| MeSH term | MeSH ID | Detail |
|---|---|---|
| Hemolysis | D006461 | 131 associated lipids |
| Uremia | D014511 | 33 associated lipids |
| Colitis, Ulcerative | D003093 | 24 associated lipids |
| Stomach Ulcer | D013276 | 75 associated lipids |
| Kidney Failure, Chronic | D007676 | 51 associated lipids |
| Diabetes Mellitus | D003920 | 90 associated lipids |
| Hypoxia | D000860 | 23 associated lipids |
| Arrhythmias, Cardiac | D001145 | 42 associated lipids |
| Hypercalcemia | D006934 | 13 associated lipids |
| Neovascularization, Pathologic | D009389 | 39 associated lipids |
| Tumor Virus Infections | D014412 | 8 associated lipids |
| Adenocarcinoma | D000230 | 166 associated lipids |
| Dermatitis, Contact | D003877 | 59 associated lipids |
| Pain | D010146 | 64 associated lipids |
| Lupus Erythematosus, Systemic | D008180 | 43 associated lipids |
| Lung Diseases | D008171 | 37 associated lipids |
| Lung Neoplasms | D008175 | 171 associated lipids |
| Pulmonary Fibrosis | D011658 | 24 associated lipids |
| Wounds and Injuries | D014947 | 20 associated lipids |
| Pleurisy | D010998 | 20 associated lipids |
Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
|---|
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
|---|
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
| Function | Cross reference | Weighted score | Related literatures |
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What lipids are associated with Platelet activating factor?
Related references are published most in these journals:
| Lipid concept | Cross reference | Weighted score | Related literatures |
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
Related references are published most in these journals:
| Model | Cross reference | Weighted score | Related literatures |
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Tao Y et al. | Platelet-activating factor enhances urokinase-type plasminogen activator gene expression in corneal epithelium. | 1996 | Invest. Ophthalmol. Vis. Sci. | pmid:8814143 |
| Durán WN et al. | Platelet-activating factor modulates leukocyte adhesion to endothelium in ischemia-reperfusion. | 1996 | Microvasc. Res. | pmid:8812764 |
| Yasugahira H et al. | [The changes of blood gas analysis values and platelet aggregability on acute phase in the experimental model of pulmonary embolism prepared by sephadex G-75 (SG-75) injection]. | 1996 | Nihon Kyobu Shikkan Gakkai Zasshi | pmid:8810754 |
| Tachibana F et al. | Platelet-activating factor and leukotrienes in acute otitis media, secretory otitis media, and chronic otitis media on the acute excerbation. | 1996 | Auris Nasus Larynx | pmid:8809319 |
| Arima S et al. | Platelet-activating factor dilates efferent arterioles through glomerulus-derived nitric oxide. | 1996 | J. Am. Soc. Nephrol. | pmid:8808114 |
| Dunlop ME et al. | Production of hyaluronan by glomerular mesangial cells in response to fibronectin and platelet-derived growth factor. | 1996 | Kidney Int. | pmid:8807570 |
| Baskin SI et al. | The effects of EDRF/NO releasers or calcium ionophore A23187 on cyanide toxicity in mice. | 1996 | Toxicol. Appl. Pharmacol. | pmid:8806852 |
| Catalán RE et al. | Nitric oxide mediates the PAF-stimulated cyclic GMP production in hippocampal slices. | 1996 | Biochem. Biophys. Res. Commun. | pmid:8806587 |
| Marrakchi N et al. | [Biochemical and pharmacologic properties of platelet aggregants and platelet antiaggregants of viper venoms in Tunisia]. | 1994 Jul-Oct | Arch Inst Pasteur Tunis | pmid:8801850 |
| Noguchi K et al. | Involvement of nitric oxide and eicosanoids in platelet-activating factor-induced haemodynamic and haematological effects in dogs. | 1996 | Br. J. Pharmacol. | pmid:8799566 |
| Civelli M et al. | The involvement of the release of nitric oxide in the pharmacological activity of the new furoxan derivative CHF 2363. | 1996 | Br. J. Pharmacol. | pmid:8799563 |
| Westmoreland SV et al. | Toxicity of TNF alpha and platelet activating factor for human NT2N neurons: a tissue culture model for human immunodeficiency virus dementia. | 1996 | J. Neurovirol. | pmid:8799203 |
| van Rossem K et al. | The role of PAF and the effect of a specific PAF antagonist on local tissue PO2 and neuronal integrity during and after photothrombotic brain infarction in unanesthetised rabbits. | 1996 | Adv. Exp. Med. Biol. | pmid:8798843 |
| Marcheselli VL and Bazan NG | Sustained induction of prostaglandin endoperoxide synthase-2 by seizures in hippocampus. Inhibition by a platelet-activating factor antagonist. | 1996 | J. Biol. Chem. | pmid:8798751 |
| Parent JL et al. | Identification of transmembrane domain residues determinant in the structure-function relationship of the human platelet-activating factor receptor by site-directed mutagenesis. | 1996 | J. Biol. Chem. | pmid:8798529 |
| Abebe W et al. | Platelet-activating factor-induced inositol 1,4,5-trisphosphate generation in undifferentiated and differentiated U937 cells: role of tyrosine kinase. | 1996 | Int. J. Immunopharmacol. | pmid:8796445 |
| Takeda H et al. | Release of fructose and hexose phosphates from perivascular cells induced by low density lipoprotein and acceleration of protein glycation in vitro. | 1996 | Diabetes Res. Clin. Pract. | pmid:8792096 |
| Weikert LF and Bernard GR | Pharmacotherapy of sepsis. | 1996 | Clin. Chest Med. | pmid:8792067 |
| Aïssa J et al. | Biochemical and cellular effects of heparin-protamine injection in rabbits are partially inhibited by a PAF-acether receptor antagonist. | 1996 | Eur. J. Pharmacol. | pmid:8791000 |
| Naraba H et al. | Inhibitory effect of arachidonic acid on platelet-activating factor production in rat neutrophils. | 1996 | Eur. J. Pharmacol. | pmid:8790999 |
| Bazan NG and Allan G | Platelet-activating factor is both a modulator of synaptic function and a mediator of cerebral injury and inflammation. | 1996 | Adv Neurol | pmid:8790822 |
| Hirafuji M et al. | Involvement of platelet cyclic GMP but not cyclic AMP suppression in leukocyte-dependent platelet adhesion to endothelial cells induced by platelet-activating factor in vitro. | 1996 | Br. J. Pharmacol. | pmid:8789382 |
| Battye KM et al. | Ovine endometrium synthesizes and releases platelet-activating factor, which can cause the release of prostaglandin F2 alpha by the uterus in situ. | 1996 | Biol. Reprod. | pmid:8788186 |
| Yoshii H et al. | Neurotropin inhibits accumulation of eosinophils induced by allergen through the suppression of sensitized T-cells. | 1995 | Int. J. Immunopharmacol. | pmid:8788117 |
| Baker RR | Enzymes of platelet activating factor synthesis in brain. | 1995 | Neurochem. Res. | pmid:8786821 |
| Ogundaini A et al. | Isolation of two new antiinflammatory biflavanoids from Sarcophyte piriei. | 1996 | J. Nat. Prod. | pmid:8786365 |
| Uhlig S et al. | Cyclooxygenase-2-dependent bronchoconstriction in perfused rat lungs exposed to endotoxin. | 1996 | Mol. Med. | pmid:8784790 |
| Sasaki T et al. | A distribution study of 11C platelet-activating factor (PAF) analogs in normal and tumor-bearing mice. | 1996 | Nucl. Med. Biol. | pmid:8782242 |
| Almer S et al. | Concentrations of platelet activating factor in rectal mucosa in patients with ulcerative colitis. | 1996 | Eur J Surg | pmid:8781921 |
| Yang X et al. | Human platelet signaling defect characterized by impaired production of inositol-1,4,5-triphosphate and phosphatidic acid and diminished Pleckstrin phosphorylation: evidence for defective phospholipase C activation. | 1996 | Blood | pmid:8781423 |
| Khoury J and Langleben D | Platelet-activating factor stimulates lung pericyte growth in vitro. | 1996 | Am. J. Physiol. | pmid:8780000 |
| Kurose I et al. | Microvascular dysfunction induced by nonsteroidal anti-inflammatory drugs: role of leukocytes. | 1996 | Am. J. Physiol. | pmid:8779980 |
| Sterner-Kock A et al. | Recombinant tumour necrosis factor-alpha and platelet-activating factor synergistically increase intercellular adhesion molecule-1 and E-selectin-dependent neutrophil adherence to endothelium in vitro. | 1996 | Immunology | pmid:8778033 |
| Izumi T et al. | Platelet-activating factor receptor. | 1995 | J Lipid Mediat Cell Signal | pmid:8777584 |
| Sobhani I et al. | Helicobacter pylori stimulates gastric acid secretion via platelet activating factor. | 1996 | J. Physiol. Pharmacol. | pmid:8777297 |
| Ayala A and Chaudry IH | Platelet activating factor and its role in trauma, shock, and sepsis. | 1996 | New Horiz | pmid:8774801 |
| Nabe T et al. | Sephadex G-200-induced eosinophil infiltration into airways in non-sensitized and sensitized guinea pigs, and responsiveness of the cells to stimuli in vitro. | 1996 | Jpn. J. Pharmacol. | pmid:8774762 |
| Ueno A et al. | The mediators involved in endotoxin-induced vascular permeability increase in the rat skin and their interactions. | 1996 | Jpn. J. Pharmacol. | pmid:8774757 |
| Moriguchi T et al. | Diamide primes neutrophils for enhanced release of superoxide anion: relationship to S-thiolation of cellular proteins. | 1996 | J. Leukoc. Biol. | pmid:8773580 |
| Kamata K et al. | Mechanisms of desensitization of vasodilatation induced by platelet-activating factor in hypertensive rats. | 1996 | Eur. J. Pharmacol. | pmid:8773455 |
| Sun XM et al. | Role of leukocyte beta 2-integrin in PAF-induced shock and intestinal injury. | 1996 | Am. J. Physiol. | pmid:8772517 |
| Reinhardt PH et al. | Monosodium urate crystals promote neutrophil adhesion via a CD18-independent and selectin-independent mechanism. | 1996 | Am. J. Physiol. | pmid:8772427 |
| Shebzukhov IuV et al. | [The effect of platelet-activating factor and its synthetic analogs on Ia-antigen expression by mouse peritoneal macrophages]. | 1996 May-Jun | Zh. Mikrobiol. Epidemiol. Immunobiol. | pmid:8771751 |
| Walcher F et al. | Platelet-activating factor is involved in the regulation of pathological leukocyte adhesion after liver transplantation. | 1996 | J. Surg. Res. | pmid:8769973 |
| Harris NR and Granger DN | Mechanisms underlying enhanced capillary filtration induced by platelet-activating factor. | 1996 | Am. J. Physiol. | pmid:8769743 |
| de Paulis A et al. | Cyclosporin H is a potent and selective competitive antagonist of human basophil activation by N-formyl-methionyl-leucyl-phenylalanine. | 1996 | J. Allergy Clin. Immunol. | pmid:8765829 |
| Baker RR and Chang HY | Alkylglycerophosphate acetyltransferase and lyso platelet activating factor acetyltransferase, two key enzymes in the synthesis of platelet activating factor, are found in neuronal nuclei isolated from cerebral cortex. | 1996 | Biochim. Biophys. Acta | pmid:8765148 |
| Xie X et al. | Interdigitation of bilayers from ether lipid analogs: (R)-PAF, (R)-Lyso-PAF and the antineoplastic (R)-ET-18-OMe. | 1996 | Biochim. Biophys. Acta | pmid:8765102 |
| Lupia E et al. | Role of tumor necrosis factor-alpha and platelet-activating factor in neoangiogenesis induced by synovial fluids of patients with rheumatoid arthritis. | 1996 | Eur. J. Immunol. | pmid:8765007 |
| DeFily DV et al. | PAF attenuates endothelium-dependent coronary arteriolar vasodilation. | 1996 | Am. J. Physiol. | pmid:8764261 |