Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Qu XW et al. | Type I nitric oxide synthase (NOS) is the predominant NOS in rat small intestine. Regulation by platelet-activating factor. | 1999 | Biochim. Biophys. Acta | pmid:10446403 |
| Shehnaz D et al. | Effect of the crude extract of Cestrum parqui on carrageenin-induced rat paw oedema and aggregation of human blood platelets. | 1999 | Phytother Res | pmid:10441792 |
| Dentelli P et al. | Human IL-3 stimulates endothelial cell motility and promotes in vivo new vessel formation. | 1999 | J. Immunol. | pmid:10438956 |
| Soybir G et al. | The effects of free oxygen radical scavenger and platelet-activating factor antagonist agents in experimental acute pancreatitis. | 1999 | Pancreas | pmid:10438161 |
| Zeng S et al. | Regulatory role of protein tyrosine phosphorylation in platelet activating factor-induced signal transduction in platelets. | 1999 | Zhongguo Yao Li Xue Bao | pmid:10437164 |
| Alloatti G et al. | Role of nitric oxide and platelet-activating factor in cardiac alterations induced by tumor necrosis factor-alpha in the guinea-pig papillary muscle. | 1999 | Cardiovasc. Res. | pmid:10435033 |
| Zouki C et al. | Endothelin-1 enhances neutrophil adhesion to human coronary artery endothelial cells: role of ET(A) receptors and platelet-activating factor. | 1999 | Br. J. Pharmacol. | pmid:10433505 |
| Tanaka R et al. | Role of platelet-activating factor acetylhydrolase gene mutation in Japanese childhood IgA nephropathy. | 1999 | Am. J. Kidney Dis. | pmid:10430976 |
| Schifitto G et al. | Randomized trial of the platelet-activating factor antagonist lexipafant in HIV-associated cognitive impairment. Neurological AIDS Research Consortium. | 1999 | Neurology | pmid:10430432 |
| Fiotti N et al. | Atherosclerosis and inflammation. Patterns of cytokine regulation in patients with peripheral arterial disease. | 1999 | Atherosclerosis | pmid:10428295 |
| Maggirwar SB et al. | HIV-1 Tat-mediated activation of glycogen synthase kinase-3beta contributes to Tat-mediated neurotoxicity. | 1999 | J. Neurochem. | pmid:10428053 |
| Ambrosio G and Tritto I | Reperfusion injury: experimental evidence and clinical implications. | 1999 | Am. Heart J. | pmid:10426862 |
| Rodrigues CR et al. | Proposal of a new PAF pharmacophoric map by the AM1 method. | 1999 | Eur J Pharm Sci | pmid:10425381 |
| Asano K et al. | Cellular source(s) of platelet-activating-factor acetylhydrolase activity in plasma. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10425216 |
| Bocheński J et al. | Role of thromboxane A2 and platelet activating factor in early haemodynamic response to lipopolysaccharide in rats. | 1999 | J. Physiol. Pharmacol. | pmid:10424723 |
| Yamada M et al. | Possible participation of intracellular platelet-activating factor in tumor necrosis factor-alpha production by rat peritoneal macrophages. | 1999 | Eur. J. Pharmacol. | pmid:10422778 |
| Shan L et al. | Platelet-activating factor increases the expression of metalloproteinase-9 in human bronchial epithelial cells. | 1999 | Eur. J. Pharmacol. | pmid:10422651 |
| Panés J et al. | Impaired mesenteric leukocyte recruitment in experimental portal hypertension in the rat. | 1999 | Hepatology | pmid:10421653 |
| Geijsen N et al. | Regulation of p21rac activation in human neutrophils. | 1999 | Blood | pmid:10419906 |
| M'Rabet L et al. | Differential fMet-Leu-Phe- and platelet-activating factor-induced signaling toward Ral activation in primary human neutrophils. | 1999 | J. Biol. Chem. | pmid:10419502 |
| Calcerrada MC et al. | Platelet-activating factor stimulation of p125(FAK) and p130(Cas) tyrosine phosphorylation in brain. | 1999 | Brain Res. | pmid:10415383 |
| Salas A et al. | Reperfusion-induced oxidative stress in diabetes: cellular and enzymatic sources. | 1999 | J. Leukoc. Biol. | pmid:10410990 |
| Kudolo GB and DeFronzo RA | Urinary platelet-activating factor excretion is elevated in non-insulin dependent diabetes mellitus. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10410380 |
| Li L et al. | Estrogen effects on platelet-activating factor and platelet-activating factor acetylhydrolase activity in rat uterus during the late stages of pregnancy. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10402216 |
| Liu Q et al. | The effect of lexipafant on bacterial translocation in acute necrotizing pancreatitis in rats. | 1999 | Am Surg | pmid:10399968 |
| Shmueli O et al. | Platelet-activating factor (PAF) acetylhydrolase activity, LIS1 expression, and seizures. | 1999 | J. Neurosci. Res. | pmid:10398295 |
| Ishii S and Shimizu T | [Platelet-activating factor (PAF) receptor-related pathophysiology]. | 1999 | Tanpakushitsu Kakusan Koso | pmid:10396985 |
| Strukova SM et al. | Modulation of mast cell activity by a peptide agonist of the thrombin receptor: role of nitric oxide. | 1999 | Biochemistry Mosc. | pmid:10395981 |
| Kulikov VI and Muzya GI | Mechanisms of interaction of a plasmalogenic analog of platelet-activating factor with human platelets. | 1999 | Biochemistry Mosc. | pmid:10395976 |
| Subramanian VS et al. | Role of lecithin-cholesterol acyltransferase in the metabolism of oxidized phospholipids in plasma: studies with platelet-activating factor-acetyl hydrolase-deficient plasma. | 1999 | Biochim. Biophys. Acta | pmid:10395969 |
| Forte TM et al. | Targeted disruption of the murine lecithin:cholesterol acyltransferase gene is associated with reductions in plasma paraoxonase and platelet-activating factor acetylhydrolase activities but not in apolipoprotein J concentration. | 1999 | J. Lipid Res. | pmid:10393212 |
| Fujii E et al. | Microvascular permeability change induced by platelet-activating factor is impaired in diabetic mice. | 1999 | Microvasc. Res. | pmid:10388605 |
| Guilbert M et al. | 5-Oxo-6,8,11,14-eicosatetraenoic acid induces important eosinophil transmigration through basement membrane components: comparison of normal and asthmatic eosinophils. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10385597 |
| Bandeira-Melo C et al. | Suppressive effect of distinct bradykinin B2 receptor antagonist on allergen-evoked exudation and leukocyte infiltration in sensitized rats. | 1999 | Br. J. Pharmacol. | pmid:10385228 |
| Deigner HP et al. | Novel reversible, irreversible and fluorescent inhibitors of platelet-activating factor acetylhydrolase as mechanistic probes. | 1999 | Atherosclerosis | pmid:10381281 |
| McNeil RS et al. | Neuronal cytoskeletal alterations evoked by a platelet-activating factor (PAF) analogue. | 1999 | Cell Motil. Cytoskeleton | pmid:10379835 |
| Callea L et al. | Platelet activating factor is elevated in cerebral spinal fluid and plasma of patients with relapsing-remitting multiple sclerosis. | 1999 | J. Neuroimmunol. | pmid:10376955 |
| Wang Y et al. | Increased neutrophil-endothelial adhesion induced by placental factors is mediated by platelet-activating factor in preeclampsia. | 1999 May-Jun | J. Soc. Gynecol. Investig. | pmid:10376269 |
| Yi FX and Guo ZG | Platelet-released ADP stabilizes PAF-induced rabbit platelet aggregation by stabilizing intracellular calcium. | 1998 | Zhongguo Yao Li Xue Bao | pmid:10375790 |
| Ji Z et al. | [The role of platelet activating factor in pathogenesis of acute pancreatitis in dogs]. | 1997 | Zhonghua Wai Ke Za Zhi | pmid:10374489 |
| Xiao J et al. | Synergetic protective effects of combined blockade by two kinds of autolesion mediator receptor on neurological function after cervical cord injury. | 1998 | Chin. Med. J. | pmid:10374355 |
| Rosenbaum JT et al. | Intravitreally injected platelet activating factor induces retinitis in experimental animals. | 1999 | Curr. Eye Res. | pmid:10372995 |
| Diaz E et al. | Presence of platelet-activating factor in rhesus (Macaca mulatta) spermatozoa. | 1999 | J. Med. Primatol. | pmid:10372538 |
| Cahana A and Reiner O | LIS1 and platelet-activating factor acetylhydrolase (Ib) catalytic subunits, expression in the mouse oocyte and zygote. | 1999 | FEBS Lett. | pmid:10371146 |
| MartÃnez L et al. | Nitroprusside stimulates contractility and the synthesis of 14C-acetylated PAF-like substances in estrogen primed-mouse uterine horns. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367296 |
| Steil AA et al. | Platelet-activating factor and eicosanoids are mediators of local and systemic changes induced by immune-complexes in mice. | 1999 | Prostaglandins Other Lipid Mediat. | pmid:10367295 |
| Goldman R et al. | Calcium-dependent PAF-stimulated generation of reactive oxygen species in a human keratinocyte cell line. | 1999 | Biochim. Biophys. Acta | pmid:10366777 |
| Crawford SE et al. | Captopril and platelet-activating factor (PAF) antagonist prevent cardiac allograft vasculopathy in rats: role of endogenous PAF and PAF-like compounds. | 1999 | J. Heart Lung Transplant. | pmid:10363692 |
| Del Sorbo L et al. | The synthesis of platelet-activating factor modulates chemotaxis of monocytes induced by HIV-1 Tat. | 1999 | Eur. J. Immunol. | pmid:10359105 |
| Weber C et al. | Effects of oxidized low density lipoprotein, lipid mediators and statins on vascular cell interactions. | 1999 | Clin. Chem. Lab. Med. | pmid:10353467 |
| Svetlov SI et al. | Decreased intraplatelet Ca2+ release and ATP secretion in pediatric nephrotic syndrome. | 1999 | Pediatr. Nephrol. | pmid:10353406 |
| Cruzado JM et al. | Effect of human natural xenoantibody depletion and complement inactivation on early pig kidney function. | 1999 May-Jun | Exp. Nephrol. | pmid:10352362 |
| Rainsford KD | Inhibition by leukotriene inhibitors, and calcium and platelet-activating factor antagonists, of acute gastric and intestinal damage in arthritic rats and in cholinomimetic-treated mice. | 1999 | J. Pharm. Pharmacol. | pmid:10344635 |
| Mariano F et al. | Production of platelet-activating factor in patients with sepsis-associated acute renal failure. | 1999 | Nephrol. Dial. Transplant. | pmid:10344354 |
| Cepinskas G et al. | PAF-induced elastase-dependent neutrophil transendothelial migration is associated with the mobilization of elastase to the neutrophil surface and localization to the migrating front. | 1999 | J. Cell. Sci. | pmid:10341212 |
| Nasu K et al. | Platelet-activating factor stimulates cytokine production by human endometrial stromal cells. | 1999 | Mol. Hum. Reprod. | pmid:10341002 |
| McNulty CA et al. | Characterization of the integrin and activation steps mediating human eosinophil and neutrophil adhesion to chronically inflamed airway endothelium. | 1999 | Am. J. Respir. Cell Mol. Biol. | pmid:10340944 |
| Yoshimura T et al. | Estrogen replacement therapy decreases platelet-activating factor-acetylhydrolase activity in post-menopausal women. | 1999 | Maturitas | pmid:10340285 |
| Aliberti JC et al. | Platelet-activating factor induces nitric oxide synthesis in Trypanosoma cruzi-infected macrophages and mediates resistance to parasite infection in mice. | 1999 | Infect. Immun. | pmid:10338485 |
| Alvi SA et al. | Corticotrophin-releasing hormone and platelet-activating factor induce transcription of the type-2 cyclo-oxygenase gene in human fetal membranes. | 1999 | Mol. Hum. Reprod. | pmid:10338371 |
| Markert R and Modzelewski B | [Inflammatory mediators in the acute pancreatitis]. | 1999 | Pol. Merkur. Lekarski | pmid:10337184 |
| Huang YH et al. | Lysophosphatidylcholine (LPC) induces proinflammatory cytokines by a platelet-activating factor (PAF) receptor-dependent mechanism. | 1999 | Clin. Exp. Immunol. | pmid:10337026 |
| Latorre E et al. | Platelet-activating factor modulates brain sphingomyelin metabolism. | 1999 | Eur. J. Biochem. | pmid:10336612 |
| Rhee CK et al. | Effect of platelet activating factor and its antagonist on the mucociliary clearance of the eustachian tube in guinea pigs. | 1999 | Ann. Otol. Rhinol. Laryngol. | pmid:10335705 |
| Mori N et al. | Ischemia-reperfusion induced microvascular responses in LDL-receptor -/- mice. | 1999 | Am. J. Physiol. | pmid:10330250 |
| Flickinger BD and Olson MS | Localization of the platelet-activating factor receptor to rat pancreatic microvascular endothelial cells. | 1999 | Am. J. Pathol. | pmid:10329588 |
| Rigat B et al. | The GM2 activator protein, a novel inhibitor of platelet-activating factor. | 1999 | Biochem. Biophys. Res. Commun. | pmid:10329374 |
| Denizot Y et al. | Are lipid mediators implicated in the production of pro- and anti-inflammatory cytokines during cardiopulmonary bypass graft with extracorporeal circulation? | 1999 | Cytokine | pmid:10328869 |
| Dong JC et al. | [Experimental study on antagonism of ginkgolides against effect of platelet-activating factor on lung strip of guinea pigs]. | 1997 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:10322836 |
| Kavakli K et al. | Plasma platelet-activating factor (PAF) levels and desmopressin response in children with hemophilia A and von Willebrand's disease. | 1999 | Thromb. Haemost. | pmid:10235463 |
| Jenks PJ et al. | Comparison of weal and flare responses to platelet activating factor (PAF) and histamine, and the ultrastructural effects of PAF in the skin of atopic and normal subjects. | 1999 | Clin. Exp. Dermatol. | pmid:10233666 |
| Yamaguchi Y et al. | Platelet-activating factor antagonist (TCV-309) attenuates the priming effects of bronchoalveolar macrophages in cerulein-induced pancreatitis rats. | 1999 | Pancreas | pmid:10231840 |
| López-Novoa JM | Potential role of platelet activating factor in acute renal failure. | 1999 | Kidney Int. | pmid:10231429 |
| Reinhardt JC et al. | Immunofluorescent evidence of the platelet-activating factor receptor on human spermatozoa. | 1999 | Fertil. Steril. | pmid:10231061 |
| Hirashima Y et al. | Deficient platelet-activating factor and related enzymes in hemimegalencephaly. | 1999 | Childs Nerv Syst | pmid:10230665 |
| Tool AT et al. | Phospholipase D-derived phosphatidic acid is involved in the activation of the CD11b/CD18 integrin in human eosinophils. | 1999 | Biochem. J. | pmid:10229663 |
| Han SJ et al. | Glucocorticoids prevent NF-kappaB activation by inhibiting the early release of platelet-activating factor in response to lipopolysaccharide. | 1999 | Eur. J. Immunol. | pmid:10229101 |
| Amroyan E et al. | Inhibitory effect of andrographolide from Andrographis paniculata on PAF-induced platelet aggregation. | 1999 | Phytomedicine | pmid:10228608 |
| Bastien Y et al. | Detection of functional platelet-activating factor receptors on human tonsillar B lymphocytes. | 1999 | J. Immunol. | pmid:10228030 |
| Harrison KA et al. | Negative ion electrospray and tandem mass spectrometric analysis of platelet activating factor (PAF) (1-hexadecyl-2-acetyl-glycerophosphocholine). | 1999 | J Mass Spectrom | pmid:10226361 |
| Lee IS et al. | Structure-activity relationships of lignans from Schisandra chinensis as platelet activating factor antagonists. | 1999 | Biol. Pharm. Bull. | pmid:10220282 |
| Hüseyinov A et al. | Increased gastric production of platelet-activating factor, leukotriene-B4, and tumor necrosis factor-alpha in children with Helicobacter pylori infection. | 1999 | Dig. Dis. Sci. | pmid:10219821 |
| Van de Weerdt ML et al. | Role of the cholinergic pathway in mediating platelet-activating factor-induced pulmonary dysfunctions in unsedated calves. | 1999 | Zentralbl Veterinarmed A | pmid:10216447 |
| Zardini DM and Tschirhart EJ | [Selective differentiation and proliferation of human eosinophils from umbilical cord blood: calcium fluxes and superoxide ion secretion]. | 1999 Jan-Feb | Therapie | pmid:10216433 |
| Nagahata Y et al. | Role of platelet activating factor on severity of ischemic colitis. | 1999 | Dis. Colon Rectum | pmid:10211499 |
| Wang X et al. | Treatment with lexipafant ameliorates the severity of pancreatic microvascular endothelial barrier dysfunction in rats with acute hemorrhagic pancreatitis. | 1999 | Int. J. Pancreatol. | pmid:10211421 |
| Klettke U et al. | Platelet-activating factor inhibits ciliary beat frequency of human bronchial epithelial cells. | 1999 Mar-Apr | Allergy Asthma Proc | pmid:10209689 |
| Hasselwander O et al. | HDL composition and HDL antioxidant capacity in patients on regular haemodialysis. | 1999 | Atherosclerosis | pmid:10208487 |
| Johnson CD | Platelet-activating factor and platelet-activating factor antagonists in acute pancreatitis. | 1999 | Dig Surg | pmid:10207233 |
| Brizzi MF et al. | Thrombopoietin stimulates endothelial cell motility and neoangiogenesis by a platelet-activating factor-dependent mechanism. | 1999 | Circ. Res. | pmid:10205146 |
| Held HD et al. | Characterization of airway and vascular responses in murine lungs. | 1999 | Br. J. Pharmacol. | pmid:10205008 |
| Calcerrada MC et al. | Glutamate release is involved in PAF-increased cyclic GMP levels in hippocampus. | 1999 | Biochem. Mol. Biol. Int. | pmid:10204090 |
| Wang X et al. | Inhibition of platelet-activating factor, intercellular adhesion molecule 1 and platelet endothelial cell adhesion molecule 1 reduces experimental pancreatitis-associated gut endothelial barrier dysfunction. | 1999 | Br J Surg | pmid:10201790 |
| Yamaguchi S et al. | Effects of Y-24180, a receptor antagonist to platelet-activating factor, on allergic cutaneous eosinophilia in mice. | 1999 | Life Sci. | pmid:10201647 |
| Park TS et al. | Platelet-activating factor mediates ischemia-induced leukocyte-endothelial adherence in newborn pig brain. | 1999 | J. Cereb. Blood Flow Metab. | pmid:10197511 |
| Lim H et al. | Inhibitory effect of sulfur-containing compounds in Scorodocarpus borneensis Becc. on the aggregation of rabbit platelets. | 1999 | Biosci. Biotechnol. Biochem. | pmid:10192909 |
| Oh-hashi K et al. | Dietary alpha-linolenate suppresses endotoxin-induced platelet-activating factor production in rat kidney. | 1999 | Lipids | pmid:10188594 |
| Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 2. Local application. | 1999 | Stroke | pmid:10187895 |
| Uhl E et al. | Influence of platelet-activating factor on cerebral microcirculation in rats: part 1. Systemic application. | 1999 | Stroke | pmid:10187894 |
| Kobayashi K et al. | Platelet-activating factor receptor is not required for long-term potentiation in the hippocampal CA1 region. | 1999 | Eur. J. Neurosci. | pmid:10103126 |