| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arteriosclerosis Obliterans | D001162 | 8 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Arthus Reaction | D001183 | 8 associated lipids |
| Ascites | D001201 | 25 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
Loading... please refresh the page if content is not showing up.
Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
|---|
What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
Loading... please refresh the page if content is not showing up.
NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Mueller HW et al. | 1-O-alkyl-linked glycerophospholipids of human neutrophils: distribution of arachidonate and other acyl residues in the ether-linked and diacyl species. | 1984 | J. Lipid Res. | pmid:6427378 |
| Kamitani T et al. | Mechanism(s) of the hypotensive effect of synthetic 1-O-octadecyl-2-O-acetyl-glycero-3-phosphorylcholine. | 1984 | Eur. J. Pharmacol. | pmid:6144557 |
| Tokumura A et al. | Contractile effect of 1-O-hexadecyl-2-O-acetyl-sn-glycero-3-phosphocholine on strips of isolated rat intestine. | 1984 | J. Pharm. Pharmacol. | pmid:6144763 |
| Pirotzky E et al. | Release of platelet-activating factor, slow-reacting substance, and vasoactive amines from isolated rat kidneys. | 1984 | Kidney Int. | pmid:6144811 |
| Gómez-Cambronero J et al. | The role of calcium ions in the process of acetyltransferase activation during the formation of platelet-activating factor (PAF-acether). | 1984 | Biochem. J. | pmid:6146309 |
| Knauer KA et al. | Platelet augmentation of IgE-dependent histamine release from human basophils and mast cells. | 1984 | Int. Arch. Allergy Appl. Immunol. | pmid:6200443 |
| Kazimierczak W et al. | Deuterium-oxide-induced histamine release from basophils of allergic subjects. I. Responsiveness to deuterium oxide requires an activation step. | 1984 | Am. Rev. Respir. Dis. | pmid:6201094 |
| O'Flaherty JT et al. | Diacylglycerols enhance human neutrophil degranulation responses: relevancy to a multiple mediator hypothesis of cell function. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6433920 |
| Mendlovic F et al. | Possible involvement of cyclooxygenase products in the actions of platelet-activating factor and of lipoxygenase products in the vascular effects of epinephrine in perfused rat liver. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6435614 |
| Malpass TW et al. | The effect of prostacyclin infusion on platelet hemostatic function in patients undergoing cardiopulmonary bypass. | 1984 | J. Thorac. Cardiovasc. Surg. | pmid:6231433 |
| Willoughby WF and Willoughby JB | Immunologic mechanisms of parenchymal lung injury. | 1984 | Environ. Health Perspect. | pmid:6234162 |
| Fouque F and Vargaftig BB | Triggering by Paf-acether and adrenaline of cyclo-oxygenase-independent platelet aggregation. | 1984 | Br. J. Pharmacol. | pmid:6439269 |
| Karlsson G and Pipkorn U | Effect of disodium chromoglycate on changes in nasal airway resistance induced by platelet activating factor. | 1984 | Eur. J. Clin. Pharmacol. | pmid:6439565 |
| Sänze JU et al. | On the nature of the vasoreactivity depressing factor (VDF) in inflammation and anaphylaxis in the rat and mouse. | 1984 | Biomed. Biochim. Acta | pmid:6440544 |
| Sills RH | Thrombotic thrombocytopenic purpura. I. Pathophysiology and clinical manifestations. | 1984 | Am J Pediatr Hematol Oncol | pmid:6442830 |
| Lartigue-Mattei C et al. | Pharmacokinetic study of 3H-labelled PAF-acether II. Comparison with 3H-labelled lyso-PAF-acether after intravenous administration in the rabbit and protein binding. | 1984 | Agents Actions | pmid:6532184 |
| Kulikov VI et al. | [Incorporation of 1-0-alkyl-2-acetyl-sn-glycerol-3-phosphocholine into human plasma lipoproteins in vitro. Effect of the lecithin:cholesterol acyltransferase activity of plasma]. | 1984 | Biokhimiia | pmid:6542803 |
| Nagata K et al. | [Thrombotic thrombocytopenic purpura (TTP) with a remission following splenectomy after the failure of antiplatelet therapy and plasmapheresis]. | 1984 | Rinsho Ketsueki | pmid:6542941 |
| Pirotzky E et al. | PAF-acether-induced plasma exudation in rat skin is independent of platelets and neutrophils. | 1984 | Microcirc Endothelium Lymphatics | pmid:6546141 |
| Smith RJ et al. | Stimulation of the human neutrophil superoxide anion-generating system with 1-O-hexadecyl/octadecyl-2-acetyl-sn-glyceryl-3- phosphorylcholine. | 1984 | Biochem. Pharmacol. | pmid:6324816 |
| Buxton DB et al. | Stimulation of hepatic glycogenolysis by acetylglyceryl ether phosphorylcholine. | 1984 | J. Biol. Chem. | pmid:6693418 |
| Sakamoto H et al. | Stimulation of leukocyte phagocytic activity by the platelet release reaction. | 1984 | Pathology | pmid:6462776 |
| Shukla SD and Hanahan DJ | Acetylglyceryl ether phosphorylcholine (AGEPC; platelet-activating factor)-induced stimulation of rabbit platelets: correlation between phosphatidic acid level, 45Ca2+ uptake, and [3H]serotonin secretion. | 1984 | Arch. Biochem. Biophys. | pmid:6465886 |
| Doebber TW et al. | Platelet activating factor intravenous infusion in rats stimulates vascular lysosomal hydrolase secretion independent of blood neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6517949 |
| Heinrich J and Zimmermann RE | Compound 48/80 is a potent inhibitor of human platelet aggregation antagonizing the calmodulin-dependent platelet reaction in vitro. | 1984 | Thromb. Res. | pmid:6523451 |
| Oxholm P et al. | Lack of evidence for human lymphokines with thrombocyte aggregating activity. An in vitro study. | 1984 | Allergy | pmid:6528957 |
| Hwang SB et al. | Effects of nonsteroid antiinflammatory drugs on the specific binding of platelet activating factor to membrane preparations of rabbit platelets. | 1984 | Thromb. Res. | pmid:6429890 |
| Colditz IG and Movat HZ | Kinetics of neutrophil accumulation in acute inflammatory lesions induced by chemotaxins and chemotaxinigens. | 1984 | J. Immunol. | pmid:6470487 |
| Patterson R et al. | Airway responses to sequential challenges with platelet-activating factor and leukotriene D4 in rhesus monkeys. | 1984 | J. Lab. Clin. Med. | pmid:6470563 |
| Caramelo C et al. | Presence of platelet-activating factor in blood from humans and experimental animals. Its absence in anephric individuals. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732788 |
| Lenihan DJ and Lee TC | Regulation of platelet activating factor synthesis: modulation of 1-alkyl-2-lyso-sn-glycero-3-phosphocholine:acetyl-CoA acetyltransferase by phosphorylation and dephosphorylation in rat spleen microsomes. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6732789 |
| Ludwig JC et al. | Modulation of platelet-activating factor (PAF) synthesis and release from human polymorphonuclear leukocytes (PMN): role of extracellular Ca2+. | 1984 | Arch. Biochem. Biophys. | pmid:6430234 |
| Kasuya Y et al. | Hypotensive actions of some analogues of platelet-activating factor (PAF) with higher potencies than natural PAF. | 1984 | Can. J. Physiol. Pharmacol. | pmid:6733593 |
| Page CP et al. | Platelets and bronchospasm. | 1984 | Int. Arch. Allergy Appl. Immunol. | pmid:6735490 |
| Jouvin-Marche E et al. | Biosynthesis of Paf-acether (platelet-activating factor). VII. Precursors of Paf-acether and acetyl-transferase activity in human leukocytes. | 1984 | J. Immunol. | pmid:6736649 |
| Pipkorn U et al. | Effect of platelet activating factor on the human nasal mucosa. | 1984 | Allergy | pmid:6703263 |
| Lüthje J and Ogilvie A | Diadenosine triphosphate (Ap3A) mediates human platelet aggregation by liberation of ADP. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6704102 |
| Clare KA and Scrutton MC | The role of Ca2+ uptake in the response of human platelets to adrenaline and to 1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine (platelet-activating factor). | 1984 | Eur. J. Biochem. | pmid:6705791 |
| Kumar R et al. | A facile route to semi-synthesis of acetyl glycerylether phosphoethanolamine and its choline analogue. | 1984 | J. Lipid Res. | pmid:6707528 |
| Kester M et al. | The potentiation of arterial contraction with platelet activating factor. | 1984 | Pflugers Arch. | pmid:6718228 |
| Pelczar-Wissner CJ et al. | Absence of platelet activating factor (PAF) mediated platelet aggregation: a new platelet defect. | 1984 | Am. J. Hematol. | pmid:6720685 |
| Guay DR and Richard A | Heparin-induced thrombocytopenia--association with a platelet aggregating factor and cross-sensitivity to bovine and porcine heparin. | 1984 | Drug Intell Clin Pharm | pmid:6723517 |
| Poitevin B et al. | Paf-acether generates chemiluminescence in human neutrophils in the absence of cytochalasin B. | 1984 | Immunopharmacology | pmid:6724877 |
| Kasuya Y et al. | Possible role of endothelium in the vasodilator response of rat thoracic aorta to platelet activating factor (PAF). | 1984 | J. Pharmacobio-dyn. | pmid:6726619 |
| Archer CB et al. | Synergistic interaction between prostaglandins and PAF-acether in experimental animals and man. | 1984 | Prostaglandins | pmid:6203139 |
| Schlondorff D et al. | Effect of platelet-activating factor and serum-treated zymosan on prostaglandin E2 synthesis, arachidonic acid release, and contraction of cultured rat mesangial cells. | 1984 | J. Clin. Invest. | pmid:6423667 |
| Gunby P | A new piece for the puzzle of inflammation. | 1984 | JAMA | pmid:6420583 |
| Lian EC et al. | Purification and some properties of a protein obtained from normal human plasma which inhibits the platelet aggregation induced by thrombotic thrombocytopenic purpura plasma. | 1984 | Thromb. Res. | pmid:6420930 |
| Billah MM and Siegel MI | Calmodulin antagonists inhibit formation of platelet-activating factor in stimulated human neutrophils. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422930 |
| Prevost MC et al. | Platelet activating factor (PAF-acether) is released into rat pulmonary alveolar fluid as a consequence of hypoxia. | 1984 | Biochem. Biophys. Res. Commun. | pmid:6422938 |