Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Denizot Y et al. | PAF and hematopoiesis. VIII. Biosynthesis and metabolism of PAF by human bone marrow stromal cells. | 1996 | Exp. Hematol. | pmid:8862444 |
Wang X et al. | Potentiation of acetylcholine-induced responses in freshly isolated rabbit aortic endothelial cells. | 1996 Sep-Oct | J. Vasc. Res. | pmid:8862147 |
Saito H et al. | Histamine augments VCAM-1 expression on IL-4- and TNF-alpha-stimulated human umbilical vein endothelial cells. | 1996 | Int. Arch. Allergy Immunol. | pmid:8859220 |
Jouët P and Sarna SK | Platelet-activating factor (PAF) stimulates giant migrating contractions during ileal inflammation. | 1996 | J. Pharmacol. Exp. Ther. | pmid:8858995 |
Shi LC et al. | Guanine nucleotide regulatory proteins, Gq and Gi1/2, mediate platelet-activating factor-stimulated phosphoinositide metabolism in immortalized hippocampal cells. | 1996 | J. Neurochem. | pmid:8858930 |
Lopes-Martins R et al. | Pharmacological evidence of a role for platelet activating factor as a modulator of vasomotor tone and blood pressure. | 1996 | Eur. J. Pharmacol. | pmid:8858301 |
Abu-Zidan FM et al. | Role of platelet-activating factor antagonism in posthemorrhage septic shock in pigs. | 1996 | J Trauma | pmid:8858021 |
Mastroroberto P et al. | Elevated circulating levels of von Willebrand factor and D-dimer in patients with heart failure and mechanical prosthesis. | 1996 | Scand J Thorac Cardiovasc Surg | pmid:8857679 |
Albert DH et al. | ABT-299, a novel PAF antagonist, attenuates multiple effects of endotoxemia in conscious rats. | 1996 | Shock | pmid:8856845 |
Chen CC et al. | Tumor necrosis factor-alpha, platelet-activating factor, and hydrogen peroxide activate protein kinase C subtypes alpha and epsilon in human saphenous vein endothelial cells. | 1996 | J. Cardiovasc. Pharmacol. | pmid:8856479 |
Ebara T et al. | Role of platelet-activating factor and prostanoids in hemodynamic changes in rat experimental endotoxic shock. | 1996 | Jpn. J. Pharmacol. | pmid:8854207 |
Gaylord MS et al. | Altered platelet-activating factor levels and acetylhydrolase activities are associated with increasing severity of bronchopulmonary dysplasia. | 1996 | Am. J. Med. Sci. | pmid:8853062 |
Hoffman BF et al. | Arrhythmias caused by platelet activating factor. | 1996 | J. Cardiovasc. Electrophysiol. | pmid:8853022 |
Renesto P et al. | Protective effect of platelet activating factor antagonists on cultured endothelial cell lysis induced by elastase or activated neutrophils. | 1996 | Br. J. Pharmacol. | pmid:8851508 |
Hahn M et al. | Blockade of receptor-operated calcium channels by mibefradil (Ro 40-5967): effects on intracellular calcium and platelet aggregation. | 1995 | Cardiovasc Drugs Ther | pmid:8850387 |
Yokota K et al. | Inhibitory effects of the new anti-platelet agent KBT-3022 and its metabolite on rabbit neutrophil function in vitro. | 1996 | Jpn. J. Pharmacol. | pmid:8847836 |
Libert C et al. | Platelet-activating factor is a mediator in tumor necrosis factor/galactosamine-induced lethality. | 1995-1996 | J. Inflamm. | pmid:8844494 |
Kemény L et al. | Effect of locally applied WEB 2086, a platelet-activating factor antagonist, on inflammatory skin conditions in mice. | 1996 | Arch. Dermatol. Res. | pmid:8844132 |
Paulino N et al. | Mechanisms involved in the contractile responses induced by the hydroalcoholic extract of Phyllanthus urinaria on the guinea pig isolated trachea: evidence for participation of tachykinins and influx of extracellular Ca2+ sensitive to ruthenium red. | 1996 | Gen. Pharmacol. | pmid:8842681 |
Tenor H et al. | Effects of theophylline and rolipram on leukotriene C4 (LTC4) synthesis and chemotaxis of human eosinophils from normal and atopic subjects. | 1996 | Br. J. Pharmacol. | pmid:8842438 |
Isogai E et al. | [Platelet activating factor (PAF) and Lyme disease]. | 1996 | Nippon Saikingaku Zasshi | pmid:8840817 |
Imagawa M et al. | Modulation of platelet-activating factor synthesis by recombinant interferon-alpha in human renal cell carcinoma. | 1996 | Urol. Int. | pmid:8840484 |
Kurata M et al. | A comparative study of whole-blood platelet aggregation in laboratory animals: its species differences and comparison with turbidimetric method. | 1995 | Comp. Biochem. Physiol. C, Pharmacol. Toxicol. Endocrinol. | pmid:8838690 |
Louis RE and Radermecker MF | Acute bronchial obstruction following inhalation of PAF in asthmatic and normal subjects: comparison with methacholine. | 1996 | Eur. Respir. J. | pmid:8836652 |
Barkai U and Kraicer PF | Intrauterine signaling and embryonic implantation. | 1996 Mar-Apr | Biol. Signals | pmid:8836494 |
Taylor ML et al. | Differential expression of platelet activation markers in aspirin-sensitive asthmatics and normal subjects. | 1996 | Clin. Exp. Allergy | pmid:8835129 |
Gabryelewicz A | Etiology and pathogenesis of acute pancreatitis--current view. | 1995 | Rocz. Akad. Med. Bialymst. | pmid:8834603 |
Matsuo Y et al. | Role of platelet-activating factor and thromboxane A2 in radical production during ischemia and reperfusion of the rat brain. | 1996 | Brain Res. | pmid:8833766 |
Tsukioka K et al. | Increased plasma level of platelet-activating factor (PAF) and decreased serum PAF acetylhydrolase (PAFAH) activity in adults with bronchial asthma. | 1996 Jan-Feb | J Investig Allergol Clin Immunol | pmid:8833165 |
Savu SR et al. | Determination of 1-O-acyl-2-acetyl-sn-glyceryl-3-phosphorylcholine, platelet-activating factor and related phospholipids in biological samples by high-performance liquid chromatography--tandem mass spectrometry. | 1996 | J. Chromatogr. B, Biomed. Appl. | pmid:8832423 |
Ribaldi E et al. | Inhibition of PAF synthesis by stimulated human polymorphonuclear leucocytes with cloricromene, an inhibitor of phospholipase A2 activation. | 1996 | Br. J. Pharmacol. | pmid:8832056 |
Sandoval D et al. | The role of neutrophils and platelet-activating factor in mediating experimental pancreatitis. | 1996 | Gastroenterology | pmid:8831604 |
Galloway SW and Kingsnorth AN | Lung injury in the microembolic model of acute pancreatitis and amelioration by lexipafant (BB-882), a platelet-activating factor antagonist. | 1996 | Pancreas | pmid:8829181 |
Spangelo BL and Jarvis WD | Lysophosphatidylcholine stimulates interleukin-6 release from rat anterior pituitary cells in vitro. | 1996 | Endocrinology | pmid:8828503 |
López-Novoa JM et al. | The role of platelet-activating factor and the effect of PAF blocking receptors on the outcome of ARF. | 1996 | Ren Fail | pmid:8827995 |
Grinyó JM et al. | The role of platelet-activating factor antagonists in the prophylaxis of posttransplant acute tubular necrosis. | 1996 | Ren Fail | pmid:8827990 |
Burt RP et al. | The role of diacylglycerol and activation of protein kinase C in alpha 1A-adrenoceptor-mediated contraction to noradrenaline of rat isolated epididymal vas deferens. | 1996 | Br. J. Pharmacol. | pmid:8825367 |
Predescu D et al. | The vascular distribution of the platelet-activating factor receptor. | 1996 | Eur. J. Cell Biol. | pmid:8825027 |
Yang HO et al. | Biological and pharmacological effects of pinusolide, a novel platelet activating factor antagonist. | 1995 | Planta Med. | pmid:8824945 |
Murakami K et al. | A novel platelet activating factor antagonist, SM-12502, attenuates endotoxin-induced disseminated intravascular coagulation and acute pulmonary vascular injury by inhibiting TNF production in rats. | 1996 | Thromb. Haemost. | pmid:8822594 |
Miguélez R et al. | Anti-inflammatory effect of a PAF receptor antagonist and a new molecule with antiproteinase activity in an experimental model of acute urate crystal arthritis. | 1996 | J Lipid Mediat Cell Signal | pmid:8821809 |
Kuitert L and Barnes NC | PAF and asthma--time for an appraisal? | 1995 | Clin. Exp. Allergy | pmid:8821294 |
Lin J et al. | Effects of platelet-activating factor (PAF) receptor blockage on mucous glycoprotein secretion in cultured chinchilla middle ear epithelium. | 1996 | Acta Otolaryngol. | pmid:8820353 |
Abu-Zidan FM and Walther S | Platelet activating factor antagonism improves cardiovascular function in non-hypotensive sepsis in pigs. | 1996 | Eur J Surg | pmid:8817228 |
Le Solleu H et al. | A pharmacophore for high affinity PAF antagonists. I. Electronic model using molecular electrostatic potential. | 1996 | J Lipid Mediat Cell Signal | pmid:8816988 |
Le Texier L et al. | Structure-activity relationships in platelet-activating factor (PAF). 8. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors: anti-acetylcholinesterase activity and comparative SAR. | 1996 | J Lipid Mediat Cell Signal | pmid:8816985 |
Le Texier L et al. | Structure-activity relationships in platelet-activating factor (PAF). 7. Tetrahydrofuran derivatives as dual PAF antagonists and acetylcholinesterase inhibitors. Synthesis and PAF-antagonistic activity. | 1996 | J Lipid Mediat Cell Signal | pmid:8816984 |
Bauldry SA and Wooten RE | Leukotriene B4 and platelet activating factor production in permeabilized human neutrophils: role of cytosolic PLA2 in LTB4 and PAF generation. | 1996 | Biochim. Biophys. Acta | pmid:8816854 |
Sato E et al. | Bradykinin stimulates alveolar macrophages to release neutrophil, monocyte, and eosinophil chemotactic activity. | 1996 | J. Immunol. | pmid:8816423 |
Erger RA and Casale TB | Eosinophil migration in response to three molecular species of platelet activating factor. | 1996 | Inflamm. Res. | pmid:8814455 |