| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Archer SL and Roudebush WE | Enhancement of sperm motility using pentoxifylline and platelet-activating factor. | 2013 | Methods Mol. Biol. | pmid:22992918 |
| Grotta MB et al. | Obesity increases eosinophil activity in asthmatic children and adolescents. | 2013 | BMC Pulm Med | pmid:23773659 |
| Zhou Z et al. | Chemical constituents of Callicarpa nudiflora and their anti-platelet aggregation activity. | 2013 | Fitoterapia | pmid:23669034 |
| Wang TM et al. | Alkyl and phenolic glycosides from Saussurea stella. | 2013 | Fitoterapia | pmid:23567860 |
| Hirayama F | Current understanding of allergic transfusion reactions: incidence, pathogenesis, laboratory tests, prevention and treatment. | 2013 | Br. J. Haematol. | pmid:23215650 |
| Harleton E et al. | Ability to induce atrial fibrillation in the peri-operative period is associated with phosphorylation-dependent inhibition of TWIK protein-related acid-sensitive potassium channel 1 (TASK-1). | 2013 | J. Biol. Chem. | pmid:23229553 |
| Detopoulou P et al. | Platelet activating factor in heart failure: potential role in disease progression and novel target for therapy. | 2013 | Curr Heart Fail Rep | pmid:23389700 |
| Wang HL et al. | Differential inhibitory effects of 2-azafluorenones on PI-PLC activation but not on PC-PLC- or PC-PLD-activation induced by histamine, PAF, PMA or A23187 in C6 glioma cells. | 2013 | Chin J Physiol | pmid:23347011 |
| Alevizos M et al. | Rupatadine inhibits inflammatory mediator release from human laboratory of allergic diseases 2 cultured mast cells stimulated by platelet-activating factor. | 2013 | Ann. Allergy Asthma Immunol. | pmid:24267366 |
| Cui H et al. | Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice. | 2013 | J. Allergy Clin. Immunol. | pmid:24021572 |
| Flasiński M et al. | Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. | 2013 | Biochim. Biophys. Acta | pmid:23906729 |
| Guerrero AT et al. | The role of PAF/PAFR signaling in zymosan-induced articular inflammatory hyperalgesia. | 2013 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:23187752 |
| Kang JW et al. | Anti-platelet activity of erythro-(7S,8R)-7-acetoxy-3,4,3',5'-tetramethoxy-8-O-4'-neolignan from Myristica fragrans. | 2013 | Phytother Res | pmid:23296979 |
| Muñoz-Cano R et al. | Platelet-activating factor nasal challenge induces nasal congestion and reduces nasal volume in both healthy volunteers and allergic rhinitis patients. | 2013 Mar-Apr | Am J Rhinol Allergy | pmid:23562190 |
| Frazer CA | Heparin-induced thrombocytopenia. | 2013 Nov-Dec | Medsurg Nurs | pmid:24600938 |
| Yamauchi A et al. | Systematic single cell analysis of migration and morphological changes of human neutrophils over stimulus concentration gradients. | 2014 | J. Immunol. Methods | pmid:24370750 |
| Flasiński M et al. | Influence of platelet-activating factor, lyso-platelet-activating factor and edelfosine on Langmuir monolayers imitating plasma membranes of cell lines differing in susceptibility to anti-cancer treatment: the effect of plasmalogen level. | 2014 | J R Soc Interface | pmid:24694892 |
| Sato A et al. | C-reactive protein specifically enhances platelet-activating factor-induced inflammatory activity in vivo. | 2014 | Eur. J. Pharmacol. | pmid:25455842 |
| Zebrowska A et al. | Mediators of mast cells in bullous pemphigoid and dermatitis herpetiformis. | 2014 | Mediators Inflamm. | pmid:25400334 |
| Sahu RP et al. | Chemotherapeutic agents subvert tumor immunity by generating agonists of platelet-activating factor. | 2014 | Cancer Res. | pmid:25304264 |
| Yu Y et al. | Transactivation of epidermal growth factor receptor through platelet-activating factor/receptor in ovarian cancer cells. | 2014 | J. Exp. Clin. Cancer Res. | pmid:25261977 |
| Sirangelo I et al. | Platelet-activating factor mediates the cytotoxicity induced by W7FW14F apomyoglobin amyloid aggregates in neuroblastoma cells. | 2014 | J. Cell. Biochem. | pmid:25053109 |
| Xanthopoulou MN et al. | Effect of Robola and Cabernet Sauvignon extracts on platelet activating factor enzymes activity on U937 cells. | 2014 | Food Chem | pmid:25038648 |
| Concha C et al. | Oxidative response of neutrophils to platelet-activating factor is altered during acute ruminal acidosis induced by oligofructose in heifers. | 2014 | J. Vet. Sci. | pmid:25013355 |
| Mazereeuw G et al. | Platelet-activating factors are associated with cognitive deficits in depressed coronary artery disease patients: a hypothesis-generating study. | 2014 | J Neuroinflammation | pmid:24996486 |
| Uhlig S et al. | Differential regulation of lung endothelial permeability in vitro and in situ. | 2014 | Cell. Physiol. Biochem. | pmid:24977477 |
| Triggiani M et al. | Anaphylaxis and cardiovascular diseases: a dangerous liaison. | 2014 | Curr Opin Allergy Clin Immunol | pmid:24915548 |
| Jin XL and O'Neill C | Systematic analysis of the factors that adversely affect the rate of cell accumulation in mouse embryos during their culture in vitro. | 2014 | Reprod. Biol. Endocrinol. | pmid:24885989 |
| Wu H et al. | Lipoxin A4 and platelet activating factor are involved in E. coli or LPS-induced lung inflammation in CFTR-deficient mice. | 2014 | PLoS ONE | pmid:24671173 |
| Papakonstantinou VD et al. | In vivo effect of two first-line ART regimens on inflammatory mediators in male HIV patients. | 2014 | Lipids Health Dis | pmid:24884881 |
| Marathe GK et al. | To hydrolyze or not to hydrolyze: the dilemma of platelet-activating factor acetylhydrolase. | 2014 | J. Lipid Res. | pmid:24859738 |
| Zanatta AL et al. | Fish oil supplementation decreases oxidative stress but does not affect platelet-activating factor bioactivity in lungs of asthmatic rats. | 2014 | Lipids | pmid:24858941 |
| Mitchell MJ et al. | Fluid shear stress increases neutrophil activation via platelet-activating factor. | 2014 | Biophys. J. | pmid:24853753 |
| Carlioglu A et al. | The platelet activating factor acetyl hydrolase, oxidized low-density lipoprotein, paraoxonase 1 and arylesterase levels in treated and untreated patients with polycystic ovary syndrome. | 2014 | Arch. Gynecol. Obstet. | pmid:24840107 |
| Yu Y et al. | Epidermal growth factor induces platelet-activating factor production through receptors transactivation and cytosolic phospholipase A2 in ovarian cancer cells. | 2014 | J Ovarian Res | pmid:24721622 |
| Forkel S et al. | Inositoylated platelet-activating factor (Ino-C2-PAF) modulates dynamic lymphocyte-endothelial cell interactions and alleviates psoriasis-like skin inflammation in two complementary mouse models. | 2014 | J. Invest. Dermatol. | pmid:24714204 |
| Kim SJ et al. | Quantitative determination of major platelet activating factors from human plasma. | 2014 | Anal Bioanal Chem | pmid:24682147 |
| Kaplanis M et al. | Re(I) tricarbonyl complex of 1,10-phenanthroline-5,6-dione: DNA binding, cytotoxicity, anti-inflammatory and anti-coagulant effects towards platelet activating factor. | 2014 | J. Inorg. Biochem. | pmid:24632342 |
| Mallet de Lima CD et al. | Central role of PAFR signalling in ExoU-induced NF-κB activation. | 2014 | Cell. Microbiol. | pmid:24612488 |
| Moschos MM et al. | In vitro effects of vitamin supplements on platelet-activating factor and its metabolism in age-related macular degeneration. | 2014 | Cutan Ocul Toxicol | pmid:24147947 |
| Abdulnour RE et al. | Maresin 1 biosynthesis during platelet-neutrophil interactions is organ-protective. | 2014 | Proc. Natl. Acad. Sci. U.S.A. | pmid:25369934 |
| Chou YI et al. | Correlations of platelet-derived microparticles with thromboxane B2, platelet-activating factor, endothelin-1, and neutrophil to lymphocyte ratio in patients with coronary intermediate lesions. | 2014 | Biomarkers | pmid:25391885 |
| Chacón-Salinas R et al. | An essential role for platelet-activating factor in activating mast cell migration following ultraviolet irradiation. | 2014 | J. Leukoc. Biol. | pmid:24009177 |
| Sugatani J et al. | Antiobese function of platelet-activating factor: increased adiposity in platelet-activating factor receptor-deficient mice with age. | 2014 | FASEB J. | pmid:24100020 |
| Fang W et al. | Platelet activating factor induces transient blood-brain barrier opening to facilitate edaravone penetration into the brain. | 2014 | J. Neurochem. | pmid:24164378 |
| Chérifi F et al. | Isolation, functional characterization and proteomic identification of CC2-PLA₂ from Cerastes cerastes venom: a basic platelet-aggregation-inhibiting factor. | 2014 | Protein J. | pmid:24384926 |
| Rivera J et al. | Platelet-activating factor contributes to Bacillus anthracis lethal toxin-associated damage. | 2014 | J. Biol. Chem. | pmid:24478317 |
| Kim KJ et al. | Platelet-activating factor enhances tumour metastasis via the reactive oxygen species-dependent protein kinase casein kinase 2-mediated nuclear factor-κB activation. | 2014 | Immunology | pmid:24628121 |
| Semini G et al. | Glycosidated phospholipids - a promising group of anti-tumour lipids. | 2014 | Anticancer Agents Med Chem | pmid:24628240 |
| Tarui M et al. | Selective inhibitors of a PAF biosynthetic enzyme lysophosphatidylcholine acyltransferase 2. | 2014 | J. Lipid Res. | pmid:24850807 |