| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Prunieras M | Melanocytes, melanogenesis, and inflammation. | 1986 | Int. J. Dermatol. | pmid:2433237 |
| Simmet T and Peskar BA | Eicosanoids and the coronary circulation. | 1986 | Rev. Physiol. Biochem. Pharmacol. | pmid:3520775 |
| Moudgil GC | Anaesthesia and allergic drug reactions. | 1986 | Can Anaesth Soc J | pmid:3521800 |
| Imura Y et al. | Possible role of platelet activating factor (PAF) in disseminated intravascular coagulation (DIC), evidenced by use of a PAF antagonist, CV-3988. | 1986 | Life Sci. | pmid:3741541 |
| Foegh ML et al. | Prolongation of cardiac allograft survival with BN 52021, a specific antagonist of platelet-activating factor. | 1986 | Transplantation | pmid:3523888 |
| Kertscher HP and Ostermann G | [Synthesis and thrombocyte aggregating action of stereoisomers of PAF-acether]. | 1986 | Pharmazie | pmid:3786385 |
| Rampart M and Williams TJ | Polymorphonuclear leukocyte-dependent plasma leakage in the rabbit skin is enhanced or inhibited by prostacyclin, depending on the route of administration. | 1986 | Am. J. Pathol. | pmid:3524253 |
| Powling MJ and Hardisty RM | Differential effects of 12-O-tetradecanoylphorbol 13-acetate on platelet responses to various agonists in the presence and absence of extracellular Ca2+. | 1986 | Thromb. Res. | pmid:3787566 |
| Siffert W et al. | Inhibition of platelet aggregation by amiloride. | 1986 | Thromb. Res. | pmid:3787567 |
| Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
| Suemune H et al. | Enzymatic synthesis of 2,3-O-isopropylidene-sn-glycerol, a chiral building block for platelet-activating factor. | 1986 | Chem. Pharm. Bull. | pmid:3791517 |
| Wardlaw AJ et al. | Platelet-activating factor. A potent chemotactic and chemokinetic factor for human eosinophils. | 1986 | J. Clin. Invest. | pmid:3023451 |
| O'Flaherty JT et al. | Metabolism of 5-hydroxyicosatetraenoate by human neutrophils: production of a novel omega-oxidized derivative. | 1986 | J. Immunol. | pmid:3095426 |
| Pfueller SL and David R | Different platelet specificities of heparin-dependent platelet aggregating factors in heparin-associated immune thrombocytopenia. | 1986 | Br. J. Haematol. | pmid:3756098 |
| Hoffman DR et al. | Cytotoxicity and metabolism of alkyl phospholipid analogues in neoplastic cells. | 1986 | Cancer Res. | pmid:3756924 |
| Sage SO and Rink TJ | Effects of ionic substitution on [Ca2+]i rises evoked by thrombin and PAF in human platelets. | 1986 | Eur. J. Pharmacol. | pmid:3758190 |
| Chignard M et al. | Use of steroidal antiinflammatory drug provides further evidence for a potential role of PAF-acether in bronchial anaphylaxis. | 1986 | Int. Arch. Allergy Appl. Immunol. | pmid:3759260 |
| Roubin R et al. | Biosynthesis of paf-acether: VIII: Impairment of paf-acether production in activated macrophages does not depend upon acetyltransferase activity. | 1986 | J. Immunol. | pmid:3950403 |
| Ohno M et al. | Molecular design toward biologically significant compounds based on platelet activating factor: a highly selective agonist as a potential antihypertensive agent. | 1986 | J. Med. Chem. | pmid:3761300 |
| Parnham MJ and Bittner C | Pharmacological analysis of guinea-pig macrophage chemiluminescence responses to platelet activating factor and opsonized zymosan. | 1986 | Int. J. Immunopharmacol. | pmid:3804536 |
| D'Humières S et al. | PAF-acether-induced synthesis of prostacyclin by human endothelial cells. | 1986 | Eur. J. Pharmacol. | pmid:3102256 |
| Orchard MA et al. | Basophil histamine release induced by a substance from stimulated human platelets. | 1986 | J. Immunol. | pmid:2419428 |
| Becker EL et al. | Pertussis toxin as a probe of neutrophil activation. | 1986 | Fed. Proc. | pmid:3011523 |
| Ozaki Y et al. | Oxygen radical production by neutrophils from patients with bacterial infection and rheumatoid arthritis. Measurement of hydrogen peroxide may most accurately represent enhancement of oxygen radical production during infection. | 1986 | Inflammation | pmid:3011666 |
| Schlondorff D et al. | Different concentrations of pertussis toxin have opposite effects on agonist-induced PGE2 formation in mesangial cells. | 1986 | Biochem. Biophys. Res. Commun. | pmid:3099783 |
| Doebber TW et al. | Platelet-activating factor (PAF) mediation of rat anaphylactic responses to soluble immune complexes. Studies with PAF receptor antagonist L-652,731. | 1986 | J. Immunol. | pmid:3011900 |
| Okayasu T et al. | Metabolism of platelet-activating factor in primary cultured adult rat hepatocytes by a new pathway involving phospholipase C and alkyl monooxygenase. | 1986 | Biochim. Biophys. Acta | pmid:3947669 |
| Baranes J et al. | The effects of PAF-acether on the cardiovascular system and their inhibition by a new highly specific PAF-acether receptor antagonist BN 52021. | 1986 | Pharmacol Res Commun | pmid:3763677 |
| Cirino M et al. | A study with BN 52021 demonstrates the involvement of PAF-acether in IgE-dependent anaphylactic bronchoconstriction. | 1986 | Prostaglandins | pmid:3763941 |
| Wallace JL and Whittle BJ | Profile of gastrointestinal damage induced by platelet-activating factor. | 1986 | Prostaglandins | pmid:3763942 |
| Bourgain RH et al. | Thrombus induction by endogenic paf-acether and its inhibition by Ginkgo Biloba extracts in the guinea pig. | 1986 | Prostaglandins | pmid:3763943 |
| Guinot P et al. | Inhibition of PAF-acether induced weal and flare reaction in man by a specific PAF antagonist. | 1986 | Prostaglandins | pmid:3763944 |
| Scherf H et al. | Hemodynamic effects of platelet activating factor in the dog kidney in vivo. | 1986 | Hypertension | pmid:3744467 |
| Schleimer RP et al. | Characterization of inflammatory mediator release from purified human lung mast cells. | 1986 | Am. Rev. Respir. Dis. | pmid:3485946 |
| Herrmann DB et al. | Ether phospholipids as inhibitors of the arachidonoyl-CoA: 1-acyl-sn-glycero-3-phosphocholine acyltransferase in macrophages. | 1986 | Biochim. Biophys. Acta | pmid:3947667 |
| Robertson DN and Smith GM | CV3988 inhibits in vivo platelet aggregation induced by PAF-acether and collagen. | 1986 | Eur. J. Pharmacol. | pmid:3709663 |
| Ostermann G et al. | The role of lipoproteins in the degradation of platelet-activating factor. | 1986 | Thromb. Res. | pmid:3798402 |
| Bussolino F et al. | Interleukin 1 stimulates platelet activating factor production in cultured human endothelial cells. | 1986 | Pharmacol Res Commun | pmid:3490673 |
| Ramesha CS and Pickett WC | Metabolism of platelet-activating factor by arachidonic acid-depleted rat polymorphonuclear leukocytes. | 1986 | J. Biol. Chem. | pmid:3096991 |
| Kawaguchi H and Yasuda H | Platelet-activating factor stimulates prostaglandin synthesis in cultured cells. | 1986 | Hypertension | pmid:3081442 |
| Morley J and Sanjar S | Ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3466080 |
| Page CP | Platelet activating factor, ketotifen and asthma. | 1986 | N. Z. Med. J. | pmid:3466093 |
| Etienne A et al. | Antithrombotic activity of BN 50341, a structurally new compound with anticalcic and PAF-antagonistic properties. | 1986 | Agents Actions Suppl. | pmid:3468781 |
| Zimmerman GA et al. | Thrombin stimulates neutrophil adherence by an endothelial cell-dependent mechanism: characterization of the response and relationship to platelet-activating factor synthesis. | 1986 | Ann. N. Y. Acad. Sci. | pmid:3471149 |
| Rainsford KD | Relative roles of leukotrienes and platelet activating factor in experimentally-induced gastric ulceration. | 1986 | Pharmacol Res Commun | pmid:3774846 |
| Page CP and Morley J | Evidence favouring PAF rather than leukotrienes in the pathogenesis of asthma. | 1986 | Pharmacol Res Commun | pmid:3774847 |
| Haye-Legrand I et al. | Production of PAF-acether and leukotrienes by cultured mouse macrophages. | 1986 | Pharmacol Res Commun | pmid:3774848 |
| Dupont L et al. | Crystal and molecular structure of BN 52021, a PAF-acether antagonist. Comparison with the conformation of Kadsurenone and related compounds. | 1986 | Pharmacol Res Commun | pmid:3774849 |
| Bruynzeel PL et al. | Platelet-activating factor (PAF-acether) induced leukotriene C4 formation and luminol dependent chemiluminescence by human eosinophils. | 1986 | Pharmacol Res Commun | pmid:3774850 |
| Etienne A et al. | The relative role of PAF-acether and icosanoids in septic shock. | 1986 | Pharmacol Res Commun | pmid:3774851 |