Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Migraine without Aura D020326 1 associated lipids
Mouth, Edentulous D009066 1 associated lipids
Anthrax D000881 1 associated lipids
Egg Hypersensitivity D021181 1 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Leukostasis D018921 1 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Neurologic Manifestations D009461 1 associated lipids
Leukocyte-Adhesion Deficiency Syndrome D018370 1 associated lipids
Brain Hemorrhage, Traumatic D020201 1 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
Wang M et al. The Responses of Pulmonary and Systemic Circulation and Airway to Allergic Mediators in Anesthetized Rats. 2016 Biol. Pharm. Bull. pmid:27040628
Carretta MD et al. Butyric acid stimulates bovine neutrophil functions and potentiates the effect of platelet activating factor. 2016 Vet. Immunol. Immunopathol. pmid:27288853
Liu R et al. Pyruvate in oral rehydration salt improves hemodynamics, vasopermeability and survival after burns in dogs. 2016 Burns pmid:27130433
Grambow E et al. Differential effects of endogenous, phyto and synthetic cannabinoids on thrombogenesis and platelet activity. 2016 Biofactors pmid:27151562
Eleftheriou K et al. Comparative Experimental and Computational Study of Monoalkyl Chain Phosphatidylcholine-Containing Thermoresponsive Liposomes. 2016 J Phys Chem B pmid:27280363
Megson IL et al. Lipids and cardiovascular disease: where does dietary intervention sit alongside statin therapy? 2016 Food Funct pmid:27109548
Farbman KS and Michelson KA Anaphylaxis in children. 2016 Curr. Opin. Pediatr. pmid:26963947
Schauberger E et al. Lipid Mediators of Allergic Disease: Pathways, Treatments, and Emerging Therapeutic Targets. 2016 Curr Allergy Asthma Rep pmid:27333777
Wang JM and Chen J Damage of vascular endothelial barrier induced by explosive blast and its clinical significance. 2016 Chin. J. Traumatol. pmid:27321288
Nel JG et al. Pneumolysin Mediates Platelet Activation In Vitro. 2016 Lung pmid:27192991
Silva-Herdade AS et al. Erythrocyte deformability - A partner of the inflammatory response. 2016 Microvasc. Res. pmid:27142964
Quinn RA et al. Metabolomics of reef benthic interactions reveals a bioactive lipid involved in coral defence. 2016 Proc. Biol. Sci. pmid:27122568
Lecewicz M et al. Effects of the platelet-activating factor (PAF) on selected quality parameters of cryopreserved bull semen (AI) with reduced sperm motility. 2016 Pol J Vet Sci pmid:27096799
Damiani E and Ullrich SE Understanding the connection between platelet-activating factor, a UV-induced lipid mediator of inflammation, immune suppression and skin cancer. 2016 Prog. Lipid Res. pmid:27073146
Jacob SP et al. Lipopolysaccharide Cross-Tolerance Delays Platelet-Activating Factor-Induced Sudden Death in Swiss Albino Mice: Involvement of Cyclooxygenase in Cross-Tolerance. 2016 PLoS ONE pmid:27064683
Anandi VL et al. Platelet-activating factor promotes motility in breast cancer cells and disrupts non-transformed breast acinar structures. 2016 Oncol. Rep. pmid:26531049
Wright NR et al. Purulent Pericarditis and Abscessed Myocardium with Acute Myocardial Infarction. 2016 Am. J. Med. pmid:26524710
Yan W et al. BN52021 protects rat cardiomyocyte from doxorubicin induced cardiotoxicity. 2015 Int J Clin Exp Pathol pmid:25973059
Kim YH et al. SIRT1 attenuates PAF-induced MMP-2 production via down-regulation of PAF receptor expression in vascular smooth muscle cells. 2015 Vascul. Pharmacol. pmid:25967595
Armant DR Intracellular Ca2+ signaling and preimplantation development. 2015 Adv. Exp. Med. Biol. pmid:25956298
Puebla-Osorio N et al. Platelet-activating factor induces cell cycle arrest and disrupts the DNA damage response in mast cells. 2015 Cell Death Dis pmid:25950475
Sahu RP et al. Systemic chemotherapy is modulated by platelet-activating factor-receptor agonists. 2015 Mediators Inflamm. pmid:25922565
Shida-Sakazume T et al. Lysophosphatidylcholine acyltransferase1 overexpression promotes oral squamous cell carcinoma progression via enhanced biosynthesis of platelet-activating factor. 2015 PLoS ONE pmid:25803864
Laidlaw TM and Boyce JA Platelets in patients with aspirin-exacerbated respiratory disease. 2015 J. Allergy Clin. Immunol. pmid:26051947
Lautenschläger I et al. Quinidine, but not eicosanoid antagonists or dexamethasone, protect the gut from platelet activating factor-induced vasoconstriction, edema and paralysis. 2015 PLoS ONE pmid:25793535
Bate C and Williams A α-Synuclein-induced synapse damage in cultured neurons is mediated by cholesterol-sensitive activation of cytoplasmic phospholipase A2. 2015 Biomolecules pmid:25761116
Sahu RP Expression of the platelet-activating factor receptor enhances benzyl isothiocyanate-induced apoptosis in murine and human melanoma cells. 2015 Mol Med Rep pmid:25695262
Reznichenko A and Korstanje R The role of platelet-activating factor in mesangial pathophysiology. 2015 Am. J. Pathol. pmid:25655028
Jeewandara C et al. Platelet activating factor contributes to vascular leak in acute dengue infection. 2015 PLoS Negl Trop Dis pmid:25646838
Valli A et al. Hypoxia induces a lipogenic cancer cell phenotype via HIF1α-dependent and -independent pathways. 2015 Oncotarget pmid:25605240
Yamaguchi M et al. A platelet-activating factor (PAF) receptor deficiency exacerbates diet-induced obesity but PAF/PAF receptor signaling does not contribute to the development of obesity-induced chronic inflammation. 2015 Biochem. Pharmacol. pmid:25577975
Johnson M et al. Levocetirizine and rupatadine in chronic idiopathic urticaria. 2015 Int. J. Dermatol. pmid:25521304
Kim H et al. Higher plasma platelet-activating factor levels are associated with increased risk of vertebral fracture and lower bone mineral density in postmenopausal women. 2015 J. Bone Miner. Metab. pmid:25501698
Kooijman S et al. Hematopoietic α7 nicotinic acetylcholine receptor deficiency increases inflammation and platelet activation status, but does not aggravate atherosclerosis. 2015 J. Thromb. Haemost. pmid:25345495
Jasamai M et al. Molecular docking study on platelet-activating factor antagonistic activity of bioactive compounds isolated from Guttiferae and Ardisia species. 2015 Nat. Prod. Res. pmid:25332053
Huang JF et al. Protective effect of high concentration of BN52021 on retinal contusion in cat eyes. 2015 BMC Ophthalmol pmid:25956877
Sun L et al. PAF receptor antagonist Ginkgolide B inhibits tumourigenesis and angiogenesis in colitis-associated cancer. 2015 Int J Clin Exp Pathol pmid:25755731
Wang Y et al. Aqueous extract of Rabdosia rubescens leaves: forming nanoparticles, targeting P-selectin, and inhibiting thrombosis. 2015 Int J Nanomedicine pmid:26604756
Ohshima N et al. New members of the mammalian glycerophosphodiester phosphodiesterase family: GDE4 and GDE7 produce lysophosphatidic acid by lysophospholipase D activity. 2015 J. Biol. Chem. pmid:25528375
van Doorn R and de Gruijl F Chromatin Modifications and Mast Cell Migration in UV-Induced Immunosuppression, an Epigenetic Piece of The Puzzle. 2015 J. Invest. Dermatol. pmid:26569583
Pałgan K and Bartuzi Z Platelet activating factor in allergies. 2015 Int J Immunopathol Pharmacol pmid:26486136
Hergott CB et al. Bacterial exploitation of phosphorylcholine mimicry suppresses inflammation to promote airway infection. 2015 J. Clin. Invest. pmid:26426079
Speciani AF and Piuri G Measuring Biomarkers for an Innovative Personal Food Profile. 2015 J Am Coll Nutr pmid:26400432
Pei HX et al. Ginkgolide B Reduces the Degradation of Membrane Phospholipids to Prevent Ischemia/Reperfusion Myocardial Injury in Rats. 2015 Pharmacology pmid:26382046
Tiniakou I et al. Natural human apoA-I mutations L141RPisa and L159RFIN alter HDL structure and functionality and promote atherosclerosis development in mice. 2015 Atherosclerosis pmid:26363436
Vlachogianni IC et al. Platelet Activating Factor (PAF) biosynthesis is inhibited by phenolic compounds in U-937 cells under inflammatory conditions. 2015 Prostaglandins Other Lipid Mediat. pmid:26358846
Sato A et al. Angiotensin peptides attenuate platelet-activating factor-induced inflammatory activity in rats. 2015 Peptides pmid:26348270
Gao L et al. Steroid receptor coactivators 1 and 2 mediate fetal-to-maternal signaling that initiates parturition. 2015 J. Clin. Invest. pmid:26098214
Gill P et al. Platelets in the immune response: Revisiting platelet-activating factor in anaphylaxis. 2015 J. Allergy Clin. Immunol. pmid:26051949
de Oliveira MC et al. Platelet-activating factor modulates fat storage in the liver induced by a high-refined carbohydrate-containing diet. 2015 J. Nutr. Biochem. pmid:26013469