Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Disease | Cross reference | Weighted score | Related literature |
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Function | Cross reference | Weighted score | Related literatures |
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Model | Cross reference | Weighted score | Related literatures |
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Authors | Title | Published | Journal | PubMed Link |
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Senn N and Garay RP | Regulation of Na+ and K+ contents in rat thymocytes. | 1989 | Am. J. Physiol. | pmid:2546433 |
Sirois MG and Edelman ER | VEGF effect on vascular permeability is mediated by synthesis of platelet-activating factor. | 1997 | Am. J. Physiol. | pmid:9227554 |
Tomeo AC and Durán WN | Resistance and exchange microvessels are modulated by different PAF receptors. | 1991 | Am. J. Physiol. | pmid:1659229 |
Hines KL and Fisher RA | Regulation of hepatic glycogenolysis and vasoconstriction during antigen-induced anaphylaxis. | 1992 | Am. J. Physiol. | pmid:1375439 |
Livio M et al. | Role of platelet-activating factor in primary hemostasis. | 1988 | Am. J. Physiol. | pmid:2837916 |
Rioux KP and Wallace JL | Mast cell activation augments gastric mucosal injury through a leukotriene-dependent mechanism. | 1994 | Am. J. Physiol. | pmid:8203531 |
Whittle BJ et al. | Microvascular actions of platelet-activating factor on rat gastric mucosa and submucosa. | 1986 | Am. J. Physiol. | pmid:3789144 |
Khoury J and Langleben D | Platelet-activating factor stimulates lung pericyte growth in vitro. | 1996 | Am. J. Physiol. | pmid:8780000 |
Zimmerman BJ et al. | Molecular determinants of lipid mediator-induced leukocyte adherence and emigration in rat mesenteric venules. | 1994 | Am. J. Physiol. | pmid:8160832 |
Toyofuku T et al. | Pulmonary vascular response to platelet-activating factor in conscious sheep. | 1988 | Am. J. Physiol. | pmid:3414811 |
Gaboury J et al. | Nitric oxide prevents leukocyte adherence: role of superoxide. | 1993 | Am. J. Physiol. | pmid:8214120 |
Widdicombe JH et al. | Release of cyclooxygenase products from primary cultures of tracheal epithelia of dog and human. | 1989 | Am. J. Physiol. | pmid:2514604 |
Suematsu M et al. | In vivo visualization of oxidative changes in microvessels during neutrophil activation. | 1993 | Am. J. Physiol. | pmid:8096123 |
Huber W et al. | Leukotriene B4 and C4 production in isolated rat gastric mucosal cells. | 1993 | Am. J. Physiol. | pmid:8279553 |
Del Maschio A et al. | Platelet activation by polymorphonuclear leukocytes exposed to chemotactic agents. | 1990 | Am. J. Physiol. | pmid:2156456 |
Asako H et al. | Phalloidin prevents leukocyte emigration induced by proinflammatory stimuli in rat mesentery. | 1992 | Am. J. Physiol. | pmid:1362329 |
DeFily DV et al. | PAF attenuates endothelium-dependent coronary arteriolar vasodilation. | 1996 | Am. J. Physiol. | pmid:8764261 |
McGowan HM et al. | Increased aortic PGI2 and plasma lyso-PAF in the unclipped one-kidney hypertensive rat. | 1986 | Am. J. Physiol. | pmid:3538908 |
Xie J et al. | Dissociation of TNF-alpha from endotoxin-induced nitric oxide and acute-phase hypotension. | 1997 | Am. J. Physiol. | pmid:9249487 |
MartÃnez-Salgado C et al. | Involvement of phospholipase A2 in gentamicin-induced rat mesangial cell activation. | 1997 | Am. J. Physiol. | pmid:9249592 |
Harris NR et al. | Influence of arteriovenular pairing on PAF-induced capillary filtration. | 1999 | Am. J. Physiol. | pmid:9887023 |
Munoz NM et al. | Effects of PAF on isolated rat airways perfused with blood-free solution. | 1991 | Am. J. Physiol. | pmid:2018147 |
Olson NC et al. | Role of platelet-activating factor and eicosanoids during endotoxin-induced lung injury in pigs. | 1990 | Am. J. Physiol. | pmid:2163217 |
Yamazaki M et al. | Modulation of leukotriene B4 and platelet-activating factor binding to neutrophils. | 1991 | Am. J. Physiol. | pmid:1653524 |
Hasunuma K et al. | Endothelin 1 causes pulmonary vasodilation in rats. | 1990 | Am. J. Physiol. | pmid:2115743 |
Gaboury JP et al. | Molecular mechanisms involved in superoxide-induced leukocyte-endothelial cell interactions in vivo. | 1994 | Am. J. Physiol. | pmid:7908174 |
Bosch RJ et al. | Effects of parathyroid hormone-related protein on human mesangial cells in culture. | 1999 | Am. J. Physiol. | pmid:10600786 |
Schlondorff D et al. | Production of platelet-activating factor in glomeruli and cultured glomerular mesangial cells. | 1986 | Am. J. Physiol. | pmid:3087218 |
Sirén AL and Feuerstein G | Effects of PAF and BN 52021 on cardiac function and regional blood flow in conscious rats. | 1989 | Am. J. Physiol. | pmid:2546449 |
Wallace JL et al. | Platelet-activating factor mediates gastric damage induced by hemorrhagic shock. | 1990 | Am. J. Physiol. | pmid:2372058 |
Buerke M et al. | Isolated cardiac myocytes are sensitized by hypoxia-reoxygenation to neutrophil-released mediators. | 1994 | Am. J. Physiol. | pmid:8304493 |
Kubes P et al. | Leukocyte-induced vascular protein leakage in cat mesentery. | 1991 | Am. J. Physiol. | pmid:1684268 |
Findlay SR et al. | Contraction of guinea pig ileal smooth muscle by acetyl glyceryl ether phosphorylcholine. | 1981 | Am. J. Physiol. | pmid:7282914 |
Montrucchio G et al. | Release of platelet-activating factor from ischemic-reperfused rabbit heart. | 1989 | Am. J. Physiol. | pmid:2539755 |
Kurose I et al. | Microvascular dysfunction induced by nonsteroidal anti-inflammatory drugs: role of leukocytes. | 1996 | Am. J. Physiol. | pmid:8779980 |
Gozal D et al. | Platelet-activating factor modulates cardiorespiratory responses in the conscious rat. | 1998 | Am. J. Physiol. | pmid:9688699 |
Harris NR and Granger DN | Mechanisms underlying enhanced capillary filtration induced by platelet-activating factor. | 1996 | Am. J. Physiol. | pmid:8769743 |
Reinhardt PH et al. | Monosodium urate crystals promote neutrophil adhesion via a CD18-independent and selectin-independent mechanism. | 1996 | Am. J. Physiol. | pmid:8772427 |
Halonen M et al. | Anatomic basis for species differences in peripheral lung strip contraction to PAF. | 1990 | Am. J. Physiol. | pmid:2382734 |
Sun XM et al. | Role of leukocyte beta 2-integrin in PAF-induced shock and intestinal injury. | 1996 | Am. J. Physiol. | pmid:8772517 |
Suzuki M et al. | Continuous binding of the PAF molecule to its receptor is necessary for the long-term aggregation of platelets. | 1998 | Am. J. Physiol. | pmid:9458712 |
Neuwirth R et al. | Extra- and intracellular metabolism of platelet-activating factor by cultured mesangial cells. | 1989 | Am. J. Physiol. | pmid:2705543 |
Gao Y et al. | PAF induces relaxation of pulmonary arteries but contraction of pulmonary veins in the ferret. | 1995 | Am. J. Physiol. | pmid:7653635 |
Owen CA et al. | Cytokines regulate membrane-bound leukocyte elastase on neutrophils: a novel mechanism for effector activity. | 1997 | Am. J. Physiol. | pmid:9124593 |
Wood JG et al. | Gastric microvascular actions of platelet-activating factor: role of leukocytes. | 1992 | Am. J. Physiol. | pmid:1550241 |
Zheng ZG et al. | Platelet-activating factor stimulates resorption by rabbit osteoclasts in vitro. | 1993 | Am. J. Physiol. | pmid:8430791 |
Conyers G et al. | A factor in serum lowers resistance and opens tight junctions of MDCK cells. | 1990 | Am. J. Physiol. | pmid:2221039 |
Badr KF et al. | Glomerular responses to platelet-activating factor in the rat: role of thromboxane A2. | 1989 | Am. J. Physiol. | pmid:2912165 |
Kvietys PR et al. | Ethanol enhances leukocyte-endothelial cell interactions in mesenteric venules. | 1990 | Am. J. Physiol. | pmid:2221068 |
Harris NR et al. | Capillary filtration during acute inflammation: role of adherent neutrophils. | 1993 | Am. J. Physiol. | pmid:7902014 |
Kalra VK et al. | Hypoxia induces PECAM-1 phosphorylation and transendothelial migration of monocytes. | 1996 | Am. J. Physiol. | pmid:8945922 |
Kelly KJ et al. | An oral platelet-activating factor antagonist, Ro-24-4736, protects the rat kidney from ischemic injury. | 1996 | Am. J. Physiol. | pmid:8946001 |
Gallin EK | Evidence for a Ca-activated inwardly rectifying K channel in human macrophages. | 1989 | Am. J. Physiol. | pmid:2750892 |
Esplugues JV and Whittle BJ | Mechanisms contributing to gastric motility changes induced by PAF-acether and endotoxin in rats. | 1989 | Am. J. Physiol. | pmid:2919672 |
Ardaillou N et al. | Vasoconstrictor-evoked prostaglandin synthesis in cultured human mesangial cells. | 1985 | Am. J. Physiol. | pmid:3918460 |
Ferrer-Lopez P et al. | Activation of human platelets by C5a-stimulated neutrophils: a role for cathepsin G. | 1990 | Am. J. Physiol. | pmid:2360620 |
Beyer AJ et al. | PAF and CD18 mediate neutrophil infiltration in upper gastrointestinal tract during intra-abdominal sepsis. | 1998 | Am. J. Physiol. | pmid:9724257 |
Handa RK et al. | Platelet-activating factor is a renal vasodilator in the anesthetized rat. | 1990 | Am. J. Physiol. | pmid:2360650 |
Eakes AT and Olson MS | Regulation of endothelin synthesis in hepatic endothelial cells. | 1998 | Am. J. Physiol. | pmid:9696707 |
Zhou W et al. | Role of platelet-activating factor in hepatic responses after bile duct ligation in rats. | 1992 | Am. J. Physiol. | pmid:1443133 |
Kanwar S et al. | Nitric oxide synthesis inhibition increases epithelial permeability via mast cells. | 1994 | Am. J. Physiol. | pmid:8141295 |
Galens S et al. | Assessment of agonist- and cell-mediated responses in airway microsections by computerized videomicrometry. | 1995 | Am. J. Physiol. | pmid:7900832 |
Bonventre JV et al. | PAF and PDGF increase cytosolic [Ca2+] and phospholipase activity in mesangial cells. | 1988 | Am. J. Physiol. | pmid:3337246 |
Bussolino F et al. | Platelet activating factor induces dopamine release in PC-12 cell line. | 1988 | Am. J. Physiol. | pmid:3177629 |
Bienvenu K et al. | Modulation of leukocyte migration in mesenteric interstitium. | 1994 | Am. J. Physiol. | pmid:7943404 |
Church DJ et al. | Calcium influx in platelet activating factor-induced atrial natriuretic peptide release in rat cardiomyocytes. | 1994 | Am. J. Physiol. | pmid:8166260 |
Lang CH et al. | Platelet-activating factor-induced increases in glucose kinetics. | 1988 | Am. J. Physiol. | pmid:3348371 |
Sun X et al. | P-selectin-deficient mice are protected from PAF-induced shock, intestinal injury, and lethality. | 1997 | Am. J. Physiol. | pmid:9252509 |
Saito M et al. | Association of granular exocytosis with Ca(2+)-activated K+ channels in human eosinophils. | 1997 | Am. J. Physiol. | pmid:9252535 |
Gulbins E et al. | Effects of rC5a on the circulation of normal and split hydronephrotic rat kidneys. | 1993 | Am. J. Physiol. | pmid:8342619 |
Rainger GE et al. | Endothelial-borne platelet-activating factor and interleukin-8 rapidly immobilize rolling neutrophils. | 1997 | Am. J. Physiol. | pmid:9038929 |
Hanglow AC et al. | Effects of platelet-activating factor on ion transport in isolated rat jejunum. | 1989 | Am. J. Physiol. | pmid:2597284 |
Sánchez-Crespo M et al. | Presence in normal human urine of a hypotensive and platelet-activating phospholipid. | 1983 | Am. J. Physiol. | pmid:6859262 |
Rabe KF et al. | Contraction of human bronchial smooth muscle caused by activated human eosinophils. | 1994 | Am. J. Physiol. | pmid:7943259 |
Bradley LM et al. | Circulatory effects of PAF-acether in newborn piglets. | 1989 | Am. J. Physiol. | pmid:2912183 |
Koyama S et al. | Type II pneumocytes release chemoattractant activity for monocytes constitutively. | 1997 | Am. J. Physiol. | pmid:9176245 |
Dobrowsky RT et al. | Effect of SRI 63-675 on hemodynamics and blood PAF levels during porcine endotoxemia. | 1991 | Am. J. Physiol. | pmid:2035668 |
Mózes T et al. | Platelet-activating factor: an endogenous mediator of mesenteric ischemia-reperfusion-induced shock. | 1989 | Am. J. Physiol. | pmid:2802004 |
Kobayashi I et al. | Platelet-activating factor modulates microvascular transport by stimulation of protein kinase C. | 1994 | Am. J. Physiol. | pmid:8160825 |
Hines KL et al. | PAF increases hepatic vascular resistance and glycogenolysis in vivo. | 1991 | Am. J. Physiol. | pmid:1848410 |
Schlondorff D et al. | Relationship of GTP-binding proteins, phospholipase C, and PGE2 synthesis in rat glomerular mesangial cells. | 1989 | Am. J. Physiol. | pmid:2492160 |
Bellan JA et al. | Analysis of pulmonary and systemic vascular responses to platelet-activating factor in the cat. | 1992 | Am. J. Physiol. | pmid:1379004 |
Snyder F | Platelet-activating factor and related acetylated lipids as potent biologically active cellular mediators. | 1990 | Am. J. Physiol. | pmid:2240190 |
Arnould T et al. | Increased PMN adherence on endothelial cells after hypoxia: involvement of PAF, CD18/CD11b, and ICAM-1. | 1993 | Am. J. Physiol. | pmid:8098907 |
Kubes P et al. | Modulation of PAF-induced leukocyte adherence and increased microvascular permeability. | 1990 | Am. J. Physiol. | pmid:2240225 |
Sobhani I et al. | Platelet-activating factor stimulates gastric acid secretion in isolated rabbit gastric glands. | 1995 | Am. J. Physiol. | pmid:7611410 |
Marchetti J et al. | The parietal sheet of Bowman's capsule of rat renal glomerulus: a target of endothelin and PAF. | 1995 | Am. J. Physiol. | pmid:7611446 |
Shibamoto T et al. | PAF increases capillary pressure but not vascular permeability in isolated blood-perfused canine lungs. | 1993 | Am. J. Physiol. | pmid:8498559 |
Miller MJ et al. | SOD prevents damage and attenuates eicosanoid release in a rabbit model of necrotizing enterocolitis. | 1988 | Am. J. Physiol. | pmid:2847541 |
Koyama S et al. | Bradykinin stimulates bronchial epithelial cells to release neutrophil and monocyte chemotactic activity. | 1995 | Am. J. Physiol. | pmid:7631812 |
Wallace JL | Lipid mediators of inflammation in gastric ulcer. | 1990 | Am. J. Physiol. | pmid:2405704 |
Miura S et al. | Attenuation of endotoxin-induced intestinal microcirculatory damage by eicosapentanoic acid. | 1993 | Am. J. Physiol. | pmid:8498509 |
Martins MA et al. | Release of tachykinins by histamine, methacholine, PAF, LTD4, and substance P from guinea pig lungs. | 1991 | Am. J. Physiol. | pmid:1722649 |
Huang Q et al. | Neutrophil-dependent augmentation of PAF-induced vasoconstriction and albumin flux in coronary arterioles. | 1998 | Am. J. Physiol. | pmid:9746460 |
Duque I et al. | Effects of reactive oxygen species on cultured rat mesangial cells and isolated rat glomeruli. | 1992 | Am. J. Physiol. | pmid:1415575 |
Johnson A et al. | Tumor necrosis factor-alpha primes pulmonary hemodynamic response to N-formyl-L-methionyl-L-leucyl-L-phenylalanine. | 1991 | Am. J. Physiol. | pmid:1656789 |
Kruse-Elliott KT et al. | Differential effects of WEB 2086 and SRI 63-441 on TNF-alpha-induced alterations in cardiopulmonary function. | 1992 | Am. J. Physiol. | pmid:1415600 |
Milhoan KA et al. | Hypoxia induces endothelial cells to increase their adherence for neutrophils: role of PAF. | 1992 | Am. J. Physiol. | pmid:1415623 |
Dorn GW and Davis MG | Differential megakaryocytic desensitization to platelet agonists. | 1992 | Am. J. Physiol. | pmid:1415671 |
Faden AI and Tzendzalian PA | Platelet-activating factor antagonists limit glycine changes and behavioral deficits after brain trauma. | 1992 | Am. J. Physiol. | pmid:1415805 |