Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Van de Weerdt ML et al. | Ketoprofen and phenylbutazone attenuation of PAF-induced lung inflammation in calves. | 1999 | Vet. J. | pmid:10030127 |
| Yaffe MB et al. | Priming of the neutrophil respiratory burst is species-dependent and involves MAP kinase activation. | 1999 | Surgery | pmid:10455891 |
| Zardini DM et al. | Release of O2- by human umbilical cord blood-derived eosinophils: role of intra- and extracellular calcium. | 1999 | Cell Calcium | pmid:10463102 |
| Qu XW et al. | Type I nitric oxide synthase (NOS) is the predominant NOS in rat small intestine. Regulation by platelet-activating factor. | 1999 | Biochim. Biophys. Acta | pmid:10446403 |
| Alvi SA et al. | The production of interleukin-1beta from human fetal membranes is not obligatory for increased prostaglandin output. | 1999 | Immunology | pmid:10447739 |
| Wang H et al. | Platelet-activating factor receptor mRNA is localized in eosinophils and epithelial cells in rat small intestine: regulation by dexamethasone and gut flora. | 1999 | Immunology | pmid:10447766 |
| Birk-Sørensen L et al. | Platelet activating factor antagonism in pure skin flaps exposed to ischaemia-reperfusion injury. | 1999 | Scand J Plast Reconstr Surg Hand Surg | pmid:10450571 |
| Shen ZQ et al. | Effect of protopine on cytosolic Ca2+ in rabbit platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10452120 |
| Bandeira-Melo C et al. | Suppressive effect of distinct bradykinin B2 receptor antagonist on allergen-evoked exudation and leukocyte infiltration in sensitized rats. | 1999 | Br. J. Pharmacol. | pmid:10385228 |
| Tremblay G | BN 52021 decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. | 1999 | Mediators Inflamm. | pmid:10704058 |
| Fujii E et al. | Microvascular permeability change induced by platelet-activating factor is impaired in diabetic mice. | 1999 | Microvasc. Res. | pmid:10388605 |
| Bocheński J et al. | Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats. | 1999 | J. Physiol. Pharmacol. | pmid:10424723 |
| Lo EJ et al. | Bradykinin-induced neurogenic migration of neutrophils into the rat knee joint. | 1999 | Neuroreport | pmid:10716216 |
| Asano K et al. | Cellular source(s) of platelet-activating-factor acetylhydrolase activity in plasma. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425216 |
| Chen C and Bazan NG | Platelet-activating factor inhibits ionotropic GABA receptor activity in cultured hippocampal neurons. | 1999 | Neuroreport | pmid:10716218 |
| Fu Y and Hu YM | Prophylactic effects of tetramethyl pyrazine on mice with endotoxemia and its relationship with platelet-activating factor. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10678147 |
| McCall MR et al. | Dissociable and nondissociable forms of platelet-activating factor acetylhydrolase in human plasma LDL: implications for LDL oxidative susceptibility. | 1999 | Biochim. Biophys. Acta | pmid:9931415 |
| Cepinskas G et al. | PAF-induced elastase-dependent neutrophil transendothelial migration is associated with the mobilization of elastase to the neutrophil surface and localization to the migrating front. | 1999 | J. Cell. Sci. | pmid:10341212 |
| Ohshige A et al. | Increased platelet-activating factor-acetylhydrolase activity in the umbilical venous plasma of growth-restricted fetuses. | 1999 | Obstet Gynecol | pmid:9932551 |
| Calcerrada MC et al. | Platelet-activating factor stimulation of p125(FAK) and p130(Cas) tyrosine phosphorylation in brain. | 1999 | Brain Res. | pmid:10415383 |
| Lee LW et al. | Triflavin potentiates the antiplatelet activity of platelet activating factor receptor antagonist on activated neutrophil-induced platelet aggregation. | 1999 | Eur. J. Pharmacol. | pmid:9932729 |
| M'Rabet L et al. | Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils. | 1999 | J. Biol. Chem. | pmid:10419502 |
| Geijsen N et al. | Regulation of p21rac activation in human neutrophils. | 1999 | Blood | pmid:10419906 |
| Shan L et al. | Platelet-activating factor increases the expression of metalloproteinase-9 in human bronchial epithelial cells. | 1999 | Eur. J. Pharmacol. | pmid:10422651 |
| Harris NR et al. | Influence of arteriovenular pairing on PAF-induced capillary filtration. | 1999 | Am. J. Physiol. | pmid:9887023 |
| Wang X et al. | Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis. | 1999 | Int. J. Pancreatol. | pmid:10211421 |
| Longphre M et al. | Ozone-induced pulmonary inflammation and epithelial proliferation are partially mediated by PAF. | 1999 | J. Appl. Physiol. | pmid:9887149 |
| Nagahata Y et al. | Role of platelet activating factor on severity of ischemic colitis. | 1999 | Dis. Colon Rectum | pmid:10211499 |
| Olszanecki R and Chłopicki S | Endotoxaemia in rats: role of NO, PAF and TXA2 in pulmonary neutrophil sequestration and hyperlactataemia. | 1999 | J. Physiol. Pharmacol. | pmid:10574473 |
| Van de Weerdt ML et al. | Role of the cholinergic pathway in mediating platelet-activating factor-induced pulmonary dysfunctions in unsedated calves. | 1999 | Zentralbl Veterinarmed A | pmid:10216447 |
| Nagai H et al. | Effect of overproduction of interleukin 5 on dinitrofluorobenzene-induced allergic cutaneous response in mice. | 1999 | J. Pharmacol. Exp. Ther. | pmid:9862751 |
| Kuśnierz B and Naskalski JW | [Mediators of the inflammatory response in the course of acute pancreatitis]. | 1999 | Prz. Lek. | pmid:10575924 |
| Grassi S et al. | Platelet-activating factor and group I metabotropic glutamate receptors interact for full development and maintenance of long-term potentiation in the rat medial vestibular nuclei. | 1999 | Neuroscience | pmid:10579215 |
| Schmidt J et al. | Reduced basal and stimulated leukocyte adherence in tumor endothelium of experimental pancreatic cancer. | 1999 | Int. J. Pancreatol. | pmid:10732294 |
| Lee IS et al. | Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists. | 1999 | Biol. Pharm. Bull. | pmid:10220282 |
| Quinn JV and Slotman GJ | Platelet-activating factor and arachidonic acid metabolites mediate tumor necrosis factor and eicosanoid kinetics and cardiopulmonary dysfunction during bacteremic shock. | 1999 | Crit. Care Med. | pmid:10579269 |
| Forte TM et al. | Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. | 1999 | J. Lipid Res. | pmid:10393212 |
| Goldfarb R | Investigations into the polydeterminant nature of sepsis. | 1999 | Crit. Care Med. | pmid:10579296 |
| Subramanian VS et al. | Role of lecithin-cholesterol acyltransferase in the metabolism of oxidized phospholipids in plasma: studies with platelet-activating factor-acetyl hydrolase-deficient plasma. | 1999 | Biochim. Biophys. Acta | pmid:10395969 |
| Mizuki M et al. | Inhibition of eosinophil activation in bronchoalveolar lavage fluid from atopic asthmatics by Y-24180, an antagonist to platelet-activating factor. | 1999 | Life Sci. | pmid:10579457 |
| Shin BA et al. | Lyso-PAF analogues and lysophosphatidylcholines from the marine sponge Spirastrella abata as inhibitors of cholesterol biosynthesis. | 1999 | J. Nat. Prod. | pmid:10579872 |
| Rodrigues CO et al. | Platelet-activating factor induction of secreted phosphatase activity in Trypanosoma cruzi. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10581161 |
| Wu R et al. | Antibodies to platelet-activating factor are associated with borderline hypertension, early atherosclerosis and the metabolic syndrome. | 1999 | J. Intern. Med. | pmid:10583710 |
| Wechsung E and Houvenaghel A | Influence of platelet activating factor on gastrointestinal electrical activity and some haematological and clinical parameters in the conscious miniature pig. | 1999 | J. Vet. Pharmacol. Ther. | pmid:10597537 |
| Bosch RJ et al. | Effects of parathyroid hormone-related protein on human mesangial cells in culture. | 1999 | Am. J. Physiol. | pmid:10600786 |
| Wang MM et al. | In vivo stimulation of 12(S)-lipoxygenase in the rat skin by bradykinin and platelet activating factor: formation of 12(S)-HETE and hepoxilins, and actions on vascular permeability. | 1999 | Biochim. Biophys. Acta | pmid:9989266 |
| Deigner HP et al. | Novel reversible, irreversible and fluorescent inhibitors of platelet-activating factor acetylhydrolase as mechanistic probes. | 1999 | Atherosclerosis | pmid:10381281 |
| Kudolo GB and DeFronzo RA | Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410380 |
| Harrison KA et al. | Negative ion electrospray and tandem mass spectrometric analysis of platelet activating factor (PAF) (1-hexadecyl-2-acetyl-glycerophosphocholine). | 1999 | J Mass Spectrom | pmid:10226361 |
| Bastien Y et al. | Detection of functional platelet-activating factor receptors on human tonsillar B lymphocytes. | 1999 | J. Immunol. | pmid:10228030 |
| Amroyan E et al. | Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. | 1999 | Phytomedicine | pmid:10228608 |
| Han SJ et al. | Glucocorticoids prevent NF-kappaB activation by inhibiting the early release of platelet-activating factor in response to lipopolysaccharide. | 1999 | Eur. J. Immunol. | pmid:10229101 |
| Tool AT et al. | Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils. | 1999 | Biochem. J. | pmid:10229663 |
| Hirashima Y et al. | Deficient platelet-activating factor and related enzymes in hemimegalencephaly. | 1999 | Childs Nerv Syst | pmid:10230665 |
| Yamaguchi S et al. | Effects of Y-24180, a receptor antagonist to platelet-activating factor, on allergic cutaneous eosinophilia in mice. | 1999 | Life Sci. | pmid:10201647 |
| Wang X et al. | Inhibition of platelet-activating factor, intercellular adhesion molecule 1 and platelet endothelial cell adhesion molecule 1 reduces experimental pancreatitis-associated gut endothelial barrier dysfunction. | 1999 | Br J Surg | pmid:10201790 |
| Sawai H et al. | Function of the cloned putative neutral sphingomyelinase as lyso-platelet activating factor-phospholipase C. | 1999 | J. Biol. Chem. | pmid:10608884 |
| Calcerrada MC et al. | Glutamate release is involved in PAF-increased cyclic GMP levels in hippocampus. | 1999 | Biochem. Mol. Biol. Int. | pmid:10204090 |
| Michibayashi T | Interaction between platelet-aggregating response and vasoconstrictive response to platelet activating factor. | 1999 | J Smooth Muscle Res | pmid:10647808 |
| Brizzi MF et al. | Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism. | 1999 | Circ. Res. | pmid:10205146 |
| Torras J et al. | Long-term protective effect of UR-12670 after warm renal ischemia in uninephrectomized rats. | 1999 | Kidney Int. | pmid:10571788 |
| Grutters JC et al. | Asthma therapy modulates priming-associated blood eosinophil responsiveness in allergic asthmatics. | 1999 | Eur. Respir. J. | pmid:10573242 |
| Tekgül H et al. | Lymphocyte subsets and inflammatory mediators in patients with subacute sclerosing panencephalitis. | 1999 | J. Child Neurol. | pmid:10573462 |
| Hendrickson HS et al. | Intramolecularly quenched BODIPY-labeled phospholipid analogs in phospholipase A(2) and platelet-activating factor acetylhydrolase assays and in vivo fluorescence imaging. | 1999 | Anal. Biochem. | pmid:10585741 |
| Kitsiouli EI et al. | Differential determination of phospholipase A(2) and PAF-acetylhydrolase in biological fluids using fluorescent substrates. | 1999 | J. Lipid Res. | pmid:10588961 |
| Arbabi S et al. | Priming interleukin 8 production: role of platelet-activating factor and p38. | 1999 | Arch Surg | pmid:10593333 |
| Powell WS et al. | 5-oxo-6,8,11,14-eicosatetraenoic acid is a potent stimulator of L-selectin shedding, surface expression of CD11b, actin polymerization, and calcium mobilization in human eosinophils. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:9870930 |
| Tsai JJ and Wang TF | Different densities of human eosinophils respond differently to PAF and IL-5. | 1999 | J Microbiol Immunol Infect | pmid:11561566 |
| Okayama N et al. | Intracellular mechanisms of hydrogen peroxide-mediated neutrophil adherence to cultured human endothelial cells. | 1999 | Microvasc. Res. | pmid:10049654 |
| Satoh N et al. | Plasma platelet-activating factor acetylhydrolase deficiency in Japanese patients with asthma. | 1999 | Am. J. Respir. Crit. Care Med. | pmid:10051281 |
| Tokumura A et al. | Substrate specificity of lysophospholipase D which produces bioactive lysophosphatidic acids in rat plasma. | 1999 | Biochim. Biophys. Acta | pmid:10064906 |
| Takami M and Tsukada W | Effect of DP-1904, a thromboxane synthetase inhibitor, on antigen- and spasmogen-induced bronchoconstriction in rodents. | 1999 | Eur. J. Pharmacol. | pmid:10082207 |
| Liu Y et al. | [The role and significance of PAF in the early pulmonary injury following burns combined with endotoxemia in rats]. | 1999 | Zhonghua Zheng Xing Shao Shang Wai Ke Za Zhi | pmid:11501075 |
| Delong P et al. | Bacterial lipopolysaccharide induction of the prostaglandin G/H synthase 2 gene causes thromboxane-dependent pulmonary hypertension in rabbits. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10030848 |
| Mukherjee PK et al. | Glutamate receptor signaling interplay modulates stress-sensitive mitogen-activated protein kinases and neuronal cell death. | 1999 | J. Biol. Chem. | pmid:10037742 |
| Tsuchiya R et al. | Role of platelet activating factor in development of thrombocytopenia and neutropenia in dogs with endotoxemia. | 1999 | Am. J. Vet. Res. | pmid:10048555 |
| Merendino N et al. | Human intestinal epithelial cells express receptors for platelet-activating factor. | 1999 | Am. J. Physiol. | pmid:10516147 |
| Greenberg SG and Clark KE | Hemodynamic effects of platelet-activating factor in nonpregnant and pregnant sheep. | 1999 | Am. J. Physiol. | pmid:10516237 |
| Bernatchez PN et al. | Vascular endothelial growth factor effect on endothelial cell proliferation, migration, and platelet-activating factor synthesis is Flk-1-dependent. | 1999 | J. Biol. Chem. | pmid:10521504 |
| Sugiura T et al. | Occurrence of lysophosphatidic acid and its alkyl ether-linked analog in rat brain and comparison of their biological activities toward cultured neural cells. | 1999 | Biochim. Biophys. Acta | pmid:10521703 |
| Monteiro HS et al. | Glomerular effects of cholera toxin in isolated perfused rat kidney: a potential role for platelet activating factor. | 1999 | Pharmacol. Toxicol. | pmid:10522748 |
| Comellas A et al. | Effect of platelet activating factor (PAF) on pulmonary circulation in isolated rabbit lung. | 1999 | J. Physiol. Biochem. | pmid:10494654 |
| GamaleÄ IA et al. | [Post-receptor formation of active forms of oxygen in nonphagocytic cells]. | 1999 | Tsitologiia | pmid:10496012 |
| Dekkers PE et al. | Divergent roles of tumor necrosis factor and platelet-activating factor in endotoxin-induced release of monocyte chemoattractant protein 1 and macrophage inflammatory protein 1beta in chimpanzees. | 1999 | Infect. Immun. | pmid:10496934 |
| Tsuruta R et al. | Soluble vascular cell adhesion molecule (VCAM)-Fc fusion protein induces leukotriene C4 secretion in platelet-activating factor-stimulated eosinophils. | 1999 | J. Leukoc. Biol. | pmid:9886248 |
| Baker KE and Curtis MJ | Protection against ventricular fibrillation by the PAF antagonist, BN-50739, involves an ischaemia-selective mechanism. | 1999 | J. Cardiovasc. Pharmacol. | pmid:10470998 |
| Shah BH et al. | Inhibitory effect of curcumin, a food spice from turmeric, on platelet-activating factor- and arachidonic acid-mediated platelet aggregation through inhibition of thromboxane formation and Ca2+ signaling. | 1999 | Biochem. Pharmacol. | pmid:10484074 |
| Kültürsay N et al. | Platelet-activating factor concentrations in healthy and septic neonates. | 1999 | Eur. J. Pediatr. | pmid:10485307 |
| Koyama N and Ogawa Y | Elevated platelet activating factor in the tracheal aspirate at birth and signs of intra-uterine inflammation in infants with neonatal pulmonary emphysema. | 1999 | Eur. J. Pediatr. | pmid:10486094 |
| Piccolo MT et al. | Chemotactic mediator requirements in lung injury following skin burns in rats. | 1999 | Exp. Mol. Pathol. | pmid:10486240 |
| Blackstone MO | ICAM-1 in cerulein-induced pancreatitis. | 1999 | Gastroenterology | pmid:10490367 |
| Min JH et al. | Membrane-bound plasma platelet activating factor acetylhydrolase acts on substrate in the aqueous phase. | 1999 | Biochemistry | pmid:10504265 |
| Tiemann U et al. | Influence of inhibitors on increase in intracellular free calcium and proliferation induced by platelet-activating factor in bovine oviductal cells. | 1999 | J. Reprod. Fertil. | pmid:10505057 |
| Peplow PV | Regulation of platelet-activating factor (PAF) activity in human diseases by phospholipase A2 inhibitors, PAF acetylhydrolases, PAF receptor antagonists and free radical scavengers. | 1999 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:10509861 |
| Prescott SM et al. | Two of the usual suspects, platelet-activating factor and its receptor, implicated in acute lung injury. | 1999 | J. Clin. Invest. | pmid:10525039 |
| Nagase T et al. | Platelet-activating factor mediates acid-induced lung injury in genetically engineered mice. | 1999 | J. Clin. Invest. | pmid:10525045 |
| Wang X et al. | Platelet-activating factor induced Ca(2+) signaling in human microglia. | 1999 | Brain Res. | pmid:10526106 |
| Wang R et al. | [High performance thin layer chromatographic (HPTLC) determination of PAF in cerebrospinal fluid of patients with subarachnoid hemorrhage(SAH)]. | 1999 | Se Pu | pmid:12552702 |
| Kinlough-Rathbone RL et al. | Effects of cathepsin G pretreatment of platelets on their subsequent responses to aggregating agents. | 1999 | Thromb. Res. | pmid:10527409 |
| Vittimberga FJ et al. | Endotoxin fails to stimulate inositol triphosphate production in macrophages. | 1999 | Int. J. Surg. Investig. | pmid:11341611 |