Platelet activating factor

Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.

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Introduction

To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.

What diseases are associated with Platelet activating factor?

Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.

Related references are mostly published in these journals:

Disease Cross reference Weighted score Related literature
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Possible diseases from mapped MeSH terms on references

We collected disease MeSH terms mapped to the references associated with Platelet activating factor

MeSH term MeSH ID Detail
Hemolysis D006461 131 associated lipids
Uremia D014511 33 associated lipids
Colitis, Ulcerative D003093 24 associated lipids
Stomach Ulcer D013276 75 associated lipids
Kidney Failure, Chronic D007676 51 associated lipids
Diabetes Mellitus D003920 90 associated lipids
Hypoxia D000860 23 associated lipids
Arrhythmias, Cardiac D001145 42 associated lipids
Hypercalcemia D006934 13 associated lipids
Neovascularization, Pathologic D009389 39 associated lipids
Tumor Virus Infections D014412 8 associated lipids
Adenocarcinoma D000230 166 associated lipids
Dermatitis, Contact D003877 59 associated lipids
Pain D010146 64 associated lipids
Lupus Erythematosus, Systemic D008180 43 associated lipids
Lung Diseases D008171 37 associated lipids
Lung Neoplasms D008175 171 associated lipids
Pulmonary Fibrosis D011658 24 associated lipids
Wounds and Injuries D014947 20 associated lipids
Pleurisy D010998 20 associated lipids
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PubChem Associated disorders and diseases

What pathways are associated with Platelet activating factor

There are no associated biomedical information in the current reference collection.

PubChem Biomolecular Interactions and Pathways

Link to PubChem Biomolecular Interactions and Pathways

What cellular locations are associated with Platelet activating factor?

Related references are published most in these journals:

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What functions are associated with Platelet activating factor?


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Function Cross reference Weighted score Related literatures

What lipids are associated with Platelet activating factor?

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What genes are associated with Platelet activating factor?

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Gene Cross reference Weighted score Related literatures

What common seen animal models are associated with Platelet activating factor?

Knock-out

Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).

Mouse Model

Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).

Transgenic Model

Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).

Related references are published most in these journals:

Model Cross reference Weighted score Related literatures
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NCBI Entrez Crosslinks

All references with Platelet activating factor

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Authors Title Published Journal PubMed Link
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Kawasaki T and Snyder F The metabolism of lyso-platelet-activating factor (1-O-alkyl-2-lyso-sn-glycero-3-phosphocholine) by a calcium-dependent lysophospholipase D in rabbit kidney medulla. 1987 Biochim. Biophys. Acta pmid:3036238
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Gora S et al. The proinflammatory mediator Platelet Activating Factor is an effective substrate for human group X secreted phospholipase A2. 2006 Biochim. Biophys. Acta pmid:16962371
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Fauler J et al. Platelet-activating factor induces the production of leukotrienes by human monocytes. 1989 Biochim. Biophys. Acta pmid:2790041
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Samples BL et al. Subcellular localization of enzyme activities involved in the metabolism of platelet-activating factor in rainbow trout leukocytes. 1999 Biochim. Biophys. Acta pmid:10101269
Siafaka-Kapadai A and Hanahan D An endogenous inhibitor of PAF-induced platelet aggregation, isolated from rat liver, has been identified as free fatty acid. 1993 Biochim. Biophys. Acta pmid:8382959
Banks JB et al. Evidence for protein-catalyzed transfer of platelet activating factor by macrophage cytosol. 1988 Biochim. Biophys. Acta pmid:3382692
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Touqui L et al. 1-O-alkyl-2-acyl-sn-glycero-3-phosphorylcholine is the precursor of platelet-activating factor in stimulated rabbit platelets. Evidence for an alkylacetyl-glycerophosphorylcholine cycle. 1985 Biochim. Biophys. Acta pmid:3967037
Kishino J et al. Synergistic effect of thromboxane A2 and N-formylmethionylleucylphenylalanine on platelet-activating factor synthesis in human polymorphonuclear neutrophils. 1991 Biochim. Biophys. Acta pmid:1673352
Flasiński M et al. Cholesterol as a factor regulating the influence of natural (PAF and lysoPAF) vs synthetic (ED) ether lipids on model lipid membranes. 2013 Biochim. Biophys. Acta pmid:23906729
Bachelet M et al. Changes induced by PAF-acether in diacyl and ether phospholipids from guinea-pig alveolar macrophages. 1986 Biochim. Biophys. Acta pmid:3092866
Montero M et al. Comparative effects of cytochrome P-450 inhibitors on Ca2+ and Mn2+ entry induced by agonists or by emptying the Ca2+ stores of human neutrophils. 1993 Biochim. Biophys. Acta pmid:7684611
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Nakayama R et al. Evidence for production of platelet-activating factor by yeast Saccharomyces cerevisiae cells. 1994 Biochim. Biophys. Acta pmid:8123662
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Bratton DL et al. A model for the extracellular release of PAF: the influence of plasma membrane phospholipid asymmetry. 1991 Biochim. Biophys. Acta pmid:1705442
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Teng CM et al. Antiplatelet effect of butylidenephthalide. 1987 Biochim. Biophys. Acta pmid:3109495
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Chepenik KP and Wykle RL Synthesis of platelet activating factor and metabolism of related lipids in embryonic cells. 1992 Biochim. Biophys. Acta pmid:1627622
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Watschinger K and Werner ER Orphan enzymes in ether lipid metabolism. 2013 Biochimie pmid:22771767
Olivier JL et al. Influence of PAF-acether on lecithin-oriented multibilayers monitored by ESR: interaction of PAF-acether with cholesterol. 1989 Biochimie pmid:2541796
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Nankar SA et al. Differential interaction of peptides derived from C-terminal domain of human apolipoprotein E with platelet activating factor analogs. 2013 Biochimie pmid:23376877
Yost CC et al. The platelet activating factor (PAF) signaling cascade in systemic inflammatory responses. 2010 Biochimie pmid:20167241
Tokumura A et al. Platelet-activating factor (PAF)-like oxidized phospholipids: relevance to atherosclerosis. 2000 Biofactors pmid:11237195
Grambow E et al. Differential effects of endogenous, phyto and synthetic cannabinoids on thrombogenesis and platelet activity. 2016 Biofactors pmid:27151562
Yoshikawa T et al. alpha-Tocopherol protects against expression of adhesion molecules on neutrophils and endothelial cells. 1998 Biofactors pmid:9523024
Zinchenko VP et al. [Effect of structural analogs of platelet activating factor on the intracellular signal transduction in murine peritoneal neutrophils and macrophages of P388D1 line]. 1997 Sep-Oct Biofizika pmid:9410037
Negresku EV et al. [Biochemical features of platelet alpha2-adrenergic receptors and their connection with an increase in concentration of intracellular Ca2+]. 1989 Biokhimiia pmid:2551395
Kuznetsova TI and Kulikov VI [The effect of aldehydogenic and acyl structural analogs of platelet activating factor on the formation of superoxide radicals by human blood leukocytes]. 1992 Biokhimiia pmid:1327185
Kulikov VI and Bergel'son LD [Binding of 1-0-alkyl-2-0-acetyl-sn-glycero-3-phosphocholine (thrombocyte activating factor) by plasma components. Exchange of the thrombocyte activating factor between lipoproteins and thrombocytes]. 1984 Biokhimiia pmid:6093897
Kulikov VI et al. [Incorporation of 1-0-alkyl-2-acetyl-sn-glycerol-3-phosphocholine into human plasma lipoproteins in vitro. Effect of the lecithin:cholesterol acyltransferase activity of plasma]. 1984 Biokhimiia pmid:6542803
Muzia GI et al. [Interaction of 1-O-alkyl-2-methoxy-sn-glycero-3-phosphocholine and platelet activating factor with blood and tumor cells]. 1994 Biokhimiia pmid:7948414
Lichko LP et al. [The effect of PAF, sphingosine and heparin on certain phosphohydrolase and transport activity of yeast vacuoles]. 1994 Biokhimiia pmid:7948417
Kulikov VI and Muzia GI [Biological role of cellular metabolites--structural analogs of platelet activating factor]. 1996 Biokhimiia pmid:8724598
Muzia GI and Kulikov VI [Effect of sn-2-acetylated analogs of phosphatidalic acid on release and aggregation of human platelets]. 1996 Biokhimiia pmid:8724603
Kulikov VI and Muzia GI [Acyl and plasmalogen analogs of platelet activating factor--new lipid cellular bioregulators]. 1992 Biokhimiia pmid:1420585
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Avdonin PV and Altukhova IP [Blocking with phorbol ester, a protein kinase C activator, of receptor-dependent platelet calcium channels]. 1985 Biokhimiia pmid:2416359
Avdonin PV et al. [Mechanism of increase in Ca2+ level in platelet cytoplasm induced by aggregating factors]. 1985 Biokhimiia pmid:3000463