| MeSH term | MeSH ID | Detail |
|---|---|---|
| Brain Hemorrhage, Traumatic | D020201 | 1 associated lipids |
| Dictyocaulus Infections | D004022 | 1 associated lipids |
| Migraine without Aura | D020326 | 1 associated lipids |
| Mouth, Edentulous | D009066 | 1 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Egg Hypersensitivity | D021181 | 1 associated lipids |
| Leukostasis | D018921 | 1 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Pulmonary Atelectasis | D001261 | 1 associated lipids |
| Neurologic Manifestations | D009461 | 1 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hasan AM et al. | Phosphoinositide 3-kinase gamma mediates chemotactic responses of human eosinophils to platelet-activating factor. | 2010 | Int. Immunopharmacol. | pmid:20685403 |
| Mrówczyńska L and Hägerstrand H | Platelet-activating factor interaction with the human erythrocyte membrane. | 2009 Sep-Oct | J. Biochem. Mol. Toxicol. | pmid:19827129 |
| Babayigit A et al. | Effects of Ginkgo biloba on airway histology in a mouse model of chronic asthma. | 2009 Mar-Apr | Allergy Asthma Proc | pmid:19118503 |
| Mann O et al. | Effect of platelet-activating factor antagonist WEB 2086 on microcirculatory disorders in acute experimental pancreatitis of graded severity. | 2009 | Pancreas | pmid:18695628 |
| Cook VL et al. | The effect of lidocaine on in vitro adhesion and migration of equine neutrophils. | 2009 | Vet. Immunol. Immunopathol. | pmid:19136156 |
| Liu SH et al. | [Effects of p38 mitogen-activated protein kinase in protection of carbon monoxide against lipopolysaccharide induced rat small intestine injury]. | 2009 | Zhongguo Ying Yong Sheng Li Xue Za Zhi | pmid:21189571 |
| Castro DP et al. | Physalin B inhibits Rhodnius prolixus hemocyte phagocytosis and microaggregation by the activation of endogenous PAF-acetyl hydrolase activities. | 2009 | J. Insect Physiol. | pmid:19232405 |
| Yao Y et al. | Ultraviolet B radiation generated platelet-activating factor receptor agonist formation involves EGF-R-mediated reactive oxygen species. | 2009 | J. Immunol. | pmid:19234179 |
| Shindou H and Shimizu T | [New development of lysophospholipid acyltransferases]. | 2009 | Tanpakushitsu Kakusan Koso | pmid:19205351 |
| McIntyre TM et al. | The emerging roles of PAF acetylhydrolase. | 2009 | J. Lipid Res. | pmid:18838739 |
| Liu J et al. | New vernocuminosides from the stem barks of Vernonia cumingiana Benth. | 2009 | Steroids | pmid:18840454 |
| Brooks AC et al. | Regulation of platelet activating factor-induced equine platelet activation by intracellular kinases. | 2009 | J. Vet. Pharmacol. Ther. | pmid:19290950 |
| Eckels PC et al. | Amantadine inhibits platelet-activating factor induced clathrin-mediated endocytosis in human neutrophils. | 2009 | Am. J. Physiol., Cell Physiol. | pmid:19295175 |
| Melnikova VO and Bar-Eli M | Inflammation and melanoma metastasis. | 2009 | Pigment Cell Melanoma Res | pmid:19368690 |
| Sánchez FA et al. | Internalization of eNOS and NO delivery to subcellular targets determine agonist-induced hyperpermeability. | 2009 | Proc. Natl. Acad. Sci. U.S.A. | pmid:19342481 |
| Marotta DM et al. | Mechanisms underlying the nociceptive responses induced by platelet-activating factor (PAF) in the rat paw. | 2009 | Biochem. Pharmacol. | pmid:19283893 |
| Yost CC et al. | Impaired neutrophil extracellular trap (NET) formation: a novel innate immune deficiency of human neonates. | 2009 | Blood | pmid:19221037 |
| Tsoupras AB et al. | The implication of platelet activating factor in cancer growth and metastasis: potent beneficial role of PAF-inhibitors and antioxidants. | 2009 | Infect Disord Drug Targets | pmid:19689381 |
| Cheng L et al. | A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice. | 2009 | Am. J. Physiol. Endocrinol. Metab. | pmid:19773578 |
| Wijman CA | Is platelet activity important in acute intracerebral hemorrhage? | 2009 | Neurocrit Care | pmid:19714496 |
| Baka S et al. | Treatment of sperm with platelet-activating factor does not improve intrauterine insemination outcome in unselected cases of mild male factor infertility: a prospective double-blind randomized crossover study. | 2009 | Urology | pmid:19716589 |
| Bao GQ and Ju AZ | [Signal pathways of eryptosis-review]. | 2009 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:19698269 |
| Shi B et al. | [Influence of intensive insulin therapy on the intestinal microcirculatory dysfunction in rats with sepsis]. | 2009 | Zhongguo Wei Zhong Bing Ji Jiu Yi Xue | pmid:19695175 |
| Ereso AQ et al. | Lipoxin a(4) attenuates microvascular fluid leak during inflammation. | 2009 | J. Surg. Res. | pmid:19524267 |
| Khodoun M et al. | Peanuts can contribute to anaphylactic shock by activating complement. | 2009 | J. Allergy Clin. Immunol. | pmid:19121857 |
| Plager DA et al. | Pimecrolimus reduces eosinophil activation associated with calcium mobilization. | 2009 | Int. Arch. Allergy Immunol. | pmid:19127068 |
| Severino DN et al. | Edematogenic activity of scorpion venoms from the Buthidae family and the role of platelet-activating factor and nitric oxide in paw edema induced by Tityus venoms. | 2009 | Inflammation | pmid:19096919 |
| Mukai K et al. | New insights into the roles for basophils in acute and chronic allergy. | 2009 | Allergol Int | pmid:19153532 |
| Eigenmann PA | Mechanisms of food allergy. | 2009 | Pediatr Allergy Immunol | pmid:19154253 |
| Knezevic II et al. | Tiam1 and Rac1 are required for platelet-activating factor-induced endothelial junctional disassembly and increase in vascular permeability. | 2009 | J. Biol. Chem. | pmid:19095647 |
| Rigat B et al. | GM2 activator protein inhibits platelet activating factor signaling in rats. | 2009 | Biochem. Biophys. Res. Commun. | pmid:19486886 |
| Liu SX et al. | Platelet-activating factor induces the processing of nuclear factor-kappaB p105 into p50, which mediates acute bowel injury in mice. | 2009 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:19460845 |
| Kovacova E et al. | General changes in hemostasis in gastric cancer. | 2009 | Bratisl Lek Listy | pmid:19507648 |
| Sharif NA et al. | Human conjunctival epithelial cell responses to platelet-activating factor (PAF): signal transduction and release of proinflammatory cytokines. | 2009 | Mol. Vis. | pmid:19513187 |
| Tang WZ et al. | Rearranged prenylated C6-C3 compounds and a highly oxygenated seco-prezizaane-type sesquiterpene from the stem bark of Illicium oligandrum. | 2009 | J. Nat. Prod. | pmid:19496609 |
| Hakim-Rad K et al. | Mast cells: makers and breakers of allergic inflammation. | 2009 | Curr Opin Allergy Clin Immunol | pmid:19550301 |
| Li Y et al. | Activation of a chloride channel by a trophic ligand is required for development of the mouse preimplantation embryo in vitro. | 2009 | Biol. Reprod. | pmid:19553604 |
| Deng Y et al. | Blood-brain barrier breakdown by PAF and protection by XQ-1H due to antagonism of PAF effects. | 2009 | Eur. J. Pharmacol. | pmid:19555682 |
| Edwards LJ and Constantinescu CS | Platelet activating factor/platelet activating factor receptor pathway as a potential therapeutic target in autoimmune diseases. | 2009 | Inflamm Allergy Drug Targets | pmid:19601878 |
| Camerer E et al. | Sphingosine-1-phosphate in the plasma compartment regulates basal and inflammation-induced vascular leak in mice. | 2009 | J. Clin. Invest. | pmid:19603543 |
| Xu J et al. | Platelet-activating factor-stimulated production of reactive oxygen species in ovarian granulosa cells from periovulatory follicles. | 2009 | Cytometry A | pmid:19565634 |
| Eggert D et al. | Development of a platelet-activating factor antagonist for HIV-1 associated neurocognitive disorders. | 2009 | J. Neuroimmunol. | pmid:19541372 |
| Di Leo E et al. | Treatment of acquired cold urticaria with rupatadine. | 2009 | Allergy | pmid:19392988 |
| Chang W et al. | Common pathways for activation of proinflammatory gene expression by G protein-coupled receptors in primary lung epithelial and endothelial cells. | 2009 | Exp. Lung Res. | pmid:19415549 |
| Mayerle J | A novel role for leucocytes in determining the severity of acute pancreatitis. | 2009 | Gut | pmid:19834113 |
| Yamamura K et al. | Intracellular protein phosphorylation in eosinophils and the functional relevance in cytokine production. | 2009 | Int. Arch. Allergy Immunol. | pmid:19494504 |
| Pantaler E and Lückhoff A | Inhibitors of TRP channels reveal stimulus-dependent differential activation of Ca2+ influx pathways in human neutrophil granulocytes. | 2009 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:19894037 |
| Dorfman AL et al. | The effect of oxygen and light on the structure and function of the neonatal rat retina. | 2009 | Doc Ophthalmol | pmid:18483821 |
| Keating FK and Schneider DJ | The influence of platelet activating factor on the effects of platelet agonists and antiplatelet agents in vitro. | 2009 | J. Thromb. Thrombolysis | pmid:18574670 |
| Zhang Q et al. | Involvement of platelet-activating factor in ultraviolet B-induced hyperalgesia. | 2009 | J. Invest. Dermatol. | pmid:18580961 |