Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Thrombocytosis D013922 4 associated lipids
Toxemia D014115 3 associated lipids
Vitamin D Deficiency D014808 13 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Pregnancy Complications, Hematologic D011250 11 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Klebsiella Infections D007710 7 associated lipids
Ascites D001201 25 associated lipids
Albuminuria D000419 18 associated lipids
Infant, Premature, Diseases D007235 7 associated lipids
Hyperinsulinism D006946 27 associated lipids
Scleroderma, Systemic D012595 16 associated lipids
Parkinson Disease D010300 53 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Salmonella Infections, Animal D012481 9 associated lipids
Bronchial Diseases D001982 3 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Tangier Disease D013631 8 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Wu C et al. Evidence for the autocrine induction of capacitation of mammalian spermatozoa. 2001 J. Biol. Chem. pmid:11350972
Taylor R et al. Platelet-activating factor antagonism and streptokinase-induced hypotension in clinical acute myocardial infarction. 2001 Clin. Sci. pmid:11352774
Hayashi J et al. Platelet-activating factor antagonist, SM-12502, attenuates experimental glomerular thrombosis in rats. 2001 Nephron pmid:11287764
Choi JH et al. Platelet-activating factor-induced early activation of NF-kappa B plays a crucial role for organ clearance of Candida albicans. 2001 J. Immunol. pmid:11290796
Marathe GK et al. Identification of platelet-activating factor as the inflammatory lipid mediator in CCl4-metabolizing rat liver. 2001 J. Lipid Res. pmid:11290831
Kato M et al. Platelet activating factor degradation in tear fluid from guinea pigs with allergic conjunctivitis. 2001 J Ocul Pharmacol Ther pmid:11327052
Caplan MS et al. Effect of polyunsaturated fatty acid (PUFA) supplementation on intestinal inflammation and necrotizing enterocolitis (NEC) in a neonatal rat model. 2001 Pediatr. Res. pmid:11328947
Bassi F et al. Detection of platelet-activating factor in gingival tissue surrounding failed dental implants. 2001 J. Periodontol. pmid:11210074
de Meis L Role of the sarcoplasmic reticulum Ca2+-ATPase on heat production and thermogenesis. 2001 Biosci. Rep. pmid:11725862
Wittwer T et al. Impact of PAF antagonist BN 52021 (Ginkolide B) on post-ischemic graft function in clinical lung transplantation. 2001 J. Heart Lung Transplant. pmid:11257563
Clavijo LC et al. PAF increases vascular permeability without increasing pulmonary arterial pressure in the rat. 2001 J. Appl. Physiol. pmid:11133918
Ko TC et al. Synthesis of 4-alkoxy-2-phenylquinoline derivatives as potent antiplatelet agents. 2001 Bioorg. Med. Chem. Lett. pmid:11212091
Taggart DP Effects of a platelet-activating factor antagonist on lung injury and ventilation after cardiac operation. 2001 Ann. Thorac. Surg. pmid:11216754
Jerkić M et al. The mechanism of increased renal susceptibility to toxic substances in the elderly. Part I. The role of increased vasoconstriction. 2001 Int Urol Nephrol pmid:11989542
Caplan MS and Jilling T The role of polyunsaturated fatty acid supplementation in intestinal inflammation and neonatal necrotizing enterocolitis. 2001 Lipids pmid:11724457
Kaul DK et al. Ameliorating effects of fluorocarbon emulsion on sickle red blood cell-induced obstruction in an ex vivo vasculature. 2001 Blood pmid:11698300
Casao MA et al. Promotion of platelet aggregation by sera from brucellosis patients with antiphosphatidylcholine antibodies. 2001 J. Med. Microbiol. pmid:11699593
Lendvai B et al. Platelet-activating factor evokes Ca2+ transients after the blockade of ryanodine receptor by dantrolene in RAW 264.7 macrophages. 2001 Neurochem. Res. pmid:11699928
Houghton TJ et al. Efficient assembly of the phomactin core via two different macrocyclization protocols. 2001 Org. Lett. pmid:11700095
Adams JM et al. Entry of gut lymph into the circulation primes rat neutrophil respiratory burst in hemorrhagic shock. 2001 Crit. Care Med. pmid:11700422
Rozenfeld RA et al. Role of gut flora on intestinal group II phospholipase A2 activity and intestinal injury in shock. 2001 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:11557516
Stoddart NR et al. Exogenous platelet-activating factor stimulates cell proliferation in mouse pre-implantation embryos prior to the fourth cell cycle and shows isoform-specific stimulatory effects. 2001 Zygote pmid:11510473
Feldman C et al. Vitamin E attenuates the injurious effects of bioactive phospholipids on human ciliated epithelium in vitro. 2001 Eur. Respir. J. pmid:11510782
Mooren FC et al. Decoupling of intracellular calcium signaling in granulocytes after exhaustive exercise. 2001 Int J Sports Med pmid:11510867
Hermoso M et al. Platelet activating factor increases ciliary activity in the hamster oviduct through epithelial production of prostaglandin E2. 2001 Pflugers Arch. pmid:11484763
Sachais BS Platelet-endothelial interactions in atherosclerosis. 2001 Curr Atheroscler Rep pmid:11487452
Jantan I et al. Inhibition of platelet-activating factor receptor binding by aporphine and phenanthrenoid alkaloids from Aromadendron elegans. 2001 Planta Med. pmid:11488464
Tibiriçá E Cardiovascular properties of yangambin, a lignan isolated from Brazilian plants. 2001 Cardiovasc Drug Rev pmid:11830750
Shah BH et al. Molecular mechanisms involved in human platelet aggregation by synergistic interaction of platelet-activating factor and 5-hydroxytryptamine. 2001 Exp. Mol. Med. pmid:11795484
Cao YZ et al. Selenium modulates 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (PAF) biosynthesis in bovine aortic endothelial cells. 2001 Antioxid. Redox Signal. pmid:11813988
den Dekker E et al. Biogenesis of G-protein mediated calcium signaling in human megakaryocytes. 2001 Thromb. Haemost. pmid:11686331
Chłopicki S et al. Residual pulmonary neutrophils are involved in vaso- and bronchoconstrictor responses to platelet activating factor in the isolated buffer-perfused rat lung. 2000 May-Jun Pol J Pharmacol pmid:11055579
Iglesias-De La Cruz MC et al. Phenotypic modifications of human mesangial cells by extracellular matrix: the importance of matrix in the contractile response to reactive oxygen species. 2000 Mar-Apr Exp. Nephrol. pmid:10729749
Bastos da Silva M et al. In vitro inhibitory effect of SR 27417, a potent platelet-activating factor (PAF) receptor antagonist, on the PAF-induced bovine platelet aggregation. 2000 Mar-Apr Vet. Res. pmid:10779205
Sibelius U et al. Staphylococcal alpha-toxin provokes coronary vasoconstriction and loss in myocardial contractility in perfused rat hearts: role of thromboxane generation. 2000 Jan 4-11 Circulation pmid:10618308
Zhu X et al. A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1. 2000 J. Immunol. Methods pmid:10854610
Caslake MJ et al. Lipoprotein-associated phospholipase A(2), platelet-activating factor acetylhydrolase: a potential new risk factor for coronary artery disease. 2000 Atherosclerosis pmid:10856534
Nakajima T et al. Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation. 2000 Int. J. Biochem. Cell Biol. pmid:10856708
Lee YM et al. Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. 2000 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:10893205
Hu L et al. Alkyl and alkoxycarbonyl derivatives of ginkgolide B: synthesis and biological evaluation of PAF inhibitory activity. 2000 Bioorg. Med. Chem. pmid:10896127
Parkman HP et al. The contractile action of platelet-activating factor on gallbladder smooth muscle. 2000 Am. J. Physiol. Gastrointest. Liver Physiol. pmid:10898747
Unno N et al. Plasma platelet-activating factor acetylhydrolase deficiency is associated with atherosclerotic occlusive disease in japan. 2000 J. Vasc. Surg. pmid:10917985
Ruchaud-Sparagano MH et al. Soluble E-selectin acts in synergy with platelet-activating factor to activate neutrophil beta 2-integrins. Role of tyrosine kinases and Ca2+ mobilization. 2000 J. Biol. Chem. pmid:10748085
Henderson WR et al. Recombinant human platelet-activating factor-acetylhydrolase inhibits airway inflammation and hyperreactivity in mouse asthma model. 2000 J. Immunol. pmid:10706731
Tu W et al. [Influences of BN50739 on neutrophil elastase and phospholipase A2 in lung and tracheal mucosa of pigs with acute severe pancreatitis]. 2000 Zhonghua Jie He He Hu Xi Za Zhi pmid:11372382
McClenahan DJ et al. Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. 2000 Am. J. Vet. Res. pmid:10714514
Yamakawa Y et al. Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. 2000 Ann. Surg. pmid:10714632
Takada Y et al. Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. 2000 Transplant. Proc. pmid:10715416
Partrick DA et al. Maximal human neutrophil priming for superoxide production and elastase release requires p38 mitogen-activated protein kinase activation. 2000 Arch Surg pmid:10668885
Cowling RT and Birnboim HC Expression of serum- and glucocorticoid-regulated kinase (sgk) mRNA is up-regulated by GM-CSF and other proinflammatory mediators in human granulocytes. 2000 J. Leukoc. Biol. pmid:10670586
Werr J et al. Integrin alpha(2)beta(1) (VLA-2) is a principal receptor used by neutrophils for locomotion in extravascular tissue. 2000 Blood pmid:10688841
Bleeker WK et al. Vasoactive side effects of intravenous immunoglobulin preparations in a rat model and their treatment with recombinant platelet-activating factor acetylhydrolase. 2000 Blood pmid:10688848
Grimminger F et al. PAF-induced synthesis of tetraenoic and pentaenoic leukotrienes in the isolated rabbit lung. 2000 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:10666110
Clavijo LC et al. Platelet-activating factor and bacteremia-induced pulmonary hypertension. 2000 J. Surg. Res. pmid:10644485
Owaki T et al. Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release. 2000 Am. J. Physiol. Heart Circ. Physiol. pmid:10644608
Ibe BO et al. Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. 2000 Mol. Genet. Metab. pmid:10655157
Modschiedler K et al. Dapsone and colchicine inhibit adhesion of neutrophilic granulocytes to epidermal sections. 2000 Arch. Dermatol. Res. pmid:10664013
Hashimoto S et al. p38 MAP kinase regulates TNF alpha-, IL-1 alpha- and PAF-induced RANTES and GM-CSF production by human bronchial epithelial cells. 2000 Clin. Exp. Allergy pmid:10606930
Tokumura A et al. Platelet-activating factor (PAF)-like oxidized phospholipids: relevance to atherosclerosis. 2000 Biofactors pmid:11237195
Yamada Y et al. Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population. 2000 Atherosclerosis pmid:10781653
Smith J et al. Differences in gene density on chicken macrochromosomes and microchromosomes. 2000 Anim. Genet. pmid:10782207
Bailey SR et al. Actions and interactions of ADP, 5- HT, histamine and PAF on equine platelets. 2000 Res. Vet. Sci. pmid:10756136
Friedman E et al. Effect of hydrocortisone on platelet activating factor induced lung edema in isolated rabbit lungs. 2000 Respir Physiol pmid:10786645
Asai Y et al. A temperature study on critical micellization concentration of the novel platelet-activating factor receptor antagonist E5880 in water by electric conductivity measurements. 2000 Drug Dev Ind Pharm pmid:10789068
Balsinde J et al. Cellular regulation of cytosolic group IV phospholipase A2 by phosphatidylinositol bisphosphate levels. 2000 J. Immunol. pmid:10799904
Dearn S et al. Activation of platelet-activating factor (PAF) receptor stimulates nitric oxide (NO) release via protein kinase C-alpha in HEC-1B human endometrial epithelial cell line. 2000 Mol. Med. pmid:10803407
Kosaka T et al. Spectrophotometric assay for serum platelet-activating factor acetylhydrolase activity. 2000 Clin. Chim. Acta pmid:10807978
Triggiani M et al. Metabolism of lipid mediators in human eosinophils. 2000 Chem. Immunol. pmid:10761306
De Geest B et al. Effect of overexpression of human apo A-I in C57BL/6 and C57BL/6 apo E-deficient mice on 2 lipoprotein-associated enzymes, platelet-activating factor acetylhydrolase and paraoxonase. Comparison of adenovirus-mediated human apo A-I gene transfer and human apo A-I transgenesis. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:11031226
McLarnon JG et al. Anion channels modulate store-operated calcium influx in human microglia. 2000 Cell Calcium pmid:11032781
Fraga AG et al. Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists. 2000 Eur J Pharm Sci pmid:11033071
Choi SY et al. Capsaicin inhibits platelet-activating factor-induced cytosolic Ca2+ rise and superoxide production. 2000 J. Immunol. pmid:11034409
Koyama S et al. The potential of various lipopolysaccharides to release IL-8 and G-CSF. 2000 Am. J. Physiol. Lung Cell Mol. Physiol. pmid:10749742
Simon HU et al. Eosinophils maintain their capacity to signal and release eosinophil cationic protein upon repetitive stimulation with the same agonist. 2000 J. Immunol. pmid:11034418
Rowland BL et al. Elevated circulating concentrations of platelet activating factor in preeclampsia. 2000 Am. J. Obstet. Gynecol. pmid:11035340
Li N et al. Platelet-leukocyte cross talk in whole blood. 2000 Arterioscler. Thromb. Vasc. Biol. pmid:11116075
Le Blanc K et al. Defective platelet aggregation in polycythaemia vera is not caused by impaired calcium signaling, phospholipase D activation or decreased amounts of focal adhesion proteins. 2000 Eur. J. Haematol. pmid:11092463
Iwamoto H et al. Beneficial effect of machine perfusion preservation on liver transplantation from non-heart-beating donors. 2000 Transplant. Proc. pmid:11119873
Kim JD et al. Platelet activating factor acetylhydrolase decreases lung reperfusion injury. 2000 Ann. Thorac. Surg. pmid:10969656
Suzuki T et al. Thromboxane A(2)-mediated Cl(-) secretion induced by platelet-activating factor in isolated rat colon. 2000 Eur. J. Pharmacol. pmid:10988347
Kallan NC and Halcomb RL Synthesis of the ring system of phomactin D using a Suzuki macrocyclization. 2000 Org. Lett. pmid:10990428
Turner PJ et al. Induction by inhibitors of nitric oxide synthase of hyperresponsiveness in the human nasal airway. 2000 Br. J. Pharmacol. pmid:10991932
Gastaldello K et al. Role of complement and platelet-activating factor in the stimulation of phagocytosis and reactive oxygen species production during haemodialysis. 2000 Nephrol. Dial. Transplant. pmid:11007834
Wratten ML et al. Hemolipodialysis attenuates oxidative stress and removes hydrophobic toxins. 2000 Artif Organs pmid:11012537
Kobayashi Y et al. [Inhibitory effect of suplatast tosilate on eosinophil migration]. 2000 Arerugi pmid:10944827
Liu JK et al. Paeonilide, a novel anti-PAF-active monoterpenoid-derived metabolite from Paeonia delavayi. 2000 Biosci. Biotechnol. Biochem. pmid:10945272
Ueda T et al. Pancreatitis-associated ascitic fluid increases intracellular Ca(2+) concentration on hepatocytes. 2000 J. Surg. Res. pmid:10945960
Marathe GK et al. Bioactive phospholipid oxidation products. 2000 Free Radic. Biol. Med. pmid:10946218
Nieswandt B et al. Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. 2000 Blood pmid:11001906
Montrucchio G et al. Role of platelet-activating factor in cardiovascular pathophysiology. 2000 Physiol. Rev. pmid:11015622
Taguchi R et al. Two-dimensional analysis of phospholipids by capillary liquid chromatography/electrospray ionization mass spectrometry. 2000 J Mass Spectrom pmid:10972995
Emingil G et al. Levels of leukotriene B4 and platelet activating factor in gingival crevicular fluid in renal transplant patients receiving cyclosporine A. 2000 J. Periodontol. pmid:10695938
Clark GD et al. Neuronal platelet-activating factor receptor signal transduction involves a pertussis toxin-sensitive G-protein. 2000 Neurochem. Res. pmid:10905621
Wang JH and Sun GY Platelet activating factor (PAF) antagonists on cytokine induction of iNOS and sPLA2 in immortalized astrocytes (DITNC). 2000 Neurochem. Res. pmid:10905622
Baker RR Lipid acetylation reactions and the metabolism of platelet-activating factor. 2000 Neurochem. Res. pmid:10905630
Francescangeli E et al. Properties and regulation of microsomal PAF-synthesizing enzymes in rat brain cortex. 2000 Neurochem. Res. pmid:10905633
Viswanath M et al. Reduction of hypoxic-ischemic brain swelling in the neonatal rat with PAF antagonist WEB 2170: lack of long-term protection. 2000 Pediatr. Res. pmid:10879808
Burgermeister E et al. Inhibition of cytosolic phospholipase A(2) attenuates activation of mitogen-activated protein kinases in human monocytic cells. 2000 Eur. J. Pharmacol. pmid:10675727
Zhu W et al. Effects of platelet activating factor antagonist (BN50739) on gut mucosal injury in acute severe pancreatitis in pigs. 2000 Chin. Med. J. pmid:11776064
Xu H et al. Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome. 2000 Am. J. Kidney Dis. pmid:10873870