Platelet activating factor is a lipid of Glycerophospholipids (GP) class. Platelet activating factor is associated with abnormalities such as Atherosclerosis, Acute cholecystitis without calculus, Cholecystitis, Colitis and Cholecystitis, Acute. The involved functions are known as Cell Survival, Metabolic Inhibition, lipid oxidation, Apoptosis and Oxidation. Platelet activating factor often locates in soluble, Cellular Membrane, Smooth muscle (tissue), Intima and Tissue specimen. The associated genes with Platelet activating factor are apolipoprotein A-I Milano, Homologous Gene, TSPO gene, HBEGF gene and SLC33A1 gene. The related lipids are Hydroxycholesterols, Liposomes, 25-hydroxycholesterol, Lysophosphatidylcholines and Lipopolysaccharides. The related experimental models are Knock-out, Mouse Model and Transgenic Model.
To understand associated biological information of Platelet activating factor, we collected biological information of abnormalities, associated pathways, cellular/molecular locations, biological functions, related genes/proteins, lipids and common seen animal/experimental models with organized paragraphs from literatures.
Platelet activating factor is suspected in Ischemia, Pleurisy, Atherosclerosis, Inflammatory disorder, Retinal Diseases, Diabetes and other diseases in descending order of the highest number of associated sentences.
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We collected disease MeSH terms mapped to the references associated with Platelet activating factor
There are no associated biomedical information in the current reference collection.
Associated locations are in red color. Not associated locations are in black.
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Lipid concept | Cross reference | Weighted score | Related literatures |
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Knock-out are used in the study 'A cardioprotective role for platelet-activating factor through NOS-dependent S-nitrosylation.' (Leary PJ et al., 2008).
Mouse Model are used in the study 'A regulatory role of LPCAT1 in the synthesis of inflammatory lipids, PAF and LPC, in the retina of diabetic mice.' (Cheng L et al., 2009).
Transgenic Model are used in the study 'Heterogeneity in the sn-1 carbon chain of platelet-activating factor glycerophospholipids determines pro- or anti-apoptotic signaling in primary neurons.' (Ryan SD et al., 2008).
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Authors | Title | Published | Journal | PubMed Link |
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Fadok VA et al. | Macrophages that have ingested apoptotic cells in vitro inhibit proinflammatory cytokine production through autocrine/paracrine mechanisms involving TGF-beta, PGE2, and PAF. | 1998 | J. Clin. Invest. | pmid:9466984 |
Singh N et al. | Possible mechanism of alprazolam-induced amnesia in mice. | 1998 | Pharmacology | pmid:9467187 |
Golubeva TS et al. | [Determination of the nucleosomal fragmentation of DNA of ACL cells during their incubation with human platelets]. | 1997 | Biull Eksp Biol Med | pmid:9471253 |
Chupin VV et al. | On the synthesis of platelet-activating factor via acetylation of 1-alkyl-sn-glycero-3-phosphocholine. Formation of structural isomer of PAF in the presence of bases. | 1996 | Chem. Phys. Lipids | pmid:9471401 |
Thakur A et al. | The proinflammatory cytokines and arachidonic acid metabolites in human overnight tears: homeostatic mechanisms. | 1998 | J. Clin. Immunol. | pmid:9475355 |
Miotla JM et al. | Platelet-activating factor plays a pivotal role in the induction of experimental lung injury. | 1998 | Am. J. Respir. Cell Mol. Biol. | pmid:9476906 |
Jung KY et al. | Platelet activating factor antagonist activity of ginsenosides. | 1998 | Biol. Pharm. Bull. | pmid:9477174 |
Renis M et al. | Glutamine synthetase activity and HSP70 levels in cultured rat astrocytes: effect of 1-octadecyl-2-methyl-rac-glycero-3-phosphocholine. | 1998 | Brain Res. | pmid:9479063 |
Péterfy M et al. | Cloning and characterization of cDNAs and the gene encoding the mouse platelet-activating factor acetylhydrolase Ib alpha subunit/lissencephaly-1 protein. | 1998 | Genomics | pmid:9479492 |
Antonopoulou S et al. | Identification of a new endogenous platelet-activating factor-like molecule in gingival crevicular fluid. | 1998 | Biochem. J. | pmid:9480892 |
Mason GR et al. | Appropriate background correction for DTPA aerosol clearance. | 1998 | J. Appl. Physiol. | pmid:9480975 |
Erickson KL | Dietary fat, breast cancer, and nonspecific immunity. | 1998 | Nutr. Rev. | pmid:9481130 |
Abu-Zidan FM | Unexpected action of platelet activating factor antagonism after fluid resuscitation from traumatic shock. | 1998 | Surgery | pmid:9481416 |
Jocks T et al. | Platelet-activating factor mediates monocyte chemoattractant protein-1 expression in glomerular immune injury. | 1998 | Nephrol. Dial. Transplant. | pmid:9481713 |
Wise H | Activation of the prostaglandin EP4-receptor subtype is highly coupled to inhibition of N-formyl-methionyl-leucyl-phenylalanine-stimulated rat neutrophil aggregation. | 1998 | Prostaglandins Leukot. Essent. Fatty Acids | pmid:9482170 |
Ezeamuzie CI and Al-Hage M | Effects of some anti-asthma drugs on human eosinophil superoxide anions release and degranulation. | 1998 | Int. Arch. Allergy Immunol. | pmid:9482706 |
Yamawaki I et al. | Inhaled cromoglycate reduces airway neurogenic inflammation via tachykinin antagonism. | 1997 | Res. Commun. Mol. Pathol. Pharmacol. | pmid:9485521 |
Borman RA et al. | Investigation of the effects of platelet-activating factor (PAF) on ion transport and prostaglandin synthesis in human colonic mucosa in vitro. | 1998 | Br. J. Pharmacol. | pmid:9489610 |
Shi LC et al. | Involvement of platelet-activating factor in cell death induced under ischemia/postischemia-like conditions in an immortalized hippocampal cell line. | 1998 | J. Neurochem. | pmid:9489723 |
Matusiewicz R and Rotkiewicz-Piorun A | Inflammatory cells in skin immunological infiltrations. | 1997 Nov-Dec | J Investig Allergol Clin Immunol | pmid:9491202 |
Yang HO and Han BH | Pinusolidic acid: a platelet-activating factor inhibitor from Biota orientalis. | 1998 | Planta Med. | pmid:9491770 |
Rice SQ et al. | Expression, purification and characterization of a human serine-dependent phospholipase A2 with high specificity for oxidized phospholipids and platelet activating factor. | 1998 | Biochem. J. | pmid:9494101 |
Moritani C et al. | Activation of platelets in bronchial asthma. | 1998 | Chest | pmid:9498966 |
Pettit EJ and Hallett MB | Ca2+ signalling delays in neutrophils: effects of prior exposure to platelet activating factor or formyl-met-leu-phe. | 1998 | Cell. Signal. | pmid:9502117 |
Kimura K et al. | Modulation of platelet activating factor-induced glycogenolysis in the perfused rat liver after administration of endotoxin in vivo. | 1998 | J. Biochem. | pmid:9504421 |
Roy Baker R and Chang H | Substrate specificities of neuronal nuclear acetyltransferases involved in the synthesis of platelet-activating factor: differences in the use of 1-alkyl and 1-acyl lysophospholipid acceptors. | 1998 | Biochim. Biophys. Acta | pmid:9507140 |
Wilson PG et al. | Acute pancreatitis as a model of sepsis. | 1998 | J. Antimicrob. Chemother. | pmid:9511087 |
Fink MP | Therapeutic options directed against platelet activating factor, eicosanoids and bradykinin in sepsis. | 1998 | J. Antimicrob. Chemother. | pmid:9511090 |
Qayumi KA et al. | A new platelet-activating factor antagonist (CV-6209) in preservation of heart and lung for transplantation. | 1997 | Cardiovasc Drugs Ther | pmid:9512873 |
Webber SE et al. | PAF-induced secretory hyperresponsiveness in the ferret trachea to bradykinin and its pharmacological inhibition. | 1997 | Pulm Pharmacol Ther | pmid:9514626 |
Balsa D et al. | Effects of a new platelet-activating factor antagonist, UR-12670, on several endotoxic shock markers in rats. | 1997 | Drugs Exp Clin Res | pmid:9515229 |
Chung KF | Platelet activating factor revisited. | 1997 | Thorax | pmid:9516891 |
Shindo K et al. | Enhancement of leukotriene B4 release in stimulated asthmatic neutrophils by platelet activating factor. | 1997 | Thorax | pmid:9516893 |
Cannon TR et al. | Mechanisms of acute vasodilator response to bacterial lipopolysaccharide in the rat coronary microcirculation. | 1998 | Br. J. Pharmacol. | pmid:9517382 |
Tsuji H et al. | The presence of platelet-activating factor-acetylhydrolase in human middle ear effusions. | 1998 Jan-Feb | ORL J. Otorhinolaryngol. Relat. Spec. | pmid:9519378 |
Lukiw WJ et al. | Budesonide epimer R or dexamethasone selectively inhibit platelet-activating factor-induced or interleukin 1beta-induced DNA binding activity of cis-acting transcription factors and cyclooxygenase-2 gene expression in human epidermal keratinocytes. | 1998 | Proc. Natl. Acad. Sci. U.S.A. | pmid:9520467 |
Evangelista S et al. | Antihistaminic and antiallergic properties of dextro-mequitamium iodide in upper and lower guinea pig airways: comparison with azelastine. | 1998 | Gen. Pharmacol. | pmid:9522168 |
Yoshikawa T et al. | alpha-Tocopherol protects against expression of adhesion molecules on neutrophils and endothelial cells. | 1998 | Biofactors | pmid:9523024 |
Lopes-Martins RA et al. | The acute increases in vasomotor tone and blood pressure induced by carotid artery occlusion are modulated by platelet-activating factor (PAF) independently of nitric oxide release. | 1997 | J Lipid Mediat Cell Signal | pmid:9524924 |
Oh-hashi K et al. | Possible mechanisms for the differential effects of high linoleate safflower oil and high alpha-linolenate perilla oil diets on platelet-activating factor production by rat polymorphonuclear leukocytes. | 1997 | J Lipid Mediat Cell Signal | pmid:9524928 |
Diven WF et al. | Expression of acute otitis media after receptor blockade of platelet activating factor, thromboxane, and leukotrienes in the chinchilla. | 1998 | Ann. Otol. Rhinol. Laryngol. | pmid:9525240 |
Kulikov VI and Muzya GI | The bioregulatory role of platelet-activating factor in intracellular processes and cell-cell interactions. | 1998 | Biochemistry Mosc. | pmid:9526094 |
Mabilat-Pragnon C et al. | Urokinase localization and activity in isolated eosinophils. | 1997 | Thromb. Res. | pmid:9526961 |
Harris AG et al. | Mechanisms of cell injury in rat mesentery and cremaster muscle. | 1998 | Am. J. Physiol. | pmid:9530215 |
Ostrovsky L et al. | A juxtacrine mechanism for neutrophil adhesion on platelets involves platelet-activating factor and a selectin-dependent activation process. | 1998 | Blood | pmid:9531616 |
Michibayashi T | Different types of vasocontractile responses to noradrenaline in the presence of platelets with platelet activating factor. | 1997 | J Smooth Muscle Res | pmid:9533823 |
Yamada T et al. | Effects of inhaled nitric oxide on platelet-activating factor-induced pulmonary hypertension in dogs. | 1998 | Acta Anaesthesiol Scand | pmid:9542566 |
Ishii I et al. | Agonist-induced sequestration, recycling, and resensitization of platelet-activating factor receptor. Role of cytoplasmic tail phosphorylation in each process. | 1998 | J. Biol. Chem. | pmid:9545329 |
Bonsignore L et al. | One-step synthesis and pharmacological activity of new (N-substituted)amino-spiroalkan-dione derivatives. | 1997 | Farmaco | pmid:9550091 |
Sperber K et al. | Mucin secretion in inflammatory bowel disease: comparison of a macrophage-derived mucin secretagogue (MMS-68) to conventional secretagogues. | 1998 | Inflamm. Bowel Dis. | pmid:9552223 |