Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
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What functions are associated with Platelet activating factor?
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Ichinose M et al. | Activation of K+ current in macrophages by platelet activating factor. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1370616 |
| Mutoh H et al. | Platelet-activating factor (PAF) positively auto-regulates the expression of human PAF receptor transcript 1 (leukocyte-type) through NF-kappa B. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7802642 |
| Asano K et al. | Distribution of platelet activating factor receptor mRNA along the rat nephron segments. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8753768 |
| el Azzouzi B et al. | Immunoregulatory functions of paf-acether. IX. Modulation of apoptosis in an immature T cell line. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8427577 |
| Smith RJ et al. | Effects of an anion channel blocker, 4, 4'-diisothiocyano-2,2'-disulfonic acid stilbene (DIDS), on human neutrophil function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6329191 |
| Liu B et al. | Implication of protein kinase C alpha in PAF-stimulated phospholipase D activation in Chinese hamster ovary (CHO) cells expressing PAF receptor. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7677747 |
| Rengan R and Omann GM | Regulation of oscillations in filamentous actin content in polymorphonuclear leukocytes stimulated with leukotriene B(4) and platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10462500 |
| Doebber TW et al. | Platelet activating factor (PAF) involvement in endotoxin-induced hypotension in rats. Studies with PAF-receptor antagonist kadsurenone. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985058 |
| Pfeilschifter J et al. | Inhibition of renin secretion by platelet activating factor (acetylglyceryl ether phosphorylcholine) in cultured rat renal juxtaglomerular cells. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2985064 |
| Crouch MF and Lapetina EG | No direct correlation between Ca2+ mobilization and dissociation of Gi during platelet phospholipase A2 activation. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3132162 |
| Hwang SB et al. | Specific binding sites for platelet activating factor in human lung tissues. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2986633 |
| Steiner M et al. | Biological activity of platelet activating factor-amidophosphonate (PAF-AP), a novel phosphonolipid selective inhibitor of platelet activating factor (PAF). | 1985 | Biochem. Biophys. Res. Commun. | pmid:3936503 |
| Naccache PH et al. | Unique inhibitory profile of platelet activating factor induced calcium mobilization, polyphosphoinositide turnover and granule enzyme secretion in rabbit neutrophils towards pertussis toxin and phorbol ester. | 1985 | Biochem. Biophys. Res. Commun. | pmid:2992480 |
| Avdonin PV et al. | Stimulation of high-affinity hormone-sensitive GTPase of human platelets by 1-O-alkyl-2-O-acetyl-sn-glyceryl-3-phosphocholine (platelet activating factor). | 1985 | Biochem. Biophys. Res. Commun. | pmid:2994653 |
| López-Farré A et al. | Glomeruli from ischemic rat kidneys produce increased amounts of platelet activating factor. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3358756 |
| Clay KL et al. | Structure elucidation of platelet activating factor derived from human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6430285 |
| Kuiper J et al. | The induction of glycogenolysis in the perfused liver by platelet activating factor is mediated by prostaglandin D2 from Kupffer cells. | 1988 | Biochem. Biophys. Res. Commun. | pmid:3144970 |
| Lanara E et al. | Response of mice and mouse platelets to acetyl glyceryl ether phosphorylcholine. | 1982 | Biochem. Biophys. Res. Commun. | pmid:7168759 |
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| Blank ML et al. | Generation of the precursor (lyso-PAF) of platelet-activating factor via a CoA-dependent transacylase. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7763233 |
| Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
| Tokumura A et al. | Evidence for existence of various homologues and analogues of platelet activating factor in a lipid extract of bovine brain. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593346 |
| Touvay C et al. | Effect of cyclosporin A and the platelet-activating factor (PAF) antagonist, BN 52021, on PAF- and antigen- induced bronchoconstriction in the guinea-pig. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2775253 |
| Kojima S et al. | Cooperativity between platelet-activating factor and collagen in platelet aggregation. | 1987 | Biochem. Biophys. Res. Commun. | pmid:3593379 |
| Comminges C et al. | Differential labelings suggest two specific phospholipid subclass hydrolysis promoted by PDGF-BB in vascular smooth muscle cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8607782 |
| Weber C et al. | Platelet activating factor enhances receptor-operated Ca(++)-influx and subsequent prostacyclin synthesis in human endothelial cells. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8373423 |
| Franklin RA et al. | Platelet activating factor activates MAPK and increases in intracellular calcium via independent pathways in B lymphocytes. | 1995 | Biochem. Biophys. Res. Commun. | pmid:7733966 |
| Svetlov S and Nigam S | Evidence for the presence of specific high affinity cytosolic binding sites for platelet-activating factor in human neutrophils. | 1993 | Biochem. Biophys. Res. Commun. | pmid:8380690 |
| White GC | Effect of 1-O-alkyl-2-acetyl-sn-glyceryl-3-phosphorylcholine on calcium fluxes by human platelet microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6428395 |
| Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
| Resink T et al. | Involvement of protein kinase C in hypoxia-induced desensitization of the beta-adrenergic system in human endothelial cells. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8651917 |
| Weintraub ST et al. | Fast atom bombardment-mass spectrometric identification of molecular species of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4015656 |
| Shukla SD and Hanahan DJ | AGEPC (platelet activating factor) induced stimulation of rabbit platelets: effects on phosphatidylinositol, di- and triphosphoinositides and phosphatidic acid metabolism. | 1982 | Biochem. Biophys. Res. Commun. | pmid:6288030 |
| Doebber TW et al. | Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6517949 |
| Fernández B and Balsinde J | Receptor-mediated activation of arachidonic acid release in mouse peritoneal macrophages is linked to extracellular calcium influx. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1659393 |
| Nogami M et al. | The effect of platelet-activating factor on [14C]aminopyrine uptake by isolated guinea pig parietal cells. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2346478 |
| Kojima S et al. | Cooperativity between platelet-activating factor and collagen in aggregation of bovine platelets, II. | 1990 | Biochem. Biophys. Res. Commun. | pmid:2346486 |
| Silva-Neto MA et al. | Platelet-activating factor (PAF) activates casein kinase 2 in the protozoan parasite Herpetomonas muscarum muscarum. | 2002 | Biochem. Biophys. Res. Commun. | pmid:12054663 |
| Shindou H et al. | Roles of cytosolic phospholipase A(2) and platelet-activating factor receptor in the Ca-induced biosynthesis of PAF. | 2000 | Biochem. Biophys. Res. Commun. | pmid:10814544 |
| Filep J et al. | Increased levels of platelet-activating factor in blood following intestinal ischemia in the dog. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2916986 |
| Pinckard RN et al. | Molecular heterogeneity of platelet-activating factor produced by stimulated human polymorphonuclear leukocytes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6743335 |
| Rigat B et al. | GM2 activator protein inhibits platelet activating factor signaling in rats. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19486886 |
| Denizot Y et al. | Paf-acether production by Escherichia coli. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2660796 |
| Lüthje J and Ogilvie A | Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6704102 |
| Fisher GJ et al. | Differential activation of human skin cells by platelet activating factor: stimulation of phosphoinositide turnover and arachidonic acid mobilization in keratinocytes but not in fibroblasts. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2476985 |
| Di Marzo V et al. | Platelet activating factor-mediated leukotriene biosynthesis in rat lungs: effect of prostaglandins E1 and F1 alpha. | 1987 | Biochem. Biophys. Res. Commun. | pmid:2822041 |
| Joly F et al. | Biosynthesis of paf-acether in cultured-mouse mast cells: the role of calcium and G proteins. | 1992 | Biochem. Biophys. Res. Commun. | pmid:1317174 |
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| Domingo MT et al. | Presence of specific binding sites for platelet-activating factor (PAF) in brain. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2831903 |
| Touqui L et al. | Conversion of 3H-PAF acether by rabbit platelets is independent from aggregation: evidences for a novel metabolite. | 1983 | Biochem. Biophys. Res. Commun. | pmid:6838557 |
| Smith CS et al. | Cyclosporin A blocks induction of tumor necrosis factor-alpha in human B lymphocytes. | 1994 | Biochem. Biophys. Res. Commun. | pmid:7524500 |
| Scherer GF | 1-Alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet activating factor) stimulates plant H+ transport in vitro and growth. | 1985 | Biochem. Biophys. Res. Commun. | pmid:4084306 |
| Levine L | Regulation of arachidonic acid metabolism by phenylarsine oxide. | 1991 | Biochem. Biophys. Res. Commun. | pmid:1859423 |
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| Chau LY et al. | Photoaffinity labeling of platelet activating factor binding sites in rabbit platelet membranes. | 1989 | Biochem. Biophys. Res. Commun. | pmid:2545193 |
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| Rouis M et al. | Platelet activating factor is a potent stimulant of the production of active oxygen species by human monocyte-derived macrophages. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847729 |
| Doni MG et al. | Forskolin and prostacyclin inhibit fluoride induced platelet activation and protein kinase C dependent responses. | 1988 | Biochem. Biophys. Res. Commun. | pmid:2847730 |
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| Tou J | Platelet-activating factor promotes arachidonate incorporation into phosphatidylinositol and phosphatidylcholine in neutrophils. | 1985 | Biochem. Biophys. Res. Commun. | pmid:3921017 |
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| Di Marzo V et al. | The effect of vasoactive intestinal peptide and calcitonin gene-related peptide on peptidoleukotriene release from platelet activating factor stimulated rat lungs and ionophore stimulated guinea pig lungs. | 1986 | Biochem. Int. | pmid:2432897 |
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| Fernandez-Gallardo S et al. | Biosynthesis of platelet-activating factor in glandular gastric mucosa. Evidence for the involvement of the 'de novo' pathway and modulation by fatty acids. | 1988 | Biochem. J. | pmid:2848496 |
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| Chao W et al. | Protein tyrosine phosphorylation and regulation of the receptor for platelet-activating factor in rat Kupffer cells. Effect of sodium vanadate. | 1992 | Biochem. J. | pmid:1335232 |
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| Hill CE et al. | Location of platelet activating factor binding in rat liver. | 1988 | Biochem. J. | pmid:3178735 |
| Hallam TJ et al. | Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. | 1985 | Biochem. J. | pmid:4091795 |
| Kang JX et al. | Characterization of platelet-activating factor binding to human airway epithelial cells: modulation by fatty acids and ion-channel blockers. | 1994 | Biochem. J. | pmid:7526847 |
| Murphy JF et al. | The vitronectin receptor (alpha v beta 3) is implicated, in cooperation with P-selectin and platelet-activating factor, in the adhesion of monocytes to activated endothelial cells. | 1994 | Biochem. J. | pmid:7528011 |
| Asmis R et al. | Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells. | 1994 | Biochem. J. | pmid:8141766 |
| Evans RD et al. | Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia. | 1991 | Biochem. J. | pmid:1747129 |
| Montero M et al. | Chemotactic peptide down-regulation of calcium mobilization induced by platelet-activating factor and by leukotriene B4 in human neutrophils is uncovered by protein phosphatase inhibitors. | 1994 | Biochem. J. | pmid:7980418 |
| Murphy CT et al. | The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules. | 1991 | Biochem. J. | pmid:1883334 |