Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Zhu X et al. | A surrogate method for assessment of beta(2)-integrin-dependent adhesion of human eosinophils to ICAM-1. | 2000 | J. Immunol. Methods | pmid:10854610 |
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| Nakajima T et al. | Phospholipase A2-mediated superoxide production of murine peritoneal macrophages induced by chrysotile stimulation. | 2000 | Int. J. Biochem. Cell Biol. | pmid:10856708 |
| Lee YM et al. | Platelet-activating factor contributes to acute lung leak in rats given interleukin-1 intratracheally. | 2000 | Am. J. Physiol. Lung Cell Mol. Physiol. | pmid:10893205 |
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| Turner PJ et al. | Involvement of kinins in hyperresponsiveness induced by platelet activating factor in the human nasal airway. | 2000 | Br. J. Pharmacol. | pmid:10711351 |
| Maruoka S et al. | PAF-induced RANTES production by human airway smooth muscle cells requires both p38 MAP kinase and Erk. | 2000 | Am. J. Respir. Crit. Care Med. | pmid:10712344 |
| McClenahan DJ et al. | Role of platelet-activating factor in alveolar septal injury associated with experimentally induced pneumonic pasteurellosis in calves. | 2000 | Am. J. Vet. Res. | pmid:10714514 |
| Yamakawa Y et al. | Interaction of platelet activating factor, reactive oxygen species generated by xanthine oxidase, and leukocytes in the generation of hepatic injury after shock/resuscitation. | 2000 | Ann. Surg. | pmid:10714632 |
| Takada Y et al. | Improvement of allograft viability with organs procured from non-heart-beating donors in porcine liver transplantation. | 2000 | Transplant. Proc. | pmid:10715416 |
| Yildirim G et al. | Effects of platelet-activating factor and hyperbaric oxygenation on antioxidant defense and duodenal contractility. | 2000 | Undersea Hyperb Med | pmid:11191161 |
| Keularts IM et al. | alpha(2A)-adrenergic receptor stimulation potentiates calcium release in platelets by modulating cAMP levels. | 2000 | J. Biol. Chem. | pmid:10636873 |
| Tong N et al. | Neuronal fractalkine expression in HIV-1 encephalitis: roles for macrophage recruitment and neuroprotection in the central nervous system. | 2000 | J. Immunol. | pmid:10640747 |
| Clavijo LC et al. | Platelet-activating factor and bacteremia-induced pulmonary hypertension. | 2000 | J. Surg. Res. | pmid:10644485 |
| Owaki T et al. | Endothelial cells potentiate phagocytic killing by macrophages via platelet-activating factor release. | 2000 | Am. J. Physiol. Heart Circ. Physiol. | pmid:10644608 |
| Ibe BO et al. | Platelet activating factor acetylhydrolase activity in lamb lungs is up-regulated in the immediate newborn period. | 2000 | Mol. Genet. Metab. | pmid:10655157 |
| Modschiedler K et al. | Dapsone and colchicine inhibit adhesion of neutrophilic granulocytes to epidermal sections. | 2000 | Arch. Dermatol. Res. | pmid:10664013 |
| Martin-Chouly CA et al. | Modulation of PAF production by incorporation of arachidonic acid and eicosapentaenoic acid in phospholipids of human leukemic monocyte-like cells THP-1. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:10751643 |
| Tokumura A et al. | Platelet-activating factor (PAF)-like oxidized phospholipids: relevance to atherosclerosis. | 2000 | Biofactors | pmid:11237195 |
| Tan XD et al. | Platelet-activating factor increases mucosal permeability in rat intestine via tyrosine phosphorylation of E-cadherin. | 2000 | Br. J. Pharmacol. | pmid:10742310 |
| Wiese A et al. | Structure-dependent effects of glucose-containing analogs of platelet activating factor (PAF) on membrane integrity. | 2000 | Biol. Chem. | pmid:10746745 |
| Howard KM and Olson MS | The expression and localization of plasma platelet-activating factor acetylhydrolase in endotoxemic rats. | 2000 | J. Biol. Chem. | pmid:10748027 |
| Yamada Y et al. | Correlations between plasma platelet-activating factor acetylhydrolase (PAF-AH) activity and PAF-AH genotype, age, and atherosclerosis in a Japanese population. | 2000 | Atherosclerosis | pmid:10781653 |
| Smith J et al. | Differences in gene density on chicken macrochromosomes and microchromosomes. | 2000 | Anim. Genet. | pmid:10782207 |
| Friedman E et al. | Effect of hydrocortisone on platelet activating factor induced lung edema in isolated rabbit lungs. | 2000 | Respir Physiol | pmid:10786645 |
| Yoshimatsu Y et al. | Platelet-activating factor-induced intracellular calcium waves in human uterine myometrial cells. | 2000 | Eur. J. Obstet. Gynecol. Reprod. Biol. | pmid:11074135 |
| Walther A et al. | Role of platelet-activating factor in leukocyte-independent plasma extravasation and mast cell activation during endotoxemia. | 2000 | J. Surg. Res. | pmid:11027469 |
| Ciesla DJ et al. | Hypertonic saline inhibits neutrophil (PMN) priming via attenuation of p38 MAPK signaling. | 2000 | Shock | pmid:11028541 |
| De Geest B et al. | Effect of overexpression of human apo A-I in C57BL/6 and C57BL/6 apo E-deficient mice on 2 lipoprotein-associated enzymes, platelet-activating factor acetylhydrolase and paraoxonase. Comparison of adenovirus-mediated human apo A-I gene transfer and human apo A-I transgenesis. | 2000 | Arterioscler. Thromb. Vasc. Biol. | pmid:11031226 |
| McLarnon JG et al. | Anion channels modulate store-operated calcium influx in human microglia. | 2000 | Cell Calcium | pmid:11032781 |
| Fraga AG et al. | Synthesis and pharmacological evaluation of novel heterotricyclic acylhydrazone derivatives, designed as PAF antagonists. | 2000 | Eur J Pharm Sci | pmid:11033071 |
| Choi SY et al. | Capsaicin inhibits platelet-activating factor-induced cytosolic Ca2+ rise and superoxide production. | 2000 | J. Immunol. | pmid:11034409 |
| Shibata K et al. | Mediation by platelet-activating factor of 12-hydroxyeicosatetraenoic acid-induced cytosolic free calcium concentration elevation in neutrophils. | 2000 | Prostaglandins Other Lipid Mediat. | pmid:11060901 |
| Durán WN et al. | Stimulation of NO production and of eNOS phosphorylation in the microcirculation in vivo. | 2000 | Microvasc. Res. | pmid:10964584 |
| Wereszczynska-Siemiatkowska U et al. | Lysosomal activity of pulmonary alveolar macrophages in acute experimental pancreatitis in rats with reference to positive PAF-antagonist (BN 52021) effect. | 2000 | Exp. Toxicol. Pathol. | pmid:10965985 |
| Prescott SM et al. | Platelet-activating factor and related lipid mediators. | 2000 | Annu. Rev. Biochem. | pmid:10966465 |
| Kim JD et al. | Platelet activating factor acetylhydrolase decreases lung reperfusion injury. | 2000 | Ann. Thorac. Surg. | pmid:10969656 |
| Suzuki T et al. | Thromboxane A(2)-mediated Cl(-) secretion induced by platelet-activating factor in isolated rat colon. | 2000 | Eur. J. Pharmacol. | pmid:10988347 |
| Kallan NC and Halcomb RL | Synthesis of the ring system of phomactin D using a Suzuki macrocyclization. | 2000 | Org. Lett. | pmid:10990428 |
| Turner PJ et al. | Induction by inhibitors of nitric oxide synthase of hyperresponsiveness in the human nasal airway. | 2000 | Br. J. Pharmacol. | pmid:10991932 |
| Gastaldello K et al. | Role of complement and platelet-activating factor in the stimulation of phagocytosis and reactive oxygen species production during haemodialysis. | 2000 | Nephrol. Dial. Transplant. | pmid:11007834 |
| Wratten ML et al. | Hemolipodialysis attenuates oxidative stress and removes hydrophobic toxins. | 2000 | Artif Organs | pmid:11012537 |
| Clark WF et al. | A novel treatment for lupus nephritis: lignan precursor derived from flax. | 2000 | Lupus | pmid:10981647 |
| Klabunde RE and Anderson DE | Obligatory role of nitric oxide in platelet-activating factor-induced microvascular leakage. | 2000 | Eur. J. Pharmacol. | pmid:10996604 |
| Nieswandt B et al. | Identification of critical antigen-specific mechanisms in the development of immune thrombocytopenic purpura in mice. | 2000 | Blood | pmid:11001906 |
| Guan Z et al. | [Role of interleukin-6 and platelet-activating factor in delaying neutrophil apoptosis]. | 2000 | Wei Sheng Yan Jiu | pmid:12725051 |
| Montrucchio G et al. | Role of platelet-activating factor in cardiovascular pathophysiology. | 2000 | Physiol. Rev. | pmid:11015622 |
| Zhu W et al. | Effects of platelet activating factor antagonist (BN50739) on gut mucosal injury in acute severe pancreatitis in pigs. | 2000 | Chin. Med. J. | pmid:11776064 |
| Wagner F et al. | Ether lipids in the cell membrane of Mycoplasma fermentans. | 2000 | Eur. J. Biochem. | pmid:11012682 |
| Roudebush WE and Purnell ET | Platelet-activating factor content in human spermatozoa and pregnancy outcome. | 2000 | Fertil. Steril. | pmid:10927041 |
| Matsunaga Y et al. | Regulation of lymphocyte proliferation by eosinophils via chymotrypsin-like protease activity and adhesion molecule interaction. | 2000 | Br. J. Pharmacol. | pmid:10928955 |
| Capasso R et al. | Preventive effect of eugenol on PAF and ethanol-induced gastric mucosal damage. | 2000 | Fitoterapia | pmid:10930724 |
| Xu H et al. | Platelet-activating factor acetylhydrolase gene mutation in Japanese children with Escherichia coli O157-associated hemolytic uremic syndrome. | 2000 | Am. J. Kidney Dis. | pmid:10873870 |
| Cruzado JM et al. | Effect of human natural xenoantibody depletion and complement inactivation on early pig kidney function. | 1999 May-Jun | Exp. Nephrol. | pmid:10352362 |
| Wang Y et al. | Increased neutrophil-endothelial adhesion induced by placental factors is mediated by platelet-activating factor in preeclampsia. | 1999 May-Jun | J. Soc. Gynecol. Investig. | pmid:10376269 |
| Foitzik T et al. | Therapy for microcirculatory disorders in severe acute pancreatitis: effectiveness of platelet-activating factor receptor blockade vs. endothelin receptor blockade. | 1999 May-Jun | J. Gastrointest. Surg. | pmid:10481117 |
| Klettke U et al. | Platelet-activating factor inhibits ciliary beat frequency of human bronchial epithelial cells. | 1999 Mar-Apr | Allergy Asthma Proc | pmid:10209689 |
| Poveshchenko AF and Kozlov VA | [The effect of platelet-activating factor and its antagonist--BN 52021--on immune reactions in vivo in mice and in vitro]. | 1999 Jul-Aug | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:10852052 |
| Hocke M et al. | Platelet activating factor in stool from patients with ulcerative colitis and Crohn's disease. | 1999 Jul-Aug | Hepatogastroenterology | pmid:10521992 |
| Cijevschi I and Cijevschi D | [Ocular immunopathological characteristics and the involvement of the platelet-aggregation factor and the anti-PAF at the level of the eye]. | 1999 Jan-Jun | Rev Med Chir Soc Med Nat Iasi | pmid:10756889 |
| Zardini DM and Tschirhart EJ | [Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion]. | 1999 Jan-Feb | Therapie | pmid:10216433 |
| Sakaguchi T et al. | Acute portal hypertension increases ileal vulnerability to platelet-activating factor in rats. | 1999 | J. Surg. Res. | pmid:10452877 |
| Dervenis C et al. | Diagnosis, objective assessment of severity, and management of acute pancreatitis. Santorini consensus conference. | 1999 | Int. J. Pancreatol. | pmid:10453421 |
| Nikbakht-Sangari M et al. | Platelet-activating factor plays a role in the mechanism of major histocompatibility complex in T lymphocytes. | 1999 | Immunol. Invest. | pmid:10454000 |
| Subbanagounder G et al. | Evidence that phospholipid oxidation products and/or platelet-activating factor play an important role in early atherogenesis : in vitro and In vivo inhibition by WEB 2086. | 1999 | Circ. Res. | pmid:10455059 |
| Parrish PR and Larson DF | Pharmacological effect of nitroprusside on platelet aggregation. | 1999 | J Extra Corpor Technol | pmid:10915472 |
| Kavakli K et al. | Plasma platelet-activating factor (PAF) levels and desmopressin response in children with hemophilia A and von Willebrand's disease. | 1999 | Thromb. Haemost. | pmid:10235463 |
| Mariano F et al. | Production of platelet-activating factor in patients with sepsis-associated acute renal failure. | 1999 | Nephrol. Dial. Transplant. | pmid:10344354 |
| Snyder F | The ether lipid trail: a historical perspective. | 1999 | Biochim. Biophys. Acta | pmid:9989259 |
| Alvi SA et al. | Corticotrophin-releasing hormone and platelet-activating factor induce transcription of the type-2 cyclo-oxygenase gene in human fetal membranes. | 1999 | Mol. Hum. Reprod. | pmid:10338371 |
| Aliberti JC et al. | Platelet-activating factor induces nitric oxide synthesis in Trypanosoma cruzi-infected macrophages and mediates resistance to parasite infection in mice. | 1999 | Infect. Immun. | pmid:10338485 |
| Yoshimura T et al. | Estrogen replacement therapy decreases platelet-activating factor-acetylhydrolase activity in post-menopausal women. | 1999 | Maturitas | pmid:10340285 |
| McNulty CA et al. | Characterization of the integrin and activation steps mediating human eosinophil and neutrophil adhesion to chronically inflamed airway endothelium. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10340944 |
| Yu R et al. | Studies on the callus cultures of Ginkgo biloba and its metabolites-ginkgolides. | 1999 | Chin. J. Biotechnol. | pmid:10668135 |
| Nasu K et al. | Platelet-activating factor stimulates cytokine production by human endometrial stromal cells. | 1999 | Mol. Hum. Reprod. | pmid:10341002 |
| Gelbard HA | Neuroprotective strategies for HIV-1-associated neurologic disease. | 1999 | Ann. N. Y. Acad. Sci. | pmid:10668436 |
| Rainsford KD | Inhibition by leukotriene inhibitors, and calcium and platelet-activating factor antagonists, of acute gastric and intestinal damage in arthritic rats and in cholinomimetic-treated mice. | 1999 | J. Pharm. Pharmacol. | pmid:10344635 |
| Callea L et al. | Platelet activating factor is elevated in cerebral spinal fluid and plasma of patients with relapsing-remitting multiple sclerosis. | 1999 | J. Neuroimmunol. | pmid:10376955 |
| McNeil RS et al. | Neuronal cytoskeletal alterations evoked by a platelet-activating factor (PAF) analogue. | 1999 | Cell Motil. Cytoskeleton | pmid:10379835 |
| Tamaoki J et al. | Effect of azelastine on platelet-activating factor-induced microvascular leakage in rat airways. | 1999 | Am. J. Physiol. | pmid:9950898 |
| Hayani KC et al. | Impaired phagocyte oxidative capacity in human immunodeficiency virus-infected children. | 1999 | J. Infect. Dis. | pmid:9952364 |
| Falk S et al. | Quinolines attenuate PAF-induced pulmonary pressor responses and edema formation. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10556149 |
| Lauener RW et al. | A role for phosphatidylinositol 3-kinase in platelet aggregation in response to low, but not high, concentrations of PAF or thrombin. | 1999 | Biochim. Biophys. Acta | pmid:10559473 |
| Fuentes E et al. | Lysophospholipids trigger calcium signals but not DNA synthesis in cortical astrocytes. | 1999 | Glia | pmid:10559786 |
| Ozaki N et al. | Mechanosensitive properties of gastric vagal afferent fibers in the rat. | 1999 | J. Neurophysiol. | pmid:10561400 |
| Berger A et al. | Dioleylphosphatidylglycerol inhibits the expression of type II phospholipase A2 in macrophages. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:9927381 |
| Flickinger BD and Olson MS | Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. | 1999 | Am. J. Pathol. | pmid:10329588 |
| Mori N et al. | Ischemia-reperfusion induced microvascular responses in LDL-receptor -/- mice. | 1999 | Am. J. Physiol. | pmid:10330250 |
| Denizot Y et al. | Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? | 1999 | Cytokine | pmid:10328869 |
| Held HD et al. | Characterization of airway and vascular responses in murine lungs. | 1999 | Br. J. Pharmacol. | pmid:10205008 |
| Hüseyinov A et al. | Increased gastric production of platelet-activating factor, leukotriene-B4, and tumor necrosis factor-alpha in children with Helicobacter pylori infection. | 1999 | Dig. Dis. Sci. | pmid:10219821 |
| Bussolati B et al. | Interleukin-12 is synthesized by mesangial cells and stimulates platelet-activating factor synthesis, cytoskeletal reorganization, and cell shape change. | 1999 | Am. J. Pathol. | pmid:10027419 |
| Kim KA et al. | Pinusolide from the leaves of Biota orientalis as potent platelet activating factor antagonist. | 1999 | Planta Med. | pmid:10083843 |
| Karasawa K et al. | Purification and characterization from rat kidney membranes of a novel platelet-activating factor (PAF)-dependent transacetylase that catalyzes the hydrolysis of PAF, formation of PAF analogs, and C2-ceramide. | 1999 | J. Biol. Chem. | pmid:10085103 |
| Zallen G et al. | Postinjury suppression of human neutrophil cytokine production results from the stabilization of inhibitory kappaB. | 1999 | Shock | pmid:10030791 |
| Miyao Y et al. | Role of cytokines and adhesion molecules in ischemia and reperfusion in patients with acute myocardial infarction. | 1999 | Jpn. Circ. J. | pmid:10943615 |
| Kaminski JJ et al. | Conformational considerations in the design of dual antagonists of platelet-activating factor (PAF) and histamine. | 1999 | Bioorg. Med. Chem. | pmid:10465415 |
| Conroy DM and Sirois P | Early bronchial hyperresponsiveness following injection of sephadex beads in the guinea pig: involvement of platelet activating factor and thromboxane A2. | 1999 | Inflammation | pmid:10466580 |
| Ho YS et al. | Probing the substrate specificity of the intracellular brain platelet-activating factor acetylhydrolase. | 1999 | Protein Eng. | pmid:10469831 |
| Denham W and Norman J | The potential role of therapeutic cytokine manipulation in acute pancreatitis. | 1999 | Surg. Clin. North Am. | pmid:10470326 |