| MeSH term | MeSH ID | Detail |
|---|---|---|
| Adenocarcinoma | D000230 | 166 associated lipids |
| Agranulocytosis | D000380 | 7 associated lipids |
| Albuminuria | D000419 | 18 associated lipids |
| Alzheimer Disease | D000544 | 76 associated lipids |
| Amnesia | D000647 | 12 associated lipids |
| Anaphylaxis | D000707 | 35 associated lipids |
| Anemia, Sickle Cell | D000755 | 34 associated lipids |
| Angina Pectoris | D000787 | 27 associated lipids |
| Angina, Unstable | D000789 | 14 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Anthrax | D000881 | 1 associated lipids |
| Arenaviridae Infections | D001117 | 1 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Arterial Occlusive Diseases | D001157 | 12 associated lipids |
| Arteriosclerosis | D001161 | 86 associated lipids |
| Arteriosclerosis Obliterans | D001162 | 8 associated lipids |
| Arthritis | D001168 | 41 associated lipids |
| Arthritis, Experimental | D001169 | 24 associated lipids |
| Arthus Reaction | D001183 | 8 associated lipids |
| Ascites | D001201 | 25 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
- J. Lipid Res. (5)
- Proc. Natl. Acad. Sci. U.S.A. (2)
- Am. J. Physiol. Gastrointest. Liver Physiol. (2)
- Others (26)
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
|---|
What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
|---|
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Gabrijelcic J et al. | Formoterol protects against platelet-activating factor-induced effects in asthma. | 2004 | Eur. Respir. J. | pmid:14738234 |
| Geiser T | The role of neutrophils and neutrophil products in pulmonary hemodynamics of endotoxin in oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742354 |
| Hill LL et al. | Neutrophils and neutrophil products do not mediate pulmonary hemodynamic effects of endotoxin on oleic acid-induced lung injury. | 2004 | Anesth. Analg. | pmid:14742386 |
| Bouayad A et al. | Developmental regulation of prostaglandin E2 synthase in porcine ductus arteriosus. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:14715488 |
| Axelrad TW et al. | Platelet-activating factor (PAF) induces activation of matrix metalloproteinase 2 activity and vascular endothelial cell invasion and migration. | 2004 | FASEB J. | pmid:14715700 |
| Kondratskaya EL et al. | Inhibition of hippocampal LTP by ginkgolide B is mediated by its blocking action on PAF rather than glycine receptors. | 2004 | Neurochem. Int. | pmid:14568560 |
| Crawford SE et al. | Captopril suppresses post-transplantation angiogenic activity in rat allograft coronary vessels. | 2004 | J. Heart Lung Transplant. | pmid:15366425 |
| Seo KH et al. | Estrogen enhances angiogenesis through a pathway involving platelet-activating factor-mediated nuclear factor-kappaB activation. | 2004 | Cancer Res. | pmid:15374958 |
| Ma X et al. | Platelet-activating factor (PAF) induces corneal neovascularization and upregulates VEGF expression in endothelial cells. | 2004 | Invest. Ophthalmol. Vis. Sci. | pmid:15326102 |
| Wright CS et al. | Evidence for lipid packaging in the crystal structure of the GM2-activator complex with platelet activating factor. | 2004 | J. Mol. Biol. | pmid:15327957 |
| Thanou PG and Tsoukatos DC | Non-enzymatic platelet-activating factor formation by acetylated proteins. | 2004 | FEBS Lett. | pmid:15327967 |
| Chou KJ et al. | Platelet hyperreactivity in hemodialysis patients with frequently occluded vascular access. | 2004 | Thromb. Haemost. | pmid:15351860 |
| Llodrá J et al. | Emigration of monocyte-derived cells from atherosclerotic lesions characterizes regressive, but not progressive, plaques. | 2004 | Proc. Natl. Acad. Sci. U.S.A. | pmid:15280540 |
| Zhu L et al. | Internalization of caveolin-1 scaffolding domain facilitated by Antennapedia homeodomain attenuates PAF-induced increase in microvessel permeability. | 2004 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12946927 |
| Kato M et al. | Apafant, a potent platelet-activating factor antagonist, blocks eosinophil activation and is effective in the chronic phase of experimental allergic conjunctivitis in guinea pigs. | 2004 | J. Pharmacol. Sci. | pmid:15286429 |
| Slomiany BL and Slomiany A | Platelet-activating factor mediates Helicobacter pylori lipopolysaccharide interference with gastric mucin synthesis. | 2004 | IUBMB Life | pmid:14992379 |
| Jung TT et al. | Effect of platelet activating factor with and without receptor antagonist (WEB2170) on morphology of isolated cochlear outer hair cells. | 2004 | Ann. Otol. Rhinol. Laryngol. | pmid:14994775 |
| Fourcade O et al. | Propofol inhibits human platelet aggregation induced by proinflammatory lipid mediators. | 2004 | Anesth. Analg. | pmid:15271713 |
| Getting SJ et al. | Investigation into the potential anti-inflammatory effects of endothelin antagonists in a murine model of experimental monosodium urate peritonitis. | 2004 | J. Pharmacol. Exp. Ther. | pmid:14996949 |
| Smalling WE et al. | Protective effect of pentoxifylline on volume-induced lung injury in newborn piglets. | 2004 | Biol. Neonate | pmid:14981352 |
| Burgos RA et al. | Determination of specific receptor sites for platelet activating factor in bovine neutrophils. | 2004 | Am. J. Vet. Res. | pmid:15141884 |
| Wang J et al. | [Effect of Radix notoginseng saponins on platelet activating molecule expression and aggregation in patients with blood hyperviscosity syndrome]. | 2004 | Zhongguo Zhong Xi Yi Jie He Za Zhi | pmid:15143716 |
| Fu H et al. | The mechanism for activation of the neutrophil NADPH-oxidase by the peptides formyl-Met-Leu-Phe and Trp-Lys-Tyr-Met-Val-Met differs from that for interleukin-8. | 2004 | Immunology | pmid:15147563 |
| Beaudeux JL et al. | Activation of PAF receptor by oxidised LDL in human monocytes stimulates chemokine releases but not urokinase-type plasminogen activator expression. | 2004 | Clin. Chim. Acta | pmid:15149885 |
| Yang Y et al. | Increased hepatic platelet activating factor (PAF) and PAF receptors in carbon tetrachloride induced liver cirrhosis. | 2004 | Gut | pmid:15138217 |
| Steel HC and Anderson R | Itraconazole antagonizes store-operated influx of calcium into chemoattractant-activated human neutrophils. | 2004 | Clin. Exp. Immunol. | pmid:15086388 |
| Reeves SR and Gozal D | Platelet-activating factor receptor modulates respiratory adaptation to long-term intermittent hypoxia in mice. | 2004 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15087283 |
| Hollmann MW et al. | Time-dependent inhibition of G protein-coupled receptor signaling by local anesthetics. | 2004 | Anesthesiology | pmid:15087620 |
| Bate C et al. | The role of platelet activating factor in prion and amyloid-beta neurotoxicity. | 2004 | Neuroreport | pmid:15094513 |
| Buke AC et al. | Tumor necrosis factor alpha and interleukin 6 productions in response to platelet-activating factor in chronic hepatitis B virus infection. | 2004 Sep-Oct | Med Princ Pract | pmid:15316260 |
| Michibayashi T | Platelet aggregation and vasoconstriction related to platelet cyclooxygenase and 12-lipoxygenase pathways. | 2005 | J. Atheroscler. Thromb. | pmid:16020916 |
| Owen JS et al. | An improved assay for platelet-activating factor using HPLC-tandem mass spectrometry. | 2005 | J. Lipid Res. | pmid:15520455 |
| Lemieux C et al. | Angiopoietins can directly activate endothelial cells and neutrophils to promote proinflammatory responses. | 2005 | Blood | pmid:15498854 |
| Bazan HE | Cellular and molecular events in corneal wound healing: significance of lipid signalling. | 2005 | Exp. Eye Res. | pmid:15781273 |
| Choi IW et al. | TNF-alpha induces the late-phase airway hyperresponsiveness and airway inflammation through cytosolic phospholipase A(2) activation. | 2005 | J. Allergy Clin. Immunol. | pmid:16159621 |
| Denizot Y et al. | Platelet-activating factor and liver metastasis of colorectal cancer. | 2005 | Int. J. Cancer | pmid:15455343 |
| Jantan I et al. | Platelet-activating factor (PAF) receptor-binding antagonist activity of Malaysian medicinal plants. | 2005 | Phytomedicine | pmid:15693713 |
| El-Medany A et al. | Attenuation of bleomycin-induced lung fibrosis in rats by mesna. | 2005 | Eur. J. Pharmacol. | pmid:15713430 |
| Ninio E | Phospholipid mediators in the vessel wall: involvement in atherosclerosis. | 2005 | Curr Opin Clin Nutr Metab Care | pmid:15716789 |
| Evans L et al. | A pharmacokinetic/pharmacodynamic model for a platelet activating factor antagonist based on data arising from Phase I studies. | 2005 | J. Pharm. Pharmacol. | pmid:15720781 |
| Yoshida H et al. | Platelet-activating factor enhances the expression of nerve growth factor in normal human astrocytes under hypoxia. | 2005 | Brain Res. Mol. Brain Res. | pmid:15661369 |
| Zhu L and He P | Platelet-activating factor increases endothelial [Ca2+]i and NO production in individually perfused intact microvessels. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15665052 |
| Cuschieri J et al. | Calcium/calmodulin-dependent kinase II is required for platelet-activating factor priming. | 2005 | Shock | pmid:15665723 |
| Roudebush WE et al. | The significance of platelet-activating factor and fertility in the male primate: a review. | 2005 | J. Med. Primatol. | pmid:15667340 |
| Ottino P et al. | PAF-induced furin and MT1-MMP expression is independent of MMP-2 activation in corneal myofibroblasts. | 2005 | Invest. Ophthalmol. Vis. Sci. | pmid:15671273 |
| Hidalgo MA et al. | Andrographolide interferes with binding of nuclear factor-kappaB to DNA in HL-60-derived neutrophilic cells. | 2005 | Br. J. Pharmacol. | pmid:15678086 |
| Oku H et al. | Inhibitory effects of xanthones from guttiferae plants on PAF-induced hypotension in mice. | 2005 | Planta Med. | pmid:15678383 |
| Lin P et al. | Lysophosphatidylcholine modulates neutrophil oxidant production through elevation of cyclic AMP. | 2005 | J. Immunol. | pmid:15728511 |
| Shimada T et al. | Platelet-activating factor acts on cortisol secretion by perfused guinea-pig adrenals via calcium-/phospholipid-dependent mechanisms. | 2005 | J. Endocrinol. | pmid:15684346 |
| Yasu T et al. | Activated leukocytes and endothelial cells enhance retention of ultrasound contrast microspheres containing perfluoropropane in inflamed venules. | 2005 | Int. J. Cardiol. | pmid:15686774 |
| Fell JM | Neonatal inflammatory intestinal diseases: necrotising enterocolitis and allergic colitis. | 2005 | Early Hum. Dev. | pmid:15707723 |
| Schaloske RH et al. | Molecular characterization of the lipopolysaccharide/platelet activating factor- and zymosan-induced pathways leading to prostaglandin production in P388D1 macrophages. | 2005 | Biochim. Biophys. Acta | pmid:15708354 |
| Mann NS and Leung JW | Pathogenesis of esophageal rings in eosinophilic esophagitis. | 2005 | Med. Hypotheses | pmid:15617859 |
| Cheng L et al. | Platelet-activating factor and prostaglandin E2 impair esophageal ACh release in experimental esophagitis. | 2005 | Am. J. Physiol. Gastrointest. Liver Physiol. | pmid:15890711 |
| Cheng L et al. | Hydrogen peroxide reduces lower esophageal sphincter tone in human esophagitis. | 2005 | Gastroenterology | pmid:16285965 |
| Boccellino M et al. | Platelet-activating factor regulates cadherin-catenin adhesion system expression and beta-catenin phosphorylation during Kaposi's sarcoma cell motility. | 2005 | Am. J. Pathol. | pmid:15855650 |
| Schram MT et al. | Advanced glycation end products are associated with pulse pressure in type 1 diabetes: the EURODIAB Prospective Complications Study. | 2005 | Hypertension | pmid:15851628 |
| Denizot Y et al. | Platelet-activating factor and human thyroid cancer. | 2005 | Eur. J. Endocrinol. | pmid:15994743 |
| Fulkerson PC et al. | CXCL9 inhibits eosinophil responses by a CCR3- and Rac2-dependent mechanism. | 2005 | Blood | pmid:15802529 |
| Androulakis N et al. | Molecular and mechanistic characterization of platelet-activating factor-like bioactivity produced upon LDL oxidation. | 2005 | J. Lipid Res. | pmid:15995176 |
| Grypioti AD et al. | Platelet-activating factor (PAF) involvement in acetaminophen-induced liver toxicity and regeneration. | 2005 | Arch. Toxicol. | pmid:15995853 |
| Chatterjee BE et al. | Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro. | 2005 | J. Leukoc. Biol. | pmid:16000391 |
| Guo NJ et al. | [Activation of platelet-neutrophil mediated by platelet-activating factor]. | 2005 | Zhongguo Shi Yan Xue Ye Xue Za Zhi | pmid:15972139 |
| Souza DG and Teixeira MM | The balance between the production of tumor necrosis factor-alpha and interleukin-10 determines tissue injury and lethality during intestinal ischemia and reperfusion. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962100 |
| Castro Faria Neto HC et al. | Regulating inflammation through the anti-inflammatory enzyme platelet-activating factor-acetylhydrolase. | 2005 | Mem. Inst. Oswaldo Cruz | pmid:15962103 |
| White DC et al. | Feasibility of assessment of regulatory lipids in breath condensate as potential presymptomatic harbingers of pulmonary pathobiology. | 2005 | J. Microbiol. Methods | pmid:15963585 |
| Jeon SY et al. | Rat model of platelet-activating factor-induced rhinosinusitis. | 2005 | Ann. Otol. Rhinol. Laryngol. | pmid:15966528 |
| Tiemann U et al. | Influence of ovarian steroid hormones or platelet-activating factor on mRNA of platelet-activating factor receptor in endometrial explant perfusion cultures from ovariectomized bovine. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:15967160 |
| Lang KS et al. | Mechanisms of suicidal erythrocyte death. | 2005 | Cell. Physiol. Biochem. | pmid:15956782 |
| Kita Y et al. | A multiplex quantitation method for eicosanoids and platelet-activating factor using column-switching reversed-phase liquid chromatography-tandem mass spectrometry. | 2005 | Anal. Biochem. | pmid:15958190 |
| Fang YH et al. | [Relationship between serum vWF and PAF in type 2 diabetic patients and diabetic nephropathy]. | 2005 | Di Yi Jun Yi Da Xue Xue Bao | pmid:15958323 |
| Vinson SM et al. | Neutrophil adherence to bladder microvascular endothelial cells following platelet-activating factor acetylhydrolase inhibition. | 2005 | J. Pharmacol. Exp. Ther. | pmid:15937147 |
| Sumita C et al. | Platelet activating factor induces cytoskeletal reorganization through Rho family pathway in THP-1 macrophages. | 2005 | FEBS Lett. | pmid:16004986 |
| Echazarreta AL et al. | Lack of systemic oxidative stress during PAF challenge in mild asthma. | 2005 | Respir Med | pmid:15823446 |
| Cao HC et al. | Determination of platelet-activating factor by reverse phase high-performance liquid chromatography and its application in viral hepatitis. | 2005 | World J. Gastroenterol. | pmid:16437644 |
| Chen C and Bazan NG | Lipid signaling: sleep, synaptic plasticity, and neuroprotection. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099392 |
| Vardar S et al. | Individual and combined effects of selective cyclooxygenase-2 inhibitor and omega-3 fatty acid on endotoxin-induced periodontitis in rats. | 2005 | J. Periodontol. | pmid:15830643 |
| Rubin BB et al. | Cytosolic phospholipase A2-alpha is necessary for platelet-activating factor biosynthesis, efficient neutrophil-mediated bacterial killing, and the innate immune response to pulmonary infection: cPLA2-alpha does not regulate neutrophil NADPH oxidase activity. | 2005 | J. Biol. Chem. | pmid:15475363 |
| Uhlig S et al. | Mechanisms of platelet-activating factor (PAF)-mediated responses in the lung. | 2005 | Pharmacol Rep | pmid:16415501 |
| Zinchuk O et al. | Direct action of platelet activating factor (PAF) induces eosinophil accumulation and enhances expression of PAF receptors in conjunctivitis. | 2005 | Mol. Vis. | pmid:15735601 |
| Hudry-Clergeon H et al. | Platelet-activating factor increases VE-cadherin tyrosine phosphorylation in mouse endothelial cells and its association with the PtdIns3'-kinase. | 2005 | FASEB J. | pmid:15791001 |
| Ersoy B et al. | The role of platelet-activating factor in pathogenesis of type 1 diabetes. | 2005 | Diabetes Care | pmid:15793212 |
| Grigoriou O et al. | Effect of sperm treatment with exogenous platelet-activating factor on the outcome of intrauterine insemination. | 2005 | Fertil. Steril. | pmid:15749490 |
| Cheng HH et al. | Defect in regulation of Ca2+ movement in platelets from patients with systemic lupus erythematosus. | 2005 | Pharmacology | pmid:15591819 |
| Penna C et al. | Platelet-activating factor induces cardioprotection in isolated rat heart akin to ischemic preconditioning: role of phosphoinositide 3-kinase and protein kinase C activation. | 2005 | Am. J. Physiol. Heart Circ. Physiol. | pmid:15637120 |
| Connelly PW et al. | Paraoxonase-1 does not reduce or modify oxidation of phospholipids by peroxynitrite. | 2005 | Free Radic. Biol. Med. | pmid:15607900 |
| Ivanov AI et al. | Albumin is not an irreplaceable carrier for amphipathic mediators of thermoregulatory responses to LPS: compensatory role of alpha1-acid glycoprotein. | 2005 | Am. J. Physiol. Regul. Integr. Comp. Physiol. | pmid:15576666 |
| Denizot Y et al. | Platelet-activating factor does not stimulate cAMP formation from immature forms of freshly isolated leukaemic blasts. | 2005 | Leuk. Lymphoma | pmid:15621790 |
| Tran KC et al. | Induction of angiogenesis by platelet-activating factor in the rat striatum. | 2005 | Neuroreport | pmid:16148749 |
| Milias GA et al. | Effects of eccentric exercise-induced muscle injury on blood levels of platelet activating factor (PAF) and other inflammatory markers. | 2005 | Eur. J. Appl. Physiol. | pmid:16151835 |
| Hauser CJ et al. | Non-specific effects of 4-chloro-m-cresol may cause calcium flux and respiratory burst in human neutrophils. | 2005 | Biochem. Biophys. Res. Commun. | pmid:16168959 |
| Kihara Y et al. | Dual phase regulation of experimental allergic encephalomyelitis by platelet-activating factor. | 2005 | J. Exp. Med. | pmid:16172262 |
| Tian X and Bazan NG | Neuroprotection by platelet-activating factor antagonism. | 2005 | Ann. N. Y. Acad. Sci. | pmid:16179552 |
| Zhang Q et al. | Staphylococcal lipoteichoic acid inhibits delayed-type hypersensitivity reactions via the platelet-activating factor receptor. | 2005 | J. Clin. Invest. | pmid:16184199 |
| Pexa A and Deussen A | Modulation of ecto-5'-nucleotidase by phospholipids in human umbilical vein endothelial cells (HUVEC). | 2005 | Naunyn Schmiedebergs Arch. Pharmacol. | pmid:16200394 |
| Nagata M et al. | Effect of the cysteinyl leukotriene antagonist pranlukast on transendothelial migration of eosinophils. | 2005 | Int. Arch. Allergy Immunol. | pmid:15947477 |
| Tunc SE et al. | Platelet-activating factor and P-selectin activities in thrombotic and nonthrombotic Behçet's patients. | 2005 | Rheumatol. Int. | pmid:15004723 |
| Hu G et al. | Isoflurane prevents platelets from enhancing neutrophil-induced coronary endothelial dysfunction. | 2005 | Anesth. Analg. | pmid:16243978 |
| Löhrke B et al. | Polar phospholipids from bovine endogenously oxidized low density lipoprotein interfere with follicular thecal function. | 2005 | J. Mol. Endocrinol. | pmid:16326838 |
| Besana A et al. | Lipids and two-pore domain K+ channels in excitable cells. | 2005 | Prostaglandins Other Lipid Mediat. | pmid:16099395 |