Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Stammberger U et al. | Combined treatment with endothelin- and PAF-antagonists reduces posttransplant lung ischemia/reperfusion injury. | 1999 | J. Heart Lung Transplant. | pmid:10528748 |
Marr KA et al. | Agonist-induced adherence of equine neutrophils to fibronectin- and serum-coated plastic is CD18 dependent. | 1999 | Vet. Immunol. Immunopathol. | pmid:10532398 |
Serou MJ et al. | Interleukin-1 beta activates expression of cyclooxygenase-2 and inducible nitric oxide synthase in primary hippocampal neuronal culture: platelet-activating factor as a preferential mediator of cyclooxygenase-2 expression. | 1999 | J. Neurosci. Res. | pmid:10533051 |
Mustafa SB et al. | Suppression of lipopolysaccharide-induced nitric oxide synthase expression by platelet-activating factor receptor antagonists in the rat liver and cultured rat Kupffer cells. | 1999 | Hepatology | pmid:10534342 |
Nicholson SC et al. | Echocardiographic and survival studies in mice undergoing endotoxic shock: effects of genetic ablation of inducible nitric oxide synthase and pharmacologic antagonism of platelet-activating factor. | 1999 | J. Surg. Res. | pmid:10534424 |
McKenna CJ et al. | Familial dilated cardiomyopathy. | 1999 | Circulation | pmid:10534480 |
Tselepis AD et al. | Platelet aggregatory response to platelet activating factor (PAF), ex vivo, and PAF-acetylhydrolase activity in patients with unstable angina: effect of c7E3 Fab (abciximab) therapy. | 1999 | Cardiovasc. Res. | pmid:10536703 |
Ernest S and Bello-Reuss E | Secretion of platelet-activating factor is mediated by MDR1 P-glycoprotein in cultured human mesangial cells. | 1999 | J. Am. Soc. Nephrol. | pmid:10541289 |
Manya H et al. | Biochemical characterization of various catalytic complexes of the brain platelet-activating factor acetylhydrolase. | 1999 | J. Biol. Chem. | pmid:10542206 |
Koyama S et al. | The potential of various lipopolysaccharides to release monocyte chemotactic activity from lung epithelial cells and fibroblasts. | 1999 | Eur. Respir. J. | pmid:10543273 |