Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Leslie CC and Detty DM | Arachidonic acid turnover in response to lipopolysaccharide and opsonized zymosan in human monocyte-derived macrophages. | 1986 | Biochem. J. | pmid:3098232 |
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Gómez-Cambronero J et al. | The role of calcium ions in the process of acetyltransferase activation during the formation of platelet-activating factor (PAF-acether). | 1984 | Biochem. J. | pmid:6146309 |
Tsoukatos DC et al. | Platelet-activating factor acetylhydrolase and transacetylase activities in human plasma low-density lipoprotein. | 2001 | Biochem. J. | pmid:11439095 |
Kloprogge E and Akkerman JW | Binding kinetics of PAF-acether (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) to intact human platelets. | 1984 | Biochem. J. | pmid:6150705 |
Chao W et al. | Biosynthesis of platelet-activating factor by cultured rat Kupffer cells stimulated with calcium ionophore A23187. | 1989 | Biochem. J. | pmid:2494988 |
Dohi T et al. | Calcium-dependent biosynthesis of platelet-activating factor by submandibular gland cells. | 1991 | Biochem. J. | pmid:1645529 |
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Alonso MT et al. | Agonist-induced Ca2+ influx into human platelets is secondary to the emptying of intracellular Ca2+ stores. | 1991 | Biochem. J. | pmid:1764041 |
Murphy CT and Westwick J | Role of type 1 and type 2A phosphatases in signal transduction of platelet-activating-factor-stimulated rabbit platelets. | 1994 | Biochem. J. | pmid:8042999 |
DiCorleto PE and de la Motte CA | Thrombin causes increased monocytic-cell adhesion to endothelial cells through a protein kinase C-dependent pathway. | 1989 | Biochem. J. | pmid:2513808 |
O'Flaherty JT et al. | Regulation of platelet-activating-factor receptors and the desensitization response in polymorphonuclear neutrophils. | 1992 | Biochem. J. | pmid:1332696 |
Chao W et al. | Metabolism of platelet-activating factor (PAF; 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) and lyso-PAF (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by cultured rat Kupffer cells. | 1989 | Biochem. J. | pmid:2775221 |
Tool AT et al. | Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils. | 1999 | Biochem. J. | pmid:10229663 |
Dulioust A et al. | Biosynthesis of paf-acether. Paf-acether but not leukotriene C4 production is impaired in cultured macrophages. | 1989 | Biochem. J. | pmid:2513801 |
Rodrigo L et al. | Hydrolysis of platelet-activating factor by human serum paraoxonase. | 2001 | Biochem. J. | pmid:11171072 |
Winkler JD et al. | Influence of arachidonic acid on indices of phospholipase A2 activity in the human neutrophil. | 1993 | Biochem. J. | pmid:8387780 |
Rogers JE et al. | Solubilization of a functionally active platelet-activating factor receptor from rabbit platelets. | 1991 | Biochem. J. | pmid:1654881 |
Chao W et al. | Protein tyrosine phosphorylation and regulation of the receptor for platelet-activating factor in rat Kupffer cells. Effect of sodium vanadate. | 1992 | Biochem. J. | pmid:1335232 |
Hii CS et al. | Basal and phorbol-ester-stimulated turnover of phosphatidylcholine in HeLa cells involve different pathways. | 1992 | Biochem. J. | pmid:1335237 |
Snyder F | Platelet-activating factor: the biosynthetic and catabolic enzymes. | 1995 | Biochem. J. | pmid:7848265 |
Touqui L et al. | Human platelets stimulated by thrombin produce platelet-activating factor (1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine) when the degrading enzyme acetyl hydrolase is blocked. | 1985 | Biochem. J. | pmid:4052028 |
Alonso-Torre SR et al. | Control of Ca2+ entry into HL60 and U937 human leukaemia cells by the filling state of the intracellular Ca2+ stores. | 1993 | Biochem. J. | pmid:8382050 |
Houslay MD et al. | Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni. | 1986 | Biochem. J. | pmid:3013161 |
Halenda SP and Rehm AG | Evidence for the calcium-dependent activation of phospholipase D in thrombin-stimulated human erythroleukaemia cells. | 1990 | Biochem. J. | pmid:2159285 |
Kjeldsen L et al. | Subcellular localization and release of human neutrophil gelatinase, confirming the existence of separate gelatinase-containing granules. | 1992 | Biochem. J. | pmid:1332677 |
Grigg ME et al. | Characterization of a platelet-activating factor acetylhydrolase secreted by the nematode parasite Nippostrongylus brasiliensis. | 1996 | Biochem. J. | pmid:8713083 |
Yousufzai SY and Abdel-Latif AA | Effects of platelet-activating factor on the release of arachidonic acid and prostaglandins by rabbit iris smooth muscle. Inhibition by calcium channel antagonists. | 1985 | Biochem. J. | pmid:3927898 |
Tran K et al. | Vitamin E enhances the acylation of 1-O-alkyl-sn-glycero-3-phosphocholine in human endothelial cells. | 1994 | Biochem. J. | pmid:8129709 |
Montero M et al. | Control of plasma-membrane Ca2+ entry by the intracellular Ca2+ stores. Kinetic evidence for a short-lived mediator. | 1992 | Biochem. J. | pmid:1463455 |
Bauldry SA and Wooten RE | Induction of cytosolic phospholipase A2 activity by phosphatidic acid and diglycerides in permeabilized human neutrophils: interrelationship between phospholipases D and A2. | 1997 | Biochem. J. | pmid:9065750 |
Joly F et al. | Biosynthesis of paf-acether. Activators of protein kinase C stimulate cultured mast cell acetyltransferase without stimulating paf-acether synthesis. | 1990 | Biochem. J. | pmid:2146953 |
Fouda SI et al. | Effect of lipopolysaccharide on mitogen-activated protein kinases and cytosolic phospholipase A2. | 1995 | Biochem. J. | pmid:8948437 |
Tao W et al. | Arachidonic acid release in rabbit neutrophils. | 1989 | Biochem. J. | pmid:2494986 |
Vallance SJ et al. | Granulocyte-macrophage colony-stimulating factor can stimulate macrophage proliferation via persistent activation of Na+/H+ antiport. Evidence for two distinct roles for Na+/H+ antiport activation. | 1990 | Biochem. J. | pmid:2154185 |
Hill CE et al. | Location of platelet activating factor binding in rat liver. | 1988 | Biochem. J. | pmid:3178735 |
Kimura K et al. | Different preparations of zymosan induce glycogenolysis independently in the perfused rat liver. Involvement of mannose receptors, peptide-leukotrienes and prostaglandins. | 1992 | Biochem. J. | pmid:1317164 |
Chau LY et al. | Agonist-induced down-regulation of platelet-activating factor receptor gene expression in U937 cells. | 1994 | Biochem. J. | pmid:7519853 |
Dunlop ME and Larkins RG | Insulin-dependent contractility of glomerular mesangial cells in response to angiotensin II, platelet-activating factor and endothelin is attenuated by prostaglandin E2. | 1990 | Biochem. J. | pmid:2268285 |
Montero M et al. | Agonist-induced Ca2+ influx in human neutrophils is secondary to the emptying of intracellular calcium stores. | 1991 | Biochem. J. | pmid:1906712 |
Liu B et al. | Prolonged activation of phospholipase D in Chinese hamster ovary cells expressing platelet-activating-factor receptor lacking cytoplasmic C-terminal tail. | 1997 | Biochem. J. | pmid:9355758 |
Herbert JM | Characterization of specific binding sites of 3H-labelled platelet-activating factor ([3H]PAF) and a new antagonist, [3H]SR 27417, on guinea-pig tracheal epithelial cells. | 1992 | Biochem. J. | pmid:1318021 |
Raggers RJ et al. | Multidrug-resistance P-glycoprotein (MDR1) secretes platelet-activating factor. | 2001 | Biochem. J. | pmid:11463358 |
Garcia MC et al. | Biosynthesis of platelet-activating factor (PAF) in human polymorphonuclear leucocytes. The role of lyso-PAF disposal and free arachidonic acid. | 1990 | Biochem. J. | pmid:1693077 |
Huang SJ et al. | Platelet-activating factor-induced hydrolysis of phosphatidylinositol 4,5-bisphosphate stimulates the production of reactive oxygen intermediates in macrophages. | 1988 | Biochem. J. | pmid:2833227 |
Hallam TJ et al. | Relationship between cytoplasmic free calcium and myosin light chain phosphorylation in intact platelets. | 1985 | Biochem. J. | pmid:4091795 |
Kang JX et al. | Characterization of platelet-activating factor binding to human airway epithelial cells: modulation by fatty acids and ion-channel blockers. | 1994 | Biochem. J. | pmid:7526847 |
van Willigen G and Akkerman JW | Protein kinase C and cyclic AMP regulate reversible exposure of binding sites for fibrinogen on the glycoprotein IIB-IIIA complex of human platelets. | 1991 | Biochem. J. | pmid:1846526 |
Murphy JF et al. | The vitronectin receptor (alpha v beta 3) is implicated, in cooperation with P-selectin and platelet-activating factor, in the adhesion of monocytes to activated endothelial cells. | 1994 | Biochem. J. | pmid:7528011 |
Chao W and Olson MS | Platelet-activating factor: receptors and signal transduction. | 1993 | Biochem. J. | pmid:8391253 |
Murphy CT and Westwick J | Selective inhibition of protein kinase C. Effect on platelet-activating-factor-induced platelet functional responses. | 1992 | Biochem. J. | pmid:1567363 |
van Willigen G et al. | Exposure of ligand-binding sites on platelet integrin alpha IIB/beta 3 by phosphorylation of the beta 3 subunit. | 1996 | Biochem. J. | pmid:8615768 |
Asmis R et al. | Intracellular Ca2+, inositol 1,4,5-trisphosphate and additional signalling in the stimulation by platelet-activating factor of prostaglandin E2 formation in P388D1 macrophage-like cells. | 1994 | Biochem. J. | pmid:8141766 |
Sebaldt RJ et al. | Quantification of contributions of phospholipid precursors to diradylglycerols in stimulated mononuclear phagocytes. | 1992 | Biochem. J. | pmid:1599420 |
Churchill L et al. | Interaction of platelet-activating factor with cultured guinea pig tracheal epithelial cells. | 1991 | Biochem. J. | pmid:2064601 |
Tripathi YB et al. | Involvement of tyrosine kinase and protein kinase C in platelet-activating-factor-induced c-fos gene expression in A-431 cells. | 1992 | Biochem. J. | pmid:1382409 |
Stephens LR et al. | Synthesis of myo-inositol 1,3,4,5,6-pentakisphosphate from inositol phosphates generated by receptor activation. | 1988 | Biochem. J. | pmid:2845930 |
Krump E et al. | Leukotriene synthesis in calcium-depleted human neutrophils: arachidonic acid release correlates with calcium influx. | 1995 | Biochem. J. | pmid:7654211 |
Altin JG et al. | Evidence that Ca2+ fluxes and respiratory, glycogenolytic and vasoconstrictive effects induced by the action of platelet-activating factor and L-alpha-lysophosphatidylcholine in the perfused rat liver are mediated by products of the cyclo-oxygenase pathway. | 1987 | Biochem. J. | pmid:3117040 |
Evans RD et al. | Effects of platelet-activating factor on lipid metabolism in rats in vivo. Origin of the hypertriglyceridaemia. | 1991 | Biochem. J. | pmid:1747129 |
Kloprogge E and Akkerman JW | Platelet-activating factor (PAF-acether) induces high- and low-affinity binding of fibrinogen to human platelets via independent mechanisms. | 1986 | Biochem. J. | pmid:3101672 |
Rice SQ et al. | Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. | 1998 | Biochem. J. | pmid:9494101 |
Wu J et al. | Intestinal alkaline sphingomyelinase hydrolyses and inactivates platelet-activating factor by a phospholipase C activity. | 2006 | Biochem. J. | pmid:16255717 |
Montero M et al. | Chemotactic peptide down-regulation of calcium mobilization induced by platelet-activating factor and by leukotriene B4 in human neutrophils is uncovered by protein phosphatase inhibitors. | 1994 | Biochem. J. | pmid:7980418 |
Soubeyrand S et al. | Phospholipase A2 from bovine seminal plasma is a platelet-activating factor acetylhydrolase. | 1998 | Biochem. J. | pmid:9405273 |
Coffer PJ et al. | Comparison of the roles of mitogen-activated protein kinase kinase and phosphatidylinositol 3-kinase signal transduction in neutrophil effector function. | 1998 | Biochem. J. | pmid:9405284 |
Turner JS et al. | Plasmin modulates the thrombin-evoked calcium response in C6 glioma cells. | 1994 | Biochem. J. | pmid:8280096 |
Murphy CT et al. | The relationship between cytosolic Ca2+, sn-1,2-diacylglycerol and inositol 1,4,5-trisphosphate elevation in platelet-activating-factor-stimulated rabbit platelets. Influence of protein kinase C on production of signal molecules. | 1991 | Biochem. J. | pmid:1883334 |
Antonopoulou S et al. | Identification of a new endogenous platelet-activating factor-like molecule in gingival crevicular fluid. | 1998 | Biochem. J. | pmid:9480892 |
Takano H et al. | Platelet aggregation induced by platelet-activating factor is suppressed by cystine protease inhibitor. | 1991 | Biochem. Med. Metab. Biol. | pmid:2015107 |
Akiba S et al. | Inhibitory effect of the leaf extract of Ginkgo biloba L. on oxidative stress-induced platelet aggregation. | 1998 | Biochem. Mol. Biol. Int. | pmid:9891858 |
Tanfani F et al. | A sensitive detection of neutrophil activation by fluorescence quenching of membrane inserted singlet oxygen probe. | 1994 | Biochem. Mol. Biol. Int. | pmid:8061626 |
Calcerrada MC et al. | Glutamate release is involved in PAF-increased cyclic GMP levels in hippocampus. | 1999 | Biochem. Mol. Biol. Int. | pmid:10204090 |
Suzuki H et al. | Evidence for the production of platelet-activating factor by murine embryos and its putative role in the maternal physiology. | 1995 | Biochem. Mol. Biol. Int. | pmid:8589634 |
Shah BH et al. | The inhibitory effect of cinchonine on human platelet aggregation due to blockade of calcium influx. | 1998 | Biochem. Pharmacol. | pmid:9776305 |
Yamaguchi M et al. | A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation. | 2015 | Biochem. Pharmacol. | pmid:25577975 |
Winkler JD et al. | Evidence for different mechanisms involved in the formation of lyso platelet-activating factor and the calcium-dependent release of arachidonic acid from human neutrophils. | 1992 | Biochem. Pharmacol. | pmid:1449523 |
Yamazaki Y et al. | A Penicillium sp. F33 metabolite and its synthetic derivatives inhibit acetyl-CoA:1-O-alkyl-sn-glycero-3-phosphocholine acetyltransferase (a key enzyme in platelet-activating factor biosynthesis) and carrageenan-induced paw edema in mice. | 2013 | Biochem. Pharmacol. | pmid:23817078 |
Le Blanc K et al. | 1-O-hexadecyl-2-metoxy-glycero-3-phosphatidylcholine--a methoxy ether lipid inhibiting platelet activating factor-induced platelet aggregation and neutrophil oxidative metabolism. | 1995 | Biochem. Pharmacol. | pmid:7786298 |
Ukena D et al. | PAF-receptors on eosinophils: identification with a novel ligand, [3H]WEB 2086. | 1989 | Biochem. Pharmacol. | pmid:2543419 |
Workman P et al. | Platelet-activating factor (PAF) antagonist WEB 2086 does not modulate the cytotoxicity of PAF or antitumour alkyl lysophospholipids ET-18-O-methyl and SRI 62-834 in HL-60 promyelocytic leukaemia cells. | 1991 | Biochem. Pharmacol. | pmid:1989642 |
Keraly CL et al. | The role of extracellular Ca2+ and Na+ in paf-acether-induced human platelet activation. | 1989 | Biochem. Pharmacol. | pmid:2818633 |
Lamant V et al. | Inhibition of the metabolism of platelet activating factor (PAF-acether) by three specific antagonists from Ginkgo biloba. | 1987 | Biochem. Pharmacol. | pmid:2820421 |
Beusenberg FD et al. | Cyclic-AMP level and eicosanoid release from alveolar macrophages are differentially affected by high and low dose of platelet activating factor. | 1994 | Biochem. Pharmacol. | pmid:8117329 |
Persico P et al. | In vivo and in vitro inhibition of platelet aggregation by SV-IV, a major protein secreted from the rat seminal vesicle epithelium. | 1990 | Biochem. Pharmacol. | pmid:2390113 |
Appleyard CB and Hillier K | Catabolism of platelet-activating factor by human colonic mucosa. Calcium dependence of the catabolizing enzymes. | 1992 | Biochem. Pharmacol. | pmid:1632809 |
Heller R et al. | Nitrovasodilators inhibit thrombin-induced platelet-activating factor synthesis in human endothelial cells. | 1992 | Biochem. Pharmacol. | pmid:1322663 |
Pretolani M and Vargaftig BB | From lung hypersensitivity to bronchial hyperreactivity. What can we learn from studies on animal models? | 1993 | Biochem. Pharmacol. | pmid:8452553 |
Borea PA et al. | Temperature dependence of [3H]PAF binding to washed human platelets. | 1991 | Biochem. Pharmacol. | pmid:1847638 |
Shah BH et al. | Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. | 1999 | Biochem. Pharmacol. | pmid:10484074 |