Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Kochanek PM et al. | Platelet activating factor antagonists do not alter normal cerebral blood flow or cerebral oxygen consumption. | 1990 | Adv. Exp. Med. Biol. | pmid:2096640 |
| Camussi G et al. | Antiflammins inhibit synthesis of platelet-activating factor and intradermal inflammatory reactions. | 1990 | Adv. Exp. Med. Biol. | pmid:2096695 |
| Bussolino F et al. | Role of platelet activating factor in the adhesion process of polymorphonuclear neutrophils to endothelial cells. | 1991 | Adv. Exp. Med. Biol. | pmid:1767755 |
| Droy-Lefaix MT et al. | Effect of the platelet-activating factor (PAF) antagonist, BN 52021, on free radical-induced intestinal ischemia-reperfusion damage in the rat. | 1990 | Adv. Exp. Med. Biol. | pmid:2244522 |
| Damas J et al. | Endotoxin shock, kinin system and PAF-acether in the rat. | 1989 | Adv. Exp. Med. Biol. | pmid:2610092 |
| Vadas P and Pruzanski W | Phospholipase A2 activation is the pivotal step in the effector pathway of inflammation. | 1990 | Adv. Exp. Med. Biol. | pmid:2239447 |
| Kornecki E et al. | Interactions of the alkyl-ether-phospholipid, platelet activating factor (PAF) with platelets, neural cells, and the psychotropic drugs triazolobenzodiazepines. | 1987 | Adv. Exp. Med. Biol. | pmid:2893525 |
| MacIntyre DE et al. | Agonist-induced inositol phospholipid metabolism and Ca++ flux in human platelet activation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010662 |
| Hallam TJ et al. | Control and interrelation of aggregation and secretion; the roles of Ca2+, diacylglycerol and thromboxane with particular reference to ADP stimulation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010663 |
| Gerrard JM et al. | Platelet protein phosphorylation. | 1985 | Adv. Exp. Med. Biol. | pmid:3010667 |
| Haslam RJ et al. | Receptor-effector coupling in platelets: roles of guanine nucleotides. | 1985 | Adv. Exp. Med. Biol. | pmid:3010668 |
| Bourgain RH et al. | Vivo effects of PAF-acether and arterial thrombosis. | 1986 | Adv. Exp. Med. Biol. | pmid:3799334 |
| Maes L et al. | In vivo arterial platelet-vessel wall interaction and thrombosis: induction, on-line registration and ultrastructural control. | 1985 | Adv. Exp. Med. Biol. | pmid:3832867 |
| Tuffin DP et al. | Specific binding of [3H]-1-O-octadecyl Paf-acether to washed human platelets. | 1985 | Adv. Exp. Med. Biol. | pmid:3834789 |
| Kurachi M et al. | Suppression of bronchial response to platelet activating factor following taurine administration. | 1987 | Adv. Exp. Med. Biol. | pmid:3434419 |
| Bourgain RH et al. | Arterial obstruction induced by PAF-acether (1-O-alkyl-sn-glycero-3-phosphocholine). | 1987 | Adv. Exp. Med. Biol. | pmid:3673721 |
| Fisher RA et al. | AGEPC: a potent calcium-dependent chemical mediator in the liver. | 1988 | Adv. Exp. Med. Biol. | pmid:3213685 |
| Bourgain RH et al. | PAF-acether induced arterial thrombosis and the effect of specific antagonists. | 1992 | Adv. Exp. Med. Biol. | pmid:1288104 |
| van Rossem K et al. | The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. | 1996 | Adv. Exp. Med. Biol. | pmid:8798843 |
| Snyder F et al. | Biosynthesis of platelet-activating factor and enzyme inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131118 |
| Satoh K et al. | Production of platelet-activating factor by brain microvascular endothelial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131120 |
| Francescangeli E et al. | PAF-synthesizing enzymes in neural cells during differentiation and in gerbil brain during ischemia. | 1996 | Adv. Exp. Med. Biol. | pmid:9131121 |
| Yamada M et al. | Platelet-activating factor production in the stimulated macrophages is enhanced by the cyclooxygenase inhibitors. | 1996 | Adv. Exp. Med. Biol. | pmid:9131122 |
| van den Bosch H et al. | The role of peroxisomes in ether lipid synthesis. Back to the roots of PAF. | 1996 | Adv. Exp. Med. Biol. | pmid:9131123 |
| Dohi T et al. | Platelet-activating factor synthesis and its role in salivary glands. | 1996 | Adv. Exp. Med. Biol. | pmid:9131124 |
| Nakayama R et al. | Physiological action of PAF in yeast Saccharomyces cerevisiae. | 1996 | Adv. Exp. Med. Biol. | pmid:9131125 |
| Demopoulos CA and Antonopoulou S | A discovery trip to compounds with PAF-like activity. | 1996 | Adv. Exp. Med. Biol. | pmid:9131127 |
| Rementzis J et al. | Biologically active lipids from S. scombrus. | 1996 | Adv. Exp. Med. Biol. | pmid:9131128 |
| Orevi M et al. | Purification and partial characterization of the PAF antagonist from the saliva of the leech Hirudo medicinalis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131129 |
| Shimizu T et al. | Platelet-activating factor receptor. Gene structure and tissue-specific regulation. | 1996 | Adv. Exp. Med. Biol. | pmid:9131130 |
| Sato S et al. | Up-regulation of the intracellular Ca2+ signaling and mRNA expression of platelet-activating factor receptor by estradiol in human uterine endometrial cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131133 |
| Dohi T et al. | Functional role of platelet-activating factor receptor in secretory response in adrenal chromaffin cells. | 1996 | Adv. Exp. Med. Biol. | pmid:9131134 |
| Lee T | Acetylation of sphingosine by PAF-dependent transacetylase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131136 |
| Muguruma K et al. | The prevention of necrotizing enterocolitis. The role of platelet-activating factor acetylhydrolase. | 1996 | Adv. Exp. Med. Biol. | pmid:9131138 |
| Baltas G et al. | Implication of PAF and acetylhydrolase (PAF-AH) activity in periodontal disease. | 1996 | Adv. Exp. Med. Biol. | pmid:9131139 |
| Ye RD et al. | Stimulation of NF-kappa B activation and gene expression by platelet-activating factor. | 1996 | Adv. Exp. Med. Biol. | pmid:9131140 |
| Shukla SD | Tyrosine kinase activation by PAF leads to downstream gene expression. | 1996 | Adv. Exp. Med. Biol. | pmid:9131141 |
| Yang HC et al. | Characterization of plasmalogen-selective phospholipase A2 from bovine brain. | 1996 | Adv. Exp. Med. Biol. | pmid:9131165 |
| Ferby I et al. | PAF-induced MAPK activation is inhibited by wortmannin in neutrophils and macrophages. | 1996 | Adv. Exp. Med. Biol. | pmid:9131167 |
| Thierse HJ et al. | Evidence for activation of cyclooxygenase-1/-2 by endogenous nitric oxide in adjuvant arthritic Lewis rats. | 1996 | Adv. Exp. Med. Biol. | pmid:9131171 |
| Curtis LD | Lexipafant (BB-882), a potent PAF antagonist in acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131174 |
| McKay C et al. | The use of lexipafant in the treatment of acute pancreatitis. | 1996 | Adv. Exp. Med. Biol. | pmid:9131175 |
| Tamura G et al. | Effect of a potent platelet-activating factor antagonist, WEB-2086, on asthma. A multicenter, double-blind placebo-controlled study in Japan. | 1996 | Adv. Exp. Med. Biol. | pmid:9131176 |
| Albert DH et al. | Ex vivo inhibition of PAF-induced beta-thromboglobulin release in man by ABT-299, a potent PAF antagonist. | 1996 | Adv. Exp. Med. Biol. | pmid:9131177 |
| Michibayashi T | Neurogenic inhibitory action through platelets of platelet activating factor (PAF) on vasoconstrictive responsiveness to pressor agents. | 1997 | Adv. Exp. Med. Biol. | pmid:9561145 |
| Ishii I et al. | High and low affinity mutants of platelet-activating factor receptor. | 1997 | Adv. Exp. Med. Biol. | pmid:9561146 |
| Bazan NG | Bioactive lipids and gene expression in neuronal plasticity. | 1998 | Adv. Exp. Med. Biol. | pmid:10079836 |
| Marshall LA et al. | Respective roles of the 14 kDa and 85 kDa phospholipase A2 enzymes in human monocyte eicosanoid formation. | 1999 | Adv. Exp. Med. Biol. | pmid:10667333 |
| Kato K | Modulation of long-term potentiation in the CA1 area of rat hippocampus by platelet-activating factor. | 1999 | Adv. Exp. Med. Biol. | pmid:10667334 |
| Goldman R et al. | Lipid mediators stimulate reactive oxygen species formation in immortalized human keratinocytes. | 1999 | Adv. Exp. Med. Biol. | pmid:10667361 |