Platelet activating factor
Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
Cross Reference
Introduction
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
What diseases are associated with Platelet activating factor?
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
Related references are mostly published in these journals:
| Disease | Cross reference | Weighted score | Related literature |
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Possible diseases from mapped MeSH terms on references
We collected disease MeSH terms mapped to the references associated with Platelet activating factor
PubChem Associated disorders and diseases
What pathways are associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
PubChem Biomolecular Interactions and Pathways
Link to PubChem Biomolecular Interactions and PathwaysWhat cellular locations are associated with Platelet activating factor?
Visualization in cellular structure
Associated locations are in red color. Not associated locations are in black.
Related references are published most in these journals:
| Location | Cross reference | Weighted score | Related literatures |
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What functions are associated with Platelet activating factor?
Related references are published most in these journals:
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What lipids are associated with Platelet activating factor?
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What genes are associated with Platelet activating factor?
Related references are published most in these journals:
| Gene | Cross reference | Weighted score | Related literatures |
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What common seen animal models are associated with Platelet activating factor?
Knock-out
Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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NCBI Entrez Crosslinks
All references with Platelet activating factor
Download all related citations| Authors | Title | Published | Journal | PubMed Link |
|---|---|---|---|---|
| Hynes AC et al. | The phosphatidylinositol signalling system in elongating bovine blastocysts; formation of phosphoinositides, inositol phosphates and stimulation by growth factors. | 2002 | Reprod. Fertil. Dev. | pmid:12617797 |
| Kulikov VI and Muzya GI | Influence of acyl and plasmalogenic analogs of platelet activating factor on chemotaxis of human leukocytes in vitro and their inflammatory and antiinflammatory activity in vivo. | 2002 | Biochemistry Mosc. | pmid:12495421 |
| Pawliczak R et al. | Oxidative stress induces arachidonate release from human lung cells through the epithelial growth factor receptor pathway. | 2002 | Am. J. Respir. Cell Mol. Biol. | pmid:12444032 |
| MacKinnon AC et al. | Sphingosine kinase: a point of convergence in the action of diverse neutrophil priming agents. | 2002 | J. Immunol. | pmid:12444147 |
| Marrache AM et al. | Proinflammatory gene induction by platelet-activating factor mediated via its cognate nuclear receptor. | 2002 | J. Immunol. | pmid:12444157 |
| Pacheco P et al. | Lipopolysaccharide-induced leukocyte lipid body formation in vivo: innate immunity elicited intracellular Loci involved in eicosanoid metabolism. | 2002 | J. Immunol. | pmid:12444160 |
| Abe Y et al. | Effect of a platelet-activating factor antagonist, E5880, on cerebrovasospasm following subarachnoid hemorrhage in a canine double-hemorrhage model. | 2002 | Eur. J. Pharmacol. | pmid:12445578 |
| Marathe GK et al. | Activation of vascular cells by PAF-like lipids in oxidized LDL. | 2002 | Vascul. Pharmacol. | pmid:12449015 |
| Lacombe J et al. | Antisense inhibition of Flk-1 by oligonucleotides composed of 2'-deoxy-2'-fluoro-beta-D-arabino- and 2'-deoxy-nucleosides. | 2002 | Can. J. Physiol. Pharmacol. | pmid:12450061 |
| Francescangeli E et al. | Activation of PAF-synthesizing enzymes in rat brain stem slices after LTP induction in the medial vestibular nuclei. | 2002 | Neurochem. Res. | pmid:12512951 |
| Roy Baker R and Chang Hy | MgATP may depress de novo neuronal nuclear PAF generation by promoting the formation of alkylacylglycerophosphate, an inhibitor of alkylglycerophosphate acetyltransferase. | 2002 | Biochim. Biophys. Acta | pmid:12457714 |
| Pan YH et al. | Crystal structure of phospholipase A2 complex with the hydrolysis products of platelet activating factor: equilibrium binding of fatty acid and lysophospholipid-ether at the active site may be mutually exclusive. | 2002 | Biochemistry | pmid:12475227 |
| Smith JM et al. | Platelet-activating factor and Escherichia coliO157:H7 infections. | 2002 | Pediatr. Nephrol. | pmid:12478356 |
| Ryan KL et al. | Platelet-activating factor does not mediate circulatory failure induced by 35-GHz microwave heating. | 2002 | Methods Find Exp Clin Pharmacol | pmid:12168504 |
| Takizawa T et al. | Inhibition of protein kinases A and C demonstrates dual modes of response in human eosinophils stimulated with platelet-activating factor. | 2002 | J. Allergy Clin. Immunol. | pmid:12170264 |
| Sun Z et al. | Effective treatment of gut barrier dysfunction using an antioxidant, a PAF inhibitor, and monoclonal antibodies against the adhesion molecule PECAM-1. | 2002 | J. Surg. Res. | pmid:12121711 |
| Mayer K et al. | Omega-3 fatty acids suppress monocyte adhesion to human endothelial cells: role of endothelial PAF generation. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:12124231 |
| Giorgi G et al. | Mass spectrometric characterization of substituted 2-thiazolin-4-one derivatives. | 2002 | J Mass Spectrom | pmid:12125004 |
| Kulikov VI and Muzya GI | Influence of platelet-activating factor, its cell analogs, and antagonist on the production of superoxide radicals by blood leukocytes of healthy and hypercholesterolemic individuals. | 2002 | Biochemistry Mosc. | pmid:12126473 |
| Leusch A et al. | Altered drug disposition of the platelet activating factor antagonist apafant in mdr1a knockout mice. | 2002 | Eur J Pharm Sci | pmid:12128165 |
| Megens AA et al. | Pharmacological profile of (2R-trans)-4-[1-[3,5-bis(trifluoromethyl)benzoyl]-2-(phenylmethyl)-4-piperidinyl]-N-(2,6-dimethylphenyl)-1-acetamide (S)-Hydroxybutanedioate (R116301), an orally and centrally active neurokinin-1 receptor antagonist. | 2002 | J. Pharmacol. Exp. Ther. | pmid:12130734 |
| Podolak-Dawidziak M | [Role of white cells and neoplastic cells in haemostasis]. | 2002 | Pol. Arch. Med. Wewn. | pmid:12189915 |
| Strømgaard K et al. | Ginkgolide derivatives for photolabeling studies: preparation and pharmacological evaluation. | 2002 | J. Med. Chem. | pmid:12190325 |
| Wong RK et al. | Augmentation of the neutrophil respiratory burst through the action of advanced glycation end products: a potential contributor to vascular oxidant stress. | 2002 | Diabetes | pmid:12196480 |
| Ahamed J and Ali H | Distinct roles of receptor phosphorylation, G protein usage, and mitogen-activated protein kinase activation on platelet activating factor-induced leukotriene C(4) generation and chemokine production. | 2002 | J. Biol. Chem. | pmid:11934880 |
| Li L et al. | Antiplatelet aggregation activity of diterpene alkaloids from Spiraea japonica. | 2002 | Eur. J. Pharmacol. | pmid:12163102 |
| Sakai H et al. | Nitric oxide-induced Cl- secretion in isolated rat colon is mediated by the release of thromboxane A2. | 2002 | J. Physiol. (Lond.) | pmid:12181297 |
| Roudebush WE et al. | Embryonic platelet-activating factor: temporal expression of the ligand and receptor. | 2002 | J. Assist. Reprod. Genet. | pmid:11958508 |
| Calcerrada MC et al. | PAF-stimulated protein tyrosine phosphorylation in hippocampus: involvement of NO synthase. | 2002 | Neurochem. Res. | pmid:11958533 |
| Fragopoulou E et al. | Biologically active lipids with antiatherogenic properties from white wine and must. | 2002 | J. Agric. Food Chem. | pmid:11958642 |
| Lloberas N et al. | The ether phospholipids trail: blood timing in renal ischemia-reperfusion injury. | 2002 | Transplant. Proc. | pmid:11959179 |
| Castellvi J et al. | Effect of the platelet-activating factor antagonist BN-52021 on liver preservation (4 degrees): experimental study in isolated reperfused rat liver model. | 2002 | Transplant. Proc. | pmid:11959181 |
| Wang LS et al. | Effects of platelet activating factor, butyrate and interleukin-6 on cyclooxygenase-2 expression in human esophageal cancer cells. | 2002 | Scand. J. Gastroenterol. | pmid:11989839 |
| Börjesson A et al. | Early treatment with lexipafant, a platelet-activating factor-receptor antagonist, is not sufficient to prevent pulmonary endothelial damage after intestinal ischaemia and reperfusion in rats. | 2002 | Dig Liver Dis | pmid:11990391 |
| Borgquist JD et al. | Adhesion to extracellular matrix proteins modulates bovine neutrophil responses to inflammatory mediators. | 2002 | J. Leukoc. Biol. | pmid:11994500 |
| Kalkanci A et al. | The role of tumour necrosis factor-alpha (TNF-alpha) and platelet-activating factor (PAF) interaction on murine candidosis. | 2002 | Mycoses | pmid:12000505 |
| Bernatchez PN et al. | Relative effects of VEGF-A and VEGF-C on endothelial cell proliferation, migration and PAF synthesis: Role of neuropilin-1. | 2002 | J. Cell. Biochem. | pmid:11968003 |
| Hostettler ME et al. | Platelet-activating factor induces cell death in cultured astrocytes and oligodendrocytes: involvement of caspase-3. | 2002 | Glia | pmid:11968060 |
| Boisfer E et al. | Antioxidant properties of HDL in transgenic mice overexpressing human apolipoprotein A-II. | 2002 | J. Lipid Res. | pmid:11971944 |
| Steel HC and Anderson R | Dissociation of the PAF-receptor from NADPH oxidase and adenylate cyclase in human neutrophils results in accelerated influx and delayed clearance of cytosolic calcium. | 2002 | Br. J. Pharmacol. | pmid:11976271 |
| McKay CJ | Recent developments in the management of acute pancreatitis. | 2002 | Dig Surg | pmid:11979001 |
| Roudebush WE et al. | Embryonic platelet-activating factor: an indicator of embryo viability. | 2002 | Hum. Reprod. | pmid:11980756 |
| Strait RT et al. | Pathways of anaphylaxis in the mouse. | 2002 | J. Allergy Clin. Immunol. | pmid:11941316 |
| Xu N et al. | Effects of platelet-activating factor, tumor necrosis factor, and interleukin-1alpha on the expression of apolipoprotein M in HepG2 cells. | 2002 | Biochem. Biophys. Res. Commun. | pmid:11944906 |
| Mohr PJ and Halcomb RL | Convergent enantioselective synthesis of the tricyclic core of phomactin A. | 2002 | Org. Lett. | pmid:12098260 |
| Yoshida H et al. | Platelet-activating factor enhances the expression of vascular endothelial growth factor in normal human astrocytes. | 2002 | Brain Res. | pmid:12106666 |
| Jaracz S et al. | Ginkgolides: selective acetylations, translactonization, and biological evaluation. | 2002 | J. Org. Chem. | pmid:12076171 |
| Downing SJ et al. | Effect of inflammatory mediators on the physiology of the human Fallopian tube. | 2002 | Hum Fertil (Camb) | pmid:12082208 |
| Honda Z et al. | Platelet-activating factor receptor. | 2002 | J. Biochem. | pmid:12038971 |
| Lloberas N et al. | Postischemic renal oxidative stress induces inflammatory response through PAF and oxidized phospholipids. Prevention by antioxidant treatment. | 2002 | FASEB J. | pmid:12039876 |
| Iatrou C et al. | Is platelet-activating factor produced during hemodialysis with AN-69 polyacrylonitrile membrane? | 2002 | Nephron | pmid:12021524 |
| Acuña AA et al. | Fluticasone propionate attenuates platelet-activating factor-induced gas exchange defects in mild asthma. | 2002 | Eur. Respir. J. | pmid:12030727 |
| Steel HC et al. | Platelet-activating factor and lyso-PAF possess direct antimicrobial properties in vitro. | 2002 | APMIS | pmid:12064871 |
| Yoshikawa M et al. | Effect of extracellular matrix proteins on platelet-activating factor-induced eosinophil chemotaxis. | 2002 | Int. Arch. Allergy Immunol. | pmid:12065903 |
| Haynes J and Obiako B | Activated polymorphonuclear cells increase sickle red blood cell retention in lung: role of phospholipids. | 2002 | Am. J. Physiol. Heart Circ. Physiol. | pmid:11748055 |
| Maul H et al. | Local application of platelet-activating factor induces cervical ripening accompanied by infiltration of polymorphonuclear leukocytes in rats. | 2002 | Am. J. Obstet. Gynecol. | pmid:12388958 |
| Christie PE and Henderson WR | Lipid inflammatory mediators: leukotrienes, prostaglandins, platelet-activating factor. | 2002 | Clin Allergy Immunol | pmid:11577541 |
| Murohisa G et al. | Involvement of platelet-activating factor in hepatic apoptosis and necrosis in chronic ethanol-fed rats given endotoxin. | 2002 | Liver | pmid:12390475 |
| Maniscalco M et al. | Nitric oxide attenuates platelet-activating factor induced nasal airway plasma extravasation in healthy subjects. | 2002 | Eur. J. Clin. Invest. | pmid:12423328 |
| Dun Y et al. | Activated polymorphonuclear leukocytes induce cardiomyocyte apoptosis and the protective effects of carvedilol. | 2002 | Methods Find Exp Clin Pharmacol | pmid:12428428 |
| Fallani A et al. | Synthesis of platelet-activating factor (PAF) in transformed cell lines of a different origin. | 2002 | Prostaglandins Other Lipid Mediat. | pmid:12428690 |
| Gélinas DS et al. | Immediate and delayed VEGF-mediated NO synthesis in endothelial cells: role of PI3K, PKC and PLC pathways. | 2002 | Br. J. Pharmacol. | pmid:12429574 |
| Mahmoud FF et al. | In vitro effects of ginkgolide B combined with cyclosporin A on T-lymphocyte activation and IL-5 expression in peripheral blood mononuclear cells from asthmatic subjects. | 2002 | Transplant. Proc. | pmid:12431672 |
| Bussolati B et al. | Expression of CD154 on renal cell carcinomas and effect on cell proliferation, motility and platelet-activating factor synthesis. | 2002 | Int. J. Cancer | pmid:12209602 |
| Cadwallader KA et al. | Regulation of phosphatidylinositol 3-kinase activity and phosphatidylinositol 3,4,5-trisphosphate accumulation by neutrophil priming agents. | 2002 | J. Immunol. | pmid:12218155 |
| Bussolati B et al. | Nitric oxide/platelet activating factor cross-talk in mesangial cells modulates the interaction with leukocytes. | 2002 | Kidney Int. | pmid:12234302 |
| Weyrich AS et al. | Platelets, endothelial cells, inflammatory chemokines, and restenosis: complex signaling in the vascular play book. | 2002 | Circulation | pmid:12234942 |
| Han SJ et al. | Molecular mechanisms for lipopolysaccharide-induced biphasic activation of nuclear factor-kappa B (NF-kappa B). | 2002 | J. Biol. Chem. | pmid:12235132 |
| Akai T et al. | Modulation of tissue-type plasminogen activator expression by platelet activating factor in human glioma cells. | 2002 | J. Neurooncol. | pmid:12241114 |
| Ibe BO et al. | Metabolism of platelet activating factor by intrapulmonary vascular smooth muscle cells. Effect of oxygen on phospholipase A2 protein expression and activities of acetyl-CoA acetyltransferase and cholinephosphotransferase. | 2002 | Mol. Genet. Metab. | pmid:12409272 |
| Childs EW et al. | In vivo visualization of reactive oxidants and leukocyte-endothelial adherence following hemorrhagic shock. | 2002 | Shock | pmid:12412620 |
| Eikelboom JW et al. | Clopidogrel does not suppress blood markers of coagulation activation in aspirin-treated patients with non-ST-elevation acute coronary syndromes. | 2002 | Eur. Heart J. | pmid:12419297 |
| Tanaka S and Koike T | Selective inflammatory stimulations enhance release of microglial response factor (MRF)-1 from cultured microglia. | 2002 | Glia | pmid:12420315 |
| Tsuyuki K et al. | Possible participation of intracellular platelet-activating factor in NF-kappaB activation in rat peritoneal macrophages. | 2002 | Biochim. Biophys. Acta | pmid:12069846 |
| Ichinowatari G et al. | Participation of prostaglandin E2 and platelet-activating factor in thapsigargin-induced production of interleukin-6. | 2002 | Eur. J. Pharmacol. | pmid:11779582 |
| Willoughby S et al. | Platelets and cardiovascular disease. | 2002 | Eur J Cardiovasc Nurs | pmid:14622657 |
| Breschi MC et al. | Protective effect of silymarin in antigen challenge- and histamine-induced bronchoconstriction in in vivo guinea-pigs. | 2002 | Eur. J. Pharmacol. | pmid:11864645 |
| Tanaka Y et al. | Anti-CD44 monoclonal antibody (IM7) induces murine systemic shock mediated by platelet activating factor. | 2002 | J. Autoimmun. | pmid:11869042 |
| Teruel MN and Meyer T | Parallel single-cell monitoring of receptor-triggered membrane translocation of a calcium-sensing protein module. | 2002 | Science | pmid:11884760 |
| Matorras R and Pijoan JI | The improvement in pregnancy rates with platelet-activating factor in intrauterine insemination was not demonstrated. | 2002 | Am. J. Obstet. Gynecol. | pmid:11904634 |
| McClenahan DJ et al. | In vitro evaluation of the role of platelet-activating factor and interleukin-8 in Mannheimia haemolytica-induced bovine pulmonary endothelial cell injury. | 2002 | Am. J. Vet. Res. | pmid:11911574 |
| Schwartzkopff F et al. | The CXC chemokine NAP-2 mediates differential heterologous desensitization of neutrophil effector functions elicited by platelet-activating factor. | 2002 | J. Interferon Cytokine Res. | pmid:11911809 |
| Royal SJ et al. | Laminar disorganisation of mitral cells in the olfactory bulb does not affect topographic targeting of primary olfactory axons. | 2002 | Brain Res. | pmid:11911856 |
| Ko HM et al. | Nuclear factor kappaB dependency of platelet-activating factor-induced angiogenesis. | 2002 | Cancer Res. | pmid:11912159 |
| Ishiguro K et al. | Bisxanthones from Hypericum japonicum: inhibitors of PAF-induced hypotension. | 2002 | Planta Med. | pmid:11914965 |
| Barabé F et al. | Cholesterol-modulating agents selectively inhibit calcium influx induced by chemoattractants in human neutrophils. | 2002 | J. Biol. Chem. | pmid:11839753 |
| Mio T et al. | Lysophosphatidic acid augments fibroblast-mediated contraction of released collagen gels. | 2002 | J. Lab. Clin. Med. | pmid:11873241 |
| Klein A et al. | Platelet-activating factor drives eotaxin production in an allergic pleurisy in mice. | 2002 | Br. J. Pharmacol. | pmid:11877329 |
| Bulger EM et al. | The macrophage response to endotoxin requires platelet activating factor. | 2002 | Shock | pmid:11900334 |
| Mitsuoka H et al. | Protease inhibition in the intestinal lumen: attenuation of systemic inflammation and early indicators of multiple organ failure in shock. | 2002 | Shock | pmid:11900339 |
| Kondratskaya EL et al. | BN52021, a platelet activating factor antagonist, is a selective blocker of glycine-gated chloride channel. | 2002 | Neurochem. Int. | pmid:11900860 |
| Unno N et al. | Association of a G994 -->T missense mutation in the plasma platelet-activating factor acetylhydrolase gene with risk of abdominal aortic aneurysm in Japanese. | 2002 | Ann. Surg. | pmid:11807372 |
| Johansson S et al. | A neutrophil multitarget functional bioassay to detect anti-inflammatory natural products. | 2002 | J. Nat. Prod. | pmid:11809061 |
| Chmiel B | [The influence of select pathophysiologic factors of acute pancreatitis on erythrocytes' deformability examined in vitro]. | 2002 | Wiad. Lek. | pmid:12715347 |
| Nagase T et al. | Airway hyperresponsiveness in transgenic mice overexpressing platelet activating factor receptor is mediated by an atropine-sensitive pathway. | 2002 | Am. J. Respir. Crit. Care Med. | pmid:11790655 |
| Roudebush WE et al. | Relationship between platelet-activating factor concentration in rhesus monkey (Macaca mulatta) spermatozoa and sperm motility. | 2002 | Am. J. Primatol. | pmid:11793409 |
| Furukawa M et al. | Presence of platelet-activating factor in nasal polyps and eosinophils. | 2002 | Acta Otolaryngol. | pmid:12542208 |
| Drost EM and MacNee W | Potential role of IL-8, platelet-activating factor and TNF-alpha in the sequestration of neutrophils in the lung: effects on neutrophil deformability, adhesion receptor expression, and chemotaxis. | 2002 | Eur. J. Immunol. | pmid:11813158 |
| Farmer PJ et al. | Inhibition of prostaglandin G/H synthase unveils a potent effect of platelet activating factor on the permeability of bovine aortic endothelial cells to albumin. | 2002 | Inflammation | pmid:12546134 |
| Claing A et al. | Comparison of the contractile and calcium-increasing properties of platelet-activating factor and endothelin-1 in the rat mesenteric artery and vein. | 2002 | Br. J. Pharmacol. | pmid:11815379 |