| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kern H et al. | Stimulation of monocytes and platelets by short-chain phosphatidylcholines with and without terminal carboxyl group. | 1998 | Biochim. Biophys. Acta | pmid:9767093 |
| Bozza PT et al. | Pathways for eosinophil lipid body induction: differing signal transduction in cells from normal and hypereosinophilic subjects. | 1998 | J. Leukoc. Biol. | pmid:9766638 |
| Marriott I et al. | Differential kinetics for induction of interleukin-6 mRNA expression in murine peritoneal macrophages: evidence for calcium-dependent and independent-signalling pathways. | 1998 | J. Cell. Physiol. | pmid:9766520 |
| Kabasakal C et al. | The role of PAF and leukotrienes in bioincompatibility of cuprophane membranes in hemodialysis. | 1998 Jul-Sep | Turk. J. Pediatr. | pmid:9763906 |
| Spoelstra FM et al. | Effect of theophylline on CD11b and L-selectin expression and density of eosinophils and neutrophils in vitro. | 1998 | Eur. Respir. J. | pmid:9762784 |
| Tamm M et al. | Hypoxia-induced interleukin-6 and interleukin-8 production is mediated by platelet-activating factor and platelet-derived growth factor in primary human lung cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9761763 |
| Kinn JW and Bache RJ | Effect of platelet activation on coronary collateral blood flow. | 1998 | Circulation | pmid:9760298 |
| El-Shazly A et al. | Human eotaxin induces eosinophil-derived neurotoxin release from normal human eosinophils. | 1998 | Int. Arch. Allergy Immunol. | pmid:9758899 |
| Matsumoto K et al. | Altered expression of CD11b and CD62L after cross-linking of CD45 isoforms on human eosinophils. | 1998 | Int. Arch. Allergy Immunol. | pmid:9758894 |
| El-Shazly A et al. | Modulation of normal human eosinophil chemotaxis in vitro by herbimycin A, erbstatin and pervanadate. | 1998 | Int. Arch. Allergy Immunol. | pmid:9758889 |
| Heath MF et al. | Dextran-70 inhibits equine platelet aggregation induced by PAF but not by other agonists. | 1998 | Equine Vet. J. | pmid:9758098 |
| Endo S et al. | Administration of methylprednisolone acetate into the subdural cavity in an infant with subdural fluid collection. PAF is a good indicator of the efficacy of the treatment. | 1998 | Childs Nerv Syst | pmid:9753399 |
| Rocha MF et al. | Intestinal secretory factor released by macrophages stimulated with Clostridium difficile toxin A: role of interleukin 1beta. | 1998 | Infect. Immun. | pmid:9746596 |
| Huang Q et al. | Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. | 1998 | Am. J. Physiol. | pmid:9746460 |
| Kruse-Elliott KT et al. | Low molecular weight heparin alters porcine neutrophil responses to platelet-activating factor. | 1998 | Shock | pmid:9744648 |
| Liu L et al. | Triple role of platelet-activating factor in eosinophil migration across monolayers of lung epithelial cells: eosinophil chemoattractant and priming agent and epithelial cell activator. | 1998 | J. Immunol. | pmid:9743372 |
| Cheryk LA et al. | Alterations in blood platelet morphology during aggregate formation in the Asian elephant (Elephas maximus). | 1998 | J. Zoo Wildl. Med. | pmid:9732033 |
| M'Rabet L et al. | Activation of the small GTPase rap1 in human neutrophils. | 1998 | Blood | pmid:9731072 |
| Burke-Gaffney A and Hellewell PG | A CD18/ICAM-1-dependent pathway mediates eosinophil adhesion to human bronchial epithelial cells. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9730868 |
| Ueno M et al. | Antiallergic action of betotastine besilate (TAU-284) in animal models: A comparison with ketotifen. | 1998 | Pharmacology | pmid:9730778 |
| Qu XW et al. | Interaction of platelet-activating factor, spleen and atrial natriuretic peptide in plasma volume regulation during endotoxaemia in rats. | 1998 | J. Physiol. (Lond.) | pmid:9729632 |
| Ibe BO et al. | Platelet-activating factor modulates pulmonary vasomotor tone in the perinatal lamb. | 1998 | J. Appl. Physiol. | pmid:9729586 |
| Matsumoto K et al. | Eosinophilic airway inflammation induced by repeated exposure to cigarette smoke. | 1998 | Eur. Respir. J. | pmid:9727790 |
| Rougier F and Denizot Y | Platelet-activating factor and the growth of fibroblasts. | 1998 | Mol. Carcinog. | pmid:9726813 |
| Beyer AJ et al. | PAF and CD18 mediate neutrophil infiltration in upper gastrointestinal tract during intra-abdominal sepsis. | 1998 | Am. J. Physiol. | pmid:9724257 |
| Mazer BD et al. | Dose-dependent agonist and antagonist effects of the platelet-activating factor analogue 1-palmitoyl-2-acetoyl-sn-glycero-3-phosphocholine on B lymphocytes. | 1998 | J. Allergy Clin. Immunol. | pmid:9723666 |
| Karzai W et al. | [Current aspects of immunomodulatory therapy initiation for sepsis]. | 1998 | Dtsch. Med. Wochenschr. | pmid:9721572 |
| Tsai IL et al. | Anti-platelet aggregation constituents from Formosan Toddalia asiatica. | 1998 | Phytochemistry | pmid:9720317 |
| Tamaoki J et al. | A human bronchial epithelial cell line releases arginine vasopressin: involvement of Ca2+ -activated K+ channels. | 1998 | Regul. Pept. | pmid:9712168 |
| Hilliquin P et al. | A double blind, placebo controlled study of a platelet activating factor antagonist in patients with rheumatoid arthritis. | 1998 | J. Rheumatol. | pmid:9712091 |
| Pei Y et al. | Activation of the epidermal platelet-activating factor receptor results in cytokine and cyclooxygenase-2 biosynthesis. | 1998 | J. Immunol. | pmid:9712066 |
| Pérez-Arellano JL et al. | BN 52021 (a platelet activating factor-receptor antagonist) decreases alveolar macrophage-mediated lung injury in experimental extrinsic allergic alveolitis. | 1998 | Mediators Inflamm. | pmid:9705608 |
| Boulay F et al. | Phagocyte chemoattractant receptors. | 1997 | Ann. N. Y. Acad. Sci. | pmid:9704038 |
| Thakur A and Willcox MD | Cytokine and lipid inflammatory mediator profile of human tears during contact lens associated inflammatory diseases. | 1998 | Exp. Eye Res. | pmid:9702174 |
| Akisü M et al. | Platelet-activating factor levels in term and preterm human milk. | 1998 | Biol. Neonate | pmid:9701651 |
| Pennings HJ et al. | Tumour necrosis factor-alpha induces hyperreactivity in tracheal smooth muscle of the guinea-pig in vitro. | 1998 | Eur. Respir. J. | pmid:9701413 |
| Andersson R et al. | Effect of a platelet-activating factor antagonist on pancreatitis-associated gut barrier dysfunction in rats. | 1998 | Pancreas | pmid:9700940 |
| Koyama S et al. | Human lung fibroblasts release chemokinetic activity for monocytes constitutively. | 1998 | Am. J. Physiol. | pmid:9700081 |
| Alves AC et al. | Effect of selective phosphodiesterase inhibitors on the rat eosinophil chemotactic response in vitro. | 1997 | Mem. Inst. Oswaldo Cruz | pmid:9698934 |
| DeCoster MA et al. | Platelet-activating factor is a downstream messenger of kainate-induced activation of mitogen-activated protein kinases in primary hippocampal neurons. | 1998 | J. Neurosci. Res. | pmid:9698157 |
| Cruzado JM et al. | Effect of a platelet-activating factor (PAF) receptor antagonist on hyperacute xenograft rejection; evaluation in a pig kidney-human blood xenoperfusion model. | 1998 | Clin. Exp. Immunol. | pmid:9697996 |
| Eakes AT and Olson MS | Regulation of endothelin synthesis in hepatic endothelial cells. | 1998 | Am. J. Physiol. | pmid:9696707 |
| Karlsson H et al. | Heparin ameliorates pulmonary hypertension induced by platelet-activating factor in pigs. | 1998 | Thromb. Res. | pmid:9694244 |
| Napoli C | Familial hypercholesterolaemia and platelet-activating factor acetylhydrolase: difference between the homozygous and heterozygous form. | 1998 | Eur. J. Clin. Invest. | pmid:9693945 |
| Moro F et al. | The beta and gamma subunits of the human platelet-activating factor acetyl hydrolase isoform Ib (PAFAH1B2 and PAFAH1B3) map to chromosome 11q23 and 19q13.1, respectively. | 1998 | Genomics | pmid:9693049 |
| Li HP et al. | Effect of chinonin on acute hypoxic pulmonary vasoconstriction in Sprague-Dawley rats. | 1998 | Respirology | pmid:9692515 |
| Kaminskaia GO et al. | [Features of oxidative metabolism and level of platelet activating factor in pulmonary and circulating phagocytes of tuberculosis-resistant animals at stages of experimental infection]. | 1998 | Probl Tuberk | pmid:9691697 |
| Ribaldi E et al. | PAF levels in saliva are regulated by inflammatory cells. | 1998 | J. Periodont. Res. | pmid:9689619 |
| Stolarek R et al. | Effect of various agonists on nitric oxide generation by human polymorphonuclear leukocytes. | 1998 | Int. J. Clin. Lab. Res. | pmid:9689552 |
| Gozal D et al. | Platelet-activating factor modulates cardiorespiratory responses in the conscious rat. | 1998 | Am. J. Physiol. | pmid:9688699 |