| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Sengoku K et al. | Effects of platelet activating factor on human sperm function in vitro. | 1993 | Hum. Reprod. | pmid:8253933 |
| Nathan N and Denziot Y | Platelet-activating factor and nonalcoholic cirrhotics. | 1993 | Gastroenterology | pmid:8253376 |
| Hotchkiss JA et al. | Platelet activating factor stimulates rapid mucin secretion in rat nasal airways in vivo. | 1993 Sep-Oct | Exp. Lung Res. | pmid:8253058 |
| Archer CB | Platelet activating factor--a mediator of inflammation in the skin--medical implications. | 1993 | Clin. Exp. Dermatol. | pmid:8252783 |
| Imai T et al. | [Relation of platelet activating factor induced airway hyperresponsiveness to thromboxane A2 and neutrophil in dogs]. | 1993 | Arerugi | pmid:8250720 |
| Zhang B and Long K | Effects of glaucocalyxin A on aggregation and cAMP levels of rabbit platelets in vitro. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249632 |
| Zeng GQ et al. | Dauricine and anisodamine inhibited leukotrienes- and platelet activating factor-induced DNA synthesis and proliferation of bovine cerebral microvascular smooth muscle cells in culture. | 1993 | Zhongguo Yao Li Xue Bao | pmid:8249627 |
| Musemeche CA et al. | Intestinal ischemia in the newborn: the role of intestinal maturation. | 1993 | J. Surg. Res. | pmid:8246492 |
| Duque I et al. | Calcium channel blockers inhibit hydrogen peroxide-induced proliferation of cultured rat mesangial cells. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8246135 |
| van der Bruggen T et al. | Transient exposure of human eosinophils to the protein kinase C inhibitors CGP39-360, CGP41-251, and CGP44-800 leads to priming of the respiratory burst induced by opsonized particles. | 1993 | J. Leukoc. Biol. | pmid:8245706 |
| McDonald PP et al. | Induction by chemokines of lipid mediator synthesis in granulocyte-macrophage colony-stimulating factor-treated human neutrophils. | 1993 | J. Immunol. | pmid:8245474 |
| Emmendörffer A et al. | Production of oxygen radicals by fibroblasts and neutrophils from a patient with x-linked chronic granulomatous disease. | 1993 | Eur. J. Haematol. | pmid:8243611 |
| Hu W et al. | Partial agonist effect of the platelet-activating factor receptor antagonists, WEB 2086 and WEB 2170, in the rat perfused heart. | 1993 | Br. J. Pharmacol. | pmid:8242237 |
| Bkaily G et al. | PAF activation of a voltage-gated R-type Ca2+ channel in human and canine aortic endothelial cells. | 1993 | Br. J. Pharmacol. | pmid:8242226 |
| Eda R et al. | Inhibitory effects of formoterol on platelet-activating factor induced eosinophil chemotaxis and degranulation. | 1993 | Int. Arch. Allergy Immunol. | pmid:8241801 |
| Saito H et al. | Platelet-activating-factor-induced augmentation of production of eosinophil-lineage cells in hematopoietic precursor cells obtained from human umbilical cord blood. | 1993 | Int. Arch. Allergy Immunol. | pmid:8241800 |
| Perez SA et al. | Eosinophil granulocyte proliferation induced by an intermediate factor generated in the pleural cavity of rats injected with platelet-activating factor-acether. | 1993 | Int. Arch. Allergy Immunol. | pmid:8241799 |
| Rochon YP and Frojmovic MM | Regulation of human neutrophil aggregation: comparable latent times, activator sensitivities, and exponential decay in aggregability for FMLP, platelet-activating factor, and leukotriene B4. | 1993 | Blood | pmid:8241512 |
| Laneuville O et al. | Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4. | 1993 | Biochem. J. | pmid:8240236 |
| Fletcher JR | Eicosanoids. Critical agents in the physiological process and cellular injury. | 1993 | Arch Surg | pmid:8239981 |
| Weintraub ST et al. | Synthesis of pentafluorobenzoic anhydride: a superior derivatizing agent for lipids. | 1993 | Anal. Chem. | pmid:8238933 |
| Ma Y et al. | [PAF antagonistic benzofuran neolignans from Piper kadsura]. | 1993 | Yao Xue Xue Bao | pmid:8237383 |
| Krämer K et al. | Studies on the metabolism of metallothionein and alkaline phosphatase of adult rat primary hepatocyte cultures: role of fetal calf serum and agonists of the phosphoinositide cascade. | 1993 | Z Ernahrungswiss | pmid:8237077 |
| Nobe K et al. | Effect of diacylglycerol kinase inhibitor, R59022 on cytosolic free calcium level and force development in guinea pig taenia coli. | 1993 | Res. Commun. Chem. Pathol. Pharmacol. | pmid:8235067 |
| Kojima T et al. | Production and secretion of progesterone in vitro and presence of platelet activating factor (PAF) in early pregnancy of the marsupial, Macropus eugenii. | 1993 | Reprod. Fertil. Dev. | pmid:8234890 |
| Kim YD et al. | Constriction of canine coronary arteries by platelet activating factor after brief ischemia. | 1993 | Prostaglandins | pmid:8234834 |
| Capasso F et al. | Effect of senna is not mediated by platelet-activating factor. | 1993 | Pharmacology | pmid:8234442 |
| Furukawa M et al. | Platelet-activating factor-induced ischemic bowel necrosis: the effect of platelet-activating factor acetylhydrolase. | 1993 | Pediatr. Res. | pmid:8233731 |
| MacKendrick W et al. | Endogenous nitric oxide protects against platelet-activating factor-induced bowel injury in the rat. | 1993 | Pediatr. Res. | pmid:8233729 |
| Green PG et al. | Trypsin enhances sympathetic neuron-dependent plasma extravasation in the rat knee joint. | 1993 | Neurosci. Lett. | pmid:8233065 |
| Green PG et al. | Further substantiation of a significant role for the sympathetic nervous system in inflammation. | 1993 | Neuroscience | pmid:8232896 |
| Satouchi K et al. | Phospholipids from the free-living nematode Caenorhabditis elegans. | 1993 | Lipids | pmid:8231660 |
| Ko W et al. | Platelet-activating factor antagonism attenuates platelet and neutrophil activation and reduces myocardial injury during coronary reperfusion. | 1993 | J. Surg. Res. | pmid:8231170 |
| Bull DA et al. | Putative vascular endothelial cell chemotactic factors: comparison in a standardized migration assay. | 1993 | J. Surg. Res. | pmid:8231165 |
| Houlihan WJ et al. | Structural modification of 5-aryl-2,3-dihydroimidazo[2,1-a]isoquinoline platelet activating factor receptor antagonists. | 1993 | J. Med. Chem. | pmid:8230095 |
| Rocha FA et al. | Platelet activating factor and histamine effects in synovial blood flow evaluated by laser-Doppler flowmetry. | 1993 | J. Rheumatol. | pmid:8230022 |
| Müller-Peddinghaus R et al. | BAY X1005, a new inhibitor of leukotriene synthesis: in vivo inflammation pharmacology and pharmacokinetics. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8229782 |
| Jeanneton O et al. | Platelet-activating factor (PAF) induces a contraction of isolated smooth muscle cells from guinea pig ileum: intracellular pathway involved. | 1993 | J. Pharmacol. Exp. Ther. | pmid:8229757 |
| Teixeira MM et al. | Mechanisms of the inflammatory response induced by extracts of Schistosoma mansoni larvae in guinea pig skin. | 1993 | J. Immunol. | pmid:8228243 |
| Mangino MJ et al. | Characterization of platelet-activating factor receptors on canine T lymphocytes. | 1993 | J. Immunol. | pmid:8228226 |
| Minor T and Isselhard W | Platelet-activating factor antagonism enhances the liver's recovery from warm ischemia in situ. | 1993 | J. Hepatol. | pmid:8228131 |
| Silvestro L et al. | Development of a high-performance liquid chromatographic-mass spectrometric technique, with an ionspray interface, for the determination of platelet-activating factor (PAF) and lyso-PAF in biological samples. | 1993 | J. Chromatogr. | pmid:8227267 |
| Garcia Rodriguez C et al. | Dissociation of platelet-activating factor production and arachidonate release by the endomembrane Ca(2+)-ATPase inhibitor thapsigargin. Evidence for the involvement of a Ca(2+)-dependent route of priming in the production of lipid mediators by human polymorphonuclear leukocytes. | 1993 | J. Biol. Chem. | pmid:8227034 |
| Persico P et al. | Protective effect of SV-IV on platelet-activating factor-induced hypotension, bronchoconstriction and gastric mucosal injury. | 1993 | Eur. J. Pharmacol. | pmid:8223928 |
| Itoh K et al. | Effects of CS-518, a thromboxane synthase inhibitor, on eosinophil function. | 1993 | Eur. J. Pharmacol. | pmid:8223890 |
| Morita M et al. | Inhibitory effects of azelastine hydrochloride on Ca2+ influx, actin polymerization and release of eosinophil cationic protein of an eosinophilic leukaemia cell line EoL-1. | 1993 | Curr Med Res Opin | pmid:8222744 |
| Hurst JS and Bazan HE | The platelet-activating factor precursor of the injured cornea is selectively implicated in arachidonate and eicosanoid release. | 1993 | Curr. Eye Res. | pmid:8222725 |
| Hagar AF et al. | Endotoxin infusion primes elicited neutrophils and Kupffer cells for platelet-activating factor-induced and tripeptide formyl-methionine-leucine-phenylalanine-induced basal free intracellular calcium concentration responses. | 1993 | Crit. Care Med. | pmid:8222693 |
| Katoh S et al. | Role of platelet activating factor in ischaemia-reperfusion injury of isolated rabbit hearts: protective effect of a specific platelet activating factor antagonist, TCV-309. | 1993 | Cardiovasc. Res. | pmid:8221795 |
| Austin CE and Foreman JC | The effect of platelet-activating factor on the responsiveness of the human nasal airway. | 1993 | Br. J. Pharmacol. | pmid:8220870 |
| Seeds EA et al. | The effect of heparin and related proteoglycans on allergen and PAF-induced eosinophil infiltration. | 1993 | J Lipid Mediat | pmid:8219006 |
| Qian C et al. | Platelet-activating factor (PAF)-induced cardiopulmonary dysfunctions and their reversal with a PAF antagonist (BN 52021) in strain 13 guinea pigs. | 1993 | J Lipid Mediat | pmid:8219003 |
| Weintraub ST et al. | Differential electron capture mass spectral response of pentafluorobenzoyl derivatives of platelet activating factor alkyl chain homologs. | 1993 | Biol. Mass Spectrom. | pmid:8218422 |
| Tsoukatos DC et al. | Studies on the subcellular distribution of 1-O-alkyl-2-acetyl-sn-glycero phosphocholine (PAF) and on the enzymic activities involved in its biosynthesis within the ciliate Tetrahymena pyriformis. | 1993 | Biochim. Biophys. Acta | pmid:8218344 |
| Chen ZN et al. | [Anti-platelet activating factor constituents, 2,5-diaryltetrahydrofuran type lignans, from Piper futokadsura Sied. et Zucc]. | 1993 | Zhongguo Zhong Yao Za Zhi | pmid:8216803 |
| Räisänen A et al. | Effect of platelet-activating factor (PAF) receptor blockers on smooth muscle cell replication in vitro and allograft arteriosclerosis in vivo. | 1993 | Transpl. Int. | pmid:8216700 |
| Tsai JJ et al. | Enhanced eosinophil luminol-dependent chemiluminescence and complement receptor expression by platelet-activating factor and interleukin-5. | 1993 | Asian Pac. J. Allergy Immunol. | pmid:8216559 |
| Ko FN et al. | Inhibition of collagen-induced platelet aggregation and adhesion by a pseudocyanide derivative of avicine isolated from Zanthoxylum integrifoliolum Merr. | 1993 | Biochem. Pharmacol. | pmid:8216367 |
| Damas J and Prunescu P | Presence of immunoreactive platelet-activating factor in peritoneal exudate induced by zymosan in rats. | 1993 Mar-Apr | Arch Int Pharmacodyn Ther | pmid:8215712 |
| Miyagawa H et al. | Density change of neutrophils from allergic subjects by granulocyte-macrophage colony stimulating factor. | 1993 | Ann Allergy | pmid:8214805 |
| Gaboury J et al. | Nitric oxide prevents leukocyte adherence: role of superoxide. | 1993 | Am. J. Physiol. | pmid:8214120 |
| Kusano K et al. | Metabolic polymorphism of E6123 in rhesus monkey. | 1993 | Xenobiotica | pmid:8212734 |
| Kusano K et al. | Pharmacokinetics of a new thienodiazepine platelet activating factor receptor antagonist (E6123) in laboratory animals. Is there a metabolic polymorphism in the rhesus monkey? | 1993 | Xenobiotica | pmid:8212733 |
| Watson CJ et al. | The platelet-activating factor antagonist WEB 2170. Its beneficial effect on dog renal allograft survival. | 1993 | Transplantation | pmid:8212192 |
| Kald B et al. | Phospholipase C from Clostridium perfringens stimulates acetyltransferase-dependent formation of platelet-activating factor in cultured intestinal epithelial cells (INT 407). | 1994 | Scand. J. Gastroenterol. | pmid:8209184 |
| Travis SP and Jewell DP | The role of platelet-activating factor in the pathogenesis of gastrointestinal disease. | 1994 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:8208748 |
| Anastasi EM et al. | Disposition and metabolism of Ro 24-4736 in the rat. | 1994 | Life Sci. | pmid:8208055 |
| Gelbard HA et al. | Platelet-activating factor: a candidate human immunodeficiency virus type 1-induced neurotoxin. | 1994 | J. Virol. | pmid:8207837 |
| Bazan HE et al. | Platelet-activating factor antagonists and ocular inflammation. | 1994 | J Ocul Pharmacol | pmid:8207336 |
| Simon HU et al. | Functional platelet-activating factor receptors are expressed by monocytes and granulocytes but not by resting or activated T and B lymphocytes from normal individuals or patients with asthma. | 1994 | J. Immunol. | pmid:8207248 |
| Kusano K et al. | Development of radioimmunoassay for the novel platelet activating factor receptor antagonist, E6123, and its application to pharmacokinetics in laboratory animals. | 1994 | Biol. Pharm. Bull. | pmid:8205134 |
| Nathan N et al. | Serum platelet-activating factor acetylhydrolase during coronary artery bypass surgery. | 1994 | J. Cardiothorac. Vasc. Anesth. | pmid:8204819 |
| Sugiura T et al. | Biochemical characterization of the interaction of lipid phosphoric acids with human platelets: comparison with platelet activating factor. | 1994 | Arch. Biochem. Biophys. | pmid:8203898 |
| Rioux KP and Wallace JL | Mast cell activation augments gastric mucosal injury through a leukotriene-dependent mechanism. | 1994 | Am. J. Physiol. | pmid:8203531 |
| Bazan NG et al. | Platelet-activating factor and retinoic acid synergistically activate the inducible prostaglandin synthase gene. | 1994 | Proc. Natl. Acad. Sci. U.S.A. | pmid:8202477 |
| Lin CH et al. | Inhibition of platelet thromboxane formation and phosphoinositides breakdown by diisoeugenol. | 1994 | J. Pharm. Pharmacol. | pmid:8201527 |
| Ambrosio G et al. | Oxygen radicals inhibit human plasma acetylhydrolase, the enzyme that catabolizes platelet-activating factor. | 1994 | J. Clin. Invest. | pmid:8200975 |
| Tashiro H et al. | Verotoxin induces hemorrhagic lesions in rat small intestine. Temporal alteration of vasoactive substances. | 1994 | Dig. Dis. Sci. | pmid:8200255 |
| Tamura K et al. | The effect of platelet-activating-factor antagonist TCV-309 on arrhythmias and functional recovery during myocardial reperfusion. | 1994 | Coron. Artery Dis. | pmid:8199742 |
| Hough SR and Parks JE | Platelet-activating factor acetylhydrolase activity in seminal plasma from the bull, stallion, rabbit, and rooster. | 1994 | Biol. Reprod. | pmid:8199270 |
| Liapikos TA et al. | Platelet-activating factor formation during oxidative modification of low-density lipoprotein when PAF-acetylhydrolase has been inactivated. | 1994 | Biochim. Biophys. Acta | pmid:8199206 |
| Kurosawa M et al. | Increased levels of blood platelet-activating factor in bronchial asthmatic patients with active symptoms. | 1994 | Allergy | pmid:8198242 |
| Chávez-Cartaya RE et al. | Rat liver blood flow after ischemia and reperfusion. The effects of the platelet-activating factor antagonist WEB-2170 and of removing circulating leukocytes. | 1994 | Transplantation | pmid:8197604 |
| Palmantier R et al. | Priming for the synthesis of 5-lipoxygenase products in human blood ex vivo by human granulocyte-macrophage colony-stimulating factor and tumor necrosis factor-alpha. | 1994 | Lab. Invest. | pmid:8196365 |
| Fukuda A et al. | Platelet activating factor enhances the acrosome reaction, fertilization in vitro by subzonal sperm injection and resulting embryonic development in the rabbit. | 1994 | Hum. Reprod. | pmid:8195361 |
| Catto-Smith AG et al. | Rat gastric motor response to food protein-induced anaphylaxis. | 1994 | Gastroenterology | pmid:8194696 |
| Cohen RA et al. | A platelet-activating factor antagonist reduces corneal allograft inflammation and neovascularization. | 1994 | Curr. Eye Res. | pmid:8194360 |
| Imanishi N et al. | Biological effects of the new platelet-activating factor receptor antagonist (+)-cis-3,5-dimethyl-2-(3-pyridyl)thiazolidin-4-one hydrochloride. | 1994 | Arzneimittelforschung | pmid:8192697 |
| Ou MC et al. | Potential etiologic role of PAF in two major septic complications; disseminated intravascular coagulation and multiple organ failure. | 1994 | Thromb. Res. | pmid:8191415 |
| Tatsumi N et al. | An anti-platelet activating factor antibody and its effects on platelet aggregation. | 1993 | Osaka City Med J | pmid:8183536 |
| Orozco C et al. | A description of the basic system of components in pregnant mice sera responsible for 'early pregnancy factor' activity. | 1994 | J. Reprod. Fertil. | pmid:8182603 |
| Alloatti G et al. | Role of platelet-activating factor (PAF) in oxygen radical-induced cardiac dysfunction. | 1994 | J. Pharmacol. Exp. Ther. | pmid:8182544 |
| Goswami S et al. | Characterization of a unique mucin-like glycoprotein secreted by a human endometrial adenocarcinoma cell line (Ishikawa). | 1994 Jan-Feb | Exp. Lung Res. | pmid:8181454 |
| Smith CS and Shearer WT | Activation of NF-kappa B and immunoglobulin expression in response to platelet-activating factor in a human B cell line. | 1994 | Cell. Immunol. | pmid:8181066 |
| Blom M et al. | Granulocyte-macrophage colony-stimulating factor, interleukin-3 (IL-3), and IL-5 greatly enhance the interaction of human eosinophils with opsonized particles by changing the affinity of complement receptor type 3. | 1994 | Blood | pmid:8180394 |
| Shirasaki H et al. | Expression of platelet-activating factor receptor mRNA in human and guinea pig lung. | 1994 | Am. J. Respir. Cell Mol. Biol. | pmid:8179916 |
| Boyle T et al. | Method for simultaneous isolation and quantitation of platelet activating factor and multiple arachidonate metabolites from small samples: analysis of effects of Staphylococcus aureus enterotoxin B in mice. | 1994 | Anal. Biochem. | pmid:8179192 |
| Barbier A et al. | [Microcirculation and rheology]. | 1994 | Presse Med | pmid:8177870 |
| Demopoulos CA et al. | A simple and precise method for the routine determination of platelet-activating factor in blood and urine. | 1994 | Lipids | pmid:8177023 |
| Gómez-Chiarri M et al. | Involvement of tumor necrosis factor and platelet-activating factor in the pathogenesis of experimental nephrosis in rats. | 1994 | Lab. Invest. | pmid:8176885 |