1993 Jul-Sep | ASAIO J. | pmid:8268642 |
Takayama K et al. | Changes in endothelial vasoactive substances under recombinant human erythropoietin therapy in hemodialysis patients. | 1991 Jul-Sep | ASAIO Trans | pmid:1836334 |
Akizawa T et al. | Endothelin and platelet activating factor. Possible indices for biocompatibility of hemodialysis. | 1991 Jul-Sep | ASAIO Trans | pmid:1751199 |
Ando M et al. | Pregnancy suppression by a platelet activating factor antagonist, ONO-6240, in mice. | 1990 | Asia Oceania J Obstet Gynaecol | pmid:2378595 |
Ando M et al. | Pregnancy suppression by a structurally related antagonist for platelet activating factor, CV-6209, in mice. | 1990 | Asia Oceania J Obstet Gynaecol | pmid:2088253 |
Roudebush WE | Role of platelet-activating factor in reproduction: sperm function. | 2001 | Asian J. Androl. | pmid:11404790 |
Tsai JJ et al. | The modulatory effect of antigen- and PAF-induced asthmatic reaction by aerosol administration of OKY-046 in guinea pigs. | 1995 | Asian Pac. J. Allergy Immunol. | pmid:8703249 |
Tsai JJ et al. | Enhanced eosinophil luminol-dependent chemiluminescence and complement receptor expression by platelet-activating factor and interleukin-5. | 1993 | Asian Pac. J. Allergy Immunol. | pmid:8216559 |
Tselepis AD and John Chapman M | Inflammation, bioactive lipids and atherosclerosis: potential roles of a lipoprotein-associated phospholipase A2, platelet activating factor-acetylhydrolase. | 2002 | Atheroscler Suppl | pmid:12573364 |
Feliste R et al. | Protective effect of BN 52021, a specific antagonist of platelet-activating factor (PAF-acether) against diet-induced cholesteryl ester deposition in rabbit aorta. | 1989 | Atherosclerosis | pmid:2783199 |
Caslake MJ et al. | Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease. | 2000 | Atherosclerosis | pmid:10856534 |
Mügge A et al. | Activation of leukocytes with complement C5a is associated with prostanoid-dependent constriction of large arteries in atherosclerotic monkeys in vivo. | 1992 | Atherosclerosis | pmid:1418094 |
Verouti SN et al. | PAF effects on MCP-1 and IL-6 secretion in U-937 monocytes in comparison with oxLDL and IL-1β effects. | 2011 | Atherosclerosis | pmid:21920519 |
Fiotti N et al. | Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease. | 1999 | Atherosclerosis | pmid:10428295 |
Croft KD et al. | Leukocyte and platelet function and eicosanoid production in subjects with hypercholesterolaemia. | 1990 | Atherosclerosis | pmid:2173612 |
Violi F et al. | Inhibition of cyclooxygenase-independent platelet aggregation by low vitamin E concentration. | 1990 | Atherosclerosis | pmid:2115784 |
Deigner HP et al. | Novel reversible, irreversible and fluorescent inhibitors of platelet-activating factor acetylhydrolase as mechanistic probes. | 1999 | Atherosclerosis | pmid:10381281 |
Hasselwander O et al. | HDL composition and HDL antioxidant capacity in patients on regular haemodialysis. | 1999 | Atherosclerosis | pmid:10208487 |
Bochkov VN et al. | Platelets in patients with homozygous familial hypercholesterolemia are sensitive to Ca(2+)-mobilizing activity of low density lipoproteins. | 1992 | Atherosclerosis | pmid:1334652 |
Imaizumi T et al. | Effect of cigarette smoking on the levels of platelet-activating factor-like lipid(s) in plasma lipoproteins. | 1991 | Atherosclerosis | pmid:1872924 |
Yamada Y et al. | Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population. | 2000 | Atherosclerosis | pmid:10781653 |
Pégorier S et al. | Oxidized phospholipid: POVPC binds to platelet-activating-factor receptor on human macrophages. Implications in atherosclerosis. | 2006 | Atherosclerosis | pmid:16386258 |
Tiniakou I et al. | Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice. | 2015 | Atherosclerosis | pmid:26363436 |
Narita S and Asakura K | The effects of anti-PAF and other agents on the nasal symptoms in sensitized guinea pigs. | 1993 | Auris Nasus Larynx | pmid:7905260 |
Tachibana F et al. | Platelet-activating factor and leukotrienes in acute otitis media, secretory otitis media, and chronic otitis media on the acute excerbation. | 1996 | Auris Nasus Larynx | pmid:8809319 |
Ogura M et al. | Platelet-activating factor (PAF) induced cytokine production and otitis media with effusion (OME) in the rat middle ear. | 2008 | Auris Nasus Larynx | pmid:17997066 |
Morley J | Asthma mortality and inhaled beta agonist therapy. | 1992 | Aust N Z J Med | pmid:1359864 |
Jackson SP and Salem HH | Platelet aggregating activity in the plasma of patients with established thrombosis. | 1989 | Aust N Z J Med | pmid:2504137 |
Gillin AG | Maintenance of high risk pregnancies: role of prostaglandins and other mediators. | 1994 | Aust N Z J Obstet Gynaecol | pmid:7848215 |
Klopper A and Saunders DM | Signals from the conceptus. | 1994 | Aust N Z J Obstet Gynaecol | pmid:7531434 |
Cooper TM and Ingram DM | Platelet function in the peri-operative period. | 1991 | Aust N Z J Surg | pmid:1829351 |
Jobe LW et al. | Protection from BB rat diabetes by the platelet-activating factor inhibitor BN50730. | 1993 | Autoimmunity | pmid:8025205 |
Beck JC et al. | Effects of ginkgolide B, a platelet-activating factor inhibitor on insulitis in the spontaneously diabetic BB rat. | 1991 | Autoimmunity | pmid:1777555 |
Jauchem JR | The role of autacoids and the autonomic nervous system in cardiovascular responses to radio-frequency energy heating. | 2006 | Auton Autacoid Pharmacol | pmid:16553641 |
Subbotina LA | [Procedure of blood agregation system analysis]. | 2006 Sep-Oct | Aviakosm Ekolog Med | pmid:17357632 |
Brady M et al. | Cytokines and acute pancreatitis. | 1999 | Baillieres Best Pract Res Clin Gastroenterol | pmid:11030606 |
Imrie CW and McKay CJ | The possible role of platelet-activating factor antagonist therapy in the management of severe acute pancreatitis. | 1999 | Baillieres Best Pract Res Clin Gastroenterol | pmid:11030612 |
Harper MJ | The implantation window. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1424330 |
Ahmed AS and Smith SK | The endometrium: prostaglandins and intracellular signalling at implantation. | 1992 | Baillieres Clin Obstet Gynaecol | pmid:1335852 |
O'Neill C | A consideration of the factors which influence and control the viability and developmental potential of the preimplantation embryo. | 1991 | Baillieres Clin Obstet Gynaecol | pmid:1855338 |
Smith SK | The role of prostaglandins in implantation. | 1991 | Baillieres Clin Obstet Gynaecol | pmid:1855344 |
Bonney RC and Franks S | The endocrinology of implantation and early pregnancy. | 1990 | Baillieres Clin. Endocrinol. Metab. | pmid:1701083 |
Pearson JD | The control of production and release of haemostatic factors in the endothelial cell. | 1993 | Baillieres Clin. Haematol. | pmid:8025346 |
Ranasinghe S and Bolsover S | Microglial calcium responses to platelet-activating factor are inhibited by analogue CAS 99103-16-9 and dihydropyridine PCA 4248 but not by ginkgolide A. | 2004 | Basic Clin. Pharmacol. Toxicol. | pmid:15379786 |
Chu WF et al. | Increasing Intracellular calcium of guinea pig ventricular myocytes induced by platelet activating factor through IP3 pathway. | 2006 | Basic Clin. Pharmacol. Toxicol. | pmid:16433899 |
Droy-Lefaix MT et al. | The amplificative role of PAF-acether in the oxidative stress following reperfusion of ischemic stomach. | 1988 | Basic Life Sci. | pmid:3250539 |
Colton CA and Gilbert DL | An endogenous source of the superoxide anion in the central nervous system. | 1988 | Basic Life Sci. | pmid:2854971 |
Fiedler VB et al. | Comparison of cardiac and hemodynamic effects of platelet-activating factor-acether and leukotriene D4 in anesthetized dogs. | 1987 Mar-Apr | Basic Res. Cardiol. | pmid:3606544 |
Napoli C et al. | Glycosylation enhances oxygen radical-induced modifications and decreases acetylhydrolase activity of human low density lipoprotein. | 1997 | Basic Res. Cardiol. | pmid:9166989 |
Auchampach JA et al. | Effect of the platelet-activating factor antagonist RP 59227 (Tulopafant) on myocardial ischemia/reperfusion injury and neutrophil function. | 1998 | Basic Res. Cardiol. | pmid:9833148 |
Felix SB et al. | Cardiovascular reactions and respiratory events during platelet activating factor-induced shock. | 1990 May-Jun | Basic Res. Cardiol. | pmid:2383216 |
Leprán I and Lefer AM | Ischemia aggravating effects of platelet-activating factor in acute myocardial ischemia. | 1985 Mar-Apr | Basic Res. Cardiol. | pmid:4039929 |
Giessler C et al. | Effects of PAF on cardiac function and eicosanoid release in the isolated perfused rat heart: comparison between normotensive and spontaneously hypertensive rats. | 1995 Jul-Aug | Basic Res. Cardiol. | pmid:8534259 |
Saraf MK et al. | Role of platelet activating factor in triazolobenzodiazepines-induced retrograde amnesia. | 2003 | Behav. Brain Res. | pmid:12798263 |
Jerusalinsky D et al. | Effect of antagonists of platelet-activating factor receptors on memory of inhibitory avoidance in rats. | 1994 | Behav. Neural Biol. | pmid:7945139 |
Lee TC et al. | Renal necrosis and the involvement of a single enzyme of the de novo pathway for the biosynthesis of platelet-activating factor in the rat kidney inner medulla. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2551264 |
Tysnes OB et al. | Neomycin inhibits agonist-stimulated polyphosphoinositide metabolism and responses in human platelets. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034251 |
Wang F et al. | A new protein kinase C, nPKC eta', and nPKC theta are expressed in human platelets: involvement of nPKC eta' and nPKC theta in signal transduction stimulated by PAF. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8447826 |
Rengan R and Omann GM | Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10462500 |
Yasuda K et al. | Platelet-activating factor in normal rat uterus. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3753495 |
López-Farré A et al. | Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3358756 |
Levy JV | Spasmogenic effect of platelet activating factor (PAF) on isolated rat stomach fundus strip. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3619905 |
Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
O'Flaherty JT et al. | Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6433920 |
O'Flaherty JT et al. | Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6277309 |
Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
White GC | Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428395 |
Sugimoto T et al. | Molecular cloning and characterization of the platelet-activating factor receptor gene expressed in the human heart. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1281995 |
Francescangeli E and Goracci G | The de novo biosynthesis of platelet-activating factor in rat brain. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543404 |
Hussaini IM and Shen TY | A specific, photolabile and irreversible antagonist (L662,025) of the PAF-receptor. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2543410 |
Doebber TW et al. | Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6517949 |
Fernández B and Balsinde J | Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1659393 |
Silva-Neto MA et al. | Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054663 |
Barr R et al. | The effect of platelet activating factor on electron transport of spinach chloroplasts. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3048258 |
Rigat B et al. | GM2 activator protein inhibits platelet activating factor signaling in rats. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19486886 |
Catalán RE et al. | PAF-induced activation of polyphosphoinositide-hydrolyzing phospholipase C in cerebral cortex. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1311925 |
Pai JK et al. | Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3422154 |
Lüthje J and Ogilvie A | Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6704102 |
Fisher GJ et al. | Differential activation of human skin cells by platelet activating factor: stimulation of phosphoinositide turnover and arachidonic acid mobilization in keratinocytes but not in fibroblasts. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2476985 |
Panetta T et al. | Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827647 |
Bazan HE et al. | The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827658 |
Molski TF et al. | Intracellular calcium rise produced by platelet-activating factor is deactivated by fMet-Leu-Phe and this requires uninterrupted activation sequence: role of protein kinase C. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3348814 |
Sugiura T et al. | 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954083 |
Nakayama R et al. | 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3355555 |
Waga I et al. | Two distinct signal transduction pathways for the activation of guinea-pig macrophages and neutrophils by endotoxin. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8267581 |
Matsumoto T et al. | G-protein dissociation, GTP-GDP exchange and GTPase activity in control and PMA treated neutrophils stimulated by fMet-Leu-Phe. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3032170 |
Mueller HW et al. | Synthesis of 1-acyl-2-[3H]acetyl-SN-glycero-3-phosphocholine, a structural analog of platelet activating factor, by vascular endothelial cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2039529 |
O'Flaherty JT and Jacobson D | Protein kinase C blockers and neutrophil receptors for leukotriene B4. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2551291 |
Dewald B and Baggiolini M | Activation of NADPH oxidase in human neutrophils. Synergism between fMLP and the neutrophil products PAF and LTB4. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985075 |
Lumb RH et al. | PAF-acether transfer activity in HL-60 cells is induced during differentiation. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2169726 |
Wirthmueller U et al. | Receptor-operated activation of polymorphonuclear leukocytes: different effects of NAP-1/IL-8 and fMet-Leu-Phe or C5a. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1645549 |
Müller E et al. | Human PAF receptor gene expression: induction during HL-60 cell differentiation. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1722407 |
Tou J | Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3921017 |
Pannocchia A and Hardisty RM | Cyclic AMP inhibits platelet activation independently of its effect on cytosolic free calcium. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2983714 |
Holtzman MJ et al. | Synthesis of the 1-O-hexadecyl molecular species of platelet-activating factor by airway epithelial and vascular endothelial cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2043121 |
Tokumura A et al. | Identification of sn-2-omega-hydroxycarboxylate-containing phospholipids in a lipid extract from bovine brain. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2043133 |