Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

Cross Reference

Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Adenocarcinoma D000230 166 associated lipids
Agranulocytosis D000380 7 associated lipids
Albuminuria D000419 18 associated lipids
Alzheimer Disease D000544 76 associated lipids
Amnesia D000647 12 associated lipids
Anaphylaxis D000707 35 associated lipids
Anemia, Sickle Cell D000755 34 associated lipids
Angina Pectoris D000787 27 associated lipids
Angina, Unstable D000789 14 associated lipids
Hypoxia D000860 23 associated lipids
Anthrax D000881 1 associated lipids
Arenaviridae Infections D001117 1 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Arterial Occlusive Diseases D001157 12 associated lipids
Arteriosclerosis D001161 86 associated lipids
Arteriosclerosis Obliterans D001162 8 associated lipids
Arthritis D001168 41 associated lipids
Arthritis, Experimental D001169 24 associated lipids
Arthus Reaction D001183 8 associated lipids
Ascites D001201 25 associated lipids
Asphyxia Neonatorum D001238 4 associated lipids
Asthma D001249 52 associated lipids
Pulmonary Atelectasis D001261 1 associated lipids
Behcet Syndrome D001528 7 associated lipids
Birth Weight D001724 23 associated lipids
Blister D001768 16 associated lipids
Blood Platelet Disorders D001791 12 associated lipids
Body Weight D001835 333 associated lipids
Bovine Virus Diarrhea-Mucosal Disease D001912 2 associated lipids
Brain Diseases D001927 27 associated lipids
Brain Edema D001929 20 associated lipids
Brain Injuries D001930 4 associated lipids
Bronchial Diseases D001982 3 associated lipids
Bronchial Spasm D001986 18 associated lipids
Bronchiectasis D001987 7 associated lipids
Bronchopulmonary Dysplasia D001997 4 associated lipids
Bronchopulmonary Sequestration D001998 3 associated lipids
Burns D002056 34 associated lipids
Burns, Inhalation D002059 4 associated lipids
Carbon Monoxide Poisoning D002249 9 associated lipids
Cardiovascular Diseases D002318 24 associated lipids
Cell Transformation, Neoplastic D002471 126 associated lipids
Central Nervous System Diseases D002493 10 associated lipids
Brain Ischemia D002545 89 associated lipids
Ischemic Attack, Transient D002546 42 associated lipids
Cerebrovascular Disorders D002561 25 associated lipids
Cholecystitis D002764 8 associated lipids
Cholestasis D002779 23 associated lipids
Cholestasis, Intrahepatic D002780 4 associated lipids
Chromoblastomycosis D002862 2 associated lipids
Cluster Headache D003027 4 associated lipids
Colitis D003092 69 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Colonic Diseases D003108 5 associated lipids
Colonic Neoplasms D003110 161 associated lipids
Conjunctivitis D003231 7 associated lipids
Constriction, Pathologic D003251 8 associated lipids
Contracture D003286 3 associated lipids
Coronary Artery Disease D003324 47 associated lipids
Coronary Disease D003327 70 associated lipids
Coronary Thrombosis D003328 7 associated lipids
Cystic Fibrosis D003550 65 associated lipids
Cystitis D003556 23 associated lipids
Death, Sudden D003645 12 associated lipids
Dermatitis, Atopic D003876 19 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Diabetes Mellitus, Type 1 D003922 56 associated lipids
Diabetes Mellitus, Type 2 D003924 87 associated lipids
Diabetic Angiopathies D003925 20 associated lipids
Diabetic Retinopathy D003930 39 associated lipids
Dictyocaulus Infections D004022 1 associated lipids
Disseminated Intravascular Coagulation D004211 7 associated lipids
Drug Hypersensitivity D004342 20 associated lipids
Duodenal Ulcer D004381 12 associated lipids
Dyslexia D004410 3 associated lipids
Ear Diseases D004427 7 associated lipids
Edema D004487 152 associated lipids
Encephalitis D004660 15 associated lipids
Encephalomyelitis, Autoimmune, Experimental D004681 26 associated lipids
Epilepsy D004827 35 associated lipids
Leukemia, Erythroblastic, Acute D004915 41 associated lipids
Escherichia coli Infections D004927 17 associated lipids
Extravasation of Diagnostic and Therapeutic Materials D005119 3 associated lipids
Fetal Growth Retardation D005317 9 associated lipids
Fever D005334 35 associated lipids
Fibrosis D005355 23 associated lipids
Gastritis D005756 27 associated lipids
Gastroesophageal Reflux D005764 10 associated lipids
Glioma D005910 112 associated lipids
Gliosis D005911 6 associated lipids
Glomerulonephritis D005921 35 associated lipids
Glomerulonephritis, IGA D005922 7 associated lipids
Rhinitis, Allergic, Seasonal D006255 7 associated lipids
Heart Arrest D006323 13 associated lipids
Heart Defects, Congenital D006330 20 associated lipids
Cardiomegaly D006332 31 associated lipids
Heart Injuries D006335 6 associated lipids
Hematoma, Subdural D006408 3 associated lipids
Hemolysis D006461 131 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

Location Cross reference Weighted score Related literatures
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What functions are associated with Platelet activating factor?


Related references are published most in these journals:

Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

Related references are published most in these journals:

Lipid concept Cross reference Weighted score Related literatures
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What genes are associated with Platelet activating factor?

Related references are published most in these journals:


Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Per page 10 20 50 100 | Total 8526
Authors Title Published Journal PubMed Link
Penna C et al. Post-ischaemic activation of kinases in the pre-conditioning-like cardioprotective effect of the platelet-activating factor. 2009 Acta Physiol (Oxf) pmid:19432589
Lang F et al. Osmotic shock-induced suicidal death of erythrocytes. 2006 May-Jun Acta Physiol (Oxf) pmid:16734755
Kecskemeti V Electrophysiological effects of platelet-activating factor (PAF) in guinea-pig cardiac preparations. 1990 Acta Physiol Hung pmid:2371852
Balogh I et al. Cytochemical effects of biologically active substances on the heart muscle. 1990 Acta Physiol Hung pmid:2371866
Alving K et al. The possible role of prostaglandin D2 in the long-lasting airways vasodilatation induced by allergen in the sensitized pig. 1991 Acta Physiol. Scand. pmid:1957709
Arner M and Högestätt ED Endothelium-dependent relaxation and effects of prostacyclin, endothelin and platelet-activating factor in human hand veins and arteries. 1991 Acta Physiol. Scand. pmid:1715111
Björk J et al. Paf-acether (platelet-activating factor) increases microvascular permeability and affects endothelium-granulocyte interaction in microvascular beds. 1983 Acta Physiol. Scand. pmid:6659994
Karlström G et al. Renal and circulatory effects of medullipin I, as studied in the in-vivo cross-circulated isolated kidney and intact Wistar-Kyoto (WKY) rat. 1989 Acta Physiol. Scand. pmid:2603751
Iversen VV et al. Platelet activating factor (PAF) increases plasma protein extravasation and induces lowering of interstitial fluid pressure (P) in rat skin. 2005 Acta Physiol. Scand. pmid:16128692
Greiff L et al. Effects of topical platelet activating factor on the guinea-pig tracheobronchial mucosa in vivo. 1997 Acta Physiol. Scand. pmid:9338520
Zia-ul-Haq M et al. Platelet aggregation and anti-inflammatory effects of garden pea, Desi chickpea and Kabuli chickpea. 2012 Jul-Aug Acta Pol Pharm pmid:22876614
Rubio de Krömer MT et al. Differences in eosinophil and neutrophil chemotactic responses in sowda and generalized form of onchocerciasis. 1995 Acta Trop. pmid:8546035
Konstantinov SM et al. Efficacy of anticancer alkylphosphocholines in Trypanosoma brucei subspecies. 1997 Acta Trop. pmid:9107362
Dutra PM et al. Stimulation of Leishmania tropica protein kinase CK2 activities by platelet-activating factor (PAF). 2009 Acta Trop. pmid:19433049
Bazan NG and Allan G Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. 1996 Adv Neurol pmid:8790822
Söling HD et al. Regulation of protein kinases in exocrine secretory cells during agonist-induced exocytosis. 1985 Adv. Enzyme Regul. pmid:4072796
van Rossem K et al. The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. 1996 Adv. Exp. Med. Biol. pmid:8798843
Shimizu T and Mutoh H Structure and regulation of platelet activating factor receptor gene. 1997 Adv. Exp. Med. Biol. pmid:9321953
Mori M et al. Localization of platelet-activating factor receptor in the rat brain. 1997 Adv. Exp. Med. Biol. pmid:9321976
Erickson KL et al. Alteration of platelet activating factor-induced macrophage tumoricidal response, IA expression, and signal transduction by N-3 fatty acids. 1997 Adv. Exp. Med. Biol. pmid:9321978
Muguruma K et al. The central role of PAF in necrotizing enterocolitis development. 1997 Adv. Exp. Med. Biol. pmid:9321979
Paubert-Braquet M et al. Platelet-activating factor amplifies tumour necrosis factor-induced superoxide generation by human neutrophils. 1990 Adv. Exp. Med. Biol. pmid:2173875
Aoki Y et al. A simple, rapid and specific radioreceptor assay for platelet-activating factor. 1997 Adv. Exp. Med. Biol. pmid:9321990
Bourgain RH et al. Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). 1987 Adv. Exp. Med. Biol. pmid:3673721
Marshall LA et al. Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. 1999 Adv. Exp. Med. Biol. pmid:10667333
Kato K Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. 1999 Adv. Exp. Med. Biol. pmid:10667334
Goldman R et al. Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. 1999 Adv. Exp. Med. Biol. pmid:10667361
Dohi T et al. Functional role of platelet-activating factor receptor in secretory response in adrenal chromaffin cells. 1996 Adv. Exp. Med. Biol. pmid:9131134
Lee T Acetylation of sphingosine by PAF-dependent transacetylase. 1996 Adv. Exp. Med. Biol. pmid:9131136
Muguruma K et al. The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. 1996 Adv. Exp. Med. Biol. pmid:9131138
Baltas G et al. Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. 1996 Adv. Exp. Med. Biol. pmid:9131139
Ye RD et al. Stimulation of NF-kappa B activation and gene expression by platelet-activating factor. 1996 Adv. Exp. Med. Biol. pmid:9131140
Shukla SD Tyrosine kinase activation by PAF leads to downstream gene expression. 1996 Adv. Exp. Med. Biol. pmid:9131141
Morooka S and Natsume Y Effect of SM-12502 on disseminated intravascular coagulation (DIC) in tumor-bearing rats. 1996 Adv. Exp. Med. Biol. pmid:9131147
Sanchez Crespo M et al. Platelet-activating factor is an effector of rapid reactions and an inductor of late responses in immune-mediated injury. 1996 Adv. Exp. Med. Biol. pmid:9131148
Ohkuni H et al. Purification and partial characterization of a novel human platelet aggregation factor in the extracellular products of Streptococcus mitis, strain Nm-65. 1997 Adv. Exp. Med. Biol. pmid:9331745
Saito K PAF response to inflammatory and non-inflammatory stimuli. 1996 Adv. Exp. Med. Biol. pmid:9131150
Silver D et al. Role of platelet-activating factor in skeletal muscle ischemia-reperfusion injury. 1996 Adv. Exp. Med. Biol. pmid:9131151
Lopes-Martins RA et al. Platelet-activating factor. A possible role in the modulation of the vasomotor tone and blood pressure. 1996 Adv. Exp. Med. Biol. pmid:9131152
Camussi G et al. Platelet-activating factor and angiogenesis. 1996 Adv. Exp. Med. Biol. pmid:9131153
Oh-Ishi S et al. Role of synergistic action of PAF and kinin in bacterial endotoxin-induced hypotension in rats. 1996 Adv. Exp. Med. Biol. pmid:9131154
Tetta C et al. The role of platelet-activating factor in the biocompatibility of hemodialysis membranes. 1996 Adv. Exp. Med. Biol. pmid:9131156
Schlondorff D Interactions of platelet activating factor and prostaglandins in the glomerulus and in mesangial cells. 1989 Adv. Exp. Med. Biol. pmid:2696352
Remuzzi G Eicosanoids and platelet activating factor as possible mediators of injury in experimental nephropathies. 1989 Adv. Exp. Med. Biol. pmid:2696353
Rabinovici R et al. PAF and TNF alpha interactions in the pathophysiology of septic shock. 1991 Adv. Exp. Med. Biol. pmid:1818486
Kosar-Hashemi B et al. Glyceryl ether monooxygenase [EC 1.14.16.5]: stoichiometry and inhibition. 1993 Adv. Exp. Med. Biol. pmid:8304231
Vernadakis A et al. C-6 glioma cells of early passage have progenitor properties in culture. 1991 Adv. Exp. Med. Biol. pmid:1685850
Jin N et al. Platelet activating factor causes relaxation of isolated pulmonary artery and aorta. 1991 Adv. Exp. Med. Biol. pmid:1803920
Kurachi M et al. Suppression of bronchial response to platelet activating factor following taurine administration. 1987 Adv. Exp. Med. Biol. pmid:3434419
Fisher RA et al. AGEPC: a potent calcium-dependent chemical mediator in the liver. 1988 Adv. Exp. Med. Biol. pmid:3213685