Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
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Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Platelet activating factor?
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Agwu DE et al. | Mass determination of receptor-mediated accumulation of phosphatidate and diglycerides in human neutrophils measured by Coomassie blue staining and densitometry. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2466463 |
| Ichinose M et al. | Activation of K+ current in macrophages by platelet activating factor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1370616 |
| Mutoh H et al. | Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-kappa B. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7802642 |
| Catalán RE et al. | Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806587 |
| Asano K et al. | Cellular source(s) of platelet-activating-factor acetylhydrolase activity in plasma. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425216 |
| Catalán RE et al. | Platelet-activating factor stimulates protein kinase C translocation in cerebral microvessels. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8484756 |
| Asano K et al. | Distribution of platelet activating factor receptor mRNA along the rat nephron segments. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8753768 |
| el Azzouzi B et al. | Immunoregulatory functions of paf-acether. IX. Modulation of apoptosis in an immature T cell line. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8427577 |
| Shindo K et al. | PAF-induced eosinophil chemotaxis increases during an asthmatic attack and is inhibited by prednisolone in vivo and in vitro. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9266847 |
| Liu B et al. | Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7677747 |
| Yasuda K et al. | Platelet-activating factor in normal rat uterus. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3753495 |
| Doebber TW et al. | Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985058 |
| Pfeilschifter J et al. | Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985064 |
| Lerner R et al. | Platelet activating factor and leukotriene B4 induce hyperpolarization of human endothelial cells but depolarization of neutrophils. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2838025 |
| Crouch MF and Lapetina EG | No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132162 |
| Hwang SB et al. | Specific binding sites for platelet activating factor in human lung tissues. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2986633 |
| Naccache PH et al. | Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2992480 |
| Rodrigues CO et al. | Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10581161 |
| GarcÃa-Sáinz JA and Hernández-Sotomayor SM | Stimulation of hepatic glycogenolysis by 12-O-tetradecanoyl-phorbol-13-acetate (TPA) via cyclooxygenase products. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3933497 |
| Elzi DJ et al. | Receptor-mediated calcium entry is required for maximal effects of platelet activating factor primed responses in human neutrophils. | 1997 | Biochem. Biophys. Res. Commun. | pmid:9398641 |
| Lanara E et al. | Response of mice and mouse platelets to acetyl glyceryl ether phosphorylcholine. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7168759 |
| Ieyasu H et al. | A role of calcium-activated, phospholipid-dependent protein kinase in platelet-activating factor-induced serotonin release from rabbit platelets. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7181916 |
| O'Flaherty JT et al. | Evidence for 5, 12-dihydroxy-6,8,10,14-eicosatetraenoate as a mediator of human neutrophil aggregation. | 1981 | Biochem. Biophys. Res. Commun. | pmid:6277309 |
| Blank ML et al. | Generation of the precursor (lyso-PAF) of platelet-activating factor via a CoA-dependent transacylase. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7763233 |
| Hanahan DJ et al. | Potent platelet stimulating activity of enantiomers of acetyl glyceryl ether phosphorylcholine and its methoxy analogues. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7236259 |
| Tokumura A et al. | Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593346 |
| Kojima S et al. | Cooperativity between platelet-activating factor and collagen in platelet aggregation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593379 |
| Tokuoka SM et al. | Alkylglycerol monooxygenase as a potential modulator for PAF synthesis in macrophages. | 2013 | Biochem. Biophys. Res. Commun. | pmid:23743196 |
| Lad PM et al. | Platelet-activating factor mediated effects on human neutrophil function are inhibited by pertussis toxin. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2990462 |
| Comminges C et al. | Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607782 |
| Weber C et al. | Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8373423 |
| Wykle RL et al. | Stereospecific activity of 1-O-alkyl-2-O-acetyl-sn-glycero-3-phosphocholine and comparison of analogs in the degranulation of platelets and neutrophils. | 1981 | Biochem. Biophys. Res. Commun. | pmid:7295320 |
| Resink TJ et al. | The influence of activating hormones on human platelet membrane Ca2+-ATPase activity. | 1986 | Biochem. Biophys. Res. Commun. | pmid:2943273 |
| Franklin RA et al. | Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7733966 |
| Hayashi M et al. | Enhanced production of platelet-activating factor in stimulated rat leukocytes pretreated with triacsin C, A novel acyl-coA synthetase inhibitor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1445360 |
| Svetlov S and Nigam S | Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8380690 |
| Blank ML et al. | Conversion of 1-alkyl-2-acetyl-sn-glycerols to platelet activating factor and related phospholipids by rabbit platelets. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6497876 |
| White GC | Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428395 |
| Fukao M et al. | Structural differences in the ability of lysophospholipids to inhibit endothelium-dependent hyperpolarization by acetylcholine in rat mesenteric arteries. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8878540 |
| Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
| Satouchi K et al. | Evidence for production of 1-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine concomitantly with platelet-activating factor. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4004866 |
| Resink T et al. | Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8651917 |
| Xu N et al. | Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944906 |
| Weintraub ST et al. | Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4015656 |
| Carveth HJ et al. | Neutrophil activating factor (NAF) induces polymorphonuclear leukocyte adherence to endothelial cells and to subendothelial matrix proteins. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2665743 |
| Kok PT et al. | Arachidonic acid can induce leukotriene C4 formation by purified human eosinophils in the absence of other stimuli. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132917 |
| Nogami M et al. | The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2346478 |
| Kojima S et al. | Cooperativity between platelet-activating factor and collagen in aggregation of bovine platelets, II. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2346486 |
| Watson F and Edwards SW | Stimulation of primed neutrophils by soluble immune complexes: priming leads to enhanced intracellular Ca2+ elevations, activation of phospholipase D, and activation of the NADPH oxidase. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9647777 |
| Caramelo C et al. | Presence of platelet-activating factor in blood from humans and experimental animals. Its absence in anephric individuals. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732788 |
| Lenihan DJ and Lee TC | Regulation of platelet activating factor synthesis: modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732789 |
| Shindou H et al. | Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814544 |
| Palmantier R et al. | Biosynthesis of paf-acether. XIV. Paf-acether output in murine peritoneal macrophages is regulated by the level of acetylhydrolase. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2751666 |
| Filep J et al. | Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2916986 |
| Pinckard RN et al. | Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743335 |
| Kato T et al. | Augmentation of DNA synthesis in guinea pig bone marrow cells by platelet-activating factor (PAF). | 1988 | Biochem. Biophys. Res. Commun. | pmid:3202869 |
| Pai JK et al. | Activation of phospholipase D by chemotactic peptide in HL-60 granulocytes. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3422154 |
| Takayasu M et al. | Endothelin-induced mobilization of Ca2+ and the possible involvement of platelet activating factor and thromboxane A2. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2655596 |
| Denizot Y et al. | Paf-acether production by Escherichia coli. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2660796 |
| Mackness B et al. | Lack of protection against oxidative modification of LDL by avian HDL. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9642147 |
| Schulam PG et al. | Evidence for a platelet-activating factor receptor on human lymphoblastoid B cells: activation of the phosphatidylinositol cycle and induction of calcium mobilization. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2154211 |
| Rodrigues CO et al. | Effect of platelet-activating factor on cell differentiation of Trypanosoma cruzi. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8687466 |
| Joly F et al. | Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1317174 |
| Panetta T et al. | Effects of a platelet activating factor antagonist (BN 52021) on free fatty acids, diacylglycerols, polyphosphoinositides and blood flow in the gerbil brain: inhibition of ischemia-reperfusion induced cerebral injury. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827647 |
| Bazan HE et al. | The accumulation of platelet activating factor in the injured cornea may be interrelated with the synthesis of lipoxygenase products. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2827658 |
| Ponpipom MM et al. | (+/-)-trans-2-(3-Methoxy-5-methylsulfonyl-4-propoxyphenyl)-5-(3,4,5- trimethoxyphenyl)tetrahydrofuran (L-659,989), a novel, potent PAF receptor antagonist. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2829894 |
| Chen JJ and Liew CC | Phosphorylation of an acid-soluble nuclear protein in response to catecholamine in cultured rat cardiocytes. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8439325 |
| Sugiura T et al. | 2-Arachidonoylglycerol, a putative endogenous cannabinoid receptor ligand, induces rapid, transient elevation of intracellular free Ca2+ in neuroblastoma x glioma hybrid NG108-15 cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8954083 |
| Domingo MT et al. | Presence of specific binding sites for platelet-activating factor (PAF) in brain. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831903 |
| Nakayama R et al. | 1-O-hexadec-1'-enyl-2-acetyl-sn-glycero-3-phosphocholine and its biological activity. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3355555 |
| Touqui L et al. | Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6838557 |
| Smith CS et al. | Cyclosporin A blocks induction of tumor necrosis factor-alpha in human B lymphocytes. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7524500 |
| Scherer GF | 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084306 |
| Levine L | Regulation of arachidonic acid metabolism by phenylarsine oxide. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1859423 |
| Diserbo M et al. | Activation of large conductance Ca(2+)-activated K+ channels in N1E-115 neuroblastoma cells by platelet-activating factor. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579584 |
| Iwamoto S et al. | Platelet microparticles: a carrier of platelet-activating factor? | 1996 | Biochem. Biophys. Res. Commun. | pmid:8579618 |
| Errasfa M et al. | Inhibition of phospholipase A2 activity of guinea-pig alveolar macrophages by lipocortin-like proteins purified from mice lung. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2968795 |
| Masugi F et al. | Potent hypotensive activity of 1-O-hexadecyl-2-O-acetyl-SN-glycero-3-phosphocholine in spontaneously hypertensive rat. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7041899 |
| Saxena SP et al. | Histamine formed in stimulated human platelets is cytoplasmic. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2803292 |
| Hauser CJ et al. | Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16168959 |
| Mueller HW et al. | Synthesis of 1-acyl-2-[3H]acetyl-SN-glycero-3-phosphocholine, a structural analog of platelet activating factor, by vascular endothelial cells. | 1991 | Biochem. Biophys. Res. Commun. | pmid:2039529 |
| Mészáros K | Magnetic field elicits hypotension mediated by platelet activating factor in rats injected with iron beads. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1930228 |
| Naoki K et al. | PAF responsiveness in Japanese subjects with plasma PAF acetylhydrolase deficiency. | 2004 | Biochem. Biophys. Res. Commun. | pmid:15047169 |
| Randell E et al. | Interaction between rat serum phosphorylcholine binding protein and platelet activating factor. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2322233 |
| Inui H et al. | Participation of diacylglycerol kinase in mitogenic signal transduction induced by platelet-derived growth factor in vascular smooth muscle cells. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7802667 |
| Hartiala KT et al. | Lack of correlation between calcium mobilization and respiratory burst activation induced by chemotactic factors in rabbit polymorphonuclear leukocytes. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3034265 |
| Chau LY et al. | Photoaffinity labeling of platelet activating factor binding sites in rabbit platelet membranes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2545193 |
| Dutra PM et al. | A novel ecto-phosphatase activity of Herpetomonas muscarum muscarum inhibited by platelet-activating factor. | 1998 | Biochem. Biophys. Res. Commun. | pmid:9875238 |
| Smith RJ and Bowman BJ | Stimulation of human neutrophil degranulation with 1-O-octadecyl-2-O-acetyl-SN-glyceryl-3-phosphorylcholine: modulation by inhibitors of arachidonic acid metabolism. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6803804 |
| Musch MW et al. | Antigen-and ionophore-stimulated synthesis of platelet-activating factor by the cloned mast cell line, MC9. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3107564 |
| Lumb RH et al. | PAF-acether transfer activity in HL-60 cells is induced during differentiation. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2169726 |
| Müller E et al. | Human PAF receptor gene expression: induction during HL-60 cell differentiation. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1722407 |
| Rubin RM and Rosenbaum JT | A platelet-activating factor antagonist inhibits interleukin 1-induced inflammation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3260779 |
| Ye RD et al. | Characterization of a human cDNA that encodes a functional receptor for platelet activating factor. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1656963 |
| Nishinaka Y et al. | A new sensitive chemiluminescence probe, L-012, for measuring the production of superoxide anion by cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390246 |
| Combadière C et al. | Staurosporine, a protein kinase inhibitor, up-regulates the stimulation of human neutrophil respiratory burst by N-formyl peptides and platelet activating factor. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2158320 |
| Shiono S et al. | Neurotransmitter release from lysophosphatidic acid stimulated PC12 cells: involvement of lysophosphatidic acid receptors. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8390248 |
| Billah MM and Siegel MI | Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422930 |
| Prevost MC et al. | Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422938 |
| Corl CM et al. | Oxidant stress enhances Lyso-PAF-AcT activity by modifying phospholipase D and phosphatidic acid in aortic endothelial cells. | 2003 | Biochem. Biophys. Res. Commun. | pmid:12615078 |